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EGCG (Epigallocatechin gallate)
Views 16760
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298 Diseases Researched for EGCG (Epigallocatechin gallate)
Name
AC
CK
Focus
Obesity
15
48
Cancers: All
24
32
Breast Cancer
18
31
Lung Cancer
19
26
Prostate Cancer
15
25
Oxidative Stress
16
24
Breast Cancer: Triple Negative
4
23
Down Syndrome
6
23
High Cholesterol
1
20
Inflammation
14
18
Atherosclerosis
4
16
Alzheimer's Disease
11
15
Cancers: Drug Resistant
13
15
Metabolic Syndrome X
4
15
Stroke: Attenuation/Recovery
4
15
Aging
3
14
Lipid Peroxidation
3
14
Multiple Sclerosis
4
13
Neurodegenerative Diseases
11
13
Brain Ischemia
2
12
Chemotherapy and Radiation Toxicity
2
12
Colorectal Cancer
7
12
Diabetic Complications
8
12
High Fat Diet
6
12
Breast Cancer: Metastatic
2
11
MRSA
2
11
Melanoma
8
11
Scars
2
11
Staphylococcus aureus: Methicillin-resistant (MRSA)
2
11
Acne
1
10
Anogenital Warts
1
10
Cardiovascular Disease: Prevention
1
10
Cholesterol: High
1
10
Cystic Fibrosis
1
10
Elderly: Age Specific Diseases
1
10
Genital Warts
1
10
Herpes Simplex Virus Type 1
1
10
Liver Cancer
9
10
Multiple Sclerosis: Relapsing-Remitting
1
10
Overweight
1
10
Prostate: PSA Doubling
1
10
Rheumatoid Arthritis
7
10
Triglycerides: Elevated
1
10
Wound Healing
1
10
Arsenic Poisoning
5
9
Diabetes Mellitus: Type 2
5
9
Head and Neck Cancer
6
9
Pancreatic Cancer
8
9
Parkinson's Disease
7
9
Human Papillomavirus (HPV)
6
8
Insulin Resistance
4
8
Air Pollution Linked Toxicity
2
7
Cardiac Hypertrophy
4
7
Cervical Cancer
8
7
Brain Inflammation
5
6
Colon Cancer
4
6
Hyperglycemia
3
6
Kidney Damage
3
6
Lipopolysaccharide-Induced Toxicity
5
6
Ovarian Cancer
6
6
Sjogren's Syndrome
4
6
Advanced Glycation End products (AGE)
3
5
Alopecia
1
5
Amyotrophic Lateral Sclerosis
3
5
Bladder Cancer
4
5
Cancer Metastasis
3
5
Chemotherapy-Induced Toxicity: Doxorubicin
4
5
Chlamydia pneumoniae
1
5
Diabetes Mellitus: Type 1
3
5
Escherichia coli Infections
5
5
Hair Loss
1
5
Influenza A
4
5
Leiomyoma
3
5
Multiple Myeloma
4
5
Prostatic Hyperplasia: Benign
3
5
Vitiligo
1
5
Asthma
2
4
Brain: Oxidative Stress
3
4
Cancers: Multi-Drug Resistant
4
4
Chemotherapy-Induced Toxicity: Cisplatin
2
4
Diabetic Nephropathy
2
4
Erectile Dysfunction
2
4
Esophageal Cancer
4
4
Gastric Cancer
3
4
Kidney Diseases
2
4
Myocardial Ischemia
2
4
Oral Cancer
4
4
Osteoporosis
2
4
Porphyromonas gingivalis
2
4
Squamous cell carcinoma
3
4
Acinetobacter baumannii infection
3
3
Acrylamide-induced toxicity
2
3
Anthrax
2
3
Autoimmune Diseases
2
3
Cancer Stem Cells
3
3
Carcinoma: Non-Small-Cell Lung
2
3
Carcinoma: Small Cell Lung
2
3
Cataract
3
3
Chemically-Induced Liver Damage
2
3
Chemotherapy-Induced Toxicity: Gentamicin
2
3
Chronic Lymphocytic Leukemia
2
3
Clostridium Infections
2
3
Glioblastoma
3
3
High Fructose Diet
2
3
Hypoglycemia
2
3
Inflammatory Bowel Diseases
2
3
Kidney Cancer
3
3
Liver Cancer: Prevention
2
3
Nasopharyngeal Cancer
2
3
Neuropathic Pain
2
3
Periodontitis
2
3
Pulmonary Fibrosis
2
3
Acetaminophen (Tylenol) Toxicity
1
2
Aging Skin
1
2
Alcohol Toxicity
1
2
Alcoholic Liver Disease
1
2
Aluminum Toxicity
1
2
Aneurysm: Aortic
1
2
Arthritis: Rheumatoid
2
2
Asbestos Toxicity
2
2
Asthma: Bronchial
1
2
Autoimmune Thyroiditis
1
2
Benzo[a]pyrene-induced Toxicity
1
2
Bone Cancer
1
2
Brain Cancer
2
2
Brain Injury: Hippocampal Damage
1
2
C-Reactive Protein
1
2
Cadmium Poisoning
1
2
Cardiac Mortality
1
2
Cardiomyopathy: Restrictive
1
2
Cardiovascular Diseases
2
2
Cerebral Hypoperfusion
1
2
Chemotherapy-Induced Toxicity: Bleomycin
1
2
Chemotherapy-Induced Toxicity: Irinotecan
1
2
Cholangiocarcinoma
2
2
Cholecystitis
1
2
Chronic Fatigue Syndrome
1
2
Cognitive Decline/Dysfunction
1
2
Colitis
1
2
Coronary Artery Disease
1
2
Coronary Bypass Surgery
1
2
Diabetes Mellitus: Type 1: Prevention
1
2
Diabetes: Cardiovascular Illness
1
2
Diabetes: Oxidative Stress
1
2
Diabetic Retinopathy
2
2
Dry Eye Syndromes
1
2
Encephalomyelitis
2
2
Endometrial Cancer
2
2
Endotoxemia
1
2
Fatty Liver
1
2
Fibroid Tumor
1
2
Fibroids: Uterine
1
2
Fish Diseases
1
2
Fluoride Toxicity
1
2
Gallbladder Inflammation
1
2
Gallstones
1
2
Gastrointestinal Inflammation
1
2
Gastrointestinal Stromal Tumors
1
2
Gestational Diabetes
1
2
Gingivitis
1
2
Glioma
2
2
Glomerulonephritis
1
2
Gout
1
2
Graft vs Host Disease
1
2
H1N1 Infection
2
2
HIV Infections
2
2
Heart Failure
1
2
Hepatitis B
2
2
Hepatitis C
2
2
High Sugar Diet
2
2
Huntington Disease
1
2
Hyperlipidemia
1
2
Hypertension
2
2
Hyperuricemia
1
2
Hypoxia
2
2
Influenza
2
2
Influenza B
2
2
Kidney Damage: Chemically-Induced
1
2
Learning disorders
1
2
Leiomyosarcoma
2
2
Leukemia: Acute promyelocytic leukemia
2
2
Leukemia: Chronic Lymphocytic Leukemia (CLL)
2
2
Leukemia: T-cell acute Lymphoblastic
2
2
Liver Damage: Drug-Induced
1
2
Liver Fibrosis
2
2
Lung Injury: Acute
1
2
Melanoma: Metastatic
1
2
Memory Loss
1
2
Middle Cerebral Artery Occlusion (MCAO)
1
2
Mitochondrial Dysfunction
2
2
Mobile Phone-Induced Oxidative Stress
1
2
Morphine Tolerance/Dependence
1
2
Muscle Atrophy
1
2
Muscular Dystrophies
1
2
Myocardial Fibrosis
1
2
Neural Tube Defects
1
2
Neuroblastoma
2
2
Nicotine/Tobacco Toxicity
1
2
Non-Hodgkin's lymphoma: B Cell
2
2
Nonalcoholic fatty liver disease (NAFLD)
1
2
Obstructive Nephropathy
1
2
Osteoarthritis
2
2
Osteosarcoma
2
2
Peripheral Nerve Diseases
1
2
Pseudomonas aeruginosa
2
2
Retinal Diseases
1
2
Sciatica
1
2
Sepsis
1
2
Skin Diseases: Photo-Aging
1
2
Steptococcus Mutans Infections
2
2
Tardive Dyskinesia
1
2
Testicular Injury: Chemical/Metal Induced
1
2
Thyroid Cancer
1
2
Thyroiditis: Autoimmune
1
2
Tongue Cancer
1
2
Williams Syndrome
1
2
Wound Healing: Delayed
1
2
Xeroderma Pigmentosum
1
2
Acid Reflux
1
1
Aging: Brain
1
1
Atrial Fibrillation
1
1
Bacterial Infections and Mycoses
1
1
Barrett Esophagus
1
1
Bile Duct Cancer
1
1
Bisphenol Toxicity
1
1
Breast Cancer Stem Cells
1
1
Burkitt Cell Leukemia
1
1
Burns
1
1
Candida Infection
1
1
Cerebral Stroke
1
1
Chikungunya Virus
1
1
Cholesterol: Oxidation
1
1
Choriocarcinoma
1
1
Chronic Myeloid Leukemia
1
1
Degenerative Disk Disease
1
1
Dengue
1
1
Dengue Fever
1
1
Diabetes: Liver Disease
1
1
Ebola Virus Infections
1
1
Encephalitis: Japanese
1
1
Endometriosis
1
1
Epstein-Barr Virus Infections
1
1
Fibrosis: Liver
1
1
Follicular Lymphoma
1
1
Foodborne Pathogens: Prevention/Food Preservation
1
1
Fungal Infections: Biofilm Formation/Resistance
1
1
Gastrointestinal Diseases
1
1
H3N2 Infection
1
1
HSV-1
1
1
HSV-2
1
1
Halitosis
1
1
Hearing Loss
1
1
Helicobacter Pylori Infection
1
1
Herpes Simplex Virus Type 2
1
1
Human T-Cell Lymphotrophic Virus type 1 associated disease
1
1
Infection: Antibiotic Resistant
1
1
Intestinal Permeability
1
1
Iron Overload
1
1
Keloid
1
1
Leaky Gut Syndrome
1
1
Leukemia: Chronic myelogenous leukemia (CML)
1
1
Liver Cancer: Metastatic
1
1
Lymphoma
1
1
Mastocytoma
1
1
Medulloblastoma
1
1
Mesothelioma
1
1
Metabolic Diseases
1
1
Mitochondrial Diseases
1
1
Multiple System Atrophy (MSA)
1
1
Nasopharyngeal Cancer Stem Cells
1
1
Neurologic Disorders
1
1
Non-Small-Cell Lung Carcinoma
1
1
Norovirus
1
1
Osteomyelitis
1
1
Periodontal Diseases
1
1
Pesticide Toxicity
1
1
Pituitary Diseases
1
1
Polio
1
1
Prostate Cancer: Prevention
1
1
Rabies
1
1
Ricin Toxicity
1
1
Salivary Gland Adenoid Cystic Carcinoma.
