Berberine

Name	AC	CK
Insulin Resistance	15	63
Diabetes Mellitus: Type 2	20	55
Hyperlipidemia	8	40
Diabetic Complications	7	22
High Cholesterol	2	22
Hypercholesterolemia	3	22
Triglycerides: Elevated	2	22
Polycystic Ovary Syndrome	2	21
Alzheimer's Disease	13	18
Myocardial Ischemia	6	18
Nonalcoholic fatty liver disease (NAFLD)	9	18
Osteoporosis	6	18
Liver Cancer	14	16
Inflammation	10	15
Metabolic Diseases	4	14
Obesity	10	14
Breast Cancer	12	13
Colon Cancer	9	13
Helicobacter Pylori Infection	3	13
Kidney Diseases	2	12
Cerebral Ischemia	6	11
Lipopolysaccharide-Induced Toxicity	7	11
Atrial Fibrillation	1	10
Depression	5	10
Endothelial Dysfunction	1	10
Oxidative Stress	6	10
Radiation Induced Illness	1	10
Breast Cancer: Triple Negative	7	9
Colorectal Cancer	5	9
Glioblastoma	6	9
High Fat Diet	5	9
Lung Cancer	5	9
Osteosarcoma	4	9
Brain Inflammation	4	8
Cancers: All	8	8
Cognitive Decline/Dysfunction	4	8
Colitis	4	8
Diabetic Nephropathy	4	8
Metabolic Syndrome X	4	8
Diabetes Mellitus: Type 1	4	7
Heart Failure	4	7
Hyperglycemia	4	7
Ischemia	4	7
Pancreatitis	4	7
Atherosclerosis	3	6
Hypoxia	4	6
Gastric Cancer	5	5
Hypertension	3	5
Psoriasis	1	5
Rheumatoid Arthritis	4	5
Acetaminophen (Tylenol) Toxicity	2	4
Advanced Glycation End products (AGE)	3	4
Alcohol Toxicity	2	4
Allergic Rhinitis	2	4
Arthritis	2	4
Autoimmune Diseases	2	4
Cancers: Drug Resistant	4	4
Cardiomyopathy	2	4
Cardiovascular Diseases	4	4
Chemically-Induced Liver Damage	2	4
Chemotherapy-Induced Toxicity: Doxorubicin	2	4
Diabetic Neuropathy	2	4
Enterocolitis: Necrotiziing	2	4
Epilepsy	2	4
Fructose-Induced Toxicity	2	4
Melanoma	4	4
Myocardial Infarction	2	4
Nasopharyngeal Cancer	3	4
Peripheral Neuropathies	2	4
Sepsis	2	4
Traumatic Brain Injury	2	4
Ulcerative Colitis	2	4
Brain Ischemia	2	3
Cancer Metastasis	3	3
Carcinoma: Non-Small-Cell Lung	3	3
Chikungunya Virus	2	3
Diabetes: Oxidative Stress	2	3
Hepatic Steatosis	2	3
Hydrogen Peroxide Induced Toxicity	3	3
Liver Fibrosis	2	3
Neurodegenerative Diseases	2	3
Ovarian Cancer	3	3
Pseudomonas aeruginosa	2	3
Acute Respiratory Distress Syndrome	1	2
Acute T cell Leukemias	2	2
Adenomyosis	2	2
Aging: Brain	1	2
Aluminum Toxicity	1	2
Aneurysm: Cerebral	1	2
Arsenic Poisoning	1	2
Asthma	1	2
Atopic Dermatitis	1	2
Blood-Brain-Barrier Disorders	1	2
Bone Diseases	1	2
Brain Injury: Traumatic	1	2
Breast Cancer: Chemically-Induced	1	2
Bubonic Plague	1	2
Candida Albicans	2	2
Chemotherapy-Induced Toxicity: Paclitaxel	1	2
Cocaine Withdrawal	1	2
Colon Cancer: Prevention	1	2
Colorectal Cancer: Prevention	1	2
Congestive Heart Failure	1	2
Convulsions	1	2
Degenerative Disk Disease	2	2
Dementia	1	2
Demyelinating Diseases	1	2
Diabesity	1	2
Diabetic Neuropathies	1	2
Diabetic Retinopathy	2	2
Diarrhea: Drug-Associated	1	2
Drug-Induced Toxicity: L-Thyroxine	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Endometrial Cancer	1	2
Fatty Liver	1	2
Fibrosis	1	2
Gastric Polyposis	1	2
Glioma	2	2
Heavy Metal Toxicity	1	2
Hepatitis: Autoimmune	1	2
High Homocysteine	1	2
Huntington Disease	1	2
