Beta-Caryophyllene

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3 Diseases Researched for Beta-Caryophyllene
NameACCKFocus
Atherosclerosis12Locked
Coronary Artery Disease12Locked
Oxidative Stress12Locked
2 Pharmacological Actions Researched for Beta-Caryophyllene
NameACCKFocus
Anti-atherogenic12Locked
Antioxidants12Locked

View the Evidence:
66 Abstracts with Beta-Caryophyllene Research

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The results suggest the occurrence of the positive relaxation and anxiolytic effects of cannabis essential oil.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:1709182. Epub 2018 Jan 17. PMID: 29576792
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Beta-Caryophyllene, Cannabis
Diseases : Anxiety
Pharmacological Actions : Anti-Anxiety Agents
Additional Keywords : Essential Oils
[+]

Anti-inflammatory activity of β-caryophyllene combined with docosahexaenoic acid in a model of sepsis.Jun 16, 2019

Pubmed Data : J Sci Food Agric. 2019 Jun 17. Epub 2019 Jun 17. PMID: 31206687
Article Published Date : Jun 16, 2019
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, DHA (Docosahexaenoic Acid)
Diseases : Sepsis, Staphylococcus aureus infection
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-4 upregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Antidepressant-like effects of β-caryophyllene on restraint plus stress-induced depression.Feb 16, 2020

Pubmed Data : Behav Brain Res. 2020 Feb 17 ;380:112439. Epub 2019 Dec 17. PMID: 31862467
Article Published Date : Feb 16, 2020
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Depression, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents
Additional Keywords : Endocannabinoid System
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Beta-caryophyllene alleviates ischemic brain damage potentially by inhibiting necroptotic neuronal death and inflammatory response.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2017 ;11:583. Epub 2017 Oct 26. PMID: 29123466
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Beta-Caryophyllene ameliorates the development of experimental autoimmune encephalomyelitis.Apr 28, 2017

Pubmed Data : Biomed Pharmacother. 2017 Apr 29 ;91:257-264. Epub 2017 Apr 29. PMID: 28463791
Article Published Date : Apr 28, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Autoimmune Diseases, Encephalomyelitis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-17 downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Beta-caryophyllene can be used to treat dyslipidemic diseases because it exerts a similar effect as simvastatin.Jan 31, 2017

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2017 Feb ;390(2):215-223. Epub 2016 Dec 2. PMID: 27913825
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Dyslipidemias, Oxidative Stress
Pharmacological Actions : Antioxidants, Hypolipidemic, Superoxide Dismutase Up-regulation
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Simvastatin, Statin Drugs
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Beta-caryophyllene constitutes an alluring therapeutic molecule towards the treatment of multiple sclerosis.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Apr 1 ;18(4). Epub 2017 Apr 1. PMID: 28368293
Article Published Date : Mar 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Inflammation: Brain, Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
Additional Keywords : Cannabinoid Receptors
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Beta-caryophyllene could be useful for prevention and treatment of antiretroviral-induced neuropathic pain.Dec 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Dec 27 ;25(1). Epub 2019 Dec 27. PMID: 31892132
Article Published Date : Dec 26, 2019
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : HIV Infections, Neuropathic Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Cannabinoid Receptors
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Beta-caryophyllene enhances wound healing through multiple routes.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2019 ;14(12):e0216104. Epub 2019 Dec 16. PMID: 31841509
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Inflammation, Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents
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Beta-caryophyllene may be highly effective in the treatment of debilitating pain states.Mar 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Neuropsychopharmacol. 2014 Apr ;24(4):608-20. Epub 2013 Oct 22. PMID: 24210682
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Hyperalgesia, Neuropathic Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
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Beta-caryophyllene may be used as a therapeutic agent for the prevention and treatment of osteoporosis.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Dec ;12(6):3602-3606. Epub 2016 Oct 18. PMID: 28105093
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
Additional Keywords : Beta-Caryophyllene, Osteoporosis, Osteoprotective
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Beta-caryophyllene may be viewed as a potential treatment or preventative agent for Parkinson's disease.Jul 05, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2017 Jul 6 ;10(3). Epub 2017 Jul 6. PMID: 28684694
Article Published Date : Jul 05, 2017
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
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Effect of β-caryophyllene from cloves extract on Helicobacter pylori eradication. Apr 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Apr 4 ;12(4). Epub 2020 Apr 4. PMID: 32260414
Article Published Date : Apr 03, 2020
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, Clove
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
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Effects of cannabidiol and beta-caryophyllene alone or in combination in a mouse model of permanent ischemia.Mar 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Mar 11 ;22(6). Epub 2021 Mar 11. PMID: 33799861
Article Published Date : Mar 10, 2021
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, Cannabidiol
Diseases : Ischemia
Pharmacological Actions : Neuroprotective Agents
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Healing activity of hydrogel containing nanoemulsified β-caryophyllene. May 29, 2020