1
1
Salmonella Infections
1
1
Skin Cancer
1
1
Smoking
1
1
Spinal Cord Injuries
1
1
Staphylococcus aureus infection
1
1
Stomach Cancer
1
1
Streptococcus pneumoniae infection
1
1
Stroke: Ischemic
1
1
Subarachnoid hemorrhage
1
1
Swine Flu Associated Virus
1
1
T-Cell Mediated Diseases
1
1
Testicular Cancer
1
1
Thrombocytopenia
1
1
Viral Infections
1
1
West Nile Fever
1
1
Zika Virus
1
1
106 Pharmacological Actions Researched for EGCG (Epigallocatechin gallate)
Name
AC
CK
Focus
Antiproliferative
69
112
Apoptotic
68
107
Anti-Inflammatory Agents
57
102
Antioxidants
56
97
Neuroprotective Agents
39
76
Chemopreventive
37
46
Anticholesteremic Agents
3
40
MicroRNA modulator
26
38
Cardioprotective
16
33
Anti-metastatic
18
32
Tumor Necrosis Factor (TNF) Alpha Inhibitor
16
30
Anti-Apoptotic
16
27
Antiviral Agents
18
27
Anticarcinogenic Agents
19
25
Chemosensitizer
16
23
Anti-Bacterial Agents
13
22
Chemotherapeutic
18
21
Immunomodulatory
11
20
Hypolipidemic
5
18
Interleukin-6 Downregulation
10
18
Matrix metalloproteinase-2 (MMP-2) inhibitor
6
17
NF-kappaB Inhibitor
12
17
Nrf2 activation
10
17
Renoprotective
8
16
Autophagy Up-regulation
6
15
Hepatoprotective
9
15
Angiogenesis Inhibitors
8
14
Matrix metalloproteinase-9 (MMP-9) inhibitor
3
13
Hypoglycemic Agents
6
12
Interleukin-1 beta downregulation
6
12
Interleukin-8 downregulation
7
12
Radioprotective
2
12
Vascular Endothelial Growth Factor Inhibitors
5
12
Vascular Endothelial Growth Factor Regulator
3
12
Cell cycle arrest
11
11
Chemoprotective Agents
8
11
Hepatocyte growth factor (HGF) inhibitor
1
10
Radiosensitizer
1
10
Thermogenic
1
10
Anti-Angiogenic
6
9
Antineoplastic Agents
6
9
Heme oxygenase-1 up-regulation
4
7
Anti-Fibrotic
4
6
Antimicrobial
5
6
Multidrug Resistance Gene Modulators
6
6
Anti-Glycation Agents
3
5
Cyclooxygenase 2 Inhibitors
5
5
NF-E2-Related Factor-2 (Nrf2) Modulator
3
5
Neuritogenic
4
5
Tumor Suppressor Protein p53 Upregulation
3
5
Hypoxia-inducible factor-1 (HIF-1) inhibitor
2
4
Prophylactic Agents
3
4
Telomerase Inhibitor
4
4
Wnt/β-catenin signaling pathway modulation
3
4
Anti-Proliferative
3
3
Epidermal growth factor receptor (EGFR) inhibitor
2
3
Gluconeogenesis Inhibitor
2
3
Glutathione Upregulation
2
3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
2
3
Quorum Sensing Inhibition
3
3
STAT3 Inhibitor
2
3
Wnt/β-catenin pathway down-regulation
2
3
Aldose reductase inhibitor
1
2
Anti-Adipogenic
2
2
Antinoceceptive
1
2
Appetite Depressants
1
2
Calcium Desensitizer
1
2
Gastrointestinal Agents
1
2
Gastroprotective
1
2
Histone deacetylase inhibitor
2
2
Immunomodulatory: Th17 downregulation
1
2
Immunostimulatory
1
2
Interleukin-10 upregulation
1
2
Interleukin-17 downregulation
1
2
Malondialdehyde Down-regulation
1
2
Matrix Metalloproteinases Inhibitors
1
2
Neurogenesis
1
2
Neurorestorative
1
2
Osteoprotective
1
2
P21 Activation
1
2
Telomere Protective
1
2
Uricosuric Agents
1
2
Vasodilator Agents
1
2
Viral Hemagglutinin Inhibitor
2
2
AMP-activated protein kinase modulation
1
1
Analgesics
1
1
Antifungal Agents
1
1
Antihypertensive Agents
1
1
Bcl-2 protein down-regulation
1
1
Brain-derived neurotrophic factor modulator
1
1
Cell Differentiation Inducer
1
1
Chemotherapeuticm
1
1
Cyclooxygenase 1 Inhibitor
1
1
Cytoprotective
1
1
Drug synergy
1
1
Interleukin-10 downregulation
1
1
Iron Chelating Agents
1
1
Lactate Dehydrogenase A Inhibitor
1
1
Neurominidase Inhibitor
1
1
P38 Mitogen-Activated Protein Kinase Modulator
1
1
Pancreato Protective Agents
1
1
Prostaglandin Antagonists
1
1
Proteasome Inhibitors
1
1
Proton Pump Inhibitor
1
1
Regenerative
1
1
STAT3-NFκB Signaling: downregulation
1
1
Research Articles
477
Cumulative Knowledge Score
771
Overall Research Rating
EXCELLENT
Related Topics
EGCG (Epigallocatechin gallate) is a Sub of the following Topic
Green Tea
View the Evidence:
553 Abstracts with EGCG (Epigallocatechin gallate) Research
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[+]
Consumption of green tea EGCG resulted in a significant reduction of low-density lipoprotein cholesterol.
Jun 19, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2016 Jun 20:1-8. Epub 2016 Jun 20. PMID:
27324590
Article Published Date
: Jun 19, 2016
Study Type
: Meta Analysis
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
High Cholesterol
Pharmacological Actions
:
Anticholesteremic Agents
[+]
Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.
Oct 17, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID:
29040973
Article Published Date
: Oct 17, 2017
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Sulforaphane
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
AverTeaX formulation containing lipophilic catechins effectively inhibited herpes simplex labialis infection with clinical significance.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec ;120(6):717-24. Epub 2015 Sep 5. PMID:
26548726
Article Published Date
: Nov 30, 2015
Study Type
: Human Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Herpes Simplex Virus Type 1
Pharmacological Actions
:
Antiviral Agents
[+]
Both both zonal priming and direct EGCG application in scar therapy has positive effects on scar thickness, erythema, hydration and elasticity.
Feb 25, 2019
Click here to read the entire abstract
Pubmed Data
: J Invest Dermatol. 2019 Feb 26. Epub 2019 Feb 26. PMID:
30822414
Article Published Date
: Feb 25, 2019
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Scars
,
Wound Healing
[+]
Both EGCG and green tea could be used as alternatives to chlorhexidine-based mouthwashes.
Apr 18, 2020
Click here to read the entire abstract
Pubmed Data
: Arch Oral Biol. 2020 Apr 19 ;114:104727. Epub 2020 Apr 19. PMID:
32361019
Article Published Date
: Apr 18, 2020
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Dental Caries: Children
Pharmacological Actions
:
Antimicrobial
Additional Keywords
:
Mouthwash
[+]
Cysteamine plus epigallocatechin gallate can be used for autophagy-dependent rescue of class II-mutated CFTR.
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Differ. 2016 Apr 1. Epub 2016 Apr 1. PMID:
27035618
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study, Human Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cystic Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Autophagy Up-regulation
[+]
Decaffeinated green tea extract resulted in significant reductions in lesions located on the nose, perioral area and chin.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2016 Apr ;25:159-63. Epub 2016 Mar 7. PMID:
27062963
Article Published Date
: Mar 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Acne
Additional Keywords
:
Plant Extracts
[+]
EGCG and coconut oil improve state anxiety and functional capacity in patients with multiple sclerosis.
Jan 22, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2020 Jan 23 ;12(2). Epub 2020 Jan 23. PMID:
31979305
Article Published Date
: Jan 22, 2020
Study Type
: Human Study
Additional Links
Substances
:
Coconut Oil
,
EGCG (Epigallocatechin gallate)
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Anti-Anxiety Agents
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
[+]
EGCG and cognitive training for 12 months led to an improving of visual recognition memory, inhibitory control, and adaptive behaviour.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Lancet Neurol. 2016 Jul ;15(8):801-10. PMID:
27302362
Article Published Date
: Jun 30, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Down Syndrome
Pharmacological Actions
:
Neuroprotective Agents
[+]
EGCG decreased skeletal muscle lactate concentrations in overweight individuals, suggesting a shift towards a more oxidative muscle phenotype.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015 ;5:17896. Epub 2015 Dec 9. PMID:
26647963
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Additional Keywords
:
Supplementation
[+]
EGCG enhances fat oxidation in men and may contribute to the anti-obesity effects of green tea.
Oct 22, 2010
Click here to read the entire abstract
Pubmed Data
: J Biol Chem. 2010 Oct 22;285(43):33520-8. Epub 2010 Aug 18. PMID:
17906192
Article Published Date
: Oct 22, 2010
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obesity
,
Overweight
Pharmacological Actions
:
Thermogenic
[+]
EGCG given to patients with multiple sclerosis over 12 weeks improved muscle metabolism during moderate exercise to a greater extent in men than in women.
Feb 28, 2015
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2015 Mar ;101(3):487-95. Epub 2015 Jan 14. PMID:
25733633
Article Published Date
: Feb 28, 2015
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Multiple Sclerosis
,
Multiple Sclerosis: Relapsing-Remitting
Therapeutic Actions
:
Exercise
Additional Keywords
:
Significant Treatment Outcome
[+]
Epigallocatechin gallate could potentially be used as a supplement of traditional rt-PA treatment among stroke patients.
Dec 08, 2016
Click here to read the entire abstract
Pubmed Data
: Clin Neuropharmacol. 2016 Dec 9. Epub 2016 Dec 9. PMID:
27941526
Article Published Date
: Dec 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Ischemia
,
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
[+]
Green tea catechins are effective in reducing atherosclerosis risk associated with oxidative stress.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr Res. 2016 Jan ;36(1):16-23. Epub 2015 Nov 3. PMID:
26773777
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Atherosclerosis
,
Lipid Peroxidation
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
Additional Keywords
:
Risk Reduction
[+]
Green tea catechins may have a therapeutic role in the treatment of metabolic syndrome.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Phytochemistry. 2009 Jan;70(1):11-24. Epub 2009 Jan 13. PMID:
19147161
Article Published Date
: Jan 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Metabolic Syndrome X
[+]
High-dose green tea extract resulted in significant weight loss, reduced waist circumference, and a consistent decrease in total cholesterol and LDL plasma levels.
May 28, 2015
Click here to read the entire abstract
Pubmed Data
: Clin Nutr. 2015 May 29. Epub 2015 May 29. PMID:
26093535
Article Published Date
: May 28, 2015
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Cholesterol: High
,
Obesity
Pharmacological Actions
:
Anticholesteremic Agents
Additional Keywords
:
Anti-Obesity Agents
,
Significant Treatment Outcome
[+]
It appears that EGCG should be taken without food in order to maximise its systemic absorption.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2015 ;4(2):373-93. Epub 2015 May 27. PMID:
26783711
Article Published Date
: Dec 31, 2014
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Additional Keywords
:
Bioavailability
[+]
Supplementation with green tea extract significantly reduced circulating triglycerides and LDL-cholesterol concentrations.
Nov 01, 2016
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2016 Nov 2. Epub 2016 Aug 2. PMID:
27806972
Article Published Date
: Nov 01, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Cardiovascular Disease: Prevention
,
Triglycerides: Elevated
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
Additional Keywords
:
Natural Substance/Drug Antagonism
,
Plant Extracts
Problem Substances
:
Statin Drugs
[+]
Tea polyphenol has potential to be a therapeutic adjuvant against human metastatic breast cancer.
Feb 01, 2012
Click here to read the entire abstract
Pubmed Data
: Curr Mol Med. 2012 Feb 1 ;12(2):163-76. PMID:
22280355
Article Published Date
: Feb 01, 2012
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Radiosensitizer
Additional Keywords
:
Drug Synergy
[+]
Tea polyphenols (primarily EGCG), significantly reduce PSA, Hepatocyte growth factor, VEG in men with prostate cancer.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila Pa). 2009 Jul;2(7):673-82. Epub 2009 Jun 19. PMID:
19542190
Article Published Date
: Jul 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
,
Polyphenols
Diseases
:
Prostate: PSA Doubling
,
Prostate Cancer
Pharmacological Actions
:
Hepatocyte growth factor (HGF) inhibitor
,
Vascular Endothelial Growth Factor Regulator
[+]
The association between green and black tea consumption on successful aging.
May 14, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2019 May 15 ;24(10). Epub 2019 May 15. PMID:
31096548
Article Published Date
: May 14, 2019
Study Type
: Human Study
Additional Links
Substances
:
Black Tea
,
Coffee
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Aging
[+]
The inhalation of tea catechin appears to suppress MRSA infection in the elderly.
Feb 01, 2006
Click here to read the entire abstract
Pubmed Data
: J Am Med Dir Assoc. 2006 Feb;7(2):79-83. Epub 2005 Jul 22. PMID:
16461248
Article Published Date
: Feb 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Elderly: Age Specific Diseases
,
MRSA
,
Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
Topical EGCG may be an effective treatment for radiation-induced dermatitis and has acceptable toxicity.
May 19, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 May 20. Epub 2016 May 20. PMID:
27224910
Article Published Date
: May 19, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Radioprotective
[+]
Topical green tea extract appears safe and effective in treating external anogenital warts.
Jan 01, 2006
Click here to read the entire abstract
Pubmed Data
: Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):85-90. Epub 2005 Oct 20. PMID:
21294779
Article Published Date
: Jan 01, 2006
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Anogenital Warts
,
Genital Warts
[+]
Twelve weeks of EGCG and resveratrol supplementation increased mitochondrial capacity and stimulated fat oxidation.
May 17, 2016
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2016 May 18. Epub 2016 May 18. PMID:
27194304
Article Published Date
: May 17, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Resveratrol
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Usage of and attitudes about green tea extract and epigallocathechin-3-gallate as a therapy in individuals with Down syndrome.
Jul 31, 2019
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2019 Aug ;45:234-241. Epub 2019 Jul 2. PMID:
31331567
Article Published Date
: Jul 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Down Syndrome
[+]
Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.