Hyperalgesia	1	2
Hypersensitivity: Type IV	1	2
Hypertension: Pulmonary	1	2
Hypertension: Renal	1	2
Immune Dysregulation: TH1 dominance	1	2
Immune Dysregulation: TH17 over-expression	1	2
Influenza	1	2
Intestinal Permeability	1	2
Intestinal Polyps	1	2
Intima Media Thickening	1	2
Iron Overload	1	2
Irritable Bowel Syndrome	1	2
Kidney Fibrosis	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Leukemia	2	2
Lipid Peroxidation	1	2
Liver Steatosis	1	2
Liver Stress: Fructose-Induced	1	2
Lung Cancer: Prevention	1	2
Mastitis	1	2
Memory Disorders: Drug-Induced	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Miscarriage	1	2
Morphine Tolerance/Dependence	1	2
Multiple Sclerosis	1	2
Myocardial Fibrosis	1	2
Neuroblastoma	2	2
Neuropathic Pain	1	2
Non-Small-Cell Lung Carcinoma	2	2
Pancreatic Cancer	2	2
Parkinson's Disease	1	2
Periodontitis	1	2
Peripheral Nerve Diseases	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Postmenopausal Disorders	1	2
Postoperative Recovery	1	2
Prehypertension	1	2
Prostate Cancer	2	2
Prostatic Hyperplasia: Benign	1	2
Retinal Diseases	1	2
Schizophrenia	1	2
Seizures	1	2
Smoking Cessation: Nicotine Addiction	1	2
Staphylococcal Infections	1	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Stroke: Ischemic	1	2
Tongue Cancer	1	2
Uremia	1	2
Uveoretinitis	1	2
Varicocele	1	2
Acute Myeloid Leukemia	1	1
Allergic Airway Diseases	1	1
Allergies	1	1
Alphavirus Infections	1	1
Arthritis: Rheumatoid	1	1
Bacillus Cereus infection	1	1
Bacterial Infections and Mycoses	1	1
Breast Cancer Stem Cells	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cancer: Virus-Induced	1	1
Cancers: Multi-Drug Resistant	1	1
Candida Infection	1	1
Cardiac Arrhythmias	1	1
Cervical Cancer	1	1
Cholangiocarcinoma	1	1
Cholesterol: Oxidation	1	1
Chondrosarcoma	1	1
Clostridium Infections	1	1
Coxsackievirus Infections	1	1
Cytomegalovirus Infections	1	1
Dementia: Senile	1	1
Dental Caries	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Diabetes: Glycation/A1C	1	1
Diarrhea	1	1
Dyslipidemias	1	1
Echinococcosis	1	1
Enterovirus: Type 71	1	1
Esophageal Cancer	1	1
Eye Diseases	1	1
Friend Virus	1	1
Fungal Infection	1	1
HIV Drug-Induced Toxicity	1	1
HIV Infections	1	1
Head and Neck Cancer	1	1
High Sugar Diet	1	1
Human Papillomavirus (HPV)	1	1
Hydatid Cyst	1	1
Inflammatory Bowel Diseases	1	1
Kidney Damage	1	1
Laryngeal Cancer	1	1
Leaky Gut Syndrome	1	1
Leishmaniasis	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Virus-Induced	1	1
Lower Respiratory Infections	1	1
Lung Injury: Acute	1	1
Lymphangioendothelioma	1	1
Macular Degeneration	1	1
Malignant Melanoma	1	1
Mesothelioma	1	1
Microcystis aeruginosa	1	1
Multiple Myeloma	1	1
Myocarditis: Autoimmune	1	1
Oral Cancer	1	1
Osteoarthritis	1	1
Overweight	1	1
Periodontal Diseases	1	1
Promyelocytic leukemia	1	1
Respiratory Syncytial Virus Infections	1	1
Retinoblastoma	1	1
Salmonella Infections	1	1
Skin Cancer: Squamous Cell	1	1
Squamous cell carcinoma	1	1
Streptococcus pyogenes	1	1
Thrombocytopenia	1	1
Thyroid Cancer	1	1
Uveitis	1	1