Pubmed Data : Eur J Pharm Sci. 2020 May 30 ;148:105318. Epub 2020 Mar 20. PMID: 32205230
Article Published Date : May 29, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents
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Inhibitory effects of β-caryophyllene on Helicobacter pylori infection in vitro and in vivo.Feb 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Feb 3 ;21(3). Epub 2020 Feb 3. PMID: 32028744
Article Published Date : Feb 02, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Antimicrobial
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Monoamine involvement in the antidepressant-like effect of β-caryophyllene.Apr 19, 2018

Pubmed Data : CNS Neurol Disord Drug Targets. 2018 Apr 20. Epub 2018 Apr 20. PMID: 29676236
Article Published Date : Apr 19, 2018
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator
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Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.Mar 11, 2018

Pubmed Data : Seizure. 2018 Mar 12 ;57:22-26. Epub 2018 Mar 12. PMID: 29547827
Article Published Date : Mar 11, 2018
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
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Protective effects of combined β-caryophyllene and silymarin against ketoprofen-induced hepatotoxicity.Jun 30, 2016

Pubmed Data : Can J Physiol Pharmacol. 2016 Jul ;94(7):739-44. Epub 2016 Mar 9. PMID: 27124106
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, Silymarin
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective
Additional Keywords : Beta-Caryophyllene, Hepatoprotective, Liver Damage: Drug-Induced, Plant Extracts, SILYMARIN
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
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Role of β-caryophyllene in the antinociceptive and anti-inflammatory effects of Tagetes lucida essential oil. Feb 04, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Feb 5 ;25(3). Epub 2020 Feb 5. PMID: 32033302
Article Published Date : Feb 04, 2020
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antinoceceptive
Additional Keywords : Essential Oils
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The effect of β-caryophyllene on nonalcoholic steatohepatitis.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Toxicol Pathol. 2017 Oct ;30(4):263-273. Epub 2017 Jun 19. PMID: 29097836
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
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The phytocannabinoid β-caryophyllene can be used as an attempt to prevent or reduce atherosclerosis in hypercholesterolemic rats.May 24, 2017

Pubmed Data : Chem Biol Interact. 2017 May 25 ;270:9-14. Epub 2017 Apr 12. PMID: 28411027
Article Published Date : May 24, 2017
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Atherosclerosis, Coronary Artery Disease, Oxidative Stress
Pharmacological Actions : Anti-atherogenic, Antioxidants
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The present findings suggest that β-Caryophyllene has significant anti-nicotine effects.Apr 30, 2020

Pubmed Data : Br J Pharmacol. 2020 May ;177(9):2058-2072. Epub 2020 Feb 15. PMID: 31883107
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Smoking Cessation: Nicotine Addiction
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The results showed that β-caryophyllene has antimicrobial activity against the proliferation of dog's dental plaque-forming bacteria.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Vet Res. 2016 Oct 1 ;12(1):216. Epub 2016 Oct 1. PMID: 27716286
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Dental Plaque, Periodontal Diseases
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Anti-Bacterial Agents, Caryophyllene, Dental Plaque, Periodontal Diseases
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The study indicates a therapeutic approach to treat T2DM by Beta-caryophyllene and l-arginine combination as food and dietary supplement.Mar 31, 2020

Pubmed Data : J Food Biochem. 2020 Apr ;44(4):e13156. Epub 2020 Jan 29. PMID: 31997410
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, L-arginine
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
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These findings demonstrate that beta-caryophylleneprovides neuroprotection against rotenone-induced Parkinson disease.Jun 30, 2016

