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Berberine
Views 33340
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241 Diseases Researched for Berberine
Name
AC
CK
Focus
Insulin Resistance
15
63
Diabetes Mellitus: Type 2
20
55
Hyperlipidemia
8
40
Diabetic Complications
7
22
High Cholesterol
2
22
Hypercholesterolemia
3
22
Triglycerides: Elevated
2
22
Polycystic Ovary Syndrome
2
21
Alzheimer's Disease
13
18
Myocardial Ischemia
6
18
Nonalcoholic fatty liver disease (NAFLD)
9
18
Osteoporosis
6
18
Liver Cancer
14
16
Inflammation
10
15
Metabolic Diseases
4
14
Obesity
10
14
Breast Cancer
12
13
Colon Cancer
9
13
Helicobacter Pylori Infection
3
13
Kidney Diseases
2
12
Cerebral Ischemia
6
11
Lipopolysaccharide-Induced Toxicity
7
11
Atrial Fibrillation
1
10
Depression
5
10
Endothelial Dysfunction
1
10
Oxidative Stress
6
10
Radiation Induced Illness
1
10
Breast Cancer: Triple Negative
7
9
Colorectal Cancer
5
9
Glioblastoma
6
9
High Fat Diet
5
9
Lung Cancer
5
9
Osteosarcoma
4
9
Brain Inflammation
4
8
Cancers: All
8
8
Cognitive Decline/Dysfunction
4
8
Colitis
4
8
Diabetic Nephropathy
4
8
Metabolic Syndrome X
4
8
Diabetes Mellitus: Type 1
4
7
Heart Failure
4
7
Hyperglycemia
4
7
Ischemia
4
7
Pancreatitis
4
7
Atherosclerosis
3
6
Hypoxia
4
6
Gastric Cancer
5
5
Hypertension
3
5
Psoriasis
1
5
Rheumatoid Arthritis
4
5
Acetaminophen (Tylenol) Toxicity
2
4
Advanced Glycation End products (AGE)
3
4
Alcohol Toxicity
2
4
Allergic Rhinitis
2
4
Arthritis
2
4
Autoimmune Diseases
2
4
Cancers: Drug Resistant
4
4
Cardiomyopathy
2
4
Cardiovascular Diseases
4
4
Chemically-Induced Liver Damage
2
4
Chemotherapy-Induced Toxicity: Doxorubicin
2
4
Diabetic Neuropathy
2
4
Enterocolitis: Necrotiziing
2
4
Epilepsy
2
4
Fructose-Induced Toxicity
2
4
Melanoma
4
4
Myocardial Infarction
2
4
Nasopharyngeal Cancer
3
4
Peripheral Neuropathies
2
4
Sepsis
2
4
Traumatic Brain Injury
2
4
Ulcerative Colitis
2
4
Brain Ischemia
2
3
Cancer Metastasis
3
3
Carcinoma: Non-Small-Cell Lung
3
3
Chikungunya Virus
2
3
Diabetes: Oxidative Stress
2
3
Hepatic Steatosis
2
3
Hydrogen Peroxide Induced Toxicity
3
3
Liver Fibrosis
2
3
Neurodegenerative Diseases
2
3
Ovarian Cancer
3
3
Pseudomonas aeruginosa
2
3
Acute Respiratory Distress Syndrome
1
2
Acute T cell Leukemias
2
2
Adenomyosis
2
2
Aging: Brain
1
2
Aluminum Toxicity
1
2
Aneurysm: Cerebral
1
2
Arsenic Poisoning
1
2
Asthma
1
2
Atopic Dermatitis
1
2
Blood-Brain-Barrier Disorders
1
2
Bone Diseases
1
2
Brain Injury: Traumatic
1
2
Breast Cancer: Chemically-Induced
1
2
Bubonic Plague
1
2
Candida Albicans
2
2
Chemotherapy-Induced Toxicity: Paclitaxel
1
2
Cocaine Withdrawal
1
2
Colon Cancer: Prevention
1
2
Colorectal Cancer: Prevention
1
2
Congestive Heart Failure
1
2
Convulsions
1
2
Degenerative Disk Disease
2
2
Dementia
1
2
Demyelinating Diseases
1
2
Diabesity
1
2
Diabetic Neuropathies
1
2
Diabetic Retinopathy
2
2
Diarrhea: Drug-Associated
1
2
Drug-Induced Toxicity: L-Thyroxine
1
2
Drug-Induced Toxicity: Methotrexate
1
2
Endometrial Cancer
1
2
Fatty Liver
1
2
Fibrosis
1
2
Gastric Polyposis
1
2
Glioma
2
2
Heavy Metal Toxicity
1
2
Hepatitis: Autoimmune
1
2
High Homocysteine
1
2
Huntington Disease
1
2
Hyperalgesia
1
2
Hypersensitivity: Type IV
1
2
Hypertension: Pulmonary
1
2
Hypertension: Renal
1
2
Immune Dysregulation: TH1 dominance
1
2
Immune Dysregulation: TH17 over-expression
1
2
Influenza
1
2
Intestinal Permeability
1
2
Intestinal Polyps
1
2
Intima Media Thickening
1
2
Iron Overload
1
2
Irritable Bowel Syndrome
1
2
Kidney Fibrosis
1
2
Lead Poisoning
1
2
Learning disorders
1
2
Leukemia
2
2
Lipid Peroxidation
1
2
Liver Steatosis
1
2
Liver Stress: Fructose-Induced
1
2
Lung Cancer: Prevention
1
2
Mastitis
1
2
Memory Disorders: Drug-Induced
1
2
Middle Cerebral Artery Occlusion (MCAO)
1
2
Miscarriage
1
2
Morphine Tolerance/Dependence
1
2
Multiple Sclerosis
1
2
Myocardial Fibrosis
1
2
Neuroblastoma
2
2
Neuropathic Pain
1
2
Non-Small-Cell Lung Carcinoma
2
2
Pancreatic Cancer
2
2
Parkinson's Disease
1
2
Periodontitis
1
2
Peripheral Nerve Diseases
1
2
Post-Traumatic Stress Disorders (PTSD)
1
2
Postmenopausal Disorders
1
2
Postoperative Recovery
1
2
Prehypertension
1
2
Prostate Cancer
2
2
Prostatic Hyperplasia: Benign
1
2
Retinal Diseases
1
2
Schizophrenia
1
2
Seizures
1
2
Smoking Cessation: Nicotine Addiction
1
2
Staphylococcal Infections
1
2
Staphylococcus aureus: Methicillin-resistant (MRSA)
2
2
Stroke: Ischemic
1
2
Tongue Cancer
1
2
Uremia
1
2
Uveoretinitis
1
2
Varicocele
1
2
Acute Myeloid Leukemia
1
1
Allergic Airway Diseases
1
1
Allergies
1
1
Alphavirus Infections
1
1
Arthritis: Rheumatoid
1
1
Bacillus Cereus infection
1
1
Bacterial Infections and Mycoses
1
1
Breast Cancer Stem Cells
1
1
Breast Cancer: HER-2 Overexpressed
1
1
Cancer: Virus-Induced
1
1
Cancers: Multi-Drug Resistant
1
1
Candida Infection
1
1
Cardiac Arrhythmias
1
1
Cervical Cancer
1
1
Cholangiocarcinoma
1
1
Cholesterol: Oxidation
1
1
Chondrosarcoma
1
1
Clostridium Infections
1
1
Coxsackievirus Infections
1
1
Cytomegalovirus Infections
1
1
Dementia: Senile
1
1
Dental Caries
1
1
Diabetes Mellitus: Type 2: Prevention
1
1
Diabetes: Glycation/A1C
1
1
Diarrhea
1
1
Dyslipidemias
1
1
Echinococcosis
1
1
Enterovirus: Type 71
1
1
Esophageal Cancer
1
1
Eye Diseases
1
1
Friend Virus
1
1
Fungal Infection
1
1
HIV Drug-Induced Toxicity
1
1
HIV Infections
1
1
Head and Neck Cancer
1
1
High Sugar Diet
1
1
Human Papillomavirus (HPV)
1
1
Hydatid Cyst
1
1
Inflammatory Bowel Diseases
1
1
Kidney Damage
1
1
Laryngeal Cancer
1
1
Leaky Gut Syndrome
1
1
Leishmaniasis
1
1
Leukemia: Acute promyelocytic leukemia
1
1
Leukemia: Virus-Induced
1
1
Lower Respiratory Infections
1
1
Lung Injury: Acute
1
1
Lymphangioendothelioma
1
1
Macular Degeneration
1
1
Malignant Melanoma
1
1
Mesothelioma
1
1
Microcystis aeruginosa
1
1
Multiple Myeloma
1
1
Myocarditis: Autoimmune
1
1
Oral Cancer
1
1
Osteoarthritis
1
1
Overweight
1
1
Periodontal Diseases
1
1
Promyelocytic leukemia
1
1
Respiratory Syncytial Virus Infections
1
1
Retinoblastoma
1
1
Salmonella Infections
1
1
Skin Cancer: Squamous Cell
1
1
Squamous cell carcinoma
1
1
Streptococcus pyogenes
1
1
Thrombocytopenia
1
1
Thyroid Cancer
1
1
Uveitis
1
1
116 Pharmacological Actions Researched for Berberine
Name
AC
CK
Focus
Anti-Inflammatory Agents
71
134
Antioxidants
42
69
Hypolipidemic
14
67
Tumor Necrosis Factor (TNF) Alpha Inhibitor
27
62
Antiproliferative
48
59
Interleukin-6 Downregulation
25
56
Neuroprotective Agents
30
52
Apoptotic
40
49
Cardioprotective
19
49
Hypoglycemic Agents
14
42
Hepatoprotective
18
36
Anticholesteremic Agents
4
34
Anti-Apoptotic
20
32
Interleukin-1 beta downregulation
18
30
MicroRNA modulator
14
24
NF-kappaB Inhibitor
16
23
Chemopreventive
15
21
Anti-metastatic
17
20
Cell cycle arrest
18
20
Anti-Bacterial Agents
6
16
Renoprotective
9
16
Chemotherapeutic
12
14
Cyclooxygenase 2 Inhibitors
9
14
Gastrointestinal Agents
7
14
Antineoplastic Agents
5
13
Nrf2 activation
8
13
Matrix metalloproteinase-2 (MMP-2) inhibitor
9
11
Anti-Fibrotic
5
10
Anticarcinogenic Agents
6
10
Matrix metalloproteinase-9 (MMP-9) inhibitor
7
10
Radioprotective
1
10
Antiviral Agents
7
9
Chemosensitizer
9
9
Osteoprotective
5
9
Gastroprotective
4
8
Malondialdehyde Down-regulation
4
8
Antihypertensive Agents
4
7
Chemoprotective Agents
4
7
Tumor Suppressor Protein p53 Upregulation
6
7
Angiogenesis Inducing Agents
3
6
Antidepressive Agents
3
6
Autophagy Up-regulation
3
6
Enzyme Inhibitors
2
6
Immunomodulatory
4
6
Immunomodulatory: Th17 downregulation
3
6
Insulin Sensitizers
2
6
Anti-Adipogenic
4
5
Antimicrobial
4
5
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
4
5
Pancreato Protective Agents
3
5
Wnt/β-catenin signaling pathway modulation
4
5
Analgesics
2
4
Angiogenesis Inhibitors
3
4
Anti-Anxiety Agents
2
4
Anticonvulsants
2
4
Glucagon Like peptide 1 (GLP-1) Up-regulation
2
4
Interleukin-10 downregulation
2
4
Interleukin-10 upregulation
2
4
Interleukin-17 downregulation
2
4
Prostaglandin PGE2 downregulation
2
4
Anti-Glycation Agents
2
3
Bcl-2 protein down-regulation
3
3
Caspase-3 Activation
2
3
Heme oxygenase-1 up-regulation
2
3
Matrix metalloproteinase-3 (MMP-3) inhibitor
2
3
STAT3 Inhibitor
3
3
Vascular Endothelial Growth Factor Inhibitors
3
3
Anti-Tumor
1
2
Anti-atherogenic
1
2
Antidiarrheals
1
2
Antifungal Agents
2
2
Bax/Bcl2 Ratio: Decrease
1
2
Brain-derived neurotrophic factor modulator
1
2
Caspase-9 Activation
1
2
Cholinesterase Inhibitors
1
2
Enzyme Inhibitors: Pancreatic Amylase
1
2
Enzyme Inhibitors: Pancreatic Lipase
1
2
Epidermal growth factor receptor (EGFR) inhibitor
1
2
Fibroblast growth factor 21 upregulation
1
2
Interferon Gamma Reducer
1
2
Interleukin-4 downregulation
1
2
Interleukin-8 downregulation
2
2
Iron Chelating Agents
1
2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
2
2
Neuritogenic
1
2
Nitric Oxide Inhibitor
1
2
P21 Activation
2
2
Radiosensitizer
2
2
SIRT1 Activator
1
2
Wnt/β-catenin pathway down-regulation
1
2
interleukin-13 down-regulation
1
2
AMP-activated protein kinase modulation
1
1
Alpha-amylase inhibitor
1
1
Alpha-glucosidase inhibitor
1
1
Anti-Allergic Agents
1
1
Anti-Androgen
1
1
Anti-Proliferative
1
1
Autophagy Inhibitors
1
1
Cyclin D1 Down-Regulation
1
1
Cyclin-dependent kinase inhibitor: P16INK4
1
1
Cytoprotective
1
1
Cytotoxic
1
1
Expectorants
1
1
Gluconeogenesis Inhibitor
1
1
HIV Protease Inhibitors
1
1
Interleukin-18 down-regulation
1
1
Matrix metalloproteinase-1 (MMP-1) inhibitor
1
1
Multidrug Resistance Gene Modulators
1
1
Osteogenic
1
1
P38 Mitogen-Activated Protein Kinase Modulator
1
1
Prophylactic Agents
1
1
RANK Downregulation
1
1
Regenerative
1
1
Scolicidal
1
1
Survivin Down-Regulation
1
1
Telomerase Inhibitor
1
1
Research Articles
384
Cumulative Knowledge Score
621
Overall Research Rating
EXCELLENT
View the Evidence:
606 Abstracts with Berberine Research
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[+]
A nutraceutical combination has shown to be an effective product for the improvement of the lipid profile.
