Formononetin

Name	AC	CK	Focus
Hypothyroidism	1	2
Low Testosterone	1	2

Name	AC	CK	Focus
Secretagogue	1	2
Steroidogenesis	1	2

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Pubmed Data : PLoS One. 2021 ;16(1):e0245050. Epub 2021 Jan 7. PMID: 33411783

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Formononetin

Diseases : Hypoxia, Lung Injury: Acute

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

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Renoprotective effect of formononetin by suppressing Smad3 expression in Db/Db mice.Dec 31, 2019

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Pubmed Data : Planta Med. 2016 Jan ;82(1-2):65-9. Epub 2016 Jan 12. PMID: 26756818

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Pubmed Data : Int Immunopharmacol. 2009 Nov ;9(12):1357-65. Epub 2009 Aug 17. PMID: 19695348

Article Published Date : Oct 31, 2009

Study Type : Animal Study

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Substances : Formononetin

Diseases : Fractures: Bone, Wound Healing

Pharmacological Actions : Angiogenesis Inducing Agents

Additional Keywords : Phytotherapy, Plant Extracts

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This study has identified that calycosin and formononetin can increase the treatment effect of temozolomide.Oct 04, 2019

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Pubmed Data : Redox Biol. 2020 Sep ;36:101677. Epub 2020 Aug 6. PMID: 32823168

Article Published Date : Aug 31, 2020

Study Type : In Vitro Study

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Substances : Formononetin

Diseases : Chemotherapy-Induced Toxicity: Oxaliplatin, Chemotherapy-Induced Toxicity: Peripheral Neuropathy

Pharmacological Actions : Chemoprotective Agents

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Formononetin ameliorates the drug resistance of Taxol resistant triple negative breast cancer by inhibiting autophagy.Dec 31, 2020

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Pubmed Data : Kaohsiung J Med Sci. 2020 Nov 24. Epub 2020 Nov 24. PMID: 33231363

Article Published Date : Nov 23, 2020

Study Type : In Vitro Study

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Substances : Formononetin

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , MicroRNA modulator

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Pubmed Data : J Ethnopharmacol. 2018 Jul 15 ;221:91-99. Epub 2018 Apr 13. PMID: 29660466

Article Published Date : Jul 14, 2018

Study Type : In Vitro Study

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Substances : Formononetin

Diseases : Ovarian Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer.Apr 09, 2020

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View the Evidence: 96 Abstracts with Formononetin Research

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A hydroalcoholic extract of red propolis presented anti-nociceptive action on inflammatory and neurogenic pain without motor side effects.Jul 16, 2015

Anti-colorectal cancer mechanisms of formononetin identified by network pharmacological approach.Apr 30, 2019

Anxiolytic effects of Formononetin in an inflammatory pain model.Jan 07, 2019

Formononetin activates the Nrf2/ARE signaling pathway Via Sirt1 to improve diabetic renal fibrosis.Dec 31, 2019

Formononetin administration ameliorates dextran sulfate sodium-induced acute colitis.Dec 31, 2017

Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy.Jul 24, 2019

Formononetin ameliorates diabetic neuropathy.May 26, 2020

Formononetin ameliorates muscle atrophy.Jan 05, 2021

Formononetin ameliorates myocardial ischemia/reperfusion injury. May 06, 2020

Formononetin and biochanin A protects against ritonavir induced hepatotoxicity.Nov 14, 2018

Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice.Dec 31, 2019

Formononetin could be a promising agent for the treatment of autoimmune hepatitis.Mar 31, 2021

Formononetin could improve the cognitive function by inhibiting neuroinflammation.Aug 06, 2019

Formononetin enhances bone regeneration in a mouse model of cortical bone defect.May 31, 2017

Formononetin enhances the tumoricidal effect of everolimus by inhibiting the activity of Akt.Dec 31, 2018

Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice.Dec 31, 2016

Formononetin had the therapeutic effects in attenuating airway inflammation and oxidative stress in asthma.Dec 31, 2019

Formononetin has a protective effect on lipopolysaccharide-induced acute lung injury in mice.Nov 30, 2013

Formononetin has inhibitory effects on the proliferation of U2SO cells.Dec 31, 2014

Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway.Dec 31, 2017

Formononetin inhibits inflammation and promotes gastric mucosal angiogenesis in gastric ulcer.Oct 25, 2020

Formononetin is an effective molecule to control nephropathy in type 2 diabetes mellitus.Feb 14, 2019

Formononetin may be a promising candidate for the treatment and prevention of osteoarthritis.Jul 31, 2019

Formononetin mediates neuroprotection against cerebral ischemia/reperfusion.Sep 14, 2014

Formononetin mediates the promising anti-traumatic brain injury effects against neurocyte damage.Mar 14, 2014

