Gastrodin

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1 Diseases Researched for Gastrodin
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Tourette Syndrome12Locked
1 Pharmacological Actions Researched for Gastrodin
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Dopamine Agents12Locked

View the Evidence:
71 Abstracts with Gastrodin Research

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A combination of gastrodin, folate, and vitamin-B12 in addition to standard antiepileptic treatment can effectively control epileptic seizures.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Nov ;14(5):4801-4806. Epub 2017 Sep 14. PMID: 29201182
Article Published Date : Oct 31, 2017
Study Type : Human Study
Additional Links
Substances : Folate, Gastrodin, Vitamin B-12
Diseases : Epilepsy, Stroke: Attenuation/Recovery
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Interleukin-2 Downregulation, Interleukin-6 Downregulation
[+]

Dual restoring effects of gastrodin on dopamine in rat models of Tourette's syndrome.Feb 18, 2015

Pubmed Data : Neurosci Lett. 2015 Feb 19 ;588:62-6. Epub 2014 Dec 27. PMID: 25549540
Article Published Date : Feb 18, 2015
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Tourette Syndrome
Pharmacological Actions : Neuroprotective Agents
[+]

Early intervention with gastrodin reduces striatal neurotoxicity in adult rats with experimentally‑induced diabetes mellitus.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Apr ;19(4):3114-3122. Epub 2019 Feb 14. PMID: 30816461
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Diabetes: Cognitive Dysfunction, Diabetic Complications
Pharmacological Actions : Neuroprotective Agents
[+]

Effect of gastrodin on early brain injury and neurological outcome after subarachnoid hemorrhage in rats.Jan 22, 2019

Pubmed Data : Neurosci Bull. 2019 Jan 23. Epub 2019 Jan 23. PMID: 30673960
Article Published Date : Jan 22, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Subarachnoid hemorrhage
Pharmacological Actions : Neuroprotective Agents
[+]

Gastrodin alleviates cerebral ischemic damage in mice.Mar 31, 2015

Pubmed Data : Neurochem Res. 2015 Apr ;40(4):661-73. Epub 2015 Jan 13. PMID: 25582916
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Brain Ischemia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Gastrodin alleviates cognitive dysfunction and depressive-like behaviours.Dec 09, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Dec 10 ;19(12). Epub 2018 Dec 10. PMID: 30544722
Article Published Date : Dec 09, 2018
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Depression, Diabetes: Cognitive Dysfunction
Pharmacological Actions : Anti-Apoptotic, Antidepressive Agents, Hypoglycemic Agents, Neuroprotective Agents
[+]

Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer's disease.Jul 31, 2014

Pubmed Data : Neuropathology. 2014 Aug ;34(4):370-7. Epub 2014 Mar 25. PMID: 24661139
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Gastrodin alleviates Tourette syndrome via Nrf-2/HO-1/HMGB1/NF-кB pathway.Aug 29, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Aug 30:e22389. Epub 2019 Aug 30. PMID: 31468582
Article Published Date : Aug 29, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Tourette Syndrome
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Gastrodin alleviates vascular dementia in a 2-VO-vascular dementia rat model.Nov 20, 2019

Pubmed Data : Pharmacology. 2019 Nov 21:1-11. Epub 2019 Nov 21. PMID: 31752010
Article Published Date : Nov 20, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Dementia
Pharmacological Actions : Neuroprotective Agents
[+]

Gastrodin ameliorated rat cartilage degeneration in an osteoarthritis model of knee joints in vivo.Dec 31, 2017

Pubmed Data : Biomed Pharmacother. 2018 Jan ;97:642-651. Epub 2017 Nov 6. PMID: 29101808
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Inflammation, Osteoarthritis: Knee
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Osteoprotective , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gastrodin ameliorates acute rejection via IRE1α/TRAF2/NF-κB in rats receiving liver allografts.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:9276831. Epub 2019 Nov 20. PMID: 31828147
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Organ Transplantation
Pharmacological Actions : Anti-Apoptotic
[+]

Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells.May 31, 2014

Pubmed Data : Behav Brain Res. 2014 Jun 1 ;266:153-60. Epub 2014 Mar 5. PMID: 24613238
Article Published Date : May 31, 2014
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Brain Inflammation , Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-1 beta downregulation, Neuroprotective Agents
[+]