Apr 26, 2016
Click here to read the entire abstract
Pubmed Data
: Clin Investig Arterioscler. 2016 Apr 27. Epub 2016 Apr 27. PMID:
27131395
Article Published Date
: Apr 26, 2016
Study Type
: Meta Analysis
Additional Links
Substances
:
Berberine
,
Policosanol
,
Red Yeast Rice
Diseases
:
High Cholesterol
,
Hyperlipidemia
,
Triglycerides: Elevated
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
[+]
Berberine and dyslipidemia: different applications and biopharmaceutical formulations without statin-like molecules.
Aug 22, 2019
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2019 Aug 23. Epub 2019 Aug 23. PMID:
31441678
Article Published Date
: Aug 22, 2019
Study Type
: Meta Analysis
Additional Links
Substances
:
Berberine
Diseases
:
Dyslipidemias
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
[+]
Berberine exerted anti-tumor effects in a variety of tumors in vivo.
Jun 16, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Cancer. 2019 Jun 17 ;19(1):589. Epub 2019 Jun 17. PMID:
31208348
Article Published Date
: Jun 16, 2019
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Breast Cancer
,
Cancers: All
,
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Chemopreventive
[+]
Berberine showed a promising prospect in treating polycystic ovary syndrome patients with insulin resistance.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2018 ;2018:2532935. Epub 2018 Nov 14. PMID:
30538756
Article Published Date
: Dec 31, 2017
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
,
Polycystic Ovary Syndrome
[+]
Berberine supplementation may ameliorate the state of chronic inflammation.
Sep 30, 2019
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2019 Oct ;46:81-86. Epub 2019 Aug 4. PMID:
31519292
Article Published Date
: Sep 30, 2019
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
C-Reactive Protein
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Systematic review and meta-analysis on efficacy and safety of berberine for dyslipidemia
Jan 31, 2020
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Yao Za Zhi. 2020 Feb ;45(3):664-673. PMID:
32237527
Article Published Date
: Jan 31, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Dyslipidemias
Pharmacological Actions
:
Gastrointestinal Agents
[+]
The addition of berberine in standard triple therapy could improve Helicobacter pylori eradication rate and clinical symptom remission rate.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2019 ;10:1694. Epub 2020 Feb 4. PMID:
32116685
Article Published Date
: Dec 31, 2018
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
The results of the current study support the use of berberine supplementation for the improvement of obesity indices.
Apr 30, 2020
Click here to read the entire abstract
Pubmed Data
: Complement Ther Clin Pract. 2020 May ;39:101113. Epub 2020 Feb 1. PMID:
32379652
Article Published Date
: Apr 30, 2020
Study Type
: Meta Analysis
Additional Links
Substances
:
Berberine
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
These results found a significant reduction in waist-hip ratio following berberine consumption in adults.
Feb 29, 2020
Click here to read the entire abstract
Pubmed Data
: Complement Ther Med. 2020 Mar ;49:102337. Epub 2020 Feb 3. PMID:
32147051
Article Published Date
: Feb 29, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Barberry
,
Berberine
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
This meta-analysis found a significant reduction of body weight, BMI, WC and CRP levels associated with berberine intake.
Jul 31, 2020
Click here to read the entire abstract
Pubmed Data
: Clin Nutr ESPEN. 2020 Aug ;38:43-49. Epub 2020 May 6. PMID:
32690176
Article Published Date
: Jul 31, 2020
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Berberine
Diseases
:
C-Reactive Protein
,
Inflammation
,
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
A combination of berberine, red yeast rice and policosanol lowers lipid levels and improves endothelial function and insulin sensitivity in hypercholesterolemic patients.
Aug 19, 2009
Click here to read the entire abstract
Pubmed Data
: Nutr Metab Cardiovasc Dis. 2009 Aug 19. Epub 2009 Aug 19. PMID:
19699071
Article Published Date
: Aug 19, 2009
Study Type
: Human Study
Additional Links
Substances
:
Berberine
,
Policosanol
,
Red Yeast Rice
Diseases
:
Endothelial Dysfunction
,
Hypercholesterolemia
,
Insulin Resistance
[+]
A nutraceutical formula containing berberine, chlorogenic acid, and tocotrienols was found to improve a large number of metabolic and liver parameters in overweight subjects.
Mar 28, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr J. 2015 Mar 28 ;14:30. Epub 2015 Mar 28. PMID:
25886384
Article Published Date
: Mar 28, 2015
Study Type
: Human Study
Additional Links
Substances
:
Berberine
,
Chlorogenic Acid
,
Tocotrienols
Diseases
:
Fatty Liver
,
Hyperlipidemia
,
Insulin Resistance
Problem Substances
:
Insulin
[+]
Berberine Capsule was effective in improving blood lipid level in mild hyperlipidemia patients.
May 31, 2016
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Jun ;36(6):681-4. PMID:
27491226
Article Published Date
: May 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Hypolipidemic
[+]
Berberine containing quadruple therapy could be used for Helicobacter pylori eradication.
Jul 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Medicine (Baltimore). 2017 Aug ;96(32):e7697. PMID:
28796053
Article Published Date
: Jul 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.
Aug 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2019 Sep ;18(3):2122-2130. Epub 2019 Jul 12. PMID:
31410167
Article Published Date
: Aug 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Bacterial Vaginosis
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.
Dec 10, 2018
Click here to read the entire abstract
Pubmed Data
: Zhonghua Yi Xue Za Zhi. 2018 Dec 11 ;98(46):3756-3761. PMID:
30541217
Article Published Date
: Dec 10, 2018
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Complications
,
Kidney Diseases
[+]
Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.
Feb 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Forensic Leg Med. 2007 Feb;14(2):87-91. PMID:
19757213
Article Published Date
: Feb 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Radiation Induced Illness
Pharmacological Actions
:
Radioprotective
Anti Therapeutic Actions
:
Radiotherapy
[+]
Berberine is a potent oral hypoglycemic agent with benefical effects on lipid metabolism, comparable in efficacy to metformin.
May 01, 2008
Click here to read the entire abstract
Pubmed Data
: Metabolism. 2008 May;57(5):712-7. PMID:
18442638
Article Published Date
: May 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Additional Keywords
:
Drug: Metformin
,
Metformin Alternatives
,
Natural Substances Versus Drugs
[+]
Berberine is efficacious for the treatment of atrial fibrillation.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2017 ;2017:3146791. Epub 2017 Dec 17. PMID:
29392132
Article Published Date
: Dec 31, 2016
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Atrial Fibrillation
Pharmacological Actions
:
Cardioprotective
[+]
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.
Oct 06, 2009
Click here to read the entire abstract
Pubmed Data
: Evid Based Complement Alternat Med. 2009 Oct 6; PMID:
19800084
Article Published Date
: Oct 06, 2009
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Drug: Metformin
,
Drug: Rosiglitazone
,
Insulin Receptor Upregulation
,
Natural Substances Versus Drugs
[+]
Berberine possesses potential lipid-regulating, antiarthritis, and synovial hyperplasia inhibition activities against rheumatoid arthritis.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2019 ;2019:2580207. Epub 2019 Nov 3. PMID:
31781264
Article Published Date
: Dec 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypolipidemic
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy.
Aug 31, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Sep ;105:1050-1053. Epub 2018 Jun 19. PMID:
30021340
Article Published Date
: Aug 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine was safe and effective in reducing the risk of recurrence of colorectal adenoma.
Jan 07, 2020
Click here to read the entire abstract
Pubmed Data
: Lancet Gastroenterol Hepatol. 2020 Jan 8. Epub 2020 Jan 8. PMID:
31926918
Article Published Date
: Jan 07, 2020
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Chemopreventive
Additional Keywords
:
Risk Reduction
[+]
Dry extracts of artichoke and berberine have beneficial effects in hypercholesterolemic patients.
Feb 14, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Cardiol. 2019 Feb 15 ;123(4):588-591. Epub 2018 Nov 23. PMID:
30528419
Article Published Date
: Feb 14, 2019
Study Type
: Human Study
Additional Links
Substances
:
Artichoke
,
Berberine
Diseases
:
Hypercholesterolemia
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
[+]
Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women.
Dec 19, 2009
Click here to read the entire abstract
Pubmed Data
: J Bone Miner Metab. 2009 Dec 19. Epub 2009 Dec 19. PMID:
20024591
Article Published Date
: Dec 19, 2009
Study Type
: Human Study
Additional Links
Substances
:
Berberine
,
Hops
,
Vitamin D
,
Vitamin K
Diseases
:
Osteoporosis
[+]
Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders.
Feb 29, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Minerva Gastroenterol Dietol. 2020 Mar ;66(1):29-34. PMID:
32283882
Article Published Date
: Feb 29, 2020
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Diarrhea
,
Gastrointestinal Diseases
Pharmacological Actions
:
Antidiarrheals
,
Gastrointestinal Agents
[+]
The combined application of berberine in patients with metabolic syndrome can effectively regulate blood glucose and blood lipid of patients.
Mar 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2019 Apr ;17(4):3009-3014. Epub 2019 Feb 22. PMID:
30936971
Article Published Date
: Mar 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
,
Insulin Resistance
,
Metabolic Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hypoglycemic Agents
,
Hypolipidemic
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2020 ;15(8):e0235404. Epub 2020 Aug 12. PMID:
32785222
Article Published Date
: Dec 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
,
Polycystic Ovary Syndrome
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Insulin Sensitizers
[+]
Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.
May 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Tradit Chin Med. 2014 Jun ;34(3):302-8. PMID:
24992757
Article Published Date
: May 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Enzyme Inhibitors
,
MicroRNA modulator
Additional Keywords
:
Chinese Herbs
,
Gene Expression Regulation
[+]
Berberine induced apoptosis and DNA damage in human osteosarcoma lines that were treated.
Sep 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2014 Oct ;10(4):1734-8. Epub 2014 Jul 21. PMID:
25050485
Article Published Date
: Sep 30, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
[+]
Berberine may serve as a potential therapeutic option for patients with psoriasis.
Mar 19, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Dis. 2019 Mar 20 ;10(4):274. Epub 2019 Mar 20. PMID:
30894513
Article Published Date
: Mar 19, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Psoriasis
Pharmacological Actions
:
Antiproliferative
[+]
These results suggest that berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokine profile in human preadipocytes and metabolic syndrome patients.
Mar 07, 2012
Click here to read the entire abstract
Pubmed Data
: Evid Based Complement Alternat Med. 2012 ;2012:363845. Epub 2012 Mar 8. PMID:
22474499
Article Published Date
: Mar 07, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
,
Metabolic Syndrome X
Pharmacological Actions
:
Insulin Sensitizers
[+]
Remission of new-onset type 2 diabetes mellitus in an adolescent using an integrative medicine approach.
Oct 21, 2020
Click here to read the entire abstract
Pubmed Data
: J Integr Med. 2020 Oct 22. Epub 2020 Oct 22. PMID:
33162376
Article Published Date
: Oct 21, 2020
Study Type
: Human: Case Report
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Therapeutic Actions
:
Exercise
Additional Keywords
:
Risk Reduction
[+]
Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(5):e0123478. Epub 2015 May 8. PMID:
25954974
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Prostaglandin PGE2 downregulation
[+]
Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle.
Jul 30, 2020
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2020 Jul 31. Epub 2020 Jul 31. PMID:
32745766
Article Published Date
: Jul 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperlipidemia
,
Obesity
Pharmacological Actions
:
Hypolipidemic
[+]
Berberine improves neointima formation in a rat model.
May 01, 2006
Click here to read the entire abstract
Pubmed Data
: Atherosclerosis. 2006 May;186(1):29-37. Epub 2005 Aug 10. PMID:
16098530
Article Published Date
: May 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Atherosclerosis
,
Intima Media Thickening
[+]
A berberine derivative attenuates cardiac failure.
Feb 01, 2010
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2010 Feb;31(2):165-74. PMID:
20139899
Article Published Date
: Feb 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Heart Failure
,
Myocardial Infarction
Pharmacological Actions
:
Antioxidants
[+]
A holistic view of berberine inhibiting intestinal carcinogenesis.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Immunol. 2020 ;11:588079. Epub 2020 Sep 24. PMID:
33072135
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
A relatively low dose berberine exhibited strong neuroprotective activity against 6-OHDA-induced neurotoxicity in PC12 cells.
Nov 03, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Redox Biol. 2016 Nov 4 ;11:1-11. Epub 2016 Aug 4. PMID:
27835779
Article Published Date
: Nov 03, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Administration of Berberis vulgaris could ameliorate neurotoxicity induced by beta amyloid.
