Formononetin

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View the Evidence:
77 Abstracts with Formononetin Research

[+]

A hydroalcoholic extract of red propolis presented anti-nociceptive action on inflammatory and neurogenic pain without motor side effects.Jul 16, 2015

Pubmed Data : J Ethnopharmacol. 2015 Jul 17. Epub 2015 Jul 17. PMID: 26192808
Article Published Date : Jul 16, 2015
Study Type : Animal Study
Additional Links
Substances : Formononetin, Propolis: Brazillian
Diseases : Inflammation, Pain
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive
Additional Keywords : Plant Extracts
[+]

Anti-colorectal cancer mechanisms of formononetin identified by network pharmacological approach.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 May ;23(5):3505-3511. Epub 2019 Mar 15. PMID: 30873755
Article Published Date : Apr 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Chemotherapeutic
[+]

Anxiolytic effects of Formononetin in an inflammatory pain model.Jan 07, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Brain. 2019 04 8 ;12(1):36. Epub 2019 Apr 8. PMID: 30961625
Article Published Date : Jan 07, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Anxiety Disorders, Inflammation
Pharmacological Actions : Anti-Anxiety Agents, NF-kappaB Inhibitor
[+]

Formononetin administration ameliorates dextran sulfate sodium-induced acute colitis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2018 ;2018:3048532. Epub 2018 Jan 8. PMID: 29507526
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy.Jul 24, 2019

Pubmed Data : J Nutr Biochem. 2019 Jul 25 ;73:108214. Epub 2019 Jul 25. PMID: 31520816
Article Published Date : Jul 24, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective, Hypolipidemic
[+]

Formononetin ameliorates diabetic neuropathy.May 26, 2020

Pubmed Data : Chem Biodivers. 2020 May 27. Epub 2020 May 27. PMID: 32459048
Article Published Date : May 26, 2020
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Diabetes Mellitus: Type 2, Diabetic Neuropathy
Pharmacological Actions : Renoprotective, SIRT1 Activator
[+]

Formononetin ameliorates myocardial ischemia/reperfusion injury. May 06, 2020

Pubmed Data : Biochem Biophys Res Commun. 2020 May 7 ;525(3):759-766. Epub 2020 Mar 4. PMID: 32145915
Article Published Date : May 06, 2020
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Formononetin and biochanin A protects against ritonavir induced hepatotoxicity.Nov 14, 2018

Pubmed Data : Life Sci. 2018 Nov 15 ;213:174-182. Epub 2018 Oct 13. PMID: 30326221
Article Published Date : Nov 14, 2018
Study Type : Animal Study
Additional Links
Substances : Biochanin A, Formononetin
Diseases : HIV Protease Inhibitor Ritonavir Toxicity, Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor
[+]

Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE-/- mice.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Theranostics. 2020 ;10(3):1090-1106. Epub 2020 Jan 1. PMID: 31938053
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Formononetin could improve the cognitive function by inhibiting neuroinflammation.Aug 06, 2019

Pubmed Data : CNS Neurol Disord Drug Targets. 2019 Aug 7. Epub 2019 Aug 7. PMID: 31389320
Article Published Date : Aug 06, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Alzheimer's Disease, Brain Inflammation , High Fat Diet
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Formononetin enhances bone regeneration in a mouse model of cortical bone defect.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Nutr. 2017 Jun ;117(11):1511-1522. Epub 2017 Jul 10. PMID: 28689509
Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Formononetin, Isoflavones
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
Additional Keywords : Bone Regeneration
[+]

Formononetin enhances the tumoricidal effect of everolimus by inhibiting the activity of Akt.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:9610629. Epub 2019 Mar 17. PMID: 31007702
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic
[+]

Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Biol Med (Maywood). 2017 01 ;242(2):223-230. Epub 2016 Jul 24. PMID: 27412955
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Hypoglycemic Agents
[+]

Formononetin has a protective effect on lipopolysaccharide-induced acute lung injury in mice.Nov 30, 2013

Pubmed Data : Inflammation. 2013 Dec ;36(6):1560-6. PMID: 23907652
Article Published Date : Nov 30, 2013
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Formononetin has inhibitory effects on the proliferation of U2SO cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2015 ;37(3):933-9. Epub 2015 Sep 18. PMID: 26381132
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Dose Response
[+]

Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:3675-3684. Epub 2018 Nov 1. PMID: 30464399
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Hypertension
Pharmacological Actions : Hypoglycemic Agents, Vasodilator Agents
[+]