Aug 31, 2015
Click here to read the entire abstract
Pubmed Data
: J Cancer Res Clin Oncol. 2015 Sep ;141(9):1511-22. Epub 2014 Dec 28. PMID:
25544670
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Cancers: All
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Cancer Stem Cells
,
Natural Substance/Drug Synergy
[+]
EGCG protected against the effects of Dihydrotestosterone (DHT) by altering the miRNA expression profile in human dermal papilla cells.
May 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ann Dermatol. 2016 Jun ;28(3):327-34. Epub 2016 May 25. PMID:
27274631
Article Published Date
: May 31, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Alopecia
,
Hair Loss
Pharmacological Actions
:
Anti-Apoptotic
,
MicroRNA modulator
[+]
Epigallocatechin gallate suppresses Chlamydia pneumoniae mediated IgE responses.
Jun 15, 2016
Click here to read the entire abstract
Pubmed Data
: Minerva Med. 2016 Jun 16. Epub 2016 Jun 16. PMID:
27309037
Article Published Date
: Jun 15, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chlamydia pneumoniae
Pharmacological Actions
:
Immunomodulatory
[+]
Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome.
Jan 01, 2013
Click here to read the entire abstract
Pubmed Data
: Biochim Biophys Acta. 2013 Jan 2. Epub 2013 Jan 2. PMID:
23291000
Article Published Date
: Jan 01, 2013
Study Type
: Human In Vitro
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Down Syndrome
Additional Keywords
:
Mitochondrial Biogenesis
[+]
Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.
May 08, 2012
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2012 May 8. Epub 2012 May 8. PMID:
22566066
Article Published Date
: May 08, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Ginseng
,
Green Tea
,
Panaxadiol
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemosensitizer
Additional Keywords
:
Natural Substance Synergy
[+]
Punicalagin and EGCG can rescue keratinocyte viability and attenuate the inflammatory responses of cells due to airborne particles.
Mar 21, 2018
Click here to read the entire abstract
Pubmed Data
: Skin Pharmacol Physiol. 2018 Mar 22 ;31(3):134-143. Epub 2018 Mar 22. PMID:
29566388
Article Published Date
: Mar 21, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Punicalagin
Diseases
:
Air Pollution Linked Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
These results provide new evidence for the effectiveness of EGCG in vitiligo treatment.
Sep 03, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biol Pharm Bull. 2015 Sep 4. Epub 2015 Sep 4. PMID:
26345342
Article Published Date
: Sep 03, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Vitiligo
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
VEGF is a key molecular target for specific polyphenols found in tea, apples and cocoa which potently inhibit VEGF signalling and angiogenesis at physiological concentrations.
Feb 28, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2015 Mar ;59(3):401-12. Epub 2015 Jan 22. PMID:
25546248
Article Published Date
: Feb 28, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Apple Polyphenols
,
EGCG (Epigallocatechin gallate)
,
Polyphenols
Diseases
:
Cancers: All
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Diet
[+]
A case of complete and durable molecular remission of chronic lymphocytic leukemia following treatment with epigallocatechin-3-gallate.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Cureus. 2015 ;7(12):e441. Epub 2015 Dec 29. PMID:
26858922
Article Published Date
: Dec 31, 2014
Study Type
: Human: Case Report
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chronic Lymphocytic Leukemia
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Cancer Remission
,
Significant Treatment Outcome
[+]
Epigallocatechin gallate but not catechin prevents nonalcoholic steatohepatitis in mice similar to green tea extract while differentially affecting the gut microbiota.
Jun 19, 2020
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2020 Jun 20 ;84:108455. Epub 2020 Jun 20. PMID:
32688217
Article Published Date
: Jun 19, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
"Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea."
Nov 30, 2012
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2012 Dec ;33(12):1533-41. Epub 2012 Sep 3. PMID:
22941291
Article Published Date
: Nov 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Influenza A
[+]
"Green tea catechins ameliorates adipose Insulin resistance by improving oxidative stress."
Feb 11, 2012
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2012 Feb 11. Epub 2012 Feb 11. PMID:
22330066
Article Published Date
: Feb 11, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Antioxidants
[+]
"Green tea epigallocatechin-3-gallate (EGCG) promotes neural progenitor cell proliferation and sonic hedgehog pathway activation during adult hippocampal neurogenesis."
Jul 31, 2012
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2012 Aug ;56(8):1292-303. Epub 2012 Jun 13. PMID:
22692966
Article Published Date
: Jul 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Injury: Hippocampal Damage
Pharmacological Actions
:
Neuritogenic
[+]
"Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis-induced atherosclerosis."
Sep 10, 2012
Click here to read the entire abstract
Pubmed Data
: FEMS Immunol Med Microbiol. 2012 Sep 11. Epub 2012 Sep 11. PMID:
22966806
Article Published Date
: Sep 10, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Atherosclerosis
,
Porphyromonas gingivalis
Pharmacological Actions
:
Cardioprotective
[+]
(-)-Epigallocatechin-3-gallate (EGCG) can inhibit the proliferation and invasiveness and induce apoptosis in nasopharyngeal carcinoma cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2015 ;16(2):2530-58. Epub 2015 Jan 23. PMID:
25625511
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
[+]
A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2010;5(11):e14015. Epub 2010 Nov 17. PMID:
21103342
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
,
B-complex
,
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Folic Acid
,
NAC (N-acetyl-L-cysteine)
,
Piperine
,
Vitamin C
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
A major metabolite of EGCG increased the activity of CD4(+) T cells and enhanced the cytotoxic activity of NK cells in vivo.
May 10, 2016
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2016 May 11 ;64(18):3591-7. Epub 2016 May 2. PMID:
27112424
Article Published Date
: May 10, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Pharmacological Actions
:
Immunostimulatory
Additional Keywords
:
Metabolites
[+]
A quercetin, EGCG and apple polyphenol concentrate improved disorders of lipid metabolism and pro-oxidant-antioxidant homeostasis.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Wiad Lek. 2017;70(2):200-204. PMID:
28511159
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Apple Polyphenols
,
Catechin
,
EGCG (Epigallocatechin gallate)
,
Quercetin
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
[+]
Administration of Epigallocatechin-3-gallate resulted in a significant reduction in bone loss.
Sep 06, 2015
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2015 Sep 7. Epub 2015 Sep 7. PMID:
26359545
Article Published Date
: Sep 06, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Gingivitis
,
Periodontitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-17 downregulation
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
All these findings suggest that EGCG can resist skin senility effectively.
Mar 22, 2017
Click here to read the entire abstract
Pubmed Data
: Mech Ageing Dev. 2017 Mar 23. Epub 2017 Mar 23. PMID:
28343910
Article Published Date
: Mar 22, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Aging Skin
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Antimicrobial effect of Licochalcone A and Epigallocatechin-3-gallate against Salmonella Typhimurium isolated from poultry flocks.
Jan 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Microbiol. 2018 Feb ;10(1):51-58. PMID:
29922419
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Licorice
Diseases
:
Salmonella Infections
Pharmacological Actions
:
Antimicrobial
[+]
Artificial tears containing epigallocatechin gallate and hyaluronic acid had a synergistic effect in the treatment of dry eye syndrome.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016;11(6):e0157982. Epub 2016 Jun 23. PMID:
27336157
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Dry Eye Syndromes
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Natural Substance Synergy
[+]
Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1α and activating FoxO3a.
May 11, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Transl Med. 2020 May 12 ;18(1):195. Epub 2020 May 12. PMID:
32398139
Article Published Date
: May 11, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiovascular Diseases
Pharmacological Actions
:
Anticholesteremic Agents
,
Cardioprotective
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]
Chronic treatment of diabetic rats with EGCG could prevent the abnormal functional changes in vascular reactivity in diabetic rats.
Dec 01, 1975
Click here to read the entire abstract
Pubmed Data
: Am J Med Technol. 1975 Dec;41(12):457-62. PMID:
2010
Article Published Date
: Dec 01, 1975
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetes: Cardiovascular Illness
Pharmacological Actions
:
Cardioprotective
[+]
Co-administration of EGCG and doxorubicin has potential as a feasible strategy to mitigate the drugs cardiotoxicity.
Dec 08, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Dec 9. Epub 2016 Dec 9. PMID:
27956351
Article Published Date
: Dec 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cardioprotective
,
Chemoprotective Agents
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
[+]
Coadministration of epigallocatechin-3-gallate and caffeine in low dose ameliorates obesity and nonalcoholic fatty liver disease in obese rats.
Feb 10, 2019
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2019 Feb 11. Epub 2019 Feb 11. PMID:
30746789
Article Published Date
: Feb 10, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Caffeine
,
EGCG (Epigallocatechin gallate)
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Anti-Obesity Agents
[+]
Combined treatment with the phenolics (-)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology.
Jan 21, 2019
Click here to read the entire abstract
Pubmed Data
: J Biol Chem. 2019 02 22 ;294(8):2714-2731. Epub 2018 Dec 18. PMID:
30563837
Article Published Date
: Jan 21, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Ferulic acid
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
[+]
Consumption of green tea may be beneficial in alleviating some of the deleterious aspects of aging and immunosenescence in elderly.
Mar 23, 2017
Click here to read the entire abstract
Pubmed Data
: Biogerontology. 2017 Mar 24. Epub 2017 Mar 24. PMID:
28341876
Article Published Date
: Mar 23, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Aging
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin as a permeability enhancer enhanced the antihyperlipidemic activity of dietary green tea extract.
Jun 12, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2019 Jun 13 ;19(1):129. Epub 2019 Jun 13. PMID:
31196040
Article Published Date
: Jun 12, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
Curcumin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Antioxidants
,
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin, resveratrol, and EGCG, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors.
Feb 15, 2018
Click here to read the entire abstract
Pubmed Data
: Cancer Immunol Immunother. 2018 Feb 16. Epub 2018 Feb 16. PMID:
29453519
Article Published Date
: Feb 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Resveratrol
Diseases
:
Head and Neck Cancer
,
Human Papillomavirus (HPV)
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Natural Substance Synergy
[+]
Daily consumption of EGCG might be effective in the prevention and treatment of secondary damage related to peripheral nerve injury.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Turk Neurosurg. 2015 ;25(3):453-60. PMID:
26037187
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lipid Peroxidation
,
Peripheral Nerve Diseases
,
Sciatica
Pharmacological Actions
:
Antioxidants
[+]
Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in mice.
Feb 14, 2012
Click here to read the entire abstract
Pubmed Data
: Nutr Metab (Lond). 2012 Feb 14 ;9(1):11. Epub 2012 Feb 14. PMID:
22333133
Article Published Date
: Feb 14, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Diabetes Mellitus: Type 2
Additional Keywords
:
Beta Cell Protection
[+]
Diet supplemented with phytochemical epigallocatechin gallate and probiotic Lactobacillus fermentum confers second generation synbiotic effects.
Jan 02, 2019
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2019 Jan 3. Epub 2019 Jan 3. PMID:
30607562
Article Published Date
: Jan 02, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Lactobacillus fermentum
Diseases
:
Aging
Pharmacological Actions
:
Antioxidants
[+]
Dietary supplementation of a high-temperature-processed green tea extract attenuates cognitive impairment.
Aug 28, 2019
Click here to read the entire abstract
Pubmed Data
: Biosci Biotechnol Biochem. 2019 Aug 29:1-8. Epub 2019 Aug 29. PMID:
31462168
Article Published Date
: Aug 28, 2019
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Drinking green tea may reduce the toxic potential of acute high oral doses of EGCG supplementation.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2015 Feb ;76:103-8. Epub 2014 Dec 17. PMID:
25528115
Article Published Date
: Jan 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Bioavailability
,
Natural Substance Synergy
,
Supplementation
[+]
ECG may be used as an anti-invasion agent for the adjuvant treatment and metastasis control of human lung cancer cells.
Jul 31, 2016
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2016 Aug ;94:1-10. Epub 2016 May 17. PMID:
27224248
Article Published Date
: Jul 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Fibronectin
[+]
Effects of flavonoids and Its derivatives on immune cell responses.
Dec 31, 2018
Click here to read the entire abstract
Pubmed Data
: Recent Pat Inflamm Allergy Drug Discov. 2019 ;13(2):84-104. PMID:
31814545
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Apigenin
,
EGCG (Epigallocatechin gallate)
,
Flavonoids
,
Quercetin
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory
,
Interleukin-1 beta downregulation
,
Interleukin-2 Downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG administration had neurorestorative effects after bilateral common carotid artery occlusion.