Jul 04, 2015
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2015 Jul 5 ;758:82-8. Epub 2015 Apr 8. PMID:
25861937
Article Published Date
: Jul 04, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Barberry
,
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Ameliorating effects of berberine on MK-801-induced cognitive and motor impairments in a neonatal rat model of schizophrenia.
May 15, 2019
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2019 May 16. Epub 2019 May 16. PMID:
31103726
Article Published Date
: May 15, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Schizophrenia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Ameliorating ribosylation-induced amyloid-β pathology by berberine.
Dec 22, 2020
Click here to read the entire abstract
Pubmed Data
: J Alzheimers Dis. 2020 Dec 23. Epub 2020 Dec 23. PMID:
33361598
Article Published Date
: Dec 22, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Ameliorative effect of berberine on neonatally induced type 2 diabetic neuropathy.
Jun 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Dose Response. 2019 Jul-Sep;17(3):1559325819862449. Epub 2019 Jul 16. PMID:
31360147
Article Published Date
: Jun 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Neuropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
An inhibitory effect of Berberine from herbal Coptis chinensis Franch on rat detrusor contraction in benign prostatic hyperplasia associated with lower urinary tract symptoms.
Dec 06, 2020
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2020 Dec 7 ;268:113666. Epub 2020 Dec 7. PMID:
33301912
Article Published Date
: Dec 06, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Bladder Dysfunction
,
Prostatic Hyperplasia: Benign
[+]
Anti-inflammation associated protective mechanism of berberine and its derivatives on attenuating pentylenetetrazole-induced seizures.
Jan 05, 2020
Click here to read the entire abstract
Pubmed Data
: J Neuroimmune Pharmacol. 2020 Jan 6. Epub 2020 Jan 6. PMID:
31909440
Article Published Date
: Jan 05, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Epilepsy
,
Seizures: Drug-Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticonvulsants
[+]
Anti-influenza activity of berberine improves prognosis by reducing viral replication in mice.
Oct 10, 2018
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2018 Oct 11. Epub 2018 Oct 11. PMID:
30306659
Article Published Date
: Oct 10, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Influenza
Pharmacological Actions
:
Antiviral Agents
[+]
Anticolitic effect of berberine in rat experimental model.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mediators Inflamm. 2020 ;2020:9419085. Epub 2020 Sep 29. PMID:
33061833
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis.
Aug 20, 2018
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2018 Aug 21 ;294:91-100. Epub 2018 Aug 21. PMID:
30138605
Article Published Date
: Aug 20, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Hepatoprotective
[+]
Autologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment.
Nov 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Deliv. 2020 Dec ;27(1):283-291. PMID:
32013620
Article Published Date
: Nov 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Hypolipidemic
[+]
Berbamine induces programmed cell death in human liver cancer cells and inhibits tumor growth in mice.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Asian Nat Prod Res. 2009;11(3):219-28. PMID:
19408145
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
Pharmacological Actions
:
Apoptotic
,
Tumor Suppressor Protein p53 Upregulation
[+]
Berberine (a major constituent of goldenseal) has significant cholesterol-lowering action
Dec 01, 2004
Click here to read the entire abstract
Pubmed Data
: Nat Med. 2004 Dec;10(12):1344-51. Epub 2004 Nov 7. PMID:
15531889
Article Published Date
: Dec 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hypercholesterolemia
[+]
Berberine activates apoptosis to suppress triple-negative breast cancer cells.
Aug 17, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Aug 18 ;95:18-24. Epub 2017 Aug 18. PMID:
28826092
Article Published Date
: Aug 17, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Apoptotic
,
Caspase-3 Activation
,
Caspase-9 Activation
[+]
Berberine alleviated doxorubicin induced cardiotoxicity via inhibition of the metabolism of doxorubicin and reduced accumulation of doxorubicinol selectively in hearts.
May 12, 2015
Click here to read the entire abstract
Pubmed Data
: Xenobiotica. 2015 May 13:1-6. Epub 2015 May 13. PMID:
25970816
Article Published Date
: May 12, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Cardioprotective
,
Chemoprotective Agents
[+]
Berberine alleviates adipose tissue fibrosis.
May 27, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 May 28 ;105:121-129. Epub 2018 May 28. PMID:
29852389
Article Published Date
: May 27, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Fibrosis
,
Obesity
Pharmacological Actions
:
Anti-Fibrotic
[+]
Berberine alleviates amyloid-beta pathogenesis.
Mar 14, 2019
Click here to read the entire abstract
Pubmed Data
: Curr Mol Med. 2019 Mar 15. Epub 2019 Mar 15. PMID:
30873920
Article Published Date
: Mar 14, 2019
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine alleviates amyloid-beta pathology in the brain of APP/PS1 transgenic mice.
Jun 30, 2018
Click here to read the entire abstract
Pubmed Data
: Curr Alzheimer Res. 2018 Jul 1. Epub 2018 Jul 1. PMID:
29962345
Article Published Date
: Jun 30, 2018
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine alleviates dextran sodium sulfate-induced colitis.
May 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2017 Jun ;13(6):3374-3382. Epub 2017 Apr 28. PMID:
28587416
Article Published Date
: May 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Berberine alleviates disease symptoms in mouse models mimicking the symptoms of IBS-D.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: PLoS One. 2015 ;10(12):e0145556. Epub 2015 Dec 23. PMID:
26700862
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Irritable Bowel Syndrome
Pharmacological Actions
:
Analgesics
,
MicroRNA modulator
[+]
Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS.
Oct 07, 2018
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2018 Oct 8 ;65:96-107. Epub 2018 Oct 8. PMID:
30308440
Article Published Date
: Oct 07, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Acute Respiratory Distress Syndrome
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine alleviates hepatic lipid accumulation.
Mar 01, 2018
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2018 Mar 2. Epub 2018 Mar 2. PMID:
29505790
Article Published Date
: Mar 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
,
Hypolipidemic
[+]
Berberine alleviates hyperglycemia by targeting hepatic glucokinase.
May 28, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2019 May 29 ;9(1):8003. Epub 2019 May 29. PMID:
31142783
Article Published Date
: May 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperglycemia
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Berberine alleviates monosodium glutamate induced postnatal metabolic disorders associated vascular endothelial dysfunction.
Feb 18, 2020
Click here to read the entire abstract
Pubmed Data
: Arch Physiol Biochem. 2020 Feb 19:1-12. Epub 2020 Feb 19. PMID:
32072839
Article Published Date
: Feb 18, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Endothelial Dysfunction
,
Inflammation
Pharmacological Actions
:
Vasoprotective
Problem Substances
:
Monosodium Glutamate (MSG)
[+]
Berberine alleviates NASH and its predisposing factors.
Feb 29, 2016
Click here to read the entire abstract
Pubmed Data
: Arch Iran Med. 2016 Mar ;19(3):197-203. PMID:
26923892
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Microbiota
[+]
Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.
Mar 07, 2019
Click here to read the entire abstract
Pubmed Data
: FASEB J. 2019 Mar 8:fj201802316R. Epub 2019 Mar 8. PMID:
30848932
Article Published Date
: Mar 07, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Berberine alleviates oxidative stress in islets of diabetic mice.
Apr 23, 2017
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2017 Apr 24. Epub 2017 Apr 24. PMID:
28436095
Article Published Date
: Apr 23, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes: Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
MicroRNA modulator
,
SIRT1 Activator
[+]
Berberine alleviates oxidative stress in rats with osteoporosis.
Oct 21, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Bosn J Basic Med Sci. 2017 Oct 22. Epub 2017 Oct 22. PMID:
29055350
Article Published Date
: Oct 21, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Osteoporosis
Pharmacological Actions
:
Antioxidants
,
Osteoprotective
[+]
Berberine alleviates paclitaxel-induced neuropathy.
May 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pharmacopuncture. 2019 Jun ;22(2):90-94. Epub 2019 Jun 30. PMID:
31338248
Article Published Date
: May 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemotherapy-Induced Toxicity: Paclitaxel
Pharmacological Actions
:
Chemoprotective Agents
[+]
Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder.
Feb 28, 2018
Click here to read the entire abstract
Pubmed Data
: Korean J Physiol Pharmacol. 2018 Mar ;22(2):183-192. Epub 2018 Feb 23. PMID:
29520171
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Post-Traumatic Stress Disorders (PTSD)
Pharmacological Actions
:
Anti-Anxiety Agents
Additional Keywords
:
Anti-Anxiety Agents
,
Berberine
,
Post-Traumatic Stress Disorders (PTSD)
[+]
Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.
Nov 25, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Aging Cell. 2019 Nov 26:e13060. Epub 2019 Nov 26. PMID:
31773901
Article Published Date
: Nov 25, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Aging
Pharmacological Actions
:
Cytoprotective
[+]
Berberine ameliorates collagen-induced arthritis in rats by facilitating the generation of butyrate and adjusting the intestinal hypoxia and nitrate supply.
Aug 18, 2019
Click here to read the entire abstract
Pubmed Data
: FASEB J. 2019 Aug 19:fj201900425RR. Epub 2019 Aug 19. PMID:
31425655
Article Published Date
: Aug 18, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Arthritis
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Berberine ameliorates colonic damage accompanied with the modulation of dysfunctional bacteria and functions in ulcerative colitis rats.
Jan 31, 2020
Click here to read the entire abstract
Pubmed Data
: Appl Microbiol Biotechnol. 2020 Feb ;104(4):1737-1749. Epub 2019 Dec 23. PMID:
31867696
Article Published Date
: Jan 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Gastroprotective
[+]
Berberine ameliorates diabetic nephropathy.
Mar 30, 2018
Click here to read the entire abstract
Pubmed Data
: Biol Res. 2018 Mar 31 ;51(1):9. Epub 2018 Mar 31. PMID:
29604956
Article Published Date
: Mar 30, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
[+]
Berberine ameliorates diabetic neuropathy.
Nov 08, 2017
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2017 Nov 9:1-15. Epub 2017 Nov 9. PMID:
29121795
Article Published Date
: Nov 08, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Neuropathies
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Berberine
,
Berberine ameliorates diabetic neuropathy
,
berberine substance
,
gmi berberine
,
gmi berberine substance
,
GreenMedInfo Berberine
,
GreenMedInfo Berberine ameliorates diabetic neuropathy
[+]
Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels.
Oct 16, 2018
Click here to read the entire abstract
Pubmed Data
: Andrologia. 2018 Oct 17:e13179. Epub 2018 Oct 17. PMID:
30334274
Article Published Date
: Oct 16, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Varicocele
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine ameliorates high-fat diet-induced non-alcoholic fatty liver disease.
Jan 31, 2019
Click here to read the entire abstract
Pubmed Data
: Curr Med Sci. 2019 Feb ;39(1):37-43. Epub 2019 Mar 13. PMID:
30868489
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process.
Jan 02, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Jan 3 ;87:200-208. Epub 2017 Jan 3. PMID:
28061403
Article Published Date
: Jan 02, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Brain Inflammation
,
Epilepsy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Berberine ameliorates MCAO induced cerebral ischemia-reperfusion injury.
Jan 21, 2018
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2018 Jan 22. Epub 2018 Jan 22. PMID:
29357017
Article Published Date
: Jan 21, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Brain-derived neurotrophic factor modulator
,
Neuroprotective Agents
[+]
Berberine ameliorates myocardial ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis.
Jan 24, 2016
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2016 Jan 25. Epub 2016 Jan 25. PMID:
26806299
Article Published Date
: Jan 24, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Berberine ameliorates non alcoholic fatty liver disease and related metabolic disorders.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(8):e0134172. Epub 2015 Aug 7. PMID:
26252777
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Metabolic Diseases
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
Additional Keywords
:
Gene Expression Regulation
[+]
Berberine ameliorates NSAIDs-induced intestinal injury by the repair of enteric nervous system.
Sep 12, 2019
Click here to read the entire abstract
Pubmed Data
: Fundam Clin Pharmacol. 2019 Sep 13. Epub 2019 Sep 13. PMID:
31520444
Article Published Date
: Sep 12, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Drug-Induced Toxicity: Gastrointestinal
Pharmacological Actions
:
Gastroprotective
Problem Substances
:
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]
Berberine ameliorates obesity-induced chronic inflammation.
Jul 06, 2020
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2020 Jul 7 ;86:106741. Epub 2020 Jul 7. PMID:
32650294
Article Published Date
: Jul 06, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Inflammation
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine ameliorates periodontal bone loss by regulating gut microbiota.
Sep 09, 2018
Click here to read the entire abstract
Pubmed Data
: J Dent Res. 2018 Sep 10:22034518797275. Epub 2018 Sep 10. PMID:
30199654
Article Published Date
: Sep 09, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Osteoporosis
,
Periodontitis
,
Postmenopausal Disorders
Pharmacological Actions
:
Gastrointestinal Agents
,
Osteoprotective
[+]
Berberine ameliorates prenatal dihydrotestosterone exposure-induced autism-like behaviour by suppression of androgen receptor.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Cell Neurosci. 2020 ;14:87. Epub 2020 Apr 9. PMID:
32327976
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Autism
,
Fetal Origin of Adult Disease
,
Polycystic Ovary Syndrome
Pharmacological Actions
:
Antioxidants
Additional Keywords
:
Risk Reduction
[+]
Berberine ameliorates rats model of combined Alzheimer's disease and type 2 diabetes mellitus via the suppression of endoplasmic reticulum stress.