Name	AC	CK
Anti-Inflammatory Agents	71	134
Antioxidants	42	69
Hypolipidemic	14	67
Tumor Necrosis Factor (TNF) Alpha Inhibitor	27	62
Antiproliferative	48	59
Interleukin-6 Downregulation	25	56
Neuroprotective Agents	30	52
Apoptotic	40	49
Cardioprotective	19	49
Hypoglycemic Agents	14	42
Hepatoprotective	18	36
Anticholesteremic Agents	4	34
Anti-Apoptotic	20	32
Interleukin-1 beta downregulation	18	30
MicroRNA modulator	14	24
NF-kappaB Inhibitor	16	23
Chemopreventive	15	21
Anti-metastatic	17	20
Cell cycle arrest	18	20
Anti-Bacterial Agents	6	16
Renoprotective	9	16
Chemotherapeutic	12	14
Cyclooxygenase 2 Inhibitors	9	14
Gastrointestinal Agents	7	14
Antineoplastic Agents	5	13
Nrf2 activation	8	13
Matrix metalloproteinase-2 (MMP-2) inhibitor	9	11
Anti-Fibrotic	5	10
Anticarcinogenic Agents	6	10
Matrix metalloproteinase-9 (MMP-9) inhibitor	7	10
Radioprotective	1	10
Antiviral Agents	7	9
Chemosensitizer	9	9
Osteoprotective	5	9
Gastroprotective	4	8
Malondialdehyde Down-regulation	4	8
Antihypertensive Agents	4	7
Chemoprotective Agents	4	7
Tumor Suppressor Protein p53 Upregulation	6	7
Angiogenesis Inducing Agents	3	6
Antidepressive Agents	3	6
Autophagy Up-regulation	3	6
Enzyme Inhibitors	2	6
Immunomodulatory	4	6
Immunomodulatory: Th17 downregulation	3	6
Insulin Sensitizers	2	6
Anti-Adipogenic	4	5
Antimicrobial	4	5
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	4	5
Pancreato Protective Agents	3	5
Wnt/β-catenin signaling pathway modulation	4	5
Analgesics	2	4
Angiogenesis Inhibitors	3	4
Anti-Anxiety Agents	2	4
Anticonvulsants	2	4
Glucagon Like peptide 1 (GLP-1) Up-regulation	2	4
Interleukin-10 downregulation	2	4
Interleukin-10 upregulation	2	4
Interleukin-17 downregulation	2	4
Prostaglandin PGE2 downregulation	2	4
Anti-Glycation Agents	2	3
Bcl-2 protein down-regulation	3	3
Caspase-3 Activation	2	3
Heme oxygenase-1 up-regulation	2	3
Matrix metalloproteinase-3 (MMP-3) inhibitor	2	3
STAT3 Inhibitor	3	3
Vascular Endothelial Growth Factor Inhibitors	3	3
Anti-Tumor	1	2
Anti-atherogenic	1	2
Antidiarrheals	1	2
Antifungal Agents	2	2
Bax/Bcl2 Ratio: Decrease	1	2
Brain-derived neurotrophic factor modulator	1	2
Caspase-9 Activation	1	2
Cholinesterase Inhibitors	1	2
Enzyme Inhibitors: Pancreatic Amylase	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fibroblast growth factor 21 upregulation	1	2
Interferon Gamma Reducer	1	2
Interleukin-4 downregulation	1	2
Interleukin-8 downregulation	2	2
Iron Chelating Agents	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	2
Neuritogenic	1	2
Nitric Oxide Inhibitor	1	2
P21 Activation	2	2
Radiosensitizer	2	2
SIRT1 Activator	1	2
Wnt/β-catenin pathway down-regulation	1	2
interleukin-13 down-regulation	1	2
AMP-activated protein kinase modulation	1	1
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-Allergic Agents	1	1
Anti-Androgen	1	1
Anti-Proliferative	1	1
Autophagy Inhibitors	1	1
Cyclin D1 Down-Regulation	1	1
Cyclin-dependent kinase inhibitor: P16INK4	1	1
Cytoprotective	1	1
Cytotoxic	1	1
Expectorants	1	1
Gluconeogenesis Inhibitor	1	1
HIV Protease Inhibitors	1	1
Interleukin-18 down-regulation	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Multidrug Resistance Gene Modulators	1	1
Osteogenic	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Prophylactic Agents	1	1
RANK Downregulation	1	1
Regenerative	1	1
Scolicidal	1	1
Survivin Down-Regulation	1	1
Telomerase Inhibitor	1	1

Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.Aug 31, 2019

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Pubmed Data : Exp Ther Med. 2019 Sep ;18(3):2122-2130. Epub 2019 Jul 12. PMID: 31410167

Article Published Date : Aug 31, 2019

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Bacterial Vaginosis

Pharmacological Actions : Anti-Apoptotic, Antioxidants

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Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.Dec 10, 2018

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Dec 11 ;98(46):3756-3761. PMID: 30541217

Article Published Date : Dec 10, 2018

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Diabetic Complications, Kidney Diseases

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Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.Feb 01, 2007

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Pubmed Data : J Forensic Leg Med. 2007 Feb;14(2):87-91. PMID: 19757213

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Pubmed Data : Evid Based Complement Alternat Med. 2009 Oct 6; PMID: 19800084

Article Published Date : Oct 06, 2009

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Drug: Metformin, Drug: Rosiglitazone, Insulin Receptor Upregulation, Natural Substances Versus Drugs

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Berberine possesses potential lipid-regulating, antiarthritis, and synovial hyperplasia inhibition activities against rheumatoid arthritis.Dec 31, 2018

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Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

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Pubmed Data : J Asian Nat Prod Res. 2009;11(3):219-28. PMID: 19408145

Article Published Date : Jan 01, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation

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Pubmed Data : Exp Ther Med. 2017 Jun ;13(6):3374-3382. Epub 2017 Apr 28. PMID: 28587416

Article Published Date : May 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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Berberine alleviates disease symptoms in mouse models mimicking the symptoms of IBS-D. Dec 31, 2014

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Pubmed Data : Arch Physiol Biochem. 2020 Feb 19:1-12. Epub 2020 Feb 19. PMID: 32072839

Article Published Date : Feb 18, 2020

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Endothelial Dysfunction, Inflammation

Pharmacological Actions : Vasoprotective

Problem Substances : Monosodium Glutamate (MSG)

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Berberine alleviates NASH and its predisposing factors.Feb 29, 2016

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Pubmed Data : Arch Iran Med. 2016 Mar ;19(3):197-203. PMID: 26923892

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Berberine attenuates hypoxia-induced pulmonary arterial hypertension.Feb 19, 2019

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Pubmed Data : J Cell Physiol. 2019 Feb 20. Epub 2019 Feb 20. PMID: 30786011

Article Published Date : Feb 19, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Hypertension, Hypoxia

Pharmacological Actions : Antihypertensive Agents

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Berberine attenuates intestinal tumorigenesis by inhibiting the migration and invasion of colorectal tumor cells.Dec 31, 2015

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Pubmed Data : Free Radic Biol Med. 2019 Jun 18 ;141:192-204. Epub 2019 Jun 18. PMID: 31226399

Article Published Date : Jun 17, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

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Berberine attenuates olanzapine induced-metabolic syndrome.Jul 31, 2019

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Pubmed Data : J Pak Med Assoc. 2019 Aug ;69(Suppl 3)(8):S88-S92. PMID: 31603885

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Metabolic Diseases

Pharmacological Actions : Hypolipidemic

Problem Substances : Olanzapine

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Berberine can improve insulin resistance of skeletal muscle in rats. Oct 31, 2015

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Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Nov ;46(6):827-31. PMID: 26867315

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Pubmed Data : Avicenna J Phytomed. 2016 Mar-Apr;6(2):198-204. PMID: 27222833

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Morphine Tolerance/Dependence

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Berberine can reverse chronic inflammatory pain induced by complete freund's adjuvant and alleviated the comorbid depression.Apr 09, 2018

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Apr 10 ;98(14):1103-1108. PMID: 29690724

Article Published Date : Apr 09, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Depression, Hyperalgesia, Inflammation

Pharmacological Actions : Analgesics, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Berberine can suppress the proliferation of liver cancer cells by reducing SLC1A5 expression.Dec 31, 2018