Formononetin prevents ovariectomy-induced bone loss in rats.Mar 31, 2010

Formononetin protects against cisplatin‑induced acute kidney injury.Nov 30, 2020

Formononetin protects against ox-LDL-induced endothelial dysfunction.Nov 30, 2021

Formononetin recovered injured nerve functions after ischemic stroke.Feb 16, 2020

Formononetin regulates multiple oncogenic signalling cascades and enhances sensitivity to bortezomib in a multiple myeloma mouse model.Jul 06, 2019

Formononetin treatment reduces insulin resistance and attenuate hyperglycemia in type 2 diabetes.Dec 31, 2017

Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models.Dec 28, 2015

Hydroalcoholic extracts of red propolis and formononetin are gastroprotective in acute ulcer models.Sep 25, 2020

In vitro and in vivo studies of antiosteosarcoma activities of formononetin.Jul 31, 2019

Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury.Dec 31, 2016

Inhibitory effects of formononetin on the monocrotaline‑induced pulmonary arterial hypertension.Feb 29, 2020

Neuroprotective effect of formononetin against traumatic brain injury.Sep 30, 2018

Neuroprotective effect of formononetin in ameliorating learning and memory impairment in mouse model of Alzheimer's disease.Dec 31, 2017

Phytoestrogens can stimulate testosterone synthesis during puberty in male goats by increasing the secretion of T3; a hormone known to stimulate Leydig cell steroidogenesis.Dec 10, 2009

red clover extract and biochanin A or formononetin significantly ameliorate the lipid profiles of STZ-diabetic mice.May 31, 2012

Reduction of hyperoxic acute lung injury in mice by formononetin.Dec 31, 2020

Renoprotective effect of formononetin by suppressing Smad3 expression in Db/Db mice.Dec 31, 2019

The anti-inflammatory effects of formononetin and ononin on lipopolysaccharide-induced zebrafish models based on lipidomics and targeted transcriptomics.Jan 24, 2019

The oral administration of formononetin decelerated tumor growth through.Jan 31, 2020

The protective effect of formononetin on cognitive impairment in streptozotocin-induced diabetic mice.Sep 30, 2018

These findings demonstrate that formononetin exerted the hair regrowth effect on hair loss.Dec 31, 2015

These findings indicate that formononetin exhibits significant anti-cancer effects in multiple myeloma.Dec 31, 2017

These results indicate the use of formononetin in the prevention of breast cancer carcinogenesis.Aug 31, 2011

These results suggest that formononetin promotes early fracture healing through angiogenesis activation in the early stage of fracture repair.Oct 31, 2009

This study has identified that calycosin and formononetin can increase the treatment effect of temozolomide.Oct 04, 2019

A review of formononetin and its anticancer potentials and mechanisms.Dec 31, 2018

Focus on formononetin: anticancer potential and molecular targets.Apr 30, 2019

Formononetin ameliorated mast cell-mediated allergic inflammation.Nov 30, 2017

Formononetin ameliorates high glucose‑induced endothelial dysfunction.Aug 31, 2019

Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells.Nov 30, 2021

Formononetin ameliorates oxaliplatin-induced peripheral neuropathy.Aug 31, 2020

Formononetin ameliorates the drug resistance of Taxol resistant triple negative breast cancer by inhibiting autophagy.Dec 31, 2020

Formononetin and epirubicin may pave the way for a powerful chemotherapeutic regimen for treating human cervical cancer.Oct 04, 2013

Formononetin and metformin act synergistically to inhibit growth of MCF-7 breast cancer cells in vitro.Dec 31, 2018

Formononetin attenuates atopic dermatitis by upregulating A20 expression.Sep 20, 2020

Formononetin attenuates Aβ25-35-induced cytotoxicity in HT22 cells.Jan 02, 2017

Formononetin can inhibit the growth of cervical cancer and reduce the mRNA and protein expression levels of HIF-1α and VEGF.Aug 31, 2019

Formononetin exhibits anticancer activity in gastric carcinoma cell and regulating miR-542-5p.Nov 23, 2020

Formononetin induces apoptosis in PC-3 prostate cancer cells.Dec 31, 2013

Formononetin inhibits colon carcinoma cell growth and invasion.May 31, 2018

Formononetin inhibits enterovirus 71 replication.Feb 28, 2015

Formononetin inhibits human bladder cancer cell proliferation and invasiveness.Mar 21, 2017

Formononetin inhibits lipopolysaccharide-induced release of high mobility group box.Dec 31, 2017

Formononetin inhibits proliferation and metastasis of ovarian cancer cells.Jul 14, 2018

Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer.Apr 09, 2020

Formononetin is a potential therapeutic agent for the treatment of neurodegenerative diseases.May 29, 2021

Formononetin may be developed as an antioxidant treatment in diabetic retinopathy.Dec 31, 2013

Formononetin

View the Evidence:
96 Abstracts with Formononetin Research