Jul 31, 2020
Click here to read the entire abstract
Pubmed Data
: 3 Biotech. 2020 Aug ;10(8):359. Epub 2020 Jul 29. PMID:
32832321
Article Published Date
: Jul 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
,
Diabetes: Cognitive Dysfunction
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine and cinnamaldehyde together prevent lung carcinogenesis.
Sep 28, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 Sep 29 ;8(44):76385-76397. Epub 2017 Aug 7. PMID:
29100319
Article Published Date
: Sep 28, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Cinnamaldehyde
Diseases
:
Lung Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
Berberine and coptis chinesis (goldenthread) extract prevents neurodegeneration induced by aluminum overload in rats.
Jun 01, 2009
Click here to read the entire abstract
Pubmed Data
: Saudi Med J. 2009 Jun;30(6):760-6. PMID:
19526156
Article Published Date
: Jun 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Goldenthread
Diseases
:
Aluminum Toxicity
[+]
Berberine and evodiamine regulate the expression of important genes that could be beneficial in colon cancer treatments.
Feb 28, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Mar ;37(3):1637-1645. Epub 2017 Jan 17. PMID:
28098901
Article Published Date
: Feb 28, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
,
Evodiamine
Diseases
:
Colon Cancer
Pharmacological Actions
:
Chemopreventive
,
Chemotherapeutic
,
MicroRNA modulator
[+]
Berberine attenuate staphylococcal enterotoxin B-mediated acute liver injury via regulating HDAC expression.
Sep 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: AMB Express. 2018 Oct 1 ;8(1):158. Epub 2018 Oct 1. PMID:
30276552
Article Published Date
: Sep 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Staphylococcal Infections
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
Berberine attenuates arterial plaque formation.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2020 ;14:2449-2460. Epub 2020 Jun 23. PMID:
32606611
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine attenuates arthritis in adjuvant-induced arthritis.
Feb 19, 2019
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2019 Feb 20. Epub 2019 Feb 20. PMID:
30796904
Article Published Date
: Feb 19, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-17 downregulation
,
NF-kappaB Inhibitor
[+]
Berberine attenuates experimental autoimmune encephalomyelitis in mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2010;5(10):e13489. Epub 2010 Oct 19. PMID:
20976070
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Blood-Brain-Barrier Disorders
,
Brain Inflammation
,
Multiple Sclerosis
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Berberine attenuates hepatic oxidative stress in rats with non-alcoholic fatty liver disease.
Feb 28, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2019 Mar ;17(3):2091-2098. Epub 2019 Jan 28. PMID:
30867696
Article Published Date
: Feb 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Nrf2 activation
[+]
Berberine attenuates hepatic steatosis and enhances energy expenditure.
Oct 23, 2017
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2017 Oct 24. Epub 2017 Oct 24. PMID:
29065221
Article Published Date
: Oct 23, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Fatty Liver
,
Liver Steatosis
,
Obesity
Pharmacological Actions
:
Autophagy Up-regulation
,
Fibroblast growth factor 21 upregulation
,
Hepatoprotective
[+]
Berberine attenuates hyperglycemia by inhibiting the hepatic glucagon pathway in diabetic mice
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2020 ;2020:6210526. Epub 2020 Jan 3. PMID:
31976031
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperglycemia
Pharmacological Actions
:
Antihypertensive Agents
[+]
Berberine attenuates hypoxia-induced pulmonary arterial hypertension.
Feb 19, 2019
Click here to read the entire abstract
Pubmed Data
: J Cell Physiol. 2019 Feb 20. Epub 2019 Feb 20. PMID:
30786011
Article Published Date
: Feb 19, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hypertension
,
Hypoxia
Pharmacological Actions
:
Antihypertensive Agents
[+]
Berberine attenuates intestinal tumorigenesis by inhibiting the migration and invasion of colorectal tumor cells.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2016 ;2016:5137505. Epub 2016 Jul 17. PMID:
27493671
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colon Cancer: Prevention
,
Gastric Polyposis
,
Intestinal Polyps
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
[+]
Berberine attenuates ischemia-reperfusion injury.
Sep 27, 2018
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2018 Sep 28. Epub 2018 Sep 28. PMID:
30266998
Article Published Date
: Sep 27, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine attenuates macrophages infiltration in intracranial aneurysms.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:565. Epub 2018 May 30. PMID:
29899701
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Aneurysm: Cerebral
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway.
Jun 17, 2019
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2019 Jun 18 ;141:192-204. Epub 2019 Jun 18. PMID:
31226399
Article Published Date
: Jun 17, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Berberine attenuates olanzapine induced-metabolic syndrome.
Jul 31, 2019
Click here to read the entire abstract
Pubmed Data
: J Pak Med Assoc. 2019 Aug ;69(Suppl 3)(8):S88-S92. PMID:
31603885
Article Published Date
: Jul 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Metabolic Diseases
Pharmacological Actions
:
Hypolipidemic
Problem Substances
:
Olanzapine
[+]
Berberine attenuates pulmonary arterial hypertension.
Aug 04, 2018
Click here to read the entire abstract
Pubmed Data
: J Cell Physiol. 2018 Aug 5. Epub 2018 Aug 5. PMID:
30078229
Article Published Date
: Aug 04, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Hypertension: Pulmonary
Pharmacological Actions
:
Antihypertensive Agents
[+]
Berberine attenuates severity of chronic pancreatitis and fibrosis.
Jul 24, 2020
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2020 Jul 25 ;403:115162. Epub 2020 Jul 25. PMID:
32721432
Article Published Date
: Jul 24, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Fibrosis
,
Pancreatitis
Pharmacological Actions
:
Pancreato Protective Agents
,
Transforming growth factor beta (TGF-β) inhibitor
[+]
Berberine can ameliorate pro-inflammatory cytokines induced intestinal permeability in vitro,
Feb 08, 2010
Click here to read the entire abstract
Pubmed Data
: Eur J Pharm Sci. 2010 Feb 8. Epub 2010 Feb 8. PMID:
20149867
Article Published Date
: Feb 08, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Intestinal Permeability
[+]
Berberine can ameliorate tubulointerstitial fibrosis in diabetic nephropathy.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2016 ;17(8). Epub 2016 Aug 12. PMID:
27529235
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetic Nephropathy
,
Kidney Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Heme oxygenase-1 up-regulation
,
Nrf2 activation
,
Renoprotective
[+]
Berberine can be a potential therapeutic agent for osteoclast-related bone diseases.
Mar 03, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2019 Mar 4:1-17. Epub 2019 Mar 4. PMID:
30827151
Article Published Date
: Mar 03, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Bone Diseases
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Osteoprotective
[+]
Berberine can effectively improve renal function in rats with renal ischemia-reperfusion injury.
Aug 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Sep ;16(3):2008-2012. Epub 2018 Jul 4. PMID:
30186432
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ischemia
Pharmacological Actions
:
Renoprotective
[+]
Berberine can improve insulin resistance of skeletal muscle in rats.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Nov ;46(6):827-31. PMID:
26867315
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine can improve myocardial injury and cardiac function in sepsis.
Sep 21, 2020
Click here to read the entire abstract
Pubmed Data
: Zhonghua Yi Xue Za Zhi. 2020 Sep 22 ;100(35):2779-2784. PMID:
32972060
Article Published Date
: Sep 21, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cardiomyopathy
,
Lipopolysaccharide-Induced Toxicity
,
Sepsis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Interleukin-1 beta downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine can prevent fructose-induced insulin resistance in rats
Oct 01, 2006
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2006 Oct 1;216(1):11-9. Epub 2006 May 17. PMID:
18563319
Article Published Date
: Oct 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Fructose-Induced Toxicity
,
Insulin Resistance
,
Liver Stress: Fructose-Induced
[+]
Berberine can promote angiogenesis in the rat with cerebral ischemia-reperfusion injury.
Sep 30, 2018
Click here to read the entire abstract
Pubmed Data
: J Coll Physicians Surg Pak. 2018 Oct ;28(10):753-757. PMID:
30266118
Article Published Date
: Sep 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Angiogenesis Inducing Agents
[+]
Berberine can reduce the acquisition and reinstatement of morphine-induced conditioned place preference.
Feb 29, 2016
Click here to read the entire abstract
Pubmed Data
: Avicenna J Phytomed. 2016 Mar-Apr;6(2):198-204. PMID:
27222833
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Morphine Tolerance/Dependence
[+]
Berberine can reverse chronic inflammatory pain induced by complete freund's adjuvant and alleviated the comorbid depression.
Apr 09, 2018
Click here to read the entire abstract
Pubmed Data
: Zhonghua Yi Xue Za Zhi. 2018 Apr 10 ;98(14):1103-1108. PMID:
29690724
Article Published Date
: Apr 09, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Depression
,
Hyperalgesia
,
Inflammation
Pharmacological Actions
:
Analgesics
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine can suppress the proliferation of liver cancer cells by reducing SLC1A5 expression.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Onco Targets Ther. 2019 ;12:11751-11763. Epub 2019 Dec 31. PMID:
32021249
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
[+]
Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats.
Aug 22, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Aug 23 ;95:175-185. Epub 2017 Aug 23. PMID:
28843149
Article Published Date
: Aug 22, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hypoglycemic Agents
,
NF-kappaB Inhibitor
,
Pancreato Protective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Diabetes Mellitus: Type 1
[+]
Berberine chloride may be considered as a potential treatment for cognitive deficits and neuronal injury.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Basic Med Sci. 2018 Jan ;21(1):53-58. PMID:
29372037
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Dementia
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine chloride suppresses non-small cell lung cancer.
Jun 30, 2020
Click here to read the entire abstract
Pubmed Data
: Cancer Chemother Pharmacol. 2020 Jul ;86(1):151-161. Epub 2020 Jun 30. PMID:
32607786
Article Published Date
: Jun 30, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
[+]
Berberine clears Aβ deposit and consequently ameliorates spatial learning memory impairment.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2019 ;10:1003. Epub 2019 Sep 6. PMID:
31551793
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
,
Diabetes: Cognitive Dysfunction
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models.
Feb 08, 2020
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2020 Feb 9 ;81:106205. Epub 2020 Feb 9. PMID:
32050154
Article Published Date
: Feb 08, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Graft vs Host Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
NF-kappaB Inhibitor
[+]
Berberine combined with HMQ1611 exhibited potential antitumor activities against human liver cancer in vitro and in vivo.
Dec 17, 2018
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2018 Dec 18. Epub 2018 Dec 18. PMID:
30565332
Article Published Date
: Dec 17, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Wnt/β-catenin signaling pathway modulation
[+]
Berberine confers neuroprotection in coping with focal cerebral ischemia.
May 07, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Chem Neuroanat. 2017 May 8. Epub 2017 May 8. PMID:
28495517
Article Published Date
: May 07, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Berberine could alleviate postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2016 Jul 1 ;38:426-433. Epub 2016 Jul 1. PMID:
27376853
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Brain Inflammation
,
Cognitive Decline/Dysfunction
,
Postoperative Recovery
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine could ameliorate cardiac dysfunction in a model of diabetic cardiomyopathy.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Physiol. 2018 ;9:1042. Epub 2018 Aug 2. PMID:
30131709
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cardiomyopathy
,
Diabetic Complications
Pharmacological Actions
:
Cardioprotective
[+]
Berberine could ameliorate the renal impairment and inhibit the podocyte dysfunction in diabetic rat.
Jul 22, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Diabetes Investig. 2019 Jul 23. Epub 2019 Jul 23. PMID:
31336024
Article Published Date
: Jul 22, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Renoprotective
[+]
Berberine could attenuate liver damage induced by a high fat mainly via the protection for mitochondria.
Aug 05, 2016
Click here to read the entire abstract
Pubmed Data
: Fish Physiol Biochem. 2016 Aug 6. Epub 2016 Aug 6. PMID:
27497985
Article Published Date
: Aug 05, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
High Fat Diet
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
[+]
Berberine could be a promising anti-diabetic nephropathy medicine in the future.
Apr 20, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Mol Med. 2016 Apr 21. Epub 2016 Apr 21. PMID:
27098986
Article Published Date
: Apr 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Complications
,
Diabetic Nephropathy
Pharmacological Actions
:
Renoprotective
[+]
Berberine could be used in the treatment or prevention of obesity-associated NAFLD.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 ;6:22612. Epub 2016 Mar 3. PMID:
26936230
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hepatic Steatosis
,
Inflammation
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine could effectively alleviate motor dysfunction and prolong the survival of transgenic N171-82Q HD mice.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(7):e0134142. Epub 2015 Jul 30. PMID:
26225560
Article Published Date
: Dec 31, 2014
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Huntington Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine could generate an anti-osteosarcoma property through downregulating caspase-1/IL-1β inflammatory signaling axis.
Jan 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Rep. 2017 Feb ;37(2):729-736. Epub 2016 Dec 16. PMID:
28000894
Article Published Date
: Jan 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Antiproliferative
,
Interleukin-1 beta downregulation
[+]
Berberine could significantly improve the spatial learning and memory abilities of rats with vascular cognitive impairment.
Jul 27, 2019
Click here to read the entire abstract
Pubmed Data
: Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019 Jul 28 ;35(4):359-362. PMID:
31701723
Article Published Date
: Jul 27, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Brain: Oxidative Stress
,
Brain Inflammation
,
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine decreased serum levels of glycosylated hemoglobin, total cholesterol and triglyceride and increase the secretion of insulin.