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Pubmed Data : Biomed Pharmacother. 2017 Mar 6 ;89:887-893. Epub 2017 Mar 6. PMID: 28282791

Article Published Date : Mar 05, 2017

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-17 downregulation, Interleukin-6 Downregulation

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Berberine exerted anticancer effects on human gastric cancer both in vitro and in vivo.Dec 31, 2019

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

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Pubmed Data : Med Sci Monit. 2019 Jan 4 ;25:87-97. Epub 2019 Jan 4. PMID: 30606998

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Pubmed Data : Int Immunopharmacol. 2016 Apr 12 ;35:217-225. Epub 2016 Apr 12. PMID: 27082997

Article Published Date : Apr 11, 2016

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Sepsis

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Berberine induced senescence of human glioblastoma cells.Jan 31, 2015

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Pubmed Data : Mol Cancer Ther. 2015 Feb ;14(2):355-63. Epub 2014 Dec 12. PMID: 25504754

Article Published Date : Jan 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Glioblastoma

Pharmacological Actions : Anti-Tumor, Apoptotic, Cell cycle arrest, Epidermal growth factor receptor (EGFR) inhibitor

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Berberine inhibited angiogenesis in glioblastoma xenografts.Nov 30, 2018

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Pubmed Data : Sci Rep. 2016 ;6:20848. Epub 2016 Feb 9. PMID: 26857750

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

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Berberine may be a potential therapeutic agent for the treatment of patients with neonatal necrotizing enterocolitis.Mar 31, 2018

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Pubmed Data : Mol Med Rep. 2017 May ;15(5):2765-2787. Epub 2017 Mar 14. PMID: 28447763

Article Published Date : Apr 30, 2017

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Insulin Resistance, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents

Additional Keywords : Microbiota

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Berberine produced myocardial salvaging effects in the setting of diabetes challenged with ISP induced myocardial necrosis.Feb 29, 2016

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Pubmed Data : J Clin Diagn Res. 2016 Mar ;10(3):FF13-8. Epub 2016 Mar 1. PMID: 27134894

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Diabetes Mellitus: Type 2, Diabetic Complications, Heart Failure

Pharmacological Actions : Antioxidants, Cardioprotective

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Berberine produces antidepressant-like effects in ovariectomized mice.May 01, 2017

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Pubmed Data : Zhong Yao Cai. 2011 Mar ;34(3):412-5. PMID: 21823461

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Pubmed Data : J Leukoc Biol. 2020 Apr 9. Epub 2020 Apr 9. PMID: 32272506

Article Published Date : Apr 08, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Inflammation, Influenza

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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Berberine treatment improved short-term memory in hyperlipidemia.Oct 31, 2019

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Pubmed Data : Int Neurourol J. 2019 Nov ;23(Suppl 2):S102-110. Epub 2019 Nov 30. PMID: 31795609

Article Published Date : Oct 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Brain Inflammation , Hyperlipidemia

Pharmacological Actions : Anti-Inflammatory Agents, Anticholesteremic Agents, Hypolipidemic

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Berberine treatment reduced hepatic injury caused by concanavalin A.Dec 27, 2017

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Pubmed Data : Med Sci Monit. 2017 Dec 28 ;23:6150-6161. Epub 2017 Dec 28. PMID: 29283990

Article Published Date : Dec 27, 2017

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Pubmed Data : Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):69-74. PMID: 31334048

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Diclofenac

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Combination of berberine with resveratrol improves the lipid-lowering efficacy.Dec 05, 2018

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Pubmed Data : Int J Mol Sci. 2018 Dec 6 ;19(12). Epub 2018 Dec 6. PMID: 30563192

Article Published Date : Dec 05, 2018

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Pubmed Data : Molecules. 2018 Dec 14 ;23(12). Epub 2018 Dec 14. PMID: 30558158

Article Published Date : Dec 13, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Proanthocyanidins

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Fingolimod in combination with berberine at reduced doses represents a novel therapy for ulcerative colitis.May 19, 2020

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Pubmed Data : J Nat Prod. 2020 May 20. Epub 2020 May 20. PMID: 32432470

Article Published Date : May 19, 2020

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, STAT3 Inhibitor

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Gut microbiota-mediated personalized treatment of hyperlipidemia using berberine.Dec 31, 2016