Apr 10, 2016
Click here to read the entire abstract
Pubmed Data
: Restor Neurol Neurosci. 2016 Apr 11 ;34(3):367-77. PMID:
27080069
Article Published Date
: Apr 10, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cerebral Hypoperfusion
Pharmacological Actions
:
Neurorestorative
[+]
EGCG ameliorates lethal graft versus host disease and reduces related target organ damage.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(1):e0169630. Epub 2017 Jan 19. PMID:
28103249
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Graft vs Host Disease
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory
Additional Keywords
:
Antioxidants
,
EGCG (Epigallocatechin gallate)
,
Graft vs Host Disease
,
Hematopoietic Stem Cells
,
Immunomodulatory
,
Risk Reduction
[+]
EGCG and CoQ10 ameliorate cisplatin induced nephrotoxicity.
Jun 01, 2016
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2016 Jun 2. Epub 2016 Jun 2. PMID:
27265264
Article Published Date
: Jun 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Coenzyme Q10
,
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
[+]
EGCG and ellagic acid have protective effects on cataract development via the inhibition of oxidative stress.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Ophthalmol. 2017 ;10(4):499-506. Epub 2017 Apr 18. PMID:
28503419
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Ellagic Acid
Diseases
:
Cataract
Pharmacological Actions
:
Antioxidants
[+]
EGCG appears to attenuate cardiopulmonary bypass-associated lung injury.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2016 Apr ;201(2):313-25. Epub 2015 Nov 11. PMID:
27020813
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Coronary Bypass Surgery
,
Lung Injury: Acute
Additional Keywords
:
Risk Reduction
[+]
EGCG attenuated abdominal aortic aneurysm progression in a rat model by preserving the aortic thickness and elastin content of the medial layer.
May 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Vasc Surg. 2017 Jun ;65(6):1803-1812.e2. Epub 2016 Jul 26. PMID:
27473778
Article Published Date
: May 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
EGCG can attenuate high-fat-induced hypothalamic inflammation.
Oct 12, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2019 Oct 13 ;20(20). Epub 2019 Oct 13. PMID:
31614951
Article Published Date
: Oct 12, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG can be developed into a potential agent for the prevention and treatment of smoking‑associated NSCLC.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2015 Jun ;33(6):2972-80. Epub 2015 Mar 31. PMID:
25845434
Article Published Date
: May 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Carcinoma: Small Cell Lung
,
Nicotine/Tobacco Toxicity
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-metastatic
,
Hypoxia-inducible factor-1 (HIF-1) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
EGCG can decrease obesity and epididymal white adipose tissue weight in mice.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:1366. Epub 2018 Nov 22. PMID:
30524290
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
EGCG can reduce lung injury and airway remodelling in air pollution-exposed asthmatic rats.
Apr 15, 2019
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2019 Apr 16. Epub 2019 Apr 16. PMID:
31003767
Article Published Date
: Apr 15, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Air Pollution Linked Toxicity
,
Asthma
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
EGCG consumption prevented diabetes-induced loss of cavernous smooth muscle.
May 11, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Impot Res. 2016 May 12. Epub 2016 May 12. PMID:
27169491
Article Published Date
: May 11, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetic Complications
,
Erectile Dysfunction
[+]
EGCG could attenuate cadmium induced chronic renal injury.
Jul 25, 2016
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2016 Jul 26. Epub 2016 Jul 26. PMID:
27474435
Article Published Date
: Jul 25, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cadmium Poisoning
,
Kidney Damage: Chemically-Induced
Pharmacological Actions
:
MicroRNA modulator
,
Renoprotective
[+]
EGCG could attenuate Sodium arsenite-induced cardiotoxicity.
May 07, 2016
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2016 May 8. Epub 2016 May 8. PMID:
27170490
Article Published Date
: May 07, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arsenic Poisoning
Pharmacological Actions
:
Cardioprotective
Problem Substances
:
Arsenite
[+]
EGCG could attenuate testosterone-induced benign prostatic hyperplasia and fibrosis.
Aug 31, 2018
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2018 Sep 1 ;64:162-169. Epub 2018 Sep 1. PMID:
30179845
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Prostatic Hyperplasia: Benign
Pharmacological Actions
:
Anti-Fibrotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]
EGCG could be coadministered with rt-PA, to extend its therapeutic window in treating acute brain ischemia.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Stroke Cerebrovasc Dis. 2016 Apr ;25(4):990-7. Epub 2016 Feb 3. PMID:
26851971
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Ischemia
,
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Neuroprotective Agents
[+]
EGCG could be used in the prevention or in the therapy of anthrax infections.
Mar 31, 2004
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: EMBO Rep. 2004 Apr ;5(4):418-22. Epub 2004 Mar 12. PMID:
15031715
Article Published Date
: Mar 31, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Anthrax
Pharmacological Actions
:
Anti-Apoptotic
,
Matrix Metalloproteinases Inhibitors
Additional Keywords
:
Anthrax Lethal Factor
[+]
EGCG could be useful for the prevention and treatment of rheumatoid arthritis and other inflammatory disorders.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Inflamm (Lond). 2015 ;12:53. Epub 2015 Sep 15. PMID:
26379475
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Heme oxygenase-1 up-regulation
,
Immunomodulatory
,
NF-E2-Related Factor-2 (Nrf2) Modulator
[+]
EGCG could have beneficial effects on neurogenesis and stroke recovery.
May 19, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2016 May 20. Epub 2016 May 20. PMID:
27206430
Article Published Date
: May 19, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Neurogenesis
[+]
EGCG could mitigate the teratogenic effects of hyperglycemia on the developing embryo and prevent diabetes-induced neural tube defects.
Mar 11, 2016
Click here to read the entire abstract
Pubmed Data
: Am J Obstet Gynecol. 2016 Mar 12. Epub 2016 Mar 12. PMID:
26979632
Article Published Date
: Mar 11, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Gestational Diabetes
,
Hyperglycemia
,
Neural Tube Defects
Additional Keywords
:
Hypomethylation
,
Methylation Downregulation
,
Risk Reduction
[+]
EGCG could potentially serve as an additional therapeutic intervention in the arsenal against obesity.
Feb 08, 2018
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2018 Feb 9. Epub 2018 Feb 9. PMID:
29423494
Article Published Date
: Feb 08, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
High Fat Diet
,
Insulin Resistance
,
Obesity
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
Additional Keywords
:
Anti-Obesity Agents
[+]
EGCG could restore unilateral ureteral obstruction induced kidney weight loss and renal dysfunction in a mice model.
Jan 26, 2015
Click here to read the entire abstract
Pubmed Data
: Basic Clin Pharmacol Toxicol. 2015 Jan 27. Epub 2015 Jan 27. PMID:
25625183
Article Published Date
: Jan 26, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obstructive Nephropathy
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
,
Renoprotective
Additional Keywords
:
Disease Reversal
[+]
EGCG decreased the arthritis index and showed protective effects against joint destruction in collagen-induced arthritis mice.
Mar 07, 2016
Click here to read the entire abstract
Pubmed Data
: J Leukoc Biol. 2016 Mar 8. Epub 2016 Mar 8. PMID:
26957211
Article Published Date
: Mar 07, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Heme oxygenase-1 up-regulation
,
Immunomodulatory: Th17 downregulation
,
NF-E2-Related Factor-2 (Nrf2) Modulator
,
STAT3 Inhibitor
[+]
EGCG decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion.
May 23, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2016 May 24. Epub 2016 May 24. PMID:
27218415
Article Published Date
: May 23, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Colitis
,
Gastrointestinal Inflammation
,
Inflammatory Bowel Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Macronutrient
[+]
EGCG decreases ovariectomy-induced bone loss via inhibition of osteoclasts.
Mar 21, 2012
Click here to read the entire abstract
Pubmed Data
: Calcif Tissue Int. 2012 Mar 21. Epub 2012 Mar 21. PMID:
22434366
Article Published Date
: Mar 21, 2012
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Osteoporosis
Additional Keywords
:
Ovariectomy-Induced Changes
[+]
EGCG dose-dependently improves insulin resistance in NAFLD mice
Apr 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Pharmacol Sin. 2015 May ;36(5):597-605. Epub 2015 Apr 20. PMID:
25891086
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Hyperlipidemia
,
Hypoglycemia
,
Insulin Resistance
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Phytotherapy
[+]
EGCG enhances 5FU sensitivity in chemoresistant colorectal cancer by targeting cancer stem cells.
Mar 28, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Mar 29 ;7(13):16158-71. PMID:
26930714
Article Published Date
: Mar 28, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cancers: Drug Resistant
,
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemosensitizer
,
MicroRNA modulator
Additional Keywords
:
Cancer Stem Cells
,
Chemothapeutic Synergy: 5-flourouracil
[+]
EGCG exerts a neuroprotective effect on experimental autoimmune thyroiditis.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Jan ;15(1):1087-1092. Epub 2017 Nov 14. PMID:
29434699
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Autoimmune Thyroiditis
,
Thyroiditis: Autoimmune
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
[+]
EGCG exerts anti-inflammatory effect against monosodium urate induced acute gout attack.
May 27, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2016 May 28. Epub 2016 May 28. PMID:
27234527
Article Published Date
: May 27, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Gout
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
EGCG exhibits anti-fibrotic effects in a rat model of pulmonary fibrosis.
Jul 15, 2009
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2009 Jul 15;180(2):271-80. Epub 2009 Mar 20. PMID:
19497426
Article Published Date
: Jul 15, 2009
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy-Induced Toxicity: Bleomycin
,
Pulmonary Fibrosis
[+]
EGCG from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains.
Apr 03, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Apr 4 ;7(1):619. Epub 2017 Apr 4. PMID:
28377597
Article Published Date
: Apr 03, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Down Syndrome
Pharmacological Actions
:
Neuroprotective Agents
[+]
EGCG has a beneficial effect on impaired adult neurogenesis caused by lipopolysaccharide induced neuro-inflammation.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Korean J Physiol Pharmacol. 2016 Jan ;20(1):41-51. Epub 2015 Dec 31. PMID:
26807022
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Inflammation
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
EGCG has a protective effect on rat brain injury induced by middle cerebral artery occlusion.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2018 ;2018:6473580. Epub 2018 Mar 25. PMID:
29770336
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions
:
Neuroprotective Agents
[+]
EGCG has an antiarthritic effect by regulating the oxidative-antioxidant balance and cytokine levels.
Nov 18, 2019
Click here to read the entire abstract
Pubmed Data
: Biotechnol Appl Biochem. 2019 Nov 19. Epub 2019 Nov 19. PMID:
31746064
Article Published Date
: Nov 18, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Heme oxygenase-1 up-regulation
,
Immunomodulatory: Th17 downregulation
,
Nrf2 activation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG has multifunctional therapeutic effects in the mouse model of ALS
Oct 01, 2006
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2006 Oct;31(10):1263-9. Epub 2006 Oct 5. PMID:
17021948
Article Published Date
: Oct 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Amyotrophic Lateral Sclerosis
[+]
EGCG has significant antipathogenic effects on C. difficile.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: J Food Sci. 2015 Dec ;80(12):M2925-31. Epub 2015 Nov 10. PMID:
26556797
Article Published Date
: Nov 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Clostridium Infections
Pharmacological Actions
:
Antimicrobial
,
Gastroprotective
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG has strong pharmacological activity against the development of morphine dependence.
Sep 01, 2007
Click here to read the entire abstract
Pubmed Data
: Arch Pharm Res. 2007 Sep;30(9):1111-5. PMID:
17958328
Article Published Date
: Sep 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Morphine Tolerance/Dependence
[+]
EGCG has the potential to ameliorate high fat and high fructose diet-triggered learning and memory loss.
Jul 23, 2017
Click here to read the entire abstract
Pubmed Data
: FASEB J. 2017 Jul 24. Epub 2017 Jul 24. PMID:
28739640
Article Published Date
: Jul 23, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
High Fat Diet
,
High Fructose Diet
,
Memory Loss
Pharmacological Actions
:
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG has the potential to help control hyperglycemia, reduce weight, and alleviate diabetes complications.
Dec 28, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Dec 29 ;87:73-81. Epub 2016 Dec 29. PMID:
28040599
Article Published Date
: Dec 28, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Advanced Glycation End products (AGE)
,
Diabetic Complications
,
Hyperglycemia
Pharmacological Actions
:
Anti-Glycation Agents
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
EGCG induced a reduction in Aβ accumulation and elevated neprilysin expression in vitro.
May 14, 2015
Click here to read the entire abstract
Pubmed Data
: Exp Cell Res. 2015 May 15 ;334(1):136-45. Epub 2015 Apr 14. PMID:
25882496
Article Published Date
: May 14, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Pharmacological Actions
:
Neuroprotective Agents
[+]
EGCG induces miRNA profile changes in the NNK-induced A/J mouse lung tumor.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Genomics. 2014 ;15 Suppl 11:S3. Epub 2014 Dec 16. PMID:
25559244
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
MicroRNA modulator
,
NF-kappaB Inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG inhibited SW780 bladder cancer tumor growth by down-regulation of NF-κB and MMP-9.