Pubmed Data : Mol Cell Biochem. 2016 Jul ;418(1-2):59-70. Epub 2016 Jun 17. PMID: 27316720
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Brain Inflammation , Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents
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These findings support the rationale of using natural remedies in conjunction with classical pharmacological agents to treat chronic neuropathic pain.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:711. Epub 2019 Jun 27. PMID: 31316381
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, Carnosic Acid, Myrrh, Palmitoylethanolamide
Diseases : Neuropathic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
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These observations demonstrate that β-caryophyllene has a cholesterol-lowering effect on hypercholesterolemic rats.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Biochem Nutr. 2018 May ;62(3):230-237. Epub 2018 Feb 7. PMID: 29892161
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Atherosclerosis, Fatty Liver, Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic
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These results suggest that β-caryophyllene ameliorates arthritis through a cross-talk between CB2 and PPAR-γ.Jul 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Jul 31 ;9(8). Epub 2019 Jul 31. PMID: 31370242
Article Published Date : Jul 30, 2019
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
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This study revealed the cardioprotective effect of β-caryophyllene against myocardial infarction.May 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 May 19 ;24(10). Epub 2019 May 19. PMID: 31109132
Article Published Date : May 18, 2019
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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β-caryophyllene alleviates cerebral ischemia/reperfusion injury.Jan 31, 2020

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2020 Feb ;45(4):932-936. PMID: 32237496
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Cerebral Ischemia
Pharmacological Actions : Autophagy Up-regulation, Neuroprotective Agents
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β-caryophyllene ameliorates MSU-induced gouty arthritis and inflammation.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:651305. Epub 2021 Apr 23. PMID: 33967792
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Arthritis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
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β-caryophyllene attenuates the non-inflammatory chronic muscle pain in mice and inhibits the Fos expression in the lumbar spinal cord.Mar 14, 2016

Pubmed Data : Life Sci. 2016 Mar 15 ;149:34-41. Epub 2016 Feb 13. PMID: 26883973
Article Published Date : Mar 14, 2016
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene, Cannabinoids
Diseases : Hyperalgesia, Inflammation, Muscle Soreness
Pharmacological Actions : Anti-Inflammatory Agents
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β-caryophyllene has antiallodynic effects on paclitaxel-induced peripheral neuropathy in mice.Sep 30, 2017

Pubmed Data : Neuropharmacology. 2017 Oct ;125:207-219. Epub 2017 Jul 18. PMID: 28729222
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Chemotherapy-Induced Toxicity: Paclitaxel, Chemotherapy-Induced Toxicity: Peripheral Neuropathy
Pharmacological Actions : Chemoprotective Agents
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β-caryophyllene has anticonvulsant, anxiolytic and antidepressant properties. Jan 08, 2020

Pubmed Data : Curr Mol Pharmacol. 2020 05 9. Epub 2020 May 9. PMID: 32386503
Article Published Date : Jan 08, 2020
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Anxiety, Depression
Pharmacological Actions : Anti-Anxiety Agents, Anticonvulsants, Antidepressive Agents
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β-caryophyllene is a possible therapeutic application in chemotherapy-associated cardiotoxicity.Sep 04, 2019

Pubmed Data : Eur J Pharmacol. 2019 Sep 5 ;858:172467. Epub 2019 Jun 16. PMID: 31216443
Article Published Date : Sep 04, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Chemoprotective Agents
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β-caryophyllene liposomes attenuate neurovascular unit damage after subarachnoid hemorrhage.May 21, 2020

Pubmed Data : Neurochem Res. 2020 May 22. Epub 2020 May 22. PMID: 32444923
Article Published Date : May 21, 2020
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Subarachnoid hemorrhage
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Blood Brain Barrier
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β-caryophyllene oxide is able to chemosensitizating liver cancer cells to sorafenib by favoring its intracellular accumulation.Jan 17, 2019

Pubmed Data : Arch Toxicol. 2019 Jan 18. Epub 2019 Jan 18. PMID: 30659321
Article Published Date : Jan 17, 2019
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Liver Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Sorafenib
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β-Caryophyllene pretreatment alleviates focal cerebral ischemia-reperfusion injury.Apr 30, 2017

Pubmed Data : Neurochem Res. 2017 May ;42(5):1459-1469. Epub 2017 Feb 24. PMID: 28236211
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
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β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation Dec 31, 2017

Pubmed Data : Br J Pharmacol. 2018 Jan ;175(2):320-334. Epub 2017 Feb 22. PMID: 28107775
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
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β-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced cardiotoxicity.Mar 01, 2019

Pubmed Data : Chem Biol Interact. 2019 Mar 2. Epub 2019 Mar 2. PMID: 30836069
Article Published Date : Mar 01, 2019
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents
Additional Keywords : Cannabinoid Receptors
[+]

Antibacterial activity and mode of action of β-caryophyllene on Bacillus cereus. Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pol J Microbiol. 2020 ;69:1-6. PMID: 32162852
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Bacillus Cereus infection
Pharmacological Actions : Anti-Bacterial Agents
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Beta caryophyllene and caryophyllene oxide, isolated from Aegle marmelos, as the potent anti-inflammatory agents against lymphoma and neuroblastoma cells.Feb 28, 2014