Formononetin is an effective molecule to control nephropathy in type 2 diabetes mellitus.Feb 14, 2019

Pubmed Data : Life Sci. 2019 Feb 15 ;219:109-121. Epub 2019 Jan 11. PMID: 30641085
Article Published Date : Feb 14, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2, Diabetic Nephropathy
Pharmacological Actions : Hypoglycemic Agents, Renoprotective, SIRT1 Activator
[+]

Formononetin may be a promising candidate for the treatment and prevention of osteoarthritis.Jul 31, 2019

Pubmed Data : Inflammation. 2019 Aug ;42(4):1426-1440. PMID: 30937838
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
[+]

Formononetin mediates neuroprotection against cerebral ischemia/reperfusion.Sep 14, 2014

Pubmed Data : J Neurol Sci. 2014 Sep 15 ;344(1-2):100-4. Epub 2014 Jun 22. PMID: 24996490
Article Published Date : Sep 14, 2014
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents
[+]

Formononetin mediates the promising anti-traumatic brain injury effects against neurocyte damage.Mar 14, 2014

Pubmed Data : J Neurol Sci. 2014 Mar 15 ;338(1-2):112-7. Epub 2013 Dec 27. PMID: 24411660
Article Published Date : Mar 14, 2014
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Formononetin prevents ovariectomy-induced bone loss in rats.Mar 31, 2010

Pubmed Data : Arch Pharm Res. 2010 Apr ;33(4):625-32. Epub 2010 Apr 27. PMID: 20422373
Article Published Date : Mar 31, 2010
Study Type : Animal Study
Additional Links
Substances : Formononetin
Pharmacological Actions : Osteoprotective
Additional Keywords : Ovariectomy-Induced Changes
[+]

Formononetin recovered injured nerve functions after ischemic stroke.Feb 16, 2020

Pubmed Data : Biochem Biophys Res Commun. 2020 Feb 17. Epub 2020 Feb 17. PMID: 32081422
Article Published Date : Feb 16, 2020
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Stroke: Ischemic
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neuroprotective Agents
[+]

Formononetin regulates multiple oncogenic signalling cascades and enhances sensitivity to bortezomib in a multiple myeloma mouse model.Jul 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Jul 7 ;9(7). Epub 2019 Jul 7. PMID: 31284669
Article Published Date : Jul 06, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative , Chemosensitizer
[+]

Formononetin treatment reduces insulin resistance and attenuate hyperglycemia in type 2 diabetes.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:739. Epub 2018 Jul 18. PMID: 30072892
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Hypoglycemic Agents, Insulin Sensitizers, Pancreato Protective Agents, SIRT1 Activator
[+]

Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models.Dec 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Dec 29 ;6(42):44563-78. PMID: 26575424
Article Published Date : Dec 28, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Breast Cancer, Cancers: All, Lymphoma, Multiple Myeloma
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Angiogenic, Antiproliferative
[+]

In vitro and in vivo studies of antiosteosarcoma activities of formononetin.Jul 31, 2019

Pubmed Data : J Cell Physiol. 2019 Aug ;234(10):17305-17313. Epub 2019 Feb 20. PMID: 30790283
Article Published Date : Jul 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic, MicroRNA modulator
[+]

Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2017 ;9(12):5653-5661. Epub 2017 Dec 15. PMID: 29312517
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, MicroRNA modulator, Neuroprotective Agents
[+]

Inhibitory effects of formononetin on the monocrotaline‑induced pulmonary arterial hypertension.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Mar ;21(3):1192-1200. Epub 2020 Jan 3. PMID: 31922224
Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Hypertension: Pulmonary
Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Neuroprotective effect of formononetin against traumatic brain injury.Sep 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 Oct ;106:349-354. Epub 2018 Jul 11. PMID: 29966980
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Neuroprotective effect of formononetin in ameliorating learning and memory impairment in mouse model of Alzheimer's disease.Dec 31, 2017

Pubmed Data : Biosci Biotechnol Biochem. 2018 Jan ;82(1):57-64. Epub 2017 Dec 1. PMID: 29191087
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Alzheimer's Disease, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Phytoestrogens can stimulate testosterone synthesis during puberty in male goats by increasing the secretion of T3; a hormone known to stimulate Leydig cell steroidogenesis.Dec 10, 2009