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Pubmed Data : J Transl Med. 2016 ;14(1):237. Epub 2016 Aug 5. PMID: 27495782

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Pubmed Data : Pharmacol Biochem Behav. 2015 Jul 6 ;136:13-20. Epub 2015 Jul 6. PMID: 26159088

Article Published Date : Jul 05, 2015

Study Type : Animal Study

Additional Links

Substances : Berberine, Vitamin C

Diseases : Alcohol Toxicity , Cognitive Decline/Dysfunction, Memory Disorders: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Cholinesterase Inhibitors, Neuroprotective Agents

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"Antibacterial and synergy of berberines with antibacterial agents against clinical multi-drug resistant isolates of methicillin-resistant Staphylococcus aureus (MRSA)."Dec 31, 2011

Pubmed Data : Pharmacol Res. 2018 Jan 4. Epub 2018 Jan 4. PMID: 29305909

Article Published Date : Jan 03, 2018

Study Type : Review

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Substances : 4-Shogaol, 6-Shogaol, Apigenin, Berberine, Caffeic Acid, Capsaicin, Cardamonin, Chrysin, Curcumin, EGCG (Epigallocatechin gallate), Ellagic Acid, Fisetin, Gingerol , Luteolin, Mangiferin, Piperlongumine , Polyphenols, Pterostilbene, Quercetin, Resveratrol, Rutin, Sesamin, Ursolic Acid, Wogonin, Xanthohumol

Diseases : Cancers: All

Pharmacological Actions : Chemopreventive, Chemotherapeutic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, NF-kappaB Inhibitor, STAT3 Inhibitor, Wnt/β-catenin signaling pathway modulation

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A review of the anti-cancer mechanisms of berberine.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Manag Res. 2020 ;12:695-702. Epub 2020 Jan 30. PMID: 32099466

Article Published Date : Dec 31, 2019

Study Type : Review

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Substances : Berberine

Diseases : Cancers: All

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Immunomodulatory

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A review of the anti-cancer natural products isolated from Chinese medicinal herbs.Jul 21, 2011

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Pubmed Data : Chin Med. 2011 Jul 22 ;6(1):27. Epub 2011 Jul 22. PMID: 21777476

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Pubmed Data : Biomedicine (Taipei). 2017 Dec ;7(4):23. Epub 2017 Nov 13. PMID: 29130448

Article Published Date : Nov 30, 2017

Study Type : Review

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Substances : Berberine, Cordyceps Militaris, Resveratrol

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Chemotherapeutic

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An updated review on Berberis Vulgaris and Berberine.Aug 15, 2016

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Pubmed Data : Phytother Res. 2016 Aug 16. Epub 2016 Aug 16. PMID: 27528198

Article Published Date : Aug 15, 2016

Study Type : Review

Additional Links

Substances : Barberry, Berberine

Diseases : Alzheimer's Disease, Cardiovascular Diseases, Cerebral Ischemia, Hyperlipidemia, Inflammation, Osteoporosis

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Focus Your Research

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View the Evidence: 518 Abstracts with Berberine Research

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A nutraceutical combination has shown to be an effective product for the improvement of the lipid profile.Apr 26, 2016

Berberine and dyslipidemia: different applications and biopharmaceutical formulations without statin-like molecules.Aug 22, 2019

Berberine exerted anti-tumor effects in a variety of tumors in vivo.Jun 16, 2019

Berberine showed a promising prospect in treating polycystic ovary syndrome patients with insulin resistance.Dec 31, 2017

Berberine supplementation may ameliorate the state of chronic inflammation.Sep 30, 2019

Systematic review and meta-analysis on efficacy and safety of berberine for dyslipidemiaJan 31, 2020

The addition of berberine in standard triple therapy could improve Helicobacter pylori eradication rate and clinical symptom remission rate.Dec 31, 2018

The results of the current study support the use of berberine supplementation for the improvement of obesity indices.Apr 30, 2020

These results found a significant reduction in waist-hip ratio following berberine consumption in adults.Feb 29, 2020

A combination of berberine, red yeast rice and policosanol lowers lipid levels and improves endothelial function and insulin sensitivity in hypercholesterolemic patients. Aug 19, 2009

A nutraceutical