Dec 19, 2016
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2016 Dec 20 ;41:56-64. Epub 2016 Dec 20. PMID:
28040581
Article Published Date
: Dec 19, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
[+]
EGCG inhibits arsenic-induced inflammation and apoptosis through suppression of oxidative stress in mice.
Apr 02, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2017 Apr 3 ;41(5):1788-1800. Epub 2017 Apr 3. PMID:
28365685
Article Published Date
: Apr 02, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arsenic Poisoning
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
Problem Substances
:
Arsenic
[+]
EGCG inhibits fibroid tumors in quail.
Feb 01, 2008
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2008 Feb;28(2):92-7. PMID:
19083394
Article Published Date
: Feb 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Fibroid Tumor
,
Fibroids: Uterine
,
Leiomyoma
Pharmacological Actions
:
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG is a strong combination partner of gemcitabine reducing pancreatic cancer cell growth by suppressing glycolysis.
Oct 04, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancers (Basel). 2019 Oct 5 ;11(10). Epub 2019 Oct 5. PMID:
31590367
Article Published Date
: Oct 04, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Cancer Glycolysis
,
Chemotherapeutic Synergy: Gemcitabine
[+]
EGCG is effective in inflammatory colitis because it reduces cellular and molecular inflammation, and reduces intestinal permeability.
Jul 28, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2019 Jul 29 ;11(8). Epub 2019 Jul 29. PMID:
31362373
Article Published Date
: Jul 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG may ameliorate diet-induced metabolic misalignment by regulating the rhythmic expression of the circadian clock genes in the liver and fat.
May 31, 2017
Click here to read the entire abstract
Pubmed Data
: Biochim Biophys Acta. 2017 Jun ;1863(6):1575-1589. Epub 2017 Apr 12. PMID:
28412321
Article Published Date
: May 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Metabolic Syndrome X
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
,
Circadian Clock Proteins
,
Gene Expression Regulation
[+]
EGCG may be a useful adjuvant therapeutic agent for the treatment of breast cancer.
Apr 12, 2017
Click here to read the entire abstract
Pubmed Data
: Pharmacol Rep. 2017 Apr 13 ;69(5):924-928. Epub 2017 Apr 13. PMID:
28646740
Article Published Date
: Apr 12, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Breast Cancer
Pharmacological Actions
:
Apoptotic
,
Chemotherapeutic
Additional Keywords
:
Gene Expression Regulation
,
Natural Substances Versus Drugs
[+]
EGCG may be useful as an adjuvant therapy for bronchial asthma.
Nov 27, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Med. 2017 Nov 28. Epub 2017 Nov 28. PMID:
29207033
Article Published Date
: Nov 27, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Asthma: Bronchial
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
EGCG may be useful for reducing hepatotoxicity associated with oxidative stress
Jun 20, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 Jun 21. Epub 2017 Jun 21. PMID:
28658663
Article Published Date
: Jun 20, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arsenic Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Nrf2 activation
Problem Substances
:
Arsenic
[+]
EGCG may possible have a clinically relevant therapeutic effect in preventing, delaying or even treating tardive dyskinesia.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Pharmacol Biochem Behav. 2015 Apr ;131:71-6. Epub 2015 Feb 8. PMID:
25668129
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Lipid Peroxidation
,
Oxidative Stress
,
Tardive Dyskinesia
Pharmacological Actions
:
Antioxidants
[+]
EGCG may potentially inhibit aging-induced cardiac hypertrophy, fibrosis, and apoptosis, thereby preserving cardiac function.
Jan 31, 2018
Click here to read the entire abstract
Pubmed Data
: J Cardiovasc Pharmacol. 2018 Feb ;71(2):65-75. PMID:
29419571
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiac Hypertrophy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG may provide a potential therapeutic candidate for ALS as a disease-modifying agent.
Oct 01, 2007
Click here to read the entire abstract
Pubmed Data
: Biomed Res. 2007 Oct;28(5):261-6. PMID:
16356650
Article Published Date
: Oct 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Amyotrophic Lateral Sclerosis
[+]
EGCG may regenerate the HOCl-production of MPO which is known to be impaired at chronic inflammatory diseases like RA.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(3):e0152518. Epub 2016 Mar 29. PMID:
27023113
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
EGCG may serve as a promising compound for regulating glucose homeostasis.
Apr 02, 2019
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2019 Apr 3 ;67(13):3651-3661. Epub 2019 Mar 21. PMID:
30875211
Article Published Date
: Apr 02, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Hyperglycemia
Pharmacological Actions
:
Hypoglycemic Agents
[+]
EGCG might be regarded as a prospective therapeutic candidate in modulating diabetic nephropathy.
Aug 20, 2017
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2017 Aug 21. Epub 2017 Aug 21. PMID:
28823168
Article Published Date
: Aug 20, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Fibrotic
,
Hypoglycemic Agents
[+]
EGCG might represent a new potential therapeutic or preventive approach to control white spot syndrome.
Jun 21, 2017
Click here to read the entire abstract
Pubmed Data
: Fish Shellfish Immunol. 2017 Jun 22. Epub 2017 Jun 22. PMID:
28648884
Article Published Date
: Jun 21, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Fish Diseases
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG modulates the reversal of gene silencing involved in colon carcinogenesis.
May 05, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 May 6. Epub 2016 May 6. PMID:
27167203
Article Published Date
: May 05, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
Additional Keywords
:
Dose Response
,
Epigenetic Modification In Cancer
,
Gene Expression Regulation
[+]
EGCG nanoparticles attenuate aluminum chloride induced neurobehavioral deficits.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Aging Neurosci. 2018 ;10:244. Epub 2018 Aug 13. PMID:
30150930
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Aluminum Toxicity
,
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
Problem Substances
:
Aluminum Chloride
[+]
EGCG potentially abrogates fluoride induced oxidative lung injury in rats.
Jul 25, 2016
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2016 Jul 26 ;39:128-139. Epub 2016 Jul 26. PMID:
27472294
Article Published Date
: Jul 25, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Fluoride Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Nrf2 activation
[+]
EGCG prevents cardiac hypertrophy induced by pressuer overload in rats.
Jun 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Vet Sci. 2007 Jun;8(2):121-9. PMID:
17519564
Article Published Date
: Jun 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiac Hypertrophy
[+]
EGCG promotes atherosclerotic lesion stability in apolipoprotein E-deficient mice.
Jun 03, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Kardiol Pol. 2018 Jun 4. Epub 2018 Jun 4. PMID:
29862488
Article Published Date
: Jun 03, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Coronary Artery Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
EGCG protected outer hair cells from gentamicin toxicity in a cochlear explant model.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: Otol Neurotol. 2016 Oct ;37(9):1449-56. PMID:
27631653
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions
:
Antioxidants
,
Chemoprotective Agents
[+]
EGCG protects against muscle wasting disease, in a mouse model.
Apr 14, 2010
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2010 Apr 14;58(7):4523-8. PMID:
19322813
Article Published Date
: Apr 14, 2010
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Muscle Atrophy
,
Muscular Dystrophies
Pharmacological Actions
:
Glutathione Upregulation
[+]
EGCG protects the kidney in diabetic mice via anti-oxidative stress pathway.
May 09, 2016
Click here to read the entire abstract
Pubmed Data
: Zhonghua Yi Xue Za Zhi. 2016 May 10 ;96(17):1330-5. PMID:
27180749
Article Published Date
: May 09, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetes: Oxidative Stress
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Antioxidants
,
Renoprotective
[+]
EGCG reduces the susceptibility to cholesterol gallstone formation through the regulation of inflammation.
Dec 01, 2008
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2008 Dec;62(10):677-83. Epub 2008 Jan 30. PMID:
18374538
Article Published Date
: Dec 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cholecystitis
,
Gallbladder Inflammation
,
Gallstones
[+]
EGCG reduces the testicular oxidative stress induced by arsenic poisoning and thereby protect the reproductive system.
Oct 12, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Oct 13 ;96:685-694. Epub 2017 Oct 13. PMID:
29040955
Article Published Date
: Oct 12, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arsenic Poisoning
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Antioxidants
[+]
EGCG reversed GIO in rats by protecting osteoblasts by activating the Nrf2 signaling pathway.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:447. Epub 2018 May 9. PMID:
29867459
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Osteoporosis
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
,
Osteoprotective
[+]
EGCG sensitizes breast cancer cells to paclitaxel in a mouse model of breast carcinoma.
Jan 15, 2010
Click here to read the entire abstract
Pubmed Data
: Breast Cancer Res. 2010 Jan 15;12(1):R8. Epub 2010 Jan 15. PMID:
20078855
Article Published Date
: Jan 15, 2010
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Breast Cancer
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Drug: Paclitaxel
[+]
EGCG significantly inhibited gastric tumour growth in vivo by inhibiting Wnt/β-catenin signalling.
Jun 23, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2016 Jun 24:1-10. Epub 2016 Jun 24. PMID:
27338284
Article Published Date
: Jun 23, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemopreventive
,
Wnt/β-catenin pathway down-regulation
[+]
EGCG supplement specifically counteracts daytime overeating induced by high fat diet in mice.
Jul 27, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2016 Jul 28. Epub 2016 Jul 28. PMID:
27468160
Article Published Date
: Jul 27, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
High Fat Diet
Pharmacological Actions
:
Appetite Depressants
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG supplementation before radioiodine therapy could protect from RI-induced SG damage in a manner comparable to amifostine.
May 02, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Exp Otorhinolaryngol. 2016 May 3. Epub 2016 May 3. PMID:
27136365
Article Published Date
: May 02, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Radioprotective
Additional Keywords
:
Natural Substances Versus Drugs
[+]
EGCG treatment can decrease renal ischemia-reperfusion injury by suppressing inflammation and cell apoptosis.
Jun 27, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int Urol Nephrol. 2015 Jun 28. Epub 2015 Jun 28. PMID:
26122117
Article Published Date
: Jun 27, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Kidney Damage
,
Kidney Diseases
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Renoprotective
Additional Keywords
:
Significant Treatment Outcome
[+]
EGCG treatment led to a significant decrease in the protein levels of three Alzheimer’s disease relevant phospho-tau epitopes.
Jul 23, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Neurosci. 2015 Jul 24. Epub 2015 Jul 24. PMID:
26207957
Article Published Date
: Jul 23, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
MicroRNA modulator
,
Neuroprotective Agents
[+]
EGCG treatment was able to prevent the decreased locomotor activity as well as improve the learning and memory in SRs.
Jun 26, 2015
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2015 Jun 27 ;602:27-32. Epub 2015 Jun 27. PMID:
26126814
Article Published Date
: Jun 26, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Learning disorders
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
EGCG was able to exert anti-benign prostatic hyperplasia activities in metabolic syndrome rats.
Jun 14, 2016
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2016 Jun 15 ;45:315-320. Epub 2016 Jun 15. PMID:
27348728
Article Published Date
: Jun 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Metabolic Syndrome X
,
Prostatic Hyperplasia: Benign
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
EGCG, a green tea polyphenol, inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer in vivo.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Front Biosci. 2008 Jan 1;13:440-52. PMID:
17981559
Article Published Date
: Jan 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Anti-Angiogenic
[+]
EGCG, a green tea polyphenol, prevents photocarcinogenesis in mice by enhancing DNA repair.
May 15, 2006
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2006 May 15;66(10):5512-20. PMID:
16707481
Article Published Date
: May 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Skin Diseases: Photo-Aging
,
Xeroderma Pigmentosum
[+]
EGCG, a green tea polyphenol, significantly interferes with androgen-independent prostate cancer in vivo.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2008;60(4):483-91. PMID:
18584482
Article Published Date
: Jan 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anti-Angiogenic
,
Apoptotic
Additional Keywords
:
Androgen-Independent Prostate Cancer
[+]
EGCG, a polyphenol from green tea, ameloriates chronic fatigue syndrome in mice.
Jul 27, 2009
Click here to read the entire abstract
Pubmed Data
: Behav Brain Res. 2009 Jul 27. PMID:
19643148
Article Published Date
: Jul 27, 2009
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chronic Fatigue Syndrome
[+]
EGCG-containing supplements may be important in correcting skeletal deficits associated with Down syndrome.
Jan 08, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2016 Jan 9. Epub 2016 Jan 9. PMID:
26748562
Article Published Date
: Jan 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Down Syndrome
Additional Keywords
:
Gene Expression Regulation
[+]
EGCG-induced vascular normalization in human lung adenocarcinoma may be a novel modality for enhancing chemotherapy effects.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Manag Res. 2019 ;11:2425-2439. Epub 2019 Mar 27. PMID:
30988640
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lung Cancer
Pharmacological Actions
:
Chemotherapeutic
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
[+]
EGCG3''Me supplemented diet produces promising effects on gut micro-ecology by enhancing beneficial microbial populations.