Pubmed Data : Acta Vet Scand. 2009 Dec 10;51:51. PMID: 20003293
Article Published Date : Dec 10, 2009
Study Type : Animal Study
Additional Links
Substances : Biochanin A, Daidzein, Formononetin, Genistein, phytoestrogens
Diseases : Hypothyroidism, Low Testosterone
Pharmacological Actions : Secretagogue, Steroidogenesis
[+]

red clover extract and biochanin A or formononetin significantly ameliorate the lipid profiles of STZ-diabetic mice.May 31, 2012

Pubmed Data : Phytother Res. 2012 Jun ;26(6):860-4. Epub 2011 Nov 14. PMID: 22084061
Article Published Date : May 31, 2012
Study Type : Animal Study
Additional Links
Substances : Biochanin A, Formononetin, Red Clover
Diseases : Diabetes Mellitus: Type 2, Dyslipidemias
Pharmacological Actions : Hypolipidemic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

The anti-inflammatory effects of formononetin and ononin on lipopolysaccharide-induced zebrafish models based on lipidomics and targeted transcriptomics.Jan 24, 2019

Pubmed Data : Metabolomics. 2019 11 25 ;15(12):153. Epub 2019 Nov 25. PMID: 31768751
Article Published Date : Jan 24, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

The oral administration of formononetin decelerated tumor growth through.Jan 31, 2020

Pubmed Data : Oncol Rep. 2020 Feb ;43(2):700-710. Epub 2019 Dec 13. PMID: 31894318
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Head and Neck Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemotherapeutic
[+]

The protective effect of formononetin on cognitive impairment in streptozotocin-induced diabetic mice.Sep 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 Oct ;106:1250-1257. Epub 2018 Jul 20. PMID: 30119194
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Drug: Metformin
[+]

These findings demonstrate that formononetin exerted the hair regrowth effect on hair loss.Dec 31, 2015

Pubmed Data : Planta Med. 2016 Jan ;82(1-2):65-9. Epub 2016 Jan 12. PMID: 26756818
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Hair Loss
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Hair Regeneration
[+]

These findings indicate that formononetin exhibits significant anti-cancer effects in multiple myeloma.Dec 31, 2017

Pubmed Data : Cancer Lett. 2018 09 1 ;431:123-141. Epub 2018 May 29. PMID: 29857127
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Multiple Myeloma, Oxidative Stress
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, STAT3 Inhibitor
[+]

These results indicate the use of formononetin in the prevention of breast cancer carcinogenesis.Aug 31, 2011

Pubmed Data : Horm Metab Res. 2011 Sep ;43(10):681-6. Epub 2011 Sep 19. PMID: 21932171
Article Published Date : Aug 31, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
Additional Keywords : Drug: Tamoxifen
[+]

These results suggest that formononetin promotes early fracture healing through angiogenesis activation in the early stage of fracture repair.Oct 31, 2009

Pubmed Data : Int Immunopharmacol. 2009 Nov ;9(12):1357-65. Epub 2009 Aug 17. PMID: 19695348
Article Published Date : Oct 31, 2009
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Fractures: Bone, Wound Healing
Pharmacological Actions : Angiogenesis Inducing Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

This study has identified that calycosin and formononetin can increase the treatment effect of temozolomide.Oct 04, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ethnopharmacol. 2019 Oct 5 ;242:111699. Epub 2019 Apr 18. PMID: 31005632
Article Published Date : Oct 04, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Formononetin, Isoflavones
Diseases : Gliomas
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Temozolomide
[+]

A review of formononetin and its anticancer potentials and mechanisms.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:820. Epub 2019 Jul 26. PMID: 31402861
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Formononetin
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Apoptotic, Chemopreventive, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Focus on formononetin: anticancer potential and molecular targets.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2019 May 1 ;11(5). Epub 2019 May 1. PMID: 31052435
Article Published Date : Apr 30, 2019
Study Type : Review
Additional Links
Substances : Formononetin
Diseases : Breast Cancer, Colorectal Cancer, Prostate Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Cell cycle arrest
[+]

Formononetin ameliorated mast cell-mediated allergic inflammation.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Dec ;14(6):6201-6206. Epub 2017 Oct 12. PMID: 29250144
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Allergies, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Histamine down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Formononetin ameliorates high glucose‑induced endothelial dysfunction.Aug 31, 2019

Pubmed Data : Mol Med Rep. 2019 Sep ;20(3):2893-2901. Epub 2019 Jul 19. PMID: 31524234
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Formononetin and epirubicin may pave the way for a powerful chemotherapeutic regimen for treating human cervical cancer.Oct 04, 2013