Feb 15, 2016
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2016 Feb 16. Epub 2016 Feb 16. PMID:
26888689
Article Published Date
: Feb 15, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypolipidemic
[+]
Berberine decreases insulin resistance in a polycystic ovarian syndrome model.
Nov 24, 2019
Click here to read the entire abstract
Pubmed Data
: Regul Toxicol Pharmacol. 2019 Nov 25:104544. Epub 2019 Nov 25. PMID:
31778716
Article Published Date
: Nov 24, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
,
Polycystic Ovary Syndrome
Pharmacological Actions
:
Insulin Sensitizers
[+]
Berberine decreases the expression of EBNA1 and exhibits an antitumor effects against nasopharyngeal carcinoma.
Mar 31, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Apr ;37(4):2109-2120. Epub 2017 Mar 2. PMID:
28259949
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5.
Nov 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Pharm Sin B. 2020 Dec ;10(12):2299-2312. Epub 2020 Jun 30. PMID:
33354502
Article Published Date
: Nov 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cancers: All
Pharmacological Actions
:
Immunomodulatory
[+]
Berberine down-regulated myostatin rxpression and facilitated metabolism via smad pathway in insulin resistance.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Diabetes Metab Syndr Obes. 2020 ;13:4561-4569. Epub 2020 Nov 23. PMID:
33262628
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine enhances L1 expression and axonal remyelination in rats after brachial plexus root avulsion.
Aug 06, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Brain Behav. 2020 Aug 7:e01792. Epub 2020 Aug 7. PMID:
32770668
Article Published Date
: Aug 06, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nerve Injuries
Pharmacological Actions
:
Regenerative
Additional Keywords
:
Nerve Regeneration
[+]
Berberine exerted a protective effect on gut-vascular barrier function in sepsis.
Sep 10, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2018 Sep 11 ;49(4):1342-1351. Epub 2018 Sep 11. PMID:
30205381
Article Published Date
: Sep 10, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Sepsis
Pharmacological Actions
:
Gastroprotective
[+]
Berberine exerted a superior anti-arthritic effect and the mechanism maybe involve the balance between Treg and Th17 cells.
Mar 05, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Mar 6 ;89:887-893. Epub 2017 Mar 6. PMID:
28282791
Article Published Date
: Mar 05, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-10 upregulation
,
Interleukin-17 downregulation
,
Interleukin-6 Downregulation
[+]
Berberine exerted anticancer effects on human gastric cancer both in vitro and in vivo.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2020 ;2020:6195050. Epub 2020 Apr 8. PMID:
32328135
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
[+]
Berberine exerted protective effects on lead-induced oxidative stress and hepatotoxicity in rats.
Feb 11, 2016
Click here to read the entire abstract
Pubmed Data
: Redox Rep. 2016 Feb 12. Epub 2016 Feb 12. PMID:
26871196
Article Published Date
: Feb 11, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Lead Poisoning
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
[+]
Berberine exerts a protective action against carbon tetrachloride induced acute liver injury.
Aug 05, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2019 Aug 6. Epub 2019 Aug 6. PMID:
31432116
Article Published Date
: Aug 05, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
[+]
Berberine exerts a protective effect on rats with polycystic ovary syndrome.
Jan 06, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Reprod Biol Endocrinol. 2021 Jan 7 ;19(1):3. Epub 2021 Jan 7. PMID:
33407557
Article Published Date
: Jan 06, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine exhibited protective effects against doxorubicin induced heart tissue free radical injury.
Mar 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2018 Apr ;15(4):5721-5729. Epub 2018 Feb 9. PMID:
29552206
Article Published Date
: Mar 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Cardioprotective
,
Chemoprotective Agents
[+]
Berberine exhibited renoprotective effects in diabetic nephropathy.
Jan 09, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Cell Endocrinol. 2017 Jan 10. Epub 2017 Jan 10. PMID:
28087385
Article Published Date
: Jan 09, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Advanced Glycation End products (AGE)
,
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Glycation Agents
,
Renoprotective
[+]
Berberine exhibits neuroprotective qualities against ischemic brain damage in stroke models
Dec 05, 2008
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2008 Dec 5 ;447(1):31-6. Epub 2008 Sep 30. PMID:
18838103
Article Published Date
: Dec 05, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Brain Ischemia
,
Hypoxia
,
Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Ischemia Reperfusion Injury
[+]
Berberine exhibits notable preventive effects on acetaminophen induced hepatotoxicity.
Jun 30, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID:
29864914
Article Published Date
: Jun 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Nrf2 activation
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Berberine facilitates angiogenesis against ischemic stroke.
Apr 23, 2019
Click here to read the entire abstract
Pubmed Data
: Cell Mol Neurobiol. 2019 Apr 24. Epub 2019 Apr 24. PMID:
31020571
Article Published Date
: Apr 23, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Stroke: Ischemic
Pharmacological Actions
:
Angiogenesis Inducing Agents
[+]
Berberine functions as a negative regulator in lipopolysaccharide -induced sepsis.
Oct 06, 2020
Click here to read the entire abstract
Pubmed Data
: Pathog Dis. 2020 Oct 7 ;78(7). PMID:
32857851
Article Published Date
: Oct 06, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Sepsis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine had suppressive effects on atherosclerosis.
Jan 29, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2018 Jan 30. Epub 2018 Jan 30. PMID:
29393413
Article Published Date
: Jan 29, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-atherogenic
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine has a beneficial effect against diabetic neuropathy by improving micropathology and increasing neuritin expression.
Feb 02, 2016
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2016 Feb 3. Epub 2016 Feb 3. PMID:
26849937
Article Published Date
: Feb 02, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Neuropathy
Pharmacological Actions
:
MicroRNA modulator
,
Neuroprotective Agents
[+]
Berberine has a preventive effect on experimental colon cancer.
Oct 01, 2010
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2768-73. PMID:
21246838
Article Published Date
: Oct 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colon Cancer
Pharmacological Actions
:
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Berberine has an anti-tumor effect on colitis-associated colorectal cancer.
Jul 30, 2017
Click here to read the entire abstract
Pubmed Data
: Lab Invest. 2017 Jul 31. Epub 2017 Jul 31. PMID:
28759012
Article Published Date
: Jul 30, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colitis
,
Colon Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
[+]
Berberine has anti-inflammatory effects on H. pylori-induced chronic gastritis.
Jan 17, 2018
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2018 Jan 18. Epub 2018 Jan 18. PMID:
29345340
Article Published Date
: Jan 17, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Immunomodulatory: Th17 downregulation
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
[+]
Berberine has anticonvulsant activity in mice.
Jul 01, 2010
Click here to read the entire abstract
Pubmed Data
: Epilepsy Behav. 2010 Jul;18(3):207-10. PMID:
20638957
Article Published Date
: Jul 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Convulsions
,
Seizures
Pharmacological Actions
:
Anticonvulsants
[+]
Berberine has protective effect for diabetes through increasing insulin expression, beta cell regeneration, antioxidant enzyme activity and decreasing lipid peroxidation.
Mar 15, 2009
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2009 Mar 15;606(1-3):262-8. Epub 2009 Jan 19. PMID:
19374872
Article Published Date
: Mar 15, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 1
Additional Keywords
:
Beta Cell Regeneration
[+]
Berberine has protective effects against macrovascular complications induced by diabetes mellitus.
Sep 03, 2020
Click here to read the entire abstract
Pubmed Data
: Endocr Metab Immune Disord Drug Targets. 2020 Sep 4. Epub 2020 Sep 4. PMID:
32888284
Article Published Date
: Sep 03, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cytoprotective
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Transforming growth factor beta (TGF-β) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine hydrochloride can provide mice robust protection from LPS-induced mastitis.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2018 ;2018:5164314. Epub 2018 Apr 15. PMID:
29849710
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Mastitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine impairs coxsackievirus B3-induced myocarditis through the inhibition of virus replication and host pro-inflammatory response.
Dec 17, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Med Virol. 2020 Dec 18. Epub 2020 Dec 18. PMID:
33336842
Article Published Date
: Dec 17, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Coxsackievirus Infections
,
Myocarditis: Viral
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
[+]
Berberine improved metabolic function in a mouse model fed a high-fat diet.
Jan 03, 2019
Click here to read the entire abstract
Pubmed Data
: Med Sci Monit. 2019 Jan 4 ;25:87-97. Epub 2019 Jan 4. PMID:
30606998
Article Published Date
: Jan 03, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
High Fat Diet
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine improves benign prostatic hyperplasia.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Front Pharmacol. 2018 ;9:773. Epub 2018 Jul 16. PMID:
30061836
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Prostatic Hyperplasia: Benign
[+]
Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites.
Dec 03, 2020
Click here to read the entire abstract
Pubmed Data
: Pharmacol Res. 2020 Dec 4:105358. Epub 2020 Dec 4. PMID:
33285228
Article Published Date
: Dec 03, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colitis
Pharmacological Actions
:
Gastrointestinal Agents
[+]
Berberine improves free-fatty-acid-induced insulin resistance.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Metabolism. 2009 Dec;58(12):1694-702. Epub 2009 Sep 19. PMID:
19767038
Article Published Date
: Dec 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Berberine improves inflammatory responses of diabetes mellitus.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Immunol Res. 2020 ;2020:2141508. Epub 2020 Aug 18. PMID:
32908938
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine improves intralipid-induced insulin resistance in murine.
Aug 06, 2020
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2020 Aug 7. Epub 2020 Aug 7. PMID:
32770172
Article Published Date
: Aug 06, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperglycemia
,
Insulin Resistance
[+]
Berberine in combination with yohimbine therapy attenuates neutrophil tissue infiltration and multiple organ injury in septic mice.
Apr 11, 2016
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2016 Apr 12 ;35:217-225. Epub 2016 Apr 12. PMID:
27082997
Article Published Date
: Apr 11, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Sepsis
[+]
Berberine induced senescence of human glioblastoma cells.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Cancer Ther. 2015 Feb ;14(2):355-63. Epub 2014 Dec 12. PMID:
25504754
Article Published Date
: Jan 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Glioblastoma
Pharmacological Actions
:
Anti-Tumor
,
Apoptotic
,
Cell cycle arrest
,
Epidermal growth factor receptor (EGFR) inhibitor
[+]
Berberine inhibited angiogenesis in glioblastoma xenografts.
Nov 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharm Biol. 2018 Dec ;56(1):665-671. PMID:
31070539
Article Published Date
: Nov 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Glioblastoma
Pharmacological Actions
:
Angiogenesis Inhibitors
[+]
Berberine inhibits adipogenesis in high-fat diet-induced obesity mice.
Oct 25, 2009
Click here to read the entire abstract
Pubmed Data
: Fitoterapia. 2009 Oct 25. Epub 2009 Oct 25. PMID:
19861153
Article Published Date
: Oct 25, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Obesity
Pharmacological Actions
:
Anti-Adipogenic
[+]
Berberine inhibits cardiac remodeling of heart failure after myocardial infarction.
Aug 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Sep ;16(3):2499-2505. Epub 2018 Jul 11. PMID:
30186485
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Berberine inhibits colorectal tumor growth by suppressing SHH secretion.
Sep 20, 2020
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2020 Sep 21. Epub 2020 Sep 21. PMID:
32958873
Article Published Date
: Sep 20, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Tumors
Pharmacological Actions
:
Antiproliferative
[+]
Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2020 ;15(5):e0232630. Epub 2020 May 1. PMID:
32357187
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
Berberine inhibits human tongue cancer growth in an animal xenograft model.
Mar 19, 2009
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2009 Mar 19. PMID:
19303753
Article Published Date
: Mar 19, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Tongue Cancer
[+]
Berberine inhibits inflammatory mediators and attenuates acute pancreatitis in animals.
May 01, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Immunol. 2016 May 2 ;74:27-38. Epub 2016 May 2. PMID:
27148818
Article Published Date
: May 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Pancreatitis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine inhibits macrophage M1 polarization to protect against DSS-induced colitis.
Feb 22, 2018
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2018 Feb 23 ;57:121-131. Epub 2018 Feb 23. PMID:
29482156
Article Published Date
: Feb 22, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
[+]
Berberine inhibits the ischemia-reperfusion induced testicular injury through decreasing oxidative stress.
Apr 01, 2019
Click here to read the entire abstract
Pubmed Data
: Am J Emerg Med. 2019 Apr 2. Epub 2019 Apr 2. PMID:
30971358
Article Published Date
: Apr 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ischemia
Pharmacological Actions
:
Antioxidants
[+]
Berberine is a key component in Coptis chinensis with anti-plague activity.
Mar 01, 2009
Click here to read the entire abstract
Pubmed Data
: Planta Med. 2009 Mar;75(4):396-8. Epub 2008 Dec 3. PMID:
19053015
Article Published Date
: Mar 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Coptis chinensis
Diseases
:
Bubonic Plague
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
Berberine is a potential candidate for the treatment of NASH.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2020 ;11:185. Epub 2020 Mar 3. PMID:
32194416
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
Berberine is a potential drug for the treatment of patients with ischemia-reperfusion injury.