May 14, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2018 May 15:e1800274. Epub 2018 May 15. PMID:
29762899
Article Published Date
: May 14, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obesity
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Encapsulation of EGCG in transferrin-bearing vesicles is a promising therapeutic strategy.
Jan 31, 2013
Click here to read the entire abstract
Pubmed Data
: Nanomedicine (Lond). 2013 Feb ;8(2):181-92. Epub 2012 Aug 14. PMID:
22891867
Article Published Date
: Jan 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Melanoma
,
Squamous cell carcinoma
Pharmacological Actions
:
Antiproliferative
[+]
Epigallocatechin gallate (EGCG) alters body fat and lean mass through sex-dependent metabolic mechanisms in Drosophila melanogaster.
Apr 21, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Food Sci Nutr. 2019 Apr 22:1-11. Epub 2019 Apr 22. PMID:
31010351
Article Published Date
: Apr 21, 2019
Study Type
: Insect Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Epigallocatechin gallate ameliorates airway inflammation by regulating Treg/Th17 imbalance in an asthmatic mouse model.
Apr 24, 2019
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2019 Apr 25 ;72:422-428. Epub 2019 Apr 25. PMID:
31030098
Article Published Date
: Apr 24, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Asthma
Pharmacological Actions
:
Immunomodulatory
,
Interleukin-10 upregulation
[+]
Epigallocatechin gallate and epicatechin gallate inhibited the cytotoxicity of acrylamide in PC12 cells.
Oct 25, 2017
Click here to read the entire abstract
Pubmed Data
: Drug Chem Toxicol. 2017 Oct 26:1-8. Epub 2017 Oct 26. PMID:
29072525
Article Published Date
: Oct 25, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Epicatechin
Diseases
:
Acrylamide-induced toxicity
Pharmacological Actions
:
Neuroprotective Agents
[+]
Epigallocatechin gallate attenuates arsenic induced genotoxicity via regulation of oxidative stress.
Jul 25, 2019
Click here to read the entire abstract
Pubmed Data
: Mol Biol Rep. 2019 Jul 26. Epub 2019 Jul 26. PMID:
31350662
Article Published Date
: Jul 25, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Arsenic Poisoning
,
DNA damage
Pharmacological Actions
:
Antioxidants
,
Genoprotective
Problem Substances
:
Arsenic
[+]
Epigallocatechin gallate exerts protective effects against myocardial ischemia/reperfusion injury.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2016 Jul ;38(1):328-36. Epub 2016 May 31. PMID:
27246989
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Epigallocatechin gallate has a neurorescue effect in a mouse model of parkinson disease.
Aug 22, 2017
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2017 Aug 23. Epub 2017 Aug 23. PMID:
28835392
Article Published Date
: Aug 22, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Epigallocatechin gallate prevents mitochondrial impairment and cell apoptosis.
Jan 29, 2019
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2019 Jan 30 ;61:152845. Epub 2019 Jan 30. PMID:
31029907
Article Published Date
: Jan 29, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
,
MicroRNA modulator
[+]
Epigallocatechin gallate reduces uric acid levels by regulating xanthine oxidase activity and uric acid excretion in vitro and in vivo.
Dec 21, 2019
Click here to read the entire abstract
Pubmed Data
: Ann Palliat Med. 2019 Dec 22. Epub 2019 Dec 22. PMID:
32008337
Article Published Date
: Dec 21, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Hyperuricemia
Pharmacological Actions
:
Uricosuric Agents
,
Xanthine oxidase inhibitor
[+]
Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy.
Apr 26, 2017
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2017 Apr 27. Epub 2017 Apr 27. PMID:
28457936
Article Published Date
: Apr 26, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Antioxidants
,
Nrf2 activation
[+]
Epigallocatechin gallate, a green tea phytochemical, attenuates alcohol-induced liver damage.
Jan 01, 2008
Click here to read the entire abstract
Pubmed Data
: Toxicol Mech Methods. 2008 Jan;18(8):645-52. PMID:
20020850
Article Published Date
: Jan 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Alcohol Toxicity
,
Alcoholic Liver Disease
Pharmacological Actions
:
Hepatoprotective
[+]
Epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways.
Aug 20, 2015
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2015 Aug 21. Epub 2015 Aug 21. PMID:
26386739
Article Published Date
: Aug 20, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Theaflavins
Diseases
:
Liver Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Wnt/β-catenin signaling pathway modulation
[+]
Epigallocatechin-3-gallate (EGCG) improves cognitive deficits aggravated by an obesogenic diet.
Dec 13, 2019
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2019 Dec 14. Epub 2019 Dec 14. PMID:
31838720
Article Published Date
: Dec 13, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Alzheimer's Disease
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Neuroprotective Agents
[+]
Epigallocatechin-3-gallate ameliorates atherosclerosis and modulates hepatic lipid metabolic gene expression.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:195. Epub 2018 Mar 9. PMID:
29593532
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Gene Expression Regulation
[+]
Epigallocatechin-3-gallate ameliorates erectile function in aged rats.
Apr 14, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian J Androl. 2016 Apr 15. Epub 2016 Apr 15. PMID:
27080477
Article Published Date
: Apr 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Erectile Dysfunction
[+]
Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates.
Jun 14, 2017
Click here to read the entire abstract
Pubmed Data
: Hum Mol Genet. 2017 Jun 15. Epub 2017 Jun 15. PMID:
28633380
Article Published Date
: Jun 14, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Neurodegenerative Diseases
Pharmacological Actions
:
Neuroprotective Agents
[+]
Epigallocatechin-3-gallate improves cardiac hypertrophy and short-term memory deficits in a Williams-Beuren syndrome mouse model.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2018 ;13(3):e0194476. Epub 2018 Mar 19. PMID:
29554110
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiac Hypertrophy
,
Williams Syndrome
Pharmacological Actions
:
Neuroprotective Agents
[+]
Epigallocatechin-3-gallate inhibits angiotensin II-induced C-reactive protein generation.
Aug 03, 2016
Click here to read the entire abstract
Pubmed Data
: Naunyn Schmiedebergs Arch Pharmacol. 2016 Aug 4. Epub 2016 Aug 4. PMID:
27492718
Article Published Date
: Aug 03, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
C-Reactive Protein
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Cell Int. 2019 ;19:43. Epub 2019 Feb 28. PMID:
30858760
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Thyroid Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Epidermal growth factor receptor (EGFR) inhibitor
[+]
Epigallocatechin-3-gallate reduces hepatic oxidative stress and lowers CYP-mediated bioactivation and toxicity of acetaminophen.
Aug 09, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2019 Aug 10 ;11(8). Epub 2019 Aug 10. PMID:
31405142
Article Published Date
: Aug 09, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Problem Substances
:
Acetaminophen
[+]
Epigallocatechin-3-gallate suppresses neutrophil migration speed in a transgenic zebrafish model accompanied by reduced inflammatory mediators
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Inflamm Res. 2019 ;12:231-239. Epub 2019 Aug 29. PMID:
31695470
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Inflammation
,
Inflammation: Neutrophil-Mediated
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Epigallocatechin-3-O-gallate attenuated the endoglin expression and myocardial fibrosis in vitro and in vivo.
Jun 15, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Mol Med. 2016 Jun 16. Epub 2016 Jun 16. PMID:
27306149
Article Published Date
: Jun 15, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Myocardial Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
[+]
Epigallocatechin-3-O-gallate modulates the diversity of gut microbiota in ovariectomized rats.
Jan 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Sci Nutr. 2020 Feb ;8(2):1295-1302. Epub 2020 Jan 27. PMID:
32148835
Article Published Date
: Jan 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
,
Gastrointestinal Agents
[+]
Eriodictyol synergistically potentiates the anti-tumour effect of EGCG by amplifying 67LR-dependent signalling in MM cells
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015 ;5:9474. Epub 2015 Mar 31. PMID:
25824377
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Eriodictyol
,
Yerba Santa
Diseases
:
Multiple Myeloma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
Additional Keywords
:
Bioenhancer
,
EGCG Sensitizer
,
Natural Substance Synergy
[+]
ERα36 is an effective target of epigallocatechin-3-gallate in hepatocellular carcinoma.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Pathol. 2019 ;12(9):3222-3234. Epub 2019 Sep 1. PMID:
31934166
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
Ferulic acid enhances the vasorelaxant properties of EGCG in TNF-α-induced inflammatory aorta.
Jun 30, 2014
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2014 Jul ;25(7):807-14. Epub 2014 Apr 4. PMID:
24794014
Article Published Date
: Jun 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Ferulic acid
Diseases
:
Inflammation
Pharmacological Actions
:
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Vasodilator Agents
Additional Keywords
:
Natural Substance Synergy
[+]
Green tea (-)-epigalocatechin-3-gallate induces cell death in gastrointestinal stromal tumor including imatinib-resistant cells.
Oct 01, 2009
Click here to read the entire abstract
Pubmed Data
: Cancer Biol Ther. 2009 Oct;8(20):1934-9. Epub 2009 Oct 22. PMID:
19770581
Article Published Date
: Oct 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cancers: Drug Resistant
,
Gastrointestinal Stromal Tumors
Pharmacological Actions
:
Apoptotic
[+]
Green tea catechins alleviate autoimmune symptoms and visual impairment in a murine model for human chronic intraocular inflammation.
Jan 18, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2019 02 19 ;9(1):2301. Epub 2019 Feb 19. PMID:
30783194
Article Published Date
: Jan 18, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Autoimmune Diseases
,
Uveitis
Pharmacological Actions
:
Immunomodulatory
,
Immunomodulatory: Th17 downregulation
[+]
Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis-induced atherosclerosis.
Jan 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pathog Dis. 2013 Feb ;67(1):76-83. Epub 2012 Nov 15. PMID:
23620122
Article Published Date
: Jan 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Atherosclerosis
,
Porphyromonas gingivalis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Heme oxygenase-1 up-regulation
,
MicroRNA modulator
Additional Keywords
:
Gene Expression Regulation
[+]
Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice.
Jan 12, 2010
Click here to read the entire abstract
Pubmed Data
: Am J Obstet Gynecol. 2010 Jan 12. Epub 2010 Jan 12. PMID:
20074693
Article Published Date
: Jan 12, 2010
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Leiomyoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
Green tea extract rich in epigallocatechin-3-Gallate prevents fatty liver in mice fed a high-fat diet.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(11):e0141227. Epub 2015 Nov 4. PMID:
26536464
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Fatty Liver
,
High Fat Diet
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Plant Extracts
,
Risk Reduction
[+]
Green tea extracts reversed the striatal oxidative stress and immunohistochemistry alterations in rats.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2015 ;2015:161092. Epub 2015 Jun 18. PMID:
26167188
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Neurodegenerative Diseases
,
Oxidative Stress
,
Parkinson's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
[+]
Green tea inhibits the genetic expression of hepatic enzymes associated with gluconeogenesis in vivo.
Aug 01, 2010
Click here to read the entire abstract
Pubmed Data
: South Med J. 2010 Aug;103(8):729-37. PMID:
15549673
Article Published Date
: Aug 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Gluconeogenesis Inhibitor
[+]
Green tea polyphenol improves gut dysbiosis and serum bile acids dysregulation in high-fat diet model.
Jun 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Biochem Nutr. 2019 Jul ;65(1):34-46. Epub 2019 Apr 6. PMID:
31379412
Article Published Date
: Jun 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Dysbiosis
,
High Fat Diet
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Green tea polyphenols ameliorate the early renal damage induced by a high-fat diet.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2017 ;2017:9032792. Epub 2017 Jul 26. PMID:
28814987
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
High Fat Diet
,
Kidney Damage
Pharmacological Actions
:
Renoprotective
[+]
Green tea polyphenols reduce autoimmune symptoms in a mouse model for human Sjogren's syndrome.
Mar 01, 2007
Click here to read the entire abstract
Pubmed Data
: Autoimmunity. 2007 Mar;40(2):138-47. PMID:
17364504
Article Published Date
: Mar 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Sjogren's Syndrome
[+]
Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.
Dec 31, 2008
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2009 ;4(2):e4606. Epub 2009 Feb 26. PMID:
19242551
Article Published Date
: Dec 31, 2008
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Down Syndrome
Pharmacological Actions
:
Antioxidants
[+]
Green tea rescues mice from lethal endotoxemia and sepsis.