Pubmed Data : Chem Biol Interact. 2013 Oct 5 ;205(3):188-97. Epub 2013 Jul 16. PMID: 23867903
Article Published Date : Oct 04, 2013
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Formononetin and metformin act synergistically to inhibit growth of MCF-7 breast cancer cells in vitro.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:2084-2089. Epub 2018 Nov 26. PMID: 30551465
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Hypoglycemic Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Formononetin attenuates Aβ25-35-induced cytotoxicity in HT22 cells.Jan 02, 2017

Pubmed Data : Neurosci Lett. 2017 02 3 ;639:36-42. Epub 2016 Dec 26. PMID: 28034780
Article Published Date : Jan 02, 2017
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Formononetin can inhibit the growth of cervical cancer and reduce the mRNA and protein expression levels of HIF-1α and VEGF.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2019 Sep ;18(3):2248-2253. Epub 2019 Jul 5. PMID: 31452725
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, MicroRNA modulator, Vascular Endothelial Growth Factor Inhibitors
[+]

Formononetin induces apoptosis in PC-3 prostate cancer cells.Dec 31, 2013

Pubmed Data : Nutr Cancer. 2014 ;66(4):656-61. Epub 2014 Mar 25. PMID: 24666255
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Formononetin inhibits colon carcinoma cell growth and invasion.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Jun ;17(6):7721-7729. Epub 2018 Apr 5. PMID: 29620230
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Colon Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , MicroRNA modulator, STAT3 Inhibitor
[+]

Formononetin inhibits enterovirus 71 replication.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Virol J. 2015 Mar 1 ;12:35. Epub 2015 Mar 1. PMID: 25890183
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Coxsackievirus Infections, Enterovirus: Type 71
Pharmacological Actions : Antiviral Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Formononetin inhibits human bladder cancer cell proliferation and invasiveness.Mar 21, 2017

Pubmed Data : Food Funct. 2017 Mar 22 ;8(3):1061-1066. PMID: 28139790
Article Published Date : Mar 21, 2017
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Bladder Cancer, Cancer Metastasis
Pharmacological Actions : Antiproliferative , MicroRNA modulator
Additional Keywords : Dose Response
[+]

Formononetin inhibits lipopolysaccharide-induced release of high mobility group box.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PeerJ. 2018 ;6:e4208. Epub 2018 Jan 3. PMID: 29312829
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, SIRT1 Activator
[+]

Formononetin inhibits proliferation and metastasis of ovarian cancer cells.Jul 14, 2018

Pubmed Data : J Ethnopharmacol. 2018 Jul 15 ;221:91-99. Epub 2018 Apr 13. PMID: 29660466
Article Published Date : Jul 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer.Apr 09, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2020 Apr 10 ;39(1):62. Epub 2020 Apr 10. PMID: 32276600
Article Published Date : Apr 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative
[+]

Formononetin may be developed as an antioxidant treatment in diabetic retinopathy.Dec 31, 2013

Pubmed Data : Eur Rev Med Pharmacol Sci. 2014 ;18(15):2191-7. PMID: 25070826
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Diabetic Retinopathy, Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Renoprotective, Superoxide Dismutase Up-regulation
[+]

Formononetin may be useful as anti-cancer treatment for osteosarcoma through its apoptosis-inducing effects.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2014 ;34(3):637-45. Epub 2014 Aug 12. PMID: 25170541
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Formononetin may protect aged hearts from ischemia/reperfusion damage by enhancing autophagic degradation.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Dec ;18(6):4821-4830. Epub 2018 Oct 10. PMID: 30320398
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Aging: Heart, Myocardial Ischemia
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Formononetin may represent an effective adjuvant that can prevent methotrexate nephrotoxicity.Sep 25, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Sep 26 ;8(10). Epub 2019 Sep 26. PMID: 31561418
Article Published Date : Sep 25, 2019
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Methotrexate
[+]

Formononetin prevents cisplatin-induced acute kidney injury.Dec 31, 2016

Pubmed Data : Toxicol Appl Pharmacol. 2017 07 1 ;326:15-24. Epub 2017 Apr 13. PMID: 28414026
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Formononetin promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2014 ;34(4):1351-8. Epub 2014 Oct 2. PMID: 25301361
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Formononetin promotes endothelial repair and wound healing.Dec 31, 2010

Pubmed Data : Int Immunopharmacol. 2011 Jan ;11(1):46-54. Epub 2010 Oct 16. PMID: 20959155
Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Wound Healing
[+]

Formononetin protects neurons against hypoxia-induced cytotoxicity through upregulation of ADAM10 and sAβPPα.Dec 31, 2011