Pubmed Data : Antiinflamm Antiallergy Agents Med Chem. 2014 Mar ;13(1):45-55. PMID: 24484210
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bael , Beta-Caryophyllene
Diseases : Acute T cell Leukemias, Lymphoma, Neuroblastoma
Pharmacological Actions : 15-Lipoxygenase (15-LOX) Inhibitor, Anti-Inflammatory Agents, Apoptotic
Additional Keywords : Plant Extracts
[+]

Beta-caryophyllene administration could be a novel treatment to reduce hyper-inflammation in human sepsis.Dec 31, 2017

Pubmed Data : Med Hypotheses. 2018 Jan ;110:68-70. Epub 2017 Nov 4. PMID: 29317072
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Substances : Beta-Caryophyllene
Diseases : Sepsis
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Cannabinoid Receptors
[+]

Beta-caryophyllene could be used as chemosensitizing agents for doxorubicin chemotherapy and to re-sensitize cancer-resistant cells.Dec 31, 2016

Pubmed Data : Anticancer Res. 2017 03 ;37(3):1191-1196. PMID: 28314281
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Beta-caryophyllene has anticancer and analgesic properties.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Med. 2016 Oct ;5(10):3007-3017. Epub 2016 Sep 30. PMID: 27696789
Article Published Date : Sep 30, 2016
Study Type : Review
Additional Links
Substances : Beta-Caryophyllene
Diseases : Cancer: Pain , Cancers: All, Chronic Pain
Pharmacological Actions : Analgesics, Antineoplastic Agents
[+]

Beta-caryophyllene has the potential efficacy in preventing and ameliorating nonalcoholic fatty liver disease and its associated metabolic disorders.Sep 30, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Oct ;60(10):2228-2242. Epub 2016 Jun 16. PMID: 27234712
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Beta-caryophyllene might act as a promising therapeutic agent against MPP+ toxicity in neuronal cells.Apr 24, 2018

Pubmed Data : Biomed Pharmacother. 2018 Apr 25 ;103:1086-1091. Epub 2018 Apr 25. PMID: 29710667
Article Published Date : Apr 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Beta-caryophyllene suppresses ovarian cancer proliferation by inducing cell cycle arrest and apoptosis. Feb 25, 2020

Pubmed Data : Anticancer Agents Med Chem. 2020 Feb 26. Epub 2020 Feb 26. PMID: 32106806
Article Published Date : Feb 25, 2020
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-Apoptotic, Antiproliferative , Cell cycle arrest
[+]

Beta-caryophyllene treatment could improve the immune response during hypercholesterolemia through purinergic pathway.Apr 20, 2017

Pubmed Data : Mol Cell Biochem. 2017 Apr 21. Epub 2017 Apr 21. PMID: 28432556
Article Published Date : Apr 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Hypercholesterolemia
Pharmacological Actions : Enzyme Inhibitors
Additional Keywords : Dose Response
[+]

Efficacy of β-caryophyllene for periodontal disease related factors.Feb 20, 2019

Pubmed Data : Arch Oral Biol. 2019 Feb 21 ;100:113-118. Epub 2019 Feb 21. PMID: 30826504
Article Published Date : Feb 20, 2019
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Periodontal Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antimicrobial
[+]

Improvement of oxidative stress and mitochondrial dysfunction by β-caryophyllene.Mar 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2021 Apr 1 ;10(4). Epub 2021 Apr 1. PMID: 33915950
Article Published Date : Mar 31, 2021
Study Type : Review
Additional Links
Substances : Beta-Caryophyllene
Diseases : Mitochondrial Dysfunction
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Metaxalone has synergistic effect with β-caryophyllene production of inflammatory cytokines.Feb 15, 2020

Pubmed Data : Curr Mol Med. 2020 Feb 16. Epub 2020 Feb 16. PMID: 32065089
Article Published Date : Feb 15, 2020
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells.May 01, 2020

Pubmed Data : J Biochem Mol Toxicol. 2020 May 2:e22514. Epub 2020 May 2. PMID: 32359221
Article Published Date : May 01, 2020
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic, STAT3 Activation
[+]

The cannabinoid 2 receptor agonist β-caryophyllene modulates the inflammatory reaction induced by Mycobacterium bovis.Oct 31, 2016