Nov 07, 2007
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2007 Nov 7;2(11):e1153. PMID:
17987129
Article Published Date
: Nov 07, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Endotoxemia
,
Sepsis
[+]
Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Am J Transl Res. 2009;1(1):72-9. Epub 2009 Jan 1. PMID:
19966940
Article Published Date
: Jan 01, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Pharmacological Actions
:
Neuroprotective Agents
[+]
Green teaGreen tea polyphenol administration partly ameliorates irinotecan chemotherapy-induced side effects in the small intestine of mice.
Mar 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2007 Mar;137(3):634-40. PMID:
17311952
Article Published Date
: Mar 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
,
Polyphenols
Diseases
:
Chemotherapy-Induced Toxicity: Irinotecan
Pharmacological Actions
:
Antineoplastic Agents
[+]
Induction of p21 by EGCG could provide clinically useful normalization of salivary glands by promoting differentiation and reducing PCNA levels.
Jan 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Inflamm Allergy Drug Targets. 2014 Feb ;13(1):15-24. PMID:
24329914
Article Published Date
: Jan 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Autoimmune Diseases
,
Diabetes Mellitus: Type 1: Prevention
,
Sjogren's Syndrome
Pharmacological Actions
:
Anticarcinogenic Agents
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Intra-tumoral injection of TriCurin significantly inhibited tumor growth by 85.5%.
Jul 15, 2016
Click here to read the entire abstract
Pubmed Data
: Oncotarget. 2016 Jul 16. Epub 2016 Jul 16. PMID:
27437871
Article Published Date
: Jul 15, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Resveratrol
Diseases
:
Head and Neck Cancer
,
Human Papillomavirus (HPV)
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Chemopreventive
,
Tumor Suppressor Protein p53 Upregulation
[+]
Mice receiving EGCG have a lower mortality rate and exhibit less inflammation and a better preserved cardiac function and telomere biology.
Jun 29, 2016
Click here to read the entire abstract
Pubmed Data
: J Cardiol. 2016 Jun 30. Epub 2016 Jun 30. PMID:
27374189
Article Published Date
: Jun 29, 2016
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiac Mortality
,
Heart Failure
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Telomere Protective
Additional Keywords
:
Mortality
[+]
Mobile phone radiation-induced free radical damage in the liver is inhibited by the antioxidants n-acetyl cysteine and epigallocatechin-gallate.
Sep 01, 2010
Click here to read the entire abstract
Pubmed Data
: Int J Radiat Biol. 2010 Sep 1. Epub 2010 Sep 1. PMID:
20807176
Article Published Date
: Sep 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
NAC (N-acetyl-L-cysteine)
Diseases
:
Mobile Phone-Induced Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Obesity may increase susceptibility to chronic pain often due to poor diet.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Eur J Pain. 2018 08 ;22(7):1203-1213. Epub 2018 Mar 2. PMID:
29436058
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Ginseng
,
Resveratrol
,
Sulforaphane
Diseases
:
Chronic Pain
,
Inflammation
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Inflammatory Diet
,
Risk Factors
[+]
Oral consumption of the green tea polyphenol EGCG improves disease paramaters in a mouse model of human Sjogren's syndrome.
Oct 24, 2008
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2008 Oct 24;83(17-18):581-8. Epub 2008 Sep 6. PMID:
18809413
Article Published Date
: Oct 24, 2008
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Sjogren's Syndrome
[+]
Oral intake of green tea extract or its catechin constituents attenuates sodium iodate-induced retinal degeneration.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 ;6:29546. Epub 2016 Jul 7. PMID:
27383468
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Retinal Diseases
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
Orally administered EGCG attenuates injury to the retina caused by ischemia/reperfusion where caspases were activated.
Mar 10, 2008
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2008 Mar 10 ;1198:141-52. Epub 2007 Dec 15. PMID:
18255049
Article Published Date
: Mar 10, 2008
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Glaucoma
,
Oxidative Stress
Pharmacological Actions
:
Neuroprotective Agents
,
Regenerative
[+]
Potential ameliorative effects of epigallocatechin-3-gallate against cigarette smoke exposure induced renal and hepatic deficits.
Jan 12, 2020
Click here to read the entire abstract
Pubmed Data
: Ecotoxicol Environ Saf. 2020 Jan 13 ;191:110202. Epub 2020 Jan 13. PMID:
31945511
Article Published Date
: Jan 12, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Chemically-Induced Liver Damage
,
Kidney Damage: Chemically-Induced
,
Smoking
Pharmacological Actions
:
Hepatoprotective
,
Renoprotective
[+]
Preoperative oral administration of EGCG ameliorates acute kidney injury in a cardiopulmonary bypass model of diabetic rats.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Ann Thorac Surg. 2016 Apr ;101(4):1507-13. Epub 2015 Dec 8. PMID:
26675556
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetes Mellitus: Type 2
,
Kidney Damage
Pharmacological Actions
:
Prophylactic Agents
,
Renoprotective
Additional Keywords
:
Cardiopulmonary Bypass
[+]
Protective effect of epigallocatechin gallate in ischemia-reperfusion injury of rat skeletal muscle.
Dec 05, 2019
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2019 Dec 6 ;247:1-7. Epub 2019 Dec 6. PMID:
31816476
Article Published Date
: Dec 05, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Ischemia
Pharmacological Actions
:
Antioxidants
[+]
Quercetin and green tea extract supplementation downregulates genes related to tissue inflammatory responses.
Jul 18, 2017
Click here to read the entire abstract
Pubmed Data
: Nutrients. 2017 Jul 19 ;9(7). Epub 2017 Jul 19. PMID:
28753942
Article Published Date
: Jul 18, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
,
Quercetin
Diseases
:
High Fat Diet
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Quercetin increased the cellular absorption of epigallocatechin gallate (EGCG) four-fold in A549 cells with a decreased methylation rate from 63 to 19%.
May 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Funct. 2012 Jun ;3(6):635-42. PMID:
22438067
Article Published Date
: May 31, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Quercetin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemopreventive
Additional Keywords
:
Bioavailability
,
Natural Substance Synergy
[+]
Resveratrol and EGCG restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model.
Mar 06, 2016
Click here to read the entire abstract
Pubmed Data
: Biochim Biophys Acta. 2016 Mar 7. Epub 2016 Mar 7. PMID:
26964795
Article Published Date
: Mar 06, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Resveratrol
Diseases
:
Down Syndrome
[+]
Selected dietary components alone or in combination with other therapeutic approaches could prevent diabetes-related complications.
Nov 30, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Dec ;84:502-513. Epub 2016 Sep 28. PMID:
27685794
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Gingerol
,
Phloretin
Diseases
:
Advanced Glycation End products (AGE)
,
Diabetic Complications
Pharmacological Actions
:
Aldose reductase inhibitor
,
Anti-Glycation Agents
,
Hypoglycemic Agents
[+]
Synergistic inhibition of lung cancer cells by EGCG and NF-κB inhibitor BAY11-7082.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cancer. 2019 ;10(26):6543-6556. Epub 2019 Oct 21. PMID:
31777584
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Pharmacological Actions
:
Antiproliferative
,
NF-kappaB Inhibitor
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Tea polyphenols Epigallocatechin gallate and Theaflavin restrict tongue and liver carcinogenesis.
May 31, 2016
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2016 Jun 1 ;300:34-46. Epub 2016 Apr 4. PMID:
27058323
Article Published Date
: May 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Theaflavins
Diseases
:
Liver Cancer
,
Tongue Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
The administration of EGCG after sunitinib treatment represents a promising strategy for the treatment of cancer.
Jan 04, 2016
Click here to read the entire abstract
Pubmed Data
: Tumour Biol. 2016 Jan 5. Epub 2016 Jan 5. PMID:
26733173
Article Published Date
: Jan 04, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Breast Cancer
,
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
The catechin epigallocatechin-3-gallate is effective in reversing the impaired relaxation in RCM myocardial cells and rescuing the RCM mice with diastolic dysfunction.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Arch Biochem Biophys. 2015 May 1 ;573:69-76. Epub 2015 Mar 24. PMID:
25813360
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cardiomyopathy: Restrictive
Pharmacological Actions
:
Calcium Desensitizer
Additional Keywords
:
Calcium Hypersensitivity
,
Diastolic Dysfunction
[+]
The polyphenol in green tea known as EGCG may inhibit the progression of Huntington's disease.
Sep 15, 2006
Click here to read the entire abstract
Pubmed Data
: Hum Mol Genet. 2006 Sep 15;15(18):2743-51. Epub 2006 Aug 7. PMID:
16893904
Article Published Date
: Sep 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Huntington Disease
[+]
The present study thus recommends the usefulness of white tea extract in mitigating benzo(a)pyrene induced hepatic dysfunctions.
May 31, 2018
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2018 Jun ;116(Pt B):281-291. Epub 2018 Apr 21. PMID:
29684493
Article Published Date
: May 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
White Tea
Diseases
:
Benzo[a]pyrene-induced Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
Problem Substances
:
Benzo(a)pyrene
[+]
These results indicate that EGCG feeding may reduce the metabolism and toxicity of acetaminophen in rats.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomedicine (Taipei). 2015 Sep ;5(3):15. Epub 2015 Aug 12. PMID:
26264479
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Liver Damage: Drug-Induced
Pharmacological Actions
:
Hepatoprotective
Problem Substances
:
Acetaminophen
[+]
These results presented that EGCG had obvious hypouricemic and renal protective effects on hyperuricemic mice.
Oct 25, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Oct 26 ;97:168-173. Epub 2017 Oct 26. PMID:
29091862
Article Published Date
: Oct 25, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Hyperuricemia
Pharmacological Actions
:
Renoprotective
,
Uricosuric Agents
[+]
These results provide new insight into the mechanism of EGCG-associated key pathways/genes in MDSCs in the murine breast tumor model.
Apr 09, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2020 Apr 10 ;12(4). Epub 2020 Apr 10. PMID:
32290071
Article Published Date
: Apr 09, 2020
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Breast Cancer
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Gene Expression Regulation
[+]
These results suggest a protective effect of EGCG in treating reserpine-induced impairment of memory, most probably through its powerful antioxidative activities.
Jul 19, 2015
Click here to read the entire abstract
Pubmed Data
: Behav Pharmacol. 2015 Jul 20. Epub 2015 Jul 20. PMID:
26196076
Article Published Date
: Jul 19, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain: Oxidative Stress
,
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
[+]
This evidence provides a potential clinically relevant role for EGCG in delaying or treating human Parkinson's disease.
Dec 05, 2019
Click here to read the entire abstract
Pubmed Data
: Neurotox Res. 2019 Dec 6. Epub 2019 Dec 6. PMID:
31811588
Article Published Date
: Dec 05, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
Problem Substances
:
Rotenone
[+]
This study demonstrates the efficacy of EGCG in reversing the progression of crescentic glomerulonephritis in mice by targeting multiple signaling and inflammatory pathways.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(3):e0119543. Epub 2015 Mar 18. PMID:
25785827
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Glomerulonephritis
,
Inflammation
,
Kidney Diseases
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Nrf2 activation
,
Renoprotective
Additional Keywords
:
Disease Reversal
[+]
This study established a new mechanism for using EGCG as an adjuvant chemotherapy agent through modifying microvasculature and microenvironments.
Apr 30, 2013
Click here to read the entire abstract
Pubmed Data
: Chin J Nat Med. 2013 May ;11(3):245-53. PMID:
23725836
Article Published Date
: Apr 30, 2013
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Chemotherapy-Induced Toxicity: Cisplatin
,
Lung Cancer
Pharmacological Actions
:
Anti-Angiogenic
,
Antineoplastic Agents
,
Antiproliferative
,
Chemosensitizer
,
Chemotherapeutic
Additional Keywords
:
Natural Substance/Drug Synergy
Problem Substances
:
Cisplatin
[+]
This study proposes a novel molecular rationale for antitumor activities of green tea in head and neck cancers.
Nov 14, 2016
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2016 Nov 15 ;23(12):1344-1355. Epub 2016 Aug 19. PMID:
27765354
Article Published Date
: Nov 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Head and Neck Cancer
Pharmacological Actions
:
Apoptotic
,
MicroRNA modulator
[+]
This study reveals an anti-nociceptive role for EGCG in the progression of pain caused by tumor bone metastasis.
Sep 08, 2015
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2015 Sep 9. Epub 2015 Sep 9. PMID:
26363974
Article Published Date
: Sep 08, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Bone Cancer
,
Cancer Metastasis
,
Neuropathic Pain
Pharmacological Actions
:
Antinoceceptive
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Various plant polyphenols inhibit lung cancer caused by metastatic melanoma.