Pubmed Data : J Alzheimers Dis. 2012 ;28(4):795-808. PMID: 22085862
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Hypoxia: Brain
Pharmacological Actions : Neuroprotective Agents
[+]

Formononetin sensitizes glioma cells to doxorubicin through preventing EMT via inhibition of histone deacetylase 5.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(6):6434-41. Epub 2015 Jun 1. PMID: 26261519
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Chemosensitizer, Histone deacetylase inhibitor
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Formononetin significantly increased plant height, ear height, and grain yield 22% - 76% when no phosphorus fertilizer was applied.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : An Acad Bras Cienc. 2020 ;92 Suppl 1:e20181371. Epub 2020 Jun 1. PMID: 32491139
Article Published Date : Dec 31, 2019
Study Type : Plant Study
Additional Links
Substances : Formononetin
Additional Keywords : Arbuscular Mycorrhizal Fungi
[+]

Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2014 ;7(12):8453-61. Epub 2014 Dec 1. PMID: 25674209
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive
Additional Keywords : Phytotherapy
[+]

High concentrations of formononetin-induced apoptosis in androgen-independent prostate cancer cells.Dec 19, 2013

Pubmed Data : Pharm Biol. 2013 Dec 20. Epub 2013 Dec 20. PMID: 24359236
Article Published Date : Dec 19, 2013
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic
[+]

In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa.Feb 28, 2014

Pubmed Data : Tumour Biol. 2014 Mar ;35(3):2279-84. Epub 2013 Nov 24. PMID: 24272199
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Cervical Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Dose Response
[+]

Isoflavone formononetin from red propolis acts as a fungicide against Candida sp.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Microbiol. 2016 Jan-Mar;47(1):159-66. Epub 2016 Jan 27. PMID: 26887239
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Formononetin, Propolis: Brazillian
Diseases : Candida Infection
Pharmacological Actions : Antifungal Agents, Antimicrobial
[+]

Medical findings of nasopharyngeal carcinoma patients and anti-tumor benefits of formononetin.Oct 14, 2019

Pubmed Data : Eur J Pharmacol. 2019 Oct 15 ;861:172619. Epub 2019 Aug 17. PMID: 31430458
Article Published Date : Oct 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative
[+]

Natural products may interfere With SARS-CoV-2 attachment to the host cell.May 04, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomol Struct Dyn. 2020 May 5:1-10. Epub 2020 May 5. PMID: 32340551
Article Published Date : May 04, 2020
Study Type : In Vitro Study
Additional Links
Substances : Alpha Linolenic Acid, Biochanin A, Caffeic Acid, Caffeic acid phenethyl ester, Chlorogenic Acid, Cinnamaldehyde, Formononetin, Genistein, Hydroxytyrosol, Thymoquinone
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Pharmacological network analysis was used to identify the gene targets and mechanisms of formononetin treatment in patients with Alzheimer's disease.Jun 07, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2019 Jun 8 ;25:4273-4277. Epub 2019 Jun 8. PMID: 31175839
Article Published Date : Jun 07, 2019
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Potential anticancer properties and mechanisms of action of formononetin.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:5854315. Epub 2019 Jul 28. PMID: 31467899
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Formononetin
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Synergistic anticancer effects of formononetin and temozolomide on glioma C6 cells.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2018 Aug 1 ;41(8):1194-1202. Epub 2018 May 29. PMID: 29848900
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Glioma
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Chemotherapeutic Synergy: Temozolomide
[+]

The results indicate the potential value of formononetin as an anti-cancer agent in human ovarian cancer.Dec 31, 2017

Pubmed Data : J Cell Biochem. 2018 09 ;119(9):7377-7387. Epub 2018 May 15. PMID: 29761845
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Ovarian Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

These findings demonstrate a potentially new therapeutic strategy of formononetin as anti-invasive agent for breast cancer.Sep 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Horm Metab Res. 2014 Oct ;46(11):753-60. Epub 2014 Jun 30. PMID: 24977660
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Breast Cancer, Breast Cancer: Triple Negative , Cancer Metastasis
Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

This is the first report of the presence of potent cyclooxygenase-2 inhibitors in Trifolium pratense L. extracts.Feb 28, 2019

Pubmed Data : J Sep Sci. 2019 Mar ;42(6):1133-1143. Epub 2019 Feb 25. PMID: 30620132
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Daidzein, Formononetin, Genistein, Isoflavones, Red Clover
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts

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