Jan 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Feb ;15(2):1225-1232. Epub 2017 Nov 27. PMID:
29403554
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
,
NF-kappaB Inhibitor
[+]
Berberine is a potential therapeutic alleviating diabetes and diabetic neuropathic pain
May 11, 2019
Click here to read the entire abstract
Pubmed Data
: Naunyn Schmiedebergs Arch Pharmacol. 2019 May 12. Epub 2019 May 12. PMID:
31079200
Article Published Date
: May 11, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Neuropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine markedly ameliorates aging-related reductions in cognitive ability and muscular function.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Nutr Health Aging. 2018 ;22(6):710-717. PMID:
29806860
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Aging: Brain
,
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Neuroprotective Agents
[+]
Berberine may act as a potential neuroprotective agent.
Oct 12, 2016
Click here to read the entire abstract
Pubmed Data
: Neurotoxicology. 2016 Oct 13 ;57:241-250. Epub 2016 Aug 13. PMID:
27746125
Article Published Date
: Oct 12, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
,
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Anxiety Agents
,
Neuroprotective Agents
[+]
Berberine may be a candidate therapeutic agent for the treatment of NASH.
Oct 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2017 Nov ;14(5):4134-4140. Epub 2017 Aug 28. PMID:
29075339
Article Published Date
: Oct 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Berberine may be a new therapeutic strategy against hepatic steatosis and non-alcoholic steatohepatitis.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 ;6:20848. Epub 2016 Feb 9. PMID:
26857750
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Hepatoprotective
[+]
Berberine may be a potential therapeutic agent for the treatment of patients with neonatal necrotizing enterocolitis.
Mar 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Apr ;15(4):3530-3536. Epub 2018 Feb 12. PMID:
29545879
Article Published Date
: Mar 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Enterocolitis: Necrotiziing
Pharmacological Actions
:
Anti-Apoptotic
[+]
Berberine may be a potential treatment for controlling bone loss in diabetic osteoporosis.
Sep 13, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Sep 14 ;108:280-287. Epub 2018 Sep 14. PMID:
30223099
Article Published Date
: Sep 13, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Complications
,
Osteoporosis
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Osteoprotective
[+]
Berberine may be a promising treatment for obesity and related metabolic disorders.
Jun 12, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Dis. 2019 Jun 13 ;10(6):468. Epub 2019 Jun 13. PMID:
31197160
Article Published Date
: Jun 12, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Obesity
Additional Keywords
:
Anti-Obesity Agents
[+]
Berberine may be an effective therapeutic strategy for the treatment of obesity and insulin resistance.
Apr 30, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2017 May ;15(5):2765-2787. Epub 2017 Mar 14. PMID:
28447763
Article Published Date
: Apr 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Insulin Resistance
,
Obesity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Gastrointestinal Agents
Additional Keywords
:
Microbiota
[+]
Berberine may be protective against retinal diseases involving oxidative stress.
Oct 13, 2015
Click here to read the entire abstract
Pubmed Data
: Exp Eye Res. 2015 Oct 14. Epub 2015 Oct 14. PMID:
26475979
Article Published Date
: Oct 13, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Retinal Diseases
Pharmacological Actions
:
Antioxidants
[+]
Berberine may be used as a novel potential primary prevention means against prehypertension-related atherosclerotic cardiovascular disease.
Oct 18, 2018
Click here to read the entire abstract
Pubmed Data
: Chin J Integr Med. 2018 Oct 19. Epub 2018 Oct 19. PMID:
30341486
Article Published Date
: Oct 18, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Prehypertension
Pharmacological Actions
:
Cardioprotective
[+]
Berberine may exert antitumor effects by suppressing tumor growth and elevating the intestinal mucosal permeability.
Oct 31, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Nov ;107:1447-1453. Epub 2018 Sep 3. PMID:
30257361
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Chemotherapeutic
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]
Berberine may have therapeutic value in those with high homocysteine by regulating liver cholesterol synthesis.
Dec 22, 2010
Click here to read the entire abstract
Pubmed Data
: Am J Physiol Regul Integr Comp Physiol. 2010 Dec 22. Epub 2010 Dec 22. PMID:
21178122
Article Published Date
: Dec 22, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
High Cholesterol
,
High Homocysteine
[+]
Berberine might attenuate the liver inflammatory response in the livers of rats with high-fat diet-induced NAFLD.
May 18, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Immunol. 2020 May 19 ;21(1):28. Epub 2020 May 19. PMID:
32429849
Article Published Date
: May 18, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
High Fat Diet
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
[+]
Berberine might be a preferable and rational therapeutic approach to ameliorate neuronal injury from hypoxia/ischemia.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Transl Res. 2016 ;8(2):1197-207. Epub 2016 Feb 15. PMID:
27158406
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Autophagy Up-regulation
,
Neuroprotective Agents
[+]
Berberine might be a promising synergist to enhance the antimicrobial activity of azithromycin in vitro and in vivo.
Jul 23, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2017 Jul 24 ;42(4):1657-1669. Epub 2017 Jul 24. PMID:
28738346
Article Published Date
: Jul 23, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Pseudomonas aeruginosa
Pharmacological Actions
:
Antimicrobial
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Berberine might be useful for prevention of the hepatotoxicity induced by methotrexate.
Oct 25, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Oct 26 ;97:233-239. Epub 2017 Oct 26. PMID:
29091871
Article Published Date
: Oct 25, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Drug-Induced Toxicity: Methotrexate
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Malondialdehyde Down-regulation
[+]
Berberine might become a new strategy for treating cardiac fibrosis in the future.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Pathol. 2015 ;8(10):12509-16. Epub 2015 Oct 1. PMID:
26722438
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Fibrosis
Pharmacological Actions
:
Cardioprotective
[+]
Berberine might provide a combinational therapy for controlling hyperglycemia and blood pressure in diabetes.
May 16, 2017
Click here to read the entire abstract
Pubmed Data
: J Mol Endocrinol. 2017 May 17. Epub 2017 May 17. PMID:
28515053
Article Published Date
: May 16, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperglycemia
,
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Hypoglycemic Agents
[+]
Berberine modulates GLP-1 via promoting GLP-1 secretion and GLP-1 biosynthesis.
Dec 01, 1995
Click here to read the entire abstract
Pubmed Data
: J Altern Complement Med. 1995 Winter;1(4):361-9. PMID:
19945441
Article Published Date
: Dec 01, 1995
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Pharmacological Actions
:
Glucagon Like peptide 1 (GLP-1) Up-regulation
[+]
Berberine nanoencapsulation attenuates hallmarks of scoplomine induced Alzheimer's-like disease.
Jun 27, 2020
Click here to read the entire abstract
Pubmed Data
: Curr Clin Pharmacol. 2020 Jun 28. Epub 2020 Jun 28. PMID:
32598269
Article Published Date
: Jun 27, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Gene Expression Regulation
[+]
Berberine prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Transl Res. 2019 ;11(5):2668-2682. Epub 2019 May 15. PMID:
31217846
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-Inflammatory Agents
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Berberine prevents stress-induced gut inflammation and visceral hypersensitivity and reduces intestinal motility in rats.
Aug 06, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2019 Aug 7 ;25(29):3956-3971. PMID:
31413530
Article Published Date
: Aug 06, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Gastrointestinal Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-10 upregulation
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
[+]
Berberine prevents the progression of type 1 diabetes in mice through decreased Th17 and Th1 cytokine secretion.
Oct 09, 2009
Click here to read the entire abstract
Pubmed Data
: J Biol Chem. 2009 Oct 9;284(41):28420-9. Epub 2009 Aug 6. PMID:
19661066
Article Published Date
: Oct 09, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Autoimmune Diseases
,
Immune Dysregulation: TH17 over-expression
,
Immune Dysregulation: TH1 dominance
[+]
Berberine prevents ulcerative colitis by modifying gut microbiota and regulating the balance of Treg/Th17.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Front Pharmacol. 2018 ;9:571. Epub 2018 May 31. PMID:
29904348
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Immunomodulatory: Th17 downregulation
Additional Keywords
:
Microbiota
[+]
Berberine produced myocardial salvaging effects in the setting of diabetes challenged with ISP induced myocardial necrosis.
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Clin Diagn Res. 2016 Mar ;10(3):FF13-8. Epub 2016 Mar 1. PMID:
27134894
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
,
Diabetic Complications
,
Heart Failure
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
[+]
Berberine produces antidepressant-like effects in ovariectomized mice.
May 01, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 May 2 ;7(1):1310. Epub 2017 May 2. PMID:
28465511
Article Published Date
: May 01, 2017
Study Type
: Insect Study
Additional Links
Substances
:
Berberine
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats.
Feb 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Endocrinol. 2009 Feb;200(2):159-65. Epub 2008 Nov 7. PMID:
18996945
Article Published Date
: Feb 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Glucagon Like peptide 1 (GLP-1) Up-regulation
,
Hypoglycemic Agents
[+]
Berberine promotes glucose uptake and inhibits gluconeogenesis by inhibiting deacetylase SIRT3.
Aug 15, 2018
Click here to read the entire abstract
Pubmed Data
: Endocrine. 2018 Aug 16. Epub 2018 Aug 16. PMID:
30117113
Article Published Date
: Aug 15, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Berberine promotes neurite extension and axonal regeneration in injured nerves of the peripheral nervous system
Apr 01, 2012
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2012 Apr ;15(4):413-7. Epub 2012 Feb 8. PMID:
22316297
Article Published Date
: Apr 01, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Goldenthread
Diseases
:
Demyelinating Diseases
,
Peripheral Nerve Diseases
,
Peripheral Neuropathies
Pharmacological Actions
:
Neuritogenic
Additional Keywords
:
Nerve Regeneration
,
Remyelination
,
Sciatic Nerve
[+]
Berberine protects against fructose-and-salt induced hypertensive renal injury.
Mar 01, 2011
Click here to read the entire abstract
Pubmed Data
: Zhong Yao Cai. 2011 Mar ;34(3):412-5. PMID:
21823461
Article Published Date
: Mar 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Fructose-Induced Toxicity
,
Hypertension: Renal
,
Kidney Diseases
Pharmacological Actions
:
Renoprotective
Problem Substances
:
Fructose
,
Sodium Chloride
Adverse Pharmacological Actions
:
Nephrotoxic
[+]
Berberine protects against gastrointestinal injuries from alcohol stress.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(7):e0134044. Epub 2015 Jul 30. PMID:
26226164
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alcohol Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Gastroprotective
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine protects against simulated ischemia/reperfusion injury-induced H9C2 cardiomyocytes apoptosis.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
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Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2020 ;11:367. Epub 2020 Mar 27. PMID:
32292345
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Cardioprotective
[+]
Berberine protects against the hepatic damage induced by Paracetamol
Feb 01, 2000
Click here to read the entire abstract
Pubmed Data
: Fitoterapia. 2000 Feb ;71(1):25-33. PMID:
11449466
Article Published Date
: Feb 01, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Hepatoprotective
Problem Substances
:
Paracetamol
[+]
Berberine protects secondary injury in mice with traumatic brain injury.
Jul 18, 2018
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2018 Jul 19. Epub 2018 Jul 19. PMID:
30027364
Article Published Date
: Jul 18, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Brain Injury: Traumatic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
[+]
Berberine protects the diabetic heart from ischemia-reperfusion injury.
Feb 03, 2016
Click here to read the entire abstract
Pubmed Data
: J Cardiovasc Pharmacol Ther. 2016 Feb 4. Epub 2016 Feb 4. PMID:
26846272
Article Published Date
: Feb 03, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Complications
,
Myocardial Ischemia
Pharmacological Actions
:
Anticholesteremic Agents
,
Cardioprotective
,
Malondialdehyde Down-regulation
[+]
Berberine protects the liver and kidneys against ferrous sulfate-induced toxicity by reduction in lipid peroxidation and ability to chelate iron.
Apr 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Basic Med Sci. 2018 May ;21(5):476-482. PMID:
29922427
Article Published Date
: Apr 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Iron Overload
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Iron Chelating Agents
,
Renoprotective
[+]
Berberine reduces endothelial injury and arterial stiffness in spontaneously hypertensive rats.
Jun 19, 2019
Click here to read the entire abstract
Pubmed Data
: Clin Exp Hypertens. 2019 Jun 20:1-9. Epub 2019 Jun 20. PMID:
31220947
Article Published Date
: Jun 19, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Arterial Hardening: Elasticity
,
Endothelial Damage
,
Hypertension
Pharmacological Actions
:
Vasoprotective
[+]
Berberine reduces insulin resistance through upregulation of insulin receptor expression.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Metabolism. 2009 Jan;58(1):109-19. PMID:
19059538
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
,
Insulin Resistance
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Insulin Receptor Upregulation
[+]
Berberine reduces intestinal mucosal barrier damage induced by uremia.
Aug 08, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biol Pharm Bull. 2016 Aug 9. Epub 2016 Aug 9. PMID:
27506986
Article Published Date
: Aug 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Uremia
Pharmacological Actions
:
Antioxidants
,
Gastroprotective
,
Malondialdehyde Down-regulation
[+]
Berberine reduces neuroglia activation and inflammation in streptozotocin-induced diabetic mice.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419866379. PMID:
31337260
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine reduces the occurrence of neonatal necrotizing enterocolitis by reducing the inflammatory response.
Nov 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Dec ;16(6):5280-5285. Epub 2018 Oct 17. PMID:
30542485
Article Published Date
: Nov 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Enterocolitis: Necrotiziing
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-10 downregulation
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine reduces thyroxine-induced diarrhea in rats.