Jul 16, 2009
Click here to read the entire abstract
Pubmed Data
: Int Urol Nephrol. 2009 Jul 16. PMID:
7656234
Article Published Date
: Jul 16, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Ellagic Acid
,
Polyphenols
,
Quercetin
Diseases
:
Lung Cancer
,
Melanoma
,
Melanoma: Metastatic
[+]
Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma.
Jun 09, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2010 Jun 10 ;5(6):e11051. Epub 2010 Jun 10. PMID:
20548792
Article Published Date
: Jun 09, 2010
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Vitamin A
Diseases
:
Melanoma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
Additional Keywords
:
Natural Substance Synergy
[+]
White Tea, Green Tea, EGCG (Epigallocatechin gallate), and Caffeine inhibit colon cancer progression.
Jan 01, 2007
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2007;58(1):60-5. PMID:
17571968
Article Published Date
: Jan 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Caffeine
,
EGCG (Epigallocatechin gallate)
,
Green Tea
,
White Tea
Diseases
:
Colon Cancer
Pharmacological Actions
:
Chemopreventive
[+]
Wound healing can be improved by (-)-epigallocatechin gallate through targeting Notch in streptozotocin-induced diabetic mice.
Aug 01, 2018
Click here to read the entire abstract
Pubmed Data
: FASEB J. 2018 Aug 2:fj201800337R. Epub 2018 Aug 2. PMID:
30070931
Article Published Date
: Aug 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetic Complications
,
Wound Healing: Delayed
[+]
Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model.
Aug 12, 2014
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2014 Aug 13 ;62(32):8085-93. Epub 2014 Jul 31. PMID:
25050823
Article Published Date
: Aug 12, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Zinc
Pharmacological Actions
:
Antioxidants
,
Immunomodulatory
,
Ionophores
[+]
"Anti-infective properties of Epigallocatechin-3-gallate (EGCG), a component of Green Tea."
Oct 15, 2012
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2012 Oct 16. Epub 2012 Oct 16. PMID:
23072320
Article Published Date
: Oct 15, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Bacterial Infections and Mycoses
,
Viral Infections
Pharmacological Actions
:
Anti-Bacterial Agents
,
Antiviral Agents
[+]
"The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition."
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Mol Signal. 2010 ;5:14. Epub 2010 Aug 18. PMID:
20718984
Article Published Date
: Jan 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Quercetin
Diseases
:
Cancer Stem Cells
,
Prostate Cancer
Pharmacological Actions
:
Anti-metastatic
Additional Keywords
:
Cancer Stem Cells
,
Natural Substance Synergy
[+]
(-)-Epigallocatechin 3-gallate inhibits pancreatic cancer cell growth.
Dec 31, 2012
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2013 Jan ;42(1):349-58. Epub 2012 Nov 6. PMID:
23135610
Article Published Date
: Dec 31, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Pancreatic Cancer
[+]
A combination of curcumin and EGCG has an enhanced antimicrobial activity against multidrug resistant Acinetobacter baumannii.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Microbiol. 2014 ;14:172. Epub 2014 Jun 27. PMID:
24969489
Article Published Date
: Dec 31, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Acinetobacter baumannii infection
Pharmacological Actions
:
Anti-Bacterial Agents
Additional Keywords
:
Drug Resistance
,
Natural Substance Synergy
[+]
A combination of LL-37 and polyphenols from cranberry and green tea acted in synergy to reduce the secretion of cytokines by an LPS-stimulated 3D co-culture model of oral mucosal cells.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Arch Oral Biol. 2015 Jun ;60(6):845-53. Epub 2015 Feb 27. PMID:
25791329
Article Published Date
: May 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Cranberry Proanthocyanidins
,
EGCG (Epigallocatechin gallate)
Diseases
:
Periodontitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-10 downregulation
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
Additional Keywords
:
Natural Substance Synergy
[+]
A green tea extract inhibits the growth of human Barrett's and aerodigestive cancer cells.
Jan 15, 2009
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2009 Jan 15;15(2):622-31. PMID:
19147768
Article Published Date
: Jan 15, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Polyphenols
Diseases
:
Barrett Esophagus
,
Esophageal Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Cell cycle arrest
,
Proteasome Inhibitors
[+]
A review of green tea catechins and their uses in treating infectious diseases.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2018 ;2018:9105261. Epub 2018 Jul 17. PMID:
30105263
Article Published Date
: Dec 31, 2017
Study Type
: Review
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Epicatechin
Diseases
:
Escherichia coli Infections
,
Helicobacter Pylori Infection
,
Pseudomonas aeruginosa
,
Staphylococcus aureus infection
,
Steptococcus Mutans Infections
Pharmacological Actions
:
Antimicrobial
,
Quorum Sensing Inhibition
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
A review of in vitro and vivo antihepatocarcinogenic effects of natural compounds.
Jul 31, 2011
Click here to read the entire abstract
Pubmed Data
: Clin J Gastroenterol. 2011 Aug ;4(4):185-97. Epub 2011 Jun 4. PMID:
26189518
Article Published Date
: Jul 31, 2011
Study Type
: Review
Additional Links
Substances
:
Caffeine
,
Capsaicin
,
Cinnamaldehyde
,
Curcumin
,
Diallyl sulfide
,
EGCG (Epigallocatechin gallate)
,
Genistein
,
Lycopene
,
Resveratrol
,
Silymarin
,
Sulforaphane
,
Xanthohumol
Diseases
:
Liver Cancer
Pharmacological Actions
:
Chemopreventive
[+]
A review of targeting oncogenic transcription factors by polyphenols.
Jan 03, 2018
Click here to read the entire abstract
Pubmed Data
: Pharmacol Res. 2018 Jan 4. Epub 2018 Jan 4. PMID:
29305909
Article Published Date
: Jan 03, 2018
Study Type
: Review
Additional Links
Substances
:
4-Shogaol
,
6-Shogaol
,
Apigenin
,
Berberine
,
Caffeic Acid
,
Capsaicin
,
Cardamonin
,
Chrysin
,
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Ellagic Acid
,
Fisetin
,
Gingerol
,
Luteolin
,
Mangiferin
,
Piperlongumine
,
Polyphenols
,
Pterostilbene
,
Quercetin
,
Resveratrol
,
Rutin
,
Sesamin
,
Ursolic Acid
,
Wogonin
,
Xanthohumol
Diseases
:
Cancers: All
Pharmacological Actions
:
Chemopreventive
,
Chemotherapeutic
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
,
NF-kappaB Inhibitor
,
STAT3 Inhibitor
,
Wnt/β-catenin signaling pathway modulation
[+]
A review of the absorption and metabolism process of EGCG and its anti-cancer effect in vitro and in vivo.
Sep 18, 2016
Click here to read the entire abstract
Pubmed Data
: Crit Rev Food Sci Nutr. 2016 Sep 19:0. Epub 2016 Aug 19. PMID:
27645804
Article Published Date
: Sep 18, 2016
Study Type
: Review
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Cancers: All
[+]
A review of the cancer chemoprevention by phytochemicals.
Mar 02, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2017 Mar 3 ;22(3). Epub 2017 Mar 3. PMID:
28273819
Article Published Date
: Mar 02, 2017
Study Type
: Review
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Honokiol
,
Resveratrol
Diseases
:
Cancers: All
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
[+]
A variety of natural substances have preventive potential in osteoarthritis and rheumatoid arthritis.
Feb 03, 2011
Click here to read the entire abstract
Pubmed Data
: Arthritis Res Ther. 2011 Feb 3;13(1):102. Epub 2011 Feb 3. PMID:
21345249
Article Published Date
: Feb 03, 2011
Study Type
: Review
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Pomegranate
,
Resveratrol
Diseases
:
Osteoarthritis
,
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Activation of autophagic flux by epigallocatechin gallate mitigates TRAIL-induced tumor cell apoptosis.
Aug 24, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Aug 25. Epub 2016 Aug 25. PMID:
27582540
Article Published Date
: Aug 24, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Apoptotic
,
Autophagy Up-regulation
[+]
Advances on natural polyphenols as anticancer agents for skin cancer.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmacol Res. 2020 01 ;151:104584. Epub 2019 Dec 3. PMID:
31809853
Article Published Date
: Dec 31, 2019
Study Type
: Review
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Polyphenols
,
Punicalagin
,
Quercetin
,
Resveratrol
,
Theaflavins
Diseases
:
Skin Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Chemopreventive
[+]
Anticancer potential of naturally occurring immunoepigenetic modulators.
Jan 14, 2019
Click here to read the entire abstract
Pubmed Data
: Cancer. 2019 05 15 ;125(10):1612-1628. Epub 2019 Mar 6. PMID:
30840315
Article Published Date
: Jan 14, 2019
Study Type
: Review
Additional Links
Substances
:
Curcumin
,
EGCG (Epigallocatechin gallate)
,
Resveratrol
Diseases
:
Cancers: All
Pharmacological Actions
:
Immunomodulatory
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
Antioxidant polysaccharides attenuate neuronal damages and alleviate cognitive and motor decline in a range of neurodegenerative models.
Jul 19, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Jul 19 ;9(7). Epub 2017 Jul 19. PMID:
28753972
Article Published Date
: Jul 19, 2017
Study Type
: Review
Additional Links
Substances
:
Antioxidant formulas
,
EGCG (Epigallocatechin gallate)
,
Green Tea
,
Tea
Diseases
:
Neurodegenerative Diseases
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Neuroprotective Agents
,
Regenerative
[+]
Antiviral effect of epigallocatechin gallate via impairing porcine circovirus type 2 attachment to host cell receptor.
Feb 03, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Viruses. 2020 Feb 4 ;12(2). Epub 2020 Feb 4. PMID:
32033244
Article Published Date
: Feb 03, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Animal Diseases: Porcine Circovirus Type 2 (PCV2)
Pharmacological Actions
:
Antiviral Agents
[+]
Antiviral properties of the natural polyphenols delphinidin and epigallocatechin gallate against the flaviviruses west nile virus, zika virus, and dengue virus.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Microbiol. 2017 ;8:1314. Epub 2017 Jul 11. PMID:
28744282
Article Published Date
: Dec 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Delphinidin
,
EGCG (Epigallocatechin gallate)
Diseases
:
Dengue
,
West Nile Fever
Pharmacological Actions
:
Antiviral Agents
[+]
Antivirals against chikungunya virus: Is the solution in nature?
Jan 28, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Viruses. 2020 02 29 ;12(3). Epub 2020 Feb 29. PMID:
32121393
Article Published Date
: Jan 28, 2020
Study Type
: Review
Additional Links
Substances
:
Apigenin
,
Berberine
,
Chrysin
,
EGCG (Epigallocatechin gallate)
,
Fisetin
,
Luteolin
,
Naringenin
,
Silibinin
,
Silymarin
,
Tannic Acid
Diseases
:
Chikungunya Virus
Pharmacological Actions
:
Antiviral Agents
[+]
Avocado soybean unsaponifiables and epigallocatechin gallate reduce inflammation in chondrocytes.
Dec 01, 2004
Click here to read the entire abstract
Pubmed Data
: J Chem Neuroanat. 2004 Dec;28(4):253-64. PMID:
19748608
Article Published Date
: Dec 01, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Avocado
,
EGCG (Epigallocatechin gallate)
,
Soy
,
Unsaponifiables
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
NF-kappaB Inhibitor
,
Prostaglandin Antagonists
[+]
Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells.
Feb 14, 2016
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2016 Feb 15 ;23(2):200-13. Epub 2016 Jan 5. PMID:
26926182
Article Published Date
: Feb 14, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Apple Polyphenols
,
EGCG (Epigallocatechin gallate)
,
Ginger
Diseases
:
Advanced Glycation End products (AGE)
,
Diabetic Complications
Pharmacological Actions
:
Anti-Glycation Agents
,
Antioxidants
,
Nrf2 activation
[+]
Biochanin A may represent a breast cancer preventive agent, either administered alone or in combination with other flavonoids.
Aug 31, 2008
Click here to read the entire abstract
Pubmed Data
: Pharm Res. 2008 Sep ;25(9):2158-63. Epub 2008 May 3. PMID:
18454305
Article Published Date
: Aug 31, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Biochanin A
,
EGCG (Epigallocatechin gallate)
,
Quercetin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Chemopreventive
[+]
Biophysical approach to mechanisms of cancer prevention and treatment with green tea catechins.
Nov 17, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2016 Nov 18 ;21(11). Epub 2016 Nov 18. PMID:
27869750
Article Published Date
: Nov 17, 2016
Study Type
: Review
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Cancers: All
,
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Chemopreventive
Additional Keywords
:
Plant Extracts
[+]
Cancer stem cells and the potential targets of Chinese medicines and their active compounds.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2016 ;17(6). Epub 2016 Jun 7. PMID:
27338343
Article Published Date
: Dec 31, 2015</