Pubmed Data : Inflamm Res. 2016 Nov ;65(11):869-879. Epub 2016 Jul 5. PMID: 27379721
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Mycobacterium Infections
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The combination of β-caryophyllene, baicalin and catechin exerts synergistic suppressive effects on macrophages in vitro.Nov 30, 2016

Pubmed Data : Int J Mol Med. 2016 Dec ;38(6):1940-1946. Epub 2016 Nov 14. PMID: 27840942
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene, Catechin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative, Beta-Caryophyllene, Catechin, Cyclooxygenase 2 Inhibitors, Inflammation, Natural Substance Synergy
[+]

The experimental data suggest that the activities of M. paniculata essential oil are due to the synergistic action among its components.Nov 30, 2017

Pubmed Data : Pharm Biol. 2017 Dec ;55(1):190-197. PMID: 27927082
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene, Essential Oils: Unspecified
Diseases : Aspergillosis, Enterococcus Infections, Escherichia coli Infections, Salmonella Infections, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Antifungal Agents, Antioxidants
Additional Keywords : Antifungal Agents, Antioxidants, Aspergillosis, Beta-Caryophyllene, Enterococcus Infections, Essential Oils: Unspecified, Phytotherapy, Plant Extracts
[+]

The present review provides a comprehensive insight of pharmacological and therapeutic potential of beta-caryophyllene.Dec 31, 2015

Pubmed Data : Curr Pharm Des. 2016 ;22(21):3237-64. PMID: 26965491
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Beta-Caryophyllene
Pharmacological Actions : Anti-Inflammatory Agents, Antimicrobial, Antioxidants, Cardioprotective, Gastroprotective, Neuroprotective Agents, Renoprotective
[+]

The protective effects of β-caryophyllene on LPS-induced primary microglia M1/M2 imbalance: A mechanistic evaluation.Feb 14, 2019

Pubmed Data : Life Sci. 2019 Feb 15 ;219:40-73. Epub 2019 Jan 5. PMID: 30620895
Article Published Date : Feb 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

The results provide evidence that cinnamaldehyde/eugenol combination may help in designing a more potent novel, natural antibiofilm blend.Apr 30, 2020

Pubmed Data : Lett Appl Microbiol. 2020 May 1. Epub 2020 May 1. PMID: 32357268
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene, Cinnamaldehyde, Eugenol
Diseases : Listeria Infections, Salmonella Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation, Essential Oils
[+]

The results suggest that curcumin synergizes with either flavocoxid or β-caryophyllene, exerting an anti-inflammatory activity.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:1347. Epub 2019 Nov 14. PMID: 31798452
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene, Curcumin, Flavonoids
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, STAT3 Inhibitor
Additional Keywords : Natural Substance Synergy
[+]

These data could suggest that β-caryophyllene, ascorbic acid and d-glucosamine exert a chondro-protective action.Mar 22, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2021 Mar 23 ;14(3). Epub 2021 Mar 23. PMID: 33806983
Article Published Date : Mar 22, 2021
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene, Glucosamine, Vitamin C
Diseases : Inflammation
Pharmacological Actions : Antioxidants, Chondroprotective
Additional Keywords : Natural Substance Synergy
[+]

β-caryophyllene inhibits cell proliferation through a direct modulation of CB2 receptors in glioblastoma cells.Apr 22, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2020 Apr 23 ;12(4). Epub 2020 Apr 23. PMID: 32340197
Article Published Date : Apr 22, 2020
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

β-caryophyllene inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells.May 11, 2020

Pubmed Data : Int Immunopharmacol. 2020 May 12 ;84:106556. Epub 2020 May 12. PMID: 32416450
Article Published Date : May 11, 2020
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Diabetic Nephropathy, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

β-caryophyllene may inhibit cariogenic biofilm and may be a candidate agent for prevention of dental caries.Mar 31, 2018

Pubmed Data : Arch Oral Biol. 2018 Apr ;88:42-46. PMID: 29407750
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Steptococcus Mutans Infections
Pharmacological Actions : Antimicrobial
Additional Keywords : Biofilm
[+]

β-Caryophyllene protects in vitro neurovascular unit against oxygen-glucose deprivation and re-oxygenation-induced injury.Jan 11, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurochem. 2016 12 ;139(5):757-768. Epub 2016 Sep 19. PMID: 27565895
Article Published Date : Jan 11, 2016
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Cerebral Ischemia, Hypoxia
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Beta-Caryophyllene, Cerebral Ischemia, Hypoxia, Neuroprotective Agents

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