Dec 01, 2001
Click here to read the entire abstract
Pubmed Data
: J Korean Med Sci. 2001 Dec;16 Suppl:S42-53. PMID:
19323986
Article Published Date
: Dec 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diarrhea: Drug-Associated
,
Drug-Induced Toxicity: L-Thyroxine
Pharmacological Actions
:
Antidiarrheals
[+]
Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota
Jan 16, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2020 Jan 17 ;124:109829. Epub 2020 Jan 17. PMID:
31958765
Article Published Date
: Jan 16, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemotherapy-Induced Toxicity: 5-fluorouracil
,
Mucositis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Chemoprotective Agents
,
Gastrointestinal Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.
Dec 15, 2020
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2020 Dec 16 ;266:118903. Epub 2020 Dec 16. PMID:
33340526
Article Published Date
: Dec 15, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Gastritis
,
Helicobacter Pylori Infection
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Gastrointestinal Agents
,
Interleukin-4 upregulation
[+]
Berberine represses human gastric cancer cell growth in vitro and in vivo.
May 22, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2020 May 23 ;128:110245. Epub 2020 May 23. PMID:
32454290
Article Published Date
: May 22, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Autophagy Up-regulation
[+]
Berberine significantly alleviated the development of colorectal cancer in mice fed with high fat diet.
Sep 07, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2018 Sep 8 ;23(9). Epub 2018 Sep 8. PMID:
30205580
Article Published Date
: Sep 07, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
,
Colorectal Cancer: Prevention
Pharmacological Actions
:
Chemopreventive
[+]
Berberine significantly promoted the excretion of cholesterol from the liver to the bile in hyperlipidemic hamsters, which decreased serum TC, TG and LDL-C levels.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: J Transl Med. 2015 ;13:278. Epub 2015 Aug 27. PMID:
26310319
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
High Fat Diet
,
Hyperlipidemia
,
Triglycerides: Elevated
Pharmacological Actions
:
Hypolipidemic
[+]
Berberine significantly reduced Chikungunya virus induced inflammatory disease in a mouse model.
Aug 16, 2016
Click here to read the entire abstract
Pubmed Data
: J Virol. 2016 Aug 17. Epub 2016 Aug 17. PMID:
27535052
Article Published Date
: Aug 16, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chikungunya Virus
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antiviral Agents
[+]
Berberine significantly reduces tumor growth in vivo.
Aug 18, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Aug 19. Epub 2016 Aug 19. PMID:
27557493
Article Published Date
: Aug 18, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Glioblastoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Autophagy Up-regulation
Additional Keywords
:
Dose Response
[+]
Berberine supplementation in psychiatric patients could be a preventive approach to reduce the metabolic adverse effects of antipsychotics.
Apr 14, 2020
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2020 Apr 15 ;247:117442. Epub 2020 Feb 17. PMID:
32081663
Article Published Date
: Apr 14, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Psychiatric Disorders
Pharmacological Actions
:
Anti-Inflammatory Agents
Additional Keywords
:
Risk Reduction
Problem Substances
:
Antipsychotic Drugs
[+]
Berberine suppresses bone loss and inflammation in ligature-induced periodontitis.
Nov 22, 2020
Click here to read the entire abstract
Pubmed Data
: Arch Oral Biol. 2020 Nov 23 ;122:104992. Epub 2020 Nov 23. PMID:
33338754
Article Published Date
: Nov 22, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Periodontitis
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREBP-1 signaling pathway-mediated lipogenesis.
Dec 22, 2019
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 2019 Dec 23 ;174:113776. Epub 2019 Dec 23. PMID:
31874145
Article Published Date
: Dec 22, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
[+]
Berberine suppresses growth and metastasis of endometrial cancer cells.
Jun 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2018 Jul ;103:1287-1293. Epub 2018 May 7. PMID:
29864910
Article Published Date
: Jun 30, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Endometrial Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Prostaglandin PGE2 downregulation
[+]
Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages.
Apr 08, 2020
Click here to read the entire abstract
Pubmed Data
: J Leukoc Biol. 2020 Apr 9. Epub 2020 Apr 9. PMID:
32272506
Article Published Date
: Apr 08, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Inflammation
,
Influenza
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
[+]
Berberine treatment improved short-term memory in hyperlipidemia.
Oct 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Int Neurourol J. 2019 Nov ;23(Suppl 2):S102-110. Epub 2019 Nov 30. PMID:
31795609
Article Published Date
: Oct 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Brain Inflammation
,
Hyperlipidemia
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticholesteremic Agents
,
Hypolipidemic
[+]
Berberine treatment reduced hepatic injury caused by concanavalin A.
Dec 27, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Med Sci Monit. 2017 Dec 28 ;23:6150-6161. Epub 2017 Dec 28. PMID:
29283990
Article Published Date
: Dec 27, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hepatitis: Autoimmune
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
,
Interferon Gamma Reducer
,
Interleukin-10 upregulation
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Anti-Inflammatory Agents
,
Berberine
,
Hepatitis: Autoimmune
,
Hepatoprotective
,
Interferon Gamma Reducer
Problem Substances
:
Concanavalin A
[+]
Berberine treatment reduces atherosclerosis by mediating gut microbiota.
Oct 31, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Nov ;107:1556-1563. Epub 2018 Sep 5. PMID:
30257374
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Gastrointestinal Agents
[+]
Berberine via upregulation of miR-29b promotes ischemia-induced angiogenesis and improves heart functions.
Jul 18, 2017
Click here to read the entire abstract
Pubmed Data
: Clin Exp Hypertens. 2017 Jul 19:1-8. Epub 2017 Jul 19. PMID:
28722488
Article Published Date
: Jul 18, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Angiogenesis Inducing Agents
,
Cardioprotective
[+]
Berberine was found to be an effective agent in the attenuation of diclofenac-induced acute kidney injury.
Jul 31, 2019
Click here to read the entire abstract
Pubmed Data
: J Pak Med Assoc. 2019 Aug ;69(Suppl 3)(8):S83-S87. PMID:
31603884
Article Published Date
: Jul 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Kidney Damage: Drug-Induced
Pharmacological Actions
:
Antioxidants
,
Renoprotective
Problem Substances
:
Diclofenac
[+]
Berberine was found to significantly reduce allergic inflammation in mice.
Aug 14, 2015
Click here to read the entire abstract
Pubmed Data
: Rhinology. 2015 Aug 15. Epub 2015 Aug 15. PMID:
26275466
Article Published Date
: Aug 14, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Allergic Rhinitis
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-10 downregulation
,
MicroRNA modulator
[+]
Berberine-loaded liposomes for the treatment of Leishmania infantum.
Sep 08, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharmaceutics. 2020 Sep 9 ;12(9). Epub 2020 Sep 9. PMID:
32916948
Article Published Date
: Sep 08, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Leishmaniasis
Pharmacological Actions
:
Leishmanicidal
[+]
Canagliflozin combined with berberine was a promising treatment for diabetes mellitus.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Chin J Nat Med. 2016 Jul ;14(7):518-26. PMID:
27507202
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 1
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Cinnamaldehyde and berberine have greater anti-diabetic efficacy than metformin.
Nov 05, 2008
Click here to read the entire abstract
Pubmed Data
: Chin Med J (Engl). 2008 Nov 5;121(21):2124-8. PMID:
19080170
Article Published Date
: Nov 05, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Cinnamaldehyde
,
Cinnamon
Diseases
:
Diabetes Mellitus: Type 2
Additional Keywords
:
Drug: Metformin
,
Metformin Alternatives
,
Superiority of Natural Substances versus Drugs
[+]
Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment.
Aug 31, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2018 Sep ;18(3):3437-3444. Epub 2018 Jul 24. PMID:
30066867
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cognitive Decline/Dysfunction
,
Pancreatitis
Pharmacological Actions
:
Neuroprotective Agents
[+]
Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.
Mar 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):69-74. PMID:
31334048
Article Published Date
: Mar 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Kidney Damage: Drug-Induced
Pharmacological Actions
:
Renoprotective
Additional Keywords
:
Natural Substance/Drug Synergy
Problem Substances
:
Diclofenac
[+]
Combination of berberine with resveratrol improves the lipid-lowering efficacy.
Dec 05, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2018 Dec 6 ;19(12). Epub 2018 Dec 6. PMID:
30563192
Article Published Date
: Dec 05, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Resveratrol
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
[+]
Coptidis rhizoma and Berberine inhibit the behavioral effects of cocaine.
Sep 01, 2000
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2000 Sep;14(6):428-31. PMID:
18955248
Article Published Date
: Sep 01, 2000
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Coptidis rhizoma
Diseases
:
Cocaine Withdrawal
[+]
Coptidis Rhizoma attenuates repeated nicotine-induced behavioural sensitization in the rat.
Dec 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 2007 Dec;59(12):1663-9. PMID:
18053328
Article Published Date
: Dec 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Coptidis rhizoma
Diseases
:
Smoking Cessation: Nicotine Addiction
[+]
Effect of berberine on atherosclerosis and gut microbiota modulation and their correlation in high-fat diet-fed ApoE-/- mice.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Front Pharmacol. 2020 ;11:223. Epub 2020 Mar 13. PMID:
32231564
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Atherosclerosis
,
High Fat Diet
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-10 upregulation
,
Interleukin-6 Downregulation
[+]
Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis.
Feb 06, 2020
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2020 Feb 7 ;81:106270. Epub 2020 Feb 7. PMID:
32044663
Article Published Date
: Feb 06, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Uveitis
Pharmacological Actions
:
Gastrointestinal Agents
,
Immunomodulatory
[+]
Effect of berberine on the HPA-axis pathway and skeletal muscle GLUT4 in type 2 diabetes mellitus rats.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Diabetes Metab Syndr Obes. 2019 ;12:1717-1725. Epub 2019 Sep 3. PMID:
31564939
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anticholesteremic Agents
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
Effects of berberine hydrochloride on methamphetamine-induced anxiety behaviors and relapse in rats.
Oct 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Iran J Basic Med Sci. 2020 Nov ;23(11):1480-1488. PMID:
33235706
Article Published Date
: Oct 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Anxiety
Pharmacological Actions
:
Anti-Anxiety Agents
Problem Substances
:
Amphetamine
[+]
Enhancement of berberine hypoglycemic activity by oligomeric proanthocyanidins.
Dec 13, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2018 Dec 14 ;23(12). Epub 2018 Dec 14. PMID:
30558158
Article Published Date
: Dec 13, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Hypoglycemic Agents
Additional Keywords
:
Proanthocyanidins
[+]
Fingolimod in combination with berberine at reduced doses represents a novel therapy for ulcerative colitis.
May 19, 2020
Click here to read the entire abstract
Pubmed Data
: J Nat Prod. 2020 May 20. Epub 2020 May 20. PMID:
32432470
Article Published Date
: May 19, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
STAT3 Inhibitor
[+]
Glucose-coated berberine nanodrug for glioma therapy through mitochondrial pathway.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Nanomedicine. 2020 ;15:7951-7965. Epub 2020 Oct 14. PMID:
33116511
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Glioma
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Gut microbiome-related effects of berberine and probiotics on type 2 diabetes.
Jan 05, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Nat Commun. 2020 10 6 ;11(1):5015. Epub 2020 Oct 6. PMID:
33024120
Article Published Date
: Jan 05, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Gastrointestinal Agents
,
Hypoglycemic Agents
[+]
Gut microbiota-mediated personalized treatment of hyperlipidemia using berberine.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Theranostics. 2017 ;7(9):2443-2451. Epub 2017 Jun 24. PMID:
28744326
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperlipidemia
Pharmacological Actions
:
Gastrointestinal Agents
,
Hypolipidemic
Additional Keywords
:
Microbiota
[+]
Hepatoprotective role of berberine against paraquat-induced liver toxicity in rat.
Dec 15, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Sci Pollut Res Int. 2019 Dec 16. Epub 2019 Dec 16. PMID:
31845254
Article Published Date
: Dec 15, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemically-Induced Liver Damage
,
Pesticide Toxicity
Pharmacological Actions
:
Hepatoprotective
Problem Substances
:
Paraquat
[+]
High concentrations of berberine markedly protects rats from various symptoms of chronic stress and depression.
Mar 21, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2017 Mar 22. Epub 2017 Mar 22. PMID:
28339024
Article Published Date
: Mar 21, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Depression
Pharmacological Actions
:
Gastroprotective
Additional Keywords
:
Microbiota
[+]
Highly bioavailable berberine formulation ameliorates diabetic nephropathy.
Jan 26, 2020
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2020 Jan 27 ;873:172955. Epub 2020 Jan 27. PMID:
32001218
Article Published Date
: Jan 26, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Autophagy Up-regulation
,
Renoprotective
[+]
Histopathological examination confirmed the neuroprotective effect of berberine.
Nov 20, 2017
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2017 Nov 21 ;111:432-444. Epub 2017 Nov 21. PMID:
29170048
Article Published Date
: Nov 20, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
,
Heavy Metal Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Neuroprotective Agents
Problem Substances
:
Heavy Metals
[+]
In vitro and in vivo biological activity of berberine chloride against uropathogenic E. coli strains.
Oct 28, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2020 Oct 29 ;25(21). Epub 2020 Oct 29. PMID:
33137930
Article Published Date
: Oct 28, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Escherichia coli Infections
Pharmacological Actions
:
Anti-Bacterial Agents
[+]
Influence of quercetin, naringenin and berberine on glucose transporters and insulin signalling molecules in brain of streptozotocin-induced diabetic rats.