Gastrodin ameliorates motor learning deficits through preserving cerebellar long-term depression pathways in diabetic rats.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2019 ;13:1239. Epub 2019 Nov 22. PMID: 31824244
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Neuroprotective Agents
[+]

Gastrodin ameliorates oxidative stress and proinflammatory response in nonalcoholic fatty liver disease.Feb 29, 2016

Pubmed Data : Phytother Res. 2016 Mar ;30(3):402-11. Epub 2015 Dec 4. PMID: 26634892
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Inflammation, Nonalcoholic fatty liver disease (NAFLD), Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Gastrodin ameliorates spinal cord injury via antioxidant and anti-inflammatory effects.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Biochim Pol. 2016 ;63(3):589-93. Epub 2016 Jul 30. PMID: 27474401
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Gastrodin ameliorates subacute phase cerebral ischemia‑reperfusion injury by inhibiting inflammation and apoptosis.Oct 31, 2016

Pubmed Data : Mol Med Rep. 2016 Nov ;14(5):4144-4152. Epub 2016 Sep 26. PMID: 27748849
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Brain Ischemia, Inflammation
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation
[+]

Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation.Apr 14, 2013

Pubmed Data : Biochem Pharmacol. 2013 Apr 15 ;85(8):1124-33. Epub 2013 Jan 29. PMID: 23376120
Article Published Date : Apr 14, 2013
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gastrodin can significantly relieve the Tourette syndrome induced by DOI in rats.Feb 19, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Feb 20:e22302. Epub 2019 Feb 20. PMID: 30790395
Article Published Date : Feb 19, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Brain Inflammation , Tourette Syndrome
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Gastrodin could be of importance for the treatment of Parkinson's disease.Aug 31, 2014

Pubmed Data : Neurochem Int. 2014 Sep ;75:79-88. Epub 2014 Jun 14. PMID: 24932697
Article Published Date : Aug 31, 2014
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Gastrodin exerts a neuroprotective effect on retinal ganglion cells in an acute glaucoma animal model.Dec 31, 2016

Pubmed Data : Int J Ophthalmol. 2017 ;10(10):1483-1489. Epub 2017 Oct 18. PMID: 29062764
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Glaucoma, Inflammation
Pharmacological Actions : Neuroprotective Agents
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Gastrodin exerts robust neuroprotection in the post-ischemic brain.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anim Cells Syst (Seoul). 2018 ;22(6):429-437. Epub 2018 Nov 30. PMID: 30533266
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Gastrodin has potential benefits for stroke and patients with epilepsy.Jun 29, 2016

Pubmed Data : Chin J Physiol. 2016 Jun 30 ;59(3):156-64. PMID: 27188468
Article Published Date : Jun 29, 2016
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Seizures, Stroke
Pharmacological Actions : Anticonvulsants
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Gastrodin improves cognitive dysfunction and decreases oxidative stress in vascular dementia rats induced by chronic ischemia.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(11):14099-109. Epub 2015 Nov 1. PMID: 26823723
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Brain Ischemia, Dementia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents
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Gastrodin improves preeclampsia-induced cell apoptosis by regulation of TLR4/NF-κB.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2020 Feb ;8(2):820-829. Epub 2020 Jan 10. PMID: 32148791
Article Published Date : Jan 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Pre-Eclampsia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
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Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(6):e39647. Epub 2012 Jun 25. PMID: 22761855
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Diabetic Neuropathy, Hyperalgesia
Pharmacological Actions : Analgesics
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Gastrodin inhibits Aβ production and accumulation by inhibiting β-secretase.Dec 31, 2015

Pubmed Data : Yao Xue Xue Bao. 2016 04 ;51(4):588-94. PMID: 29859528
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Alzheimer's Disease, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Gastrodin inhibits neuroinflammation in rotenone-induced Parkinson's disease model.Feb 14, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2012 Feb 15 ;7(5):325-31. PMID: 25774170
Article Published Date : Feb 14, 2012
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Brain Inflammation , Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
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Gastrodin is anti-inflammatory as it effectively suppresses inflammasome in oxygen-glucose-deprivation-stimulated astrocytes.Jun 18, 2019

Pubmed Data : Neuromolecular Med. 2019 Jun 19. Epub 2019 Jun 19. PMID: 31218587
Article Published Date : Jun 18, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-18 down-regulation, Neuroprotective Agents, NF-kappaB Inhibitor
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Gastrodin is efficacious in protecting liver cells from ethanol-induced injury and apoptosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2018 ;41(5):670-679. PMID: 29709905
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Alcohol Toxicity , Alcoholic Liver Disease
Pharmacological Actions : Anti-Apoptotic, Hepatoprotective
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Gastrodin may be a potential therapeutic target in autism.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurol. 2018 ;9:1052. Epub 2018 Dec 7. PMID: 30581411
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Autism
Pharmacological Actions : Neuroprotective Agents
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Gastrodin may be useful in the prevention and treatment of osteoporosis.Mar 31, 2015

Pubmed Data : Bone. 2015 Apr ;73:132-44. Epub 2014 Dec 29. PMID: 25554600
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Osteoporosis
Pharmacological Actions : Interleukin-6 Downregulation
Additional Keywords : Ovariectomy-Induced Changes
[+]

Gastrodin may have a therapeutic effect in Tourette's syndrome.Apr 01, 2009

Pubmed Data : Biosci Trends. 2009 Apr;3(2):58-62. PMID: 20103948
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Tourette Syndrome
Pharmacological Actions : Dopamine Agents
[+]

Gastrodin played a protective role in myocardial ischemia-reperfusion injury.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Jun ;17(6):4389-4394. Epub 2019 Apr 19. PMID: 31105779
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
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Gastrodin pretreatment alleviates myocardial ischemia/reperfusion injury through promoting autophagic flux.Jan 17, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 09 18 ;503(4):2421-2428. Epub 2018 Jul 3. PMID: 29969626
Article Published Date : Jan 17, 2018
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Gastrodin pretreatment alleviates rat brain injury caused by cerebral ischemic-reperfusion.May 31, 2019

Pubmed Data : Brain Res. 2019 Jun 1 ;1712:207-216. Epub 2019 Feb 8. PMID: 30742808
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Gastrodin prevents motor deficits and oxidative stress in model of Parkinson's diseaseOct 01, 2014

Pubmed Data : Life Sci. 2014 Oct 2 ;114(2):77-85. Epub 2014 Aug 14. PMID: 25132361
Article Published Date : Oct 01, 2014
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Gastrodin protects against cardiac hypertrophy and fibrosis.Dec 31, 2011

Pubmed Data : Mol Cell Biochem. 2012 Jan ;359(1-2):9-16. Epub 2011 Jul 16. PMID: 21833534
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Cardioprotective
[+]

Gastrodin protects apoptotic dopaminergic neurons in a toxin-induced Parkinson's disease model.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:514095. Epub 2013 Mar 3. PMID: 23533492
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson's disease model.Jun 16, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Neurosci. 2019 Jun 17 ;20(1):31. Epub 2019 Jun 17. PMID: 31208386
Article Published Date : Jun 16, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
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Gastrodin reversed the traumatic stress-induced depressed-like symptoms in rats.Sep 30, 2016

Pubmed Data : J Nat Med. 2016 Oct ;70(4):749-59. Epub 2016 Jul 14. PMID: 27417451
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Gastrodin suppresses the amyloid β-induced increase of spontaneous discharge in the entorhinal cortex.Dec 31, 2013

Pubmed Data : Neural Plast. 2014 ;2014:320937. Epub 2014 Oct 30. PMID: 25485157
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
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Gastrodin treatment markedly preserved the Wnt/β-Catenin signalling pathway, which could promote neurogenesis and provide neuroprotection brain injury.May 31, 2019

Pubmed Data : Brain Res. 2019 Jun 1 ;1712:7-15. Epub 2019 Feb 1. PMID: 30716287
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cerebral Stroke
Pharmacological Actions : Neurogenesis, Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation
[+]

Gastrodin was able to prevent or delay dexamethasone induced osteoporosis.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2018 Apr ;41(4):2059-2069. Epub 2018 Jan 23. PMID: 29393365
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Osteoporosis
Pharmacological Actions : Antioxidants, Nrf2 activation, Osteoprotective
Problem Substances : Dexamethasone
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Hepatoprotective effect of gastrodin against alcohol-induced liver injury.Jan 31, 2019

Pubmed Data : J Physiol Biochem. 2019 Feb ;75(1):29-37. Epub 2018 Sep 21. PMID: 30242628
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Alcohol Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Long-term gastrodin treatment could represent a novel pharmacological strategy for 3,3'-Iminodipropionitrile-induced memory impairment.May 05, 2015

Pubmed Data : Neurosci Lett. 2015 May 6 ;594:40-5. Epub 2015 Mar 26. PMID: 25817367
Article Published Date : May 05, 2015
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Memory Disorders: Drug-Induced
Pharmacological Actions : Neuroprotective Agents
[+]

Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury.Oct 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Oct 31 ;8(53):90979-90995. Epub 2017 Jun 28. PMID: 29207618
Article Published Date : Oct 30, 2017
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Stroke: Ischemic
Pharmacological Actions : Neuroprotective Agents
[+]

Protective effect of gastrodin on peripheral neuropathy induced by anti-tumor treatment.Dec 16, 2018

Pubmed Data : Drug Chem Toxicol. 2018 Dec 17:1-8. Epub 2018 Dec 17. PMID: 30554535
Article Published Date : Dec 16, 2018
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Chemotherapy-Induced Toxicity: Peripheral Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effects of gastrodin on lead-induced synaptic plasticity deficits in rat hippocampus.Jul 31, 2009

Pubmed Data : Planta Med. 2009 Aug ;75(10):1112-7. Epub 2009 Mar 16. PMID: 19291610
Article Published Date : Jul 31, 2009
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Lead Poisoning, Prenatal Chemical Exposures
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Lead
[+]

The antihypertensive mechanism of gastrodin may be attributable to the direct intervention of renin-angiotensin-aldosterone system.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:828427. Epub 2015 Oct 26. PMID: 26587048
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

The combination of gastrodin and rhynchophylline exerts neuroprotective effects by preventing ischaemia-induced inflammasome activation.Oct 10, 2019

Pubmed Data : Life Sci. 2019 Oct 11 ;239:116935. Epub 2019 Oct 11. PMID: 31610203
Article Published Date : Oct 10, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Brain Inflammation , Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, Neuroprotective Agents
[+]

The overall results indicate that gastrodin attenuates pentylenetetrazole-induced seizures in a concentration-dependent manner.Mar 31, 2018

Pubmed Data : Neurochem Res. 2018 Apr ;43(4):904-917. Epub 2018 Feb 7. PMID: 29417472
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Epilepsy, Oxidative Stress, Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Dose Response
[+]

These findings suggest that gastrodin alleviated glucocorticoid-induced osteoporosis.Feb 19, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Feb 20 ;9(14):11528-11540. Epub 2018 Jan 3. PMID: 29545917
Article Published Date : Feb 19, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Osteoporosis
Pharmacological Actions : Antioxidants, Osteogenic
[+]

These results indicate that gastrodin possesses anxiolytic effect and may be an effective herbal preparation for the treatment of PTSD.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Res. 2013 ;62(5):537-45. Epub 2013 Sep 10. PMID: 24020812
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Anxiety, Post-Traumatic Stress Disorders (PTSD)
Pharmacological Actions : Anti-Anxiety Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

These results show the efficacy and underlying mechanism of gastrodin against amyloid β (1-42)-induced neurotoxicity.Aug 31, 2016

Pubmed Data : J Mol Neurosci. 2016 Sep ;60(1):21-32. Epub 2016 Apr 26. PMID: 27112440
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

This study revealed a dramatic analgesic action of gastrodin on inflammatory pain.Jan 16, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 11 17 ;6:37251. Epub 2016 Nov 17. PMID: 27853254
Article Published Date : Jan 16, 2016
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
[+]

This study revealed a lipid regulation and anti-oxidant insights of gastrodin on NAFLD.Apr 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Apr 23 ;20(8). Epub 2019 Apr 23. PMID: 31018538
Article Published Date : Apr 22, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Antioxidants, Hypolipidemic
[+]

Gastrodin attenuates proliferation and inflammatory responses in activated microglia through Wnt/β-catenin signaling pathway.Aug 14, 2019

Pubmed Data : Brain Res. 2019 Aug 15 ;1717:190-203. Epub 2019 Apr 24. PMID: 31026457
Article Published Date : Aug 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

Gastrodin can inhibit H2O2-induced ferroptosis through its antioxidative effect in C6 cells.Dec 31, 2019

Pubmed Data : Biol Pharm Bull. 2020 ;43(3):480-487. PMID: 32115506
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Hydrogen Peroxide Induced Toxicity, Iron Overload, Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Gastrodin elicited anti-apoptotic and anti-inflammatory effects by a mechanism involving Nrf2 in SH-SY5Y cells.May 26, 2019

Pubmed Data : J Mol Neurosci. 2019 May 27. Epub 2019 May 27. PMID: 31134531
Article Published Date : May 26, 2019
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gastrodin has a potential as an anti-inflammatory treatment candidate in neurodegenerative diseases.Dec 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2011 ;6(7):e21891. Epub 2011 Jul 12. PMID: 21765922
Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gastrodin inhibits glutamate-induced apoptosis of PC12 cells.Apr 30, 2014

Pubmed Data : Cell Mol Neurobiol. 2014 May ;34(4):591-602. Epub 2014 Mar 12. PMID: 24619207
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Gastrodin inhibits high glucose‑induced human retinal endothelial cell apoptosis.May 31, 2018

Pubmed Data : Mol Med Rep. 2018 Jun ;17(6):7774-7780. Epub 2018 Apr 3. PMID: 29620267
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Diabetic Retinopathy, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic
[+]

Gastrodin is a new potential agent for the treatment of human glioblastoma .Aug 31, 2017

Pubmed Data : Food Chem Toxicol. 2017 Sep ;107(Pt A):280-292. Epub 2017 Jul 6. PMID: 28689919
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Glioblastoma, Oxidative Stress
Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Plant Extracts, Selective Cytotoxicity
[+]

Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway.May 08, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 May 9 ;8(19):32147-32156. PMID: 28389632
Article Published Date : May 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gastrodin protects rat cardiomyocytes H9c2 from hypoxia-induced injury by up-regulation of microRNA-21.Mar 31, 2019

Pubmed Data : Int J Biochem Cell Biol. 2019 Apr ;109:8-16. Epub 2019 Jan 23. PMID: 30684569
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Myocardial Infarction
Pharmacological Actions : Cardioprotective, MicroRNA modulator
[+]

Gastrodin relieves inflammation injury induced by lipopolysaccharides in MRC-5 cells by up-regulation of miR-103.Nov 24, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 Nov 25. Epub 2019 Nov 25. PMID: 31769187
Article Published Date : Nov 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, MicroRNA modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer's disease.Jan 13, 2016

Pubmed Data : Neuroscience. 2016 06 14 ;325:1-9. Epub 2016 Mar 14. PMID: 26987953
Article Published Date : Jan 13, 2016
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons.May 31, 2007

Pubmed Data : Planta Med. 2007 Jun ;73(7):650-4. Epub 2007 Jun 22. PMID: 17583824
Article Published Date : May 31, 2007
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Brain Ischemia, Hypoxia
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

The results indicate that gastrodin exerts vasorelaxation effect through activation of PKA.Nov 30, 2017

Pubmed Data : J Recept Signal Transduct Res. 2017 Dec ;37(6):543-549. Epub 2017 Aug 25. PMID: 28840751
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Vasodilator Agents
[+]

These results suggest that gastrodin is neuroprotective after intracerebral hemorrhage.Nov 10, 2019

Pubmed Data : J Stroke Cerebrovasc Dis. 2019 Nov 11:104483. Epub 2019 Nov 11. PMID: 31727597
Article Published Date : Nov 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Intracerebral Hemorrhage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

This review summarizes the beneficial effects of gastrodin acting on activated microglia along with other herbal compounds.Dec 31, 2017

Pubmed Data : Curr Med Chem. 2018 ;25(42):5958-5974. PMID: 29446722
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Substances : Gastrodin
Diseases : Brain: Microglial Activation, Inflammation, Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents

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