Sep 30, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Oct ;94:605-611. Epub 2017 Aug 4. PMID:
28783583
Article Published Date
: Sep 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Naringenin
,
Quercetin
Diseases
:
Diabetes Mellitus: Type 2
,
Insulin Resistance
[+]
iTRAQ-based pharmacoproteomics reveals potential targets of berberine, a promising therapy for ulcerative colitis.
May 04, 2019
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2019 May 5 ;850:167-179. Epub 2019 Feb 14. PMID:
30771347
Article Published Date
: May 04, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Immunomodulatory
[+]
Mechanism of berberine in treating Helicobacter pylori induced chronic atrophic gastritis.
Feb 21, 2020
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2020 Feb 22:117456. Epub 2020 Feb 22. PMID:
32097666
Article Published Date
: Feb 21, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Gastritis
,
Helicobacter Pylori Infection
Pharmacological Actions
:
Gastrointestinal Agents
,
Gastroprotective
[+]
Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease.
Jul 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Transl Med. 2020 Aug ;10(4):e112. Epub 2020 Aug 13. PMID:
32790968
Article Published Date
: Jul 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alcoholic Liver Disease
Pharmacological Actions
:
Gastrointestinal Agents
,
Hepatoprotective
,
Immunosuppressive Agents
[+]
Myocardial hypertrophy is improved with berberine treatment via long non-coding RNA MIAT-mediated autophagy.
Oct 13, 2019
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 2019 Oct 14. Epub 2019 Oct 14. PMID:
31612504
Article Published Date
: Oct 13, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Cardiac Hypertrophy
Pharmacological Actions
:
Autophagy Up-regulation
,
Cardioprotective
,
MicroRNA modulator
[+]
Nanoemulsion improves hypoglycemic efficacy of berberine by overcoming its gastrointestinal challenge.
Aug 31, 2019
Click here to read the entire abstract
Pubmed Data
: Colloids Surf B Biointerfaces. 2019 Sep 1 ;181:927-934. Epub 2019 Jun 4. PMID:
31382342
Article Published Date
: Aug 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hypoglycemia
Pharmacological Actions
:
Hypoglycemic Agents
[+]
Neuroprotective effect of berberine against learning and memory deficits in diffuse axonal injury
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Jan ;15(1):1129-1135. Epub 2017 Nov 13. PMID:
29399112
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Learning disorders
,
Traumatic Brain Injury
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury.
Mar 04, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2018 Mar 5. Epub 2018 Mar 5. PMID:
29512719
Article Published Date
: Mar 04, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Traumatic Brain Injury
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
[+]
Oral berberine exerted anti-arthritic effect through inhibiting Th17 cell response.
Jun 20, 2017
Click here to read the entire abstract
Pubmed Data
: FEBS J. 2017 Jun 21. Epub 2017 Jun 21. PMID:
28636167
Article Published Date
: Jun 20, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Arthritis
Pharmacological Actions
:
Immunomodulatory: Th17 downregulation
[+]
Our results indicate that berberine can be a potential chemoprevention and chemotherapy agent for human colon cancer by targeting Wnt/β-catenin signaling.
Apr 01, 2012
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2012 Apr 2. Epub 2012 Apr 2. PMID:
22469784
Article Published Date
: Apr 01, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colon Cancer
Pharmacological Actions
:
Wnt/β-catenin pathway down-regulation
[+]
Panax ginseng combined with berberine has a positive effect in experimental rats with chronic congestive heart failure.
Feb 01, 2009
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Yao Za Zhi. 2009 Feb;34(3):324-7. PMID:
19445159
Article Published Date
: Feb 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Panax Ginseng
Diseases
:
Congestive Heart Failure
,
Heart Failure
[+]
Pentaherbs formula can ameliorate allergic inflammation and attenuate the activation of eosinophils.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2016 ;21(4). Epub 2016 Apr 20. PMID:
27104513
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Chlorogenic Acid
,
Gallic Acid
Diseases
:
Atopic Dermatitis
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
[+]
Pre-treatment with berberine could reduce ROS generation in animals exposed to arsenic.
Feb 29, 2016
Click here to read the entire abstract
Pubmed Data
: J Environ Biol. 2016 Mar ;37(2):285-90. PMID:
27097449
Article Published Date
: Feb 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Arsenic Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
[+]
Promotion of butyrate production in gut microbiota might be one of the important mechanisms of berberine in regulating energy metabolism.
Apr 30, 2017
Click here to read the entire abstract
Pubmed Data
: Metabolism. 2017 May ;70:72-84. Epub 2017 Feb 10. PMID:
28403947
Article Published Date
: Apr 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Pharmacological Actions
:
Gastrointestinal Agents
Additional Keywords
:
Microbiota
[+]
Protective effect of Berberine on reproductive function and spermatogenesis in diabetic rats.
Feb 02, 2020
Click here to read the entire abstract
Pubmed Data
: Andrology. 2020 Feb 3. Epub 2020 Feb 3. PMID:
32012485
Article Published Date
: Feb 02, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Complications
,
Infertility: Male
Pharmacological Actions
:
Fertility Agents: Male
[+]
Protective effects of berberine against exhaustion exercise induced myocardial injury.
Aug 23, 2019
Click here to read the entire abstract
Pubmed Data
: Zhonghua Xin Xue Guan Bing Za Zhi. 2019 Aug 24 ;47(8):647-652. PMID:
31434437
Article Published Date
: Aug 23, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Muscle Damage: Exercise-Induced
Therapeutic Actions
:
Exercise
Pharmacological Actions
:
Cardioprotective
[+]
Regulation of MFN2 by berberine alleviates obesity exacerbated colitis.
Oct 14, 2020
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2020 Oct 15 ;531(2):250-255. Epub 2020 Aug 12. PMID:
32800336
Article Published Date
: Oct 14, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colitis
,
Obesity
Pharmacological Actions
:
Gastrointestinal Agents
,
Gastroprotective
[+]
Role of JAK2 in the pathogenesis of diabetic erectile dysfunction and an intervention with berberine.
Sep 25, 2019
Click here to read the entire abstract
Pubmed Data
: J Sex Med. 2019 Sep 26. Epub 2019 Sep 26. PMID:
31564534
Article Published Date
: Sep 25, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Erectile Dysfunction
[+]
Saponins, alkaloids and flavonoids can inhibit the clinical symptoms of EAU in rats to a certain extent and reduce cell apoptosis.
May 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2016 Jun ;13(6):4654-8. Epub 2016 Apr 8. PMID:
27082009
Article Published Date
: May 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Baicalein
,
Berberine
Diseases
:
Autoimmune Diseases
,
Uveoretinitis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
[+]
Sustained antidiabetic effects of a berberine-containing chinese herbal medicine through regulation of hepatic gene expression.
Mar 05, 2012
Click here to read the entire abstract
Pubmed Data
: Diabetes. 2012 Apr ;61(4):933-43. Epub 2012 Mar 6. PMID:
22396199
Article Published Date
: Mar 05, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabesity
[+]
Synergic effects of berberine and curcumin on improving cognitive function in an Alzheimer's disease mouse model.
Feb 20, 2020
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2020 Feb 21. Epub 2020 Feb 21. PMID:
32080784
Article Published Date
: Feb 20, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Curcumin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
Additional Keywords
:
Natural Substance Synergy
[+]
The administration of berberine chloride notably recovered the liver from hyperglycemia induced antioxidant imbalance, inflammation and apoptosis.
Feb 28, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Mar ;99:227-236. PMID:
29334666
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hyperglycemia
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
[+]
The ameliorative effect of berberine and coenzyme Q10 in an ovalbumin-induced allergic rhinitis model.
Sep 30, 2018
Click here to read the entire abstract
Pubmed Data
: Eur Arch Otorhinolaryngol. 2018 Oct ;275(10):2495-2505. Epub 2018 Aug 23. PMID:
30159729
Article Published Date
: Sep 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Coenzyme Q10
Diseases
:
Allergic Rhinitis
Pharmacological Actions
:
interleukin-13 down-regulation
,
Interleukin-4 downregulation
,
Malondialdehyde Down-regulation
,
Nitric Oxide Inhibitor
[+]
The antiviral alkaloid berberine ameliorates neuropathic pain in rats with peripheral nerve injury.
Aug 29, 2018
Click here to read the entire abstract
Pubmed Data
: Acta Neurol Belg. 2018 Aug 30. Epub 2018 Aug 30. PMID:
30168114
Article Published Date
: Aug 29, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Neuropathic Pain
,
Peripheral Neuropathies
Pharmacological Actions
:
MicroRNA modulator
[+]
The combination of curcumin and berberine exhibited better ameliorative effects in treating NAFLD than lovastatin.
Jan 16, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Jan 17 ;99:325-333. Epub 2018 Jan 17. PMID:
29353208
Article Published Date
: Jan 16, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Curcumin
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Superiority of Natural Substances versus Drugs
[+]
The findings of this study confirmed the antidepressant-like effect of berberine.
Jan 06, 2016
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2016 Jan 7 ;614:77-82. Epub 2016 Jan 7. PMID:
26773864
Article Published Date
: Jan 06, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Depression
Pharmacological Actions
:
Antidepressive Agents
[+]
The findings suggest berberine's therapeutic potential for diabetic cardiomyopathy associated with cardiac fibrosis.
Jun 28, 2018
Click here to read the entire abstract
Pubmed Data
: Am J Physiol Heart Circ Physiol. 2018 Jun 29. Epub 2018 Jun 29. PMID:
29957017
Article Published Date
: Jun 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Cardiomyopathy
,
Diabetic Complications
Pharmacological Actions
:
Anti-Fibrotic
,
Cardioprotective
[+]
The growth of colorectal cancer cells in mice can be inhibited by berberine treatment.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Zhonghua Zhong Liu Za Zhi. 2015 May ;37(5):342-6. PMID:
26463023
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
[+]
The present study demonstrated the anti-epileptogenic effect of berberine.
Nov 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Epilepsy Res. 2018 Dec ;8(2):66-73. Epub 2018 Dec 31. PMID:
30809499
Article Published Date
: Nov 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Epilepsy
Pharmacological Actions
:
Anti-Apoptotic
,
Anticonvulsants
,
Antioxidants
[+]
The present study determined the anti-hyperlipidemia effect of berberine compounds on diet-induced hyperlipidemic rats.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Transl Med. 2016 ;14(1):237. Epub 2016 Aug 5. PMID:
27495782
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
High Fat Diet
,
Hyperlipidemia
Pharmacological Actions
:
Gastrointestinal Agents
Additional Keywords
:
Microbiota
[+]
The protective effect of berberine against lipopolysaccharide-induced abortion.
Jul 12, 2018
Click here to read the entire abstract
Pubmed Data
: Immunopharmacol Immunotoxicol. 2018 Jul 13:1-5. Epub 2018 Jul 13. PMID:
30003821
Article Published Date
: Jul 12, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Miscarriage
Pharmacological Actions
:
Anti-Inflammatory Agents
[+]
The protective effects of berberine and hesperidin on inflammatory factor-stimulating cardiac fibroblasts.
May 31, 2019
Click here to read the entire abstract
Pubmed Data
: Eur Rev Med Pharmacol Sci. 2019 Jun ;23(12):5468-5476. PMID:
31298400
Article Published Date
: May 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
,
Hesperidin
Diseases
:
Cardiovascular Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Interleukin-1 beta downregulation
[+]
The study expands the understanding of the pharmacological properties of berberine and its applicability as a radiosensitizer towards treating liver cancer.
Nov 30, 2020
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 2020 Dec ;72(12):1893-1908. Epub 2020 Aug 20. PMID:
32815562
Article Published Date
: Nov 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Liver Cancer
Pharmacological Actions
:
Radiosensitizer
[+]
The use of berberine is a new strategy to improve the treatment of chronic myeloid leukemia patients with imatinib sensitivity or resistance.
Feb 24, 2020
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2020 Feb 25. Epub 2020 Feb 25. PMID:
32098768
Article Published Date
: Feb 24, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Cancers: Drug Resistant
,
Chronic Myeloid Leukemia
Pharmacological Actions
:
Chemosensitizer
Additional Keywords
:
Chemothapeutic Synergy: Imatinib
[+]
There is a therapeutic potential for berberine in the treatment of type IV hypersensitivity.
Nov 09, 2016
Click here to read the entire abstract
Pubmed Data
: Inflammation. 2016 Nov 10. Epub 2016 Aug 10. PMID:
27832398
Article Published Date
: Nov 09, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Hypersensitivity: Type IV
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Bax/Bcl2 Ratio: Decrease
,
Immunomodulatory
[+]
These findings demonstrate the preventive role of berberine against DMBA induced mammary carcinoma.
May 21, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 May 22 ;92:207-214. Epub 2017 May 22. PMID:
28544934
Article Published Date
: May 21, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Breast Cancer: Chemically-Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Chemopreventive
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
These findings indicate that berberine has a therapeutic effect on diabetic nephropathy.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2017 ;11:1065-1079. Epub 2017 Mar 31. PMID:
28408805
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Fibrotic
,
Renoprotective
[+]
These findings strongly support berberine as a potential drug candidate for Alzheimer's disease.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2020 Jan ;121:109670. Epub 2019 Nov 22. PMID:
31810131
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Neuroprotective Agents
[+]
These findings suggest that administration of berberine could prevent depressive-like behaviours.
Aug 21, 2017
Click here to read the entire abstract
Pubmed Data
: Brain Res Bull. 2017 Aug 22. Epub 2017 Aug 22. PMID:
28842306
Article Published Date
: Aug 21, 2017
Study Type
: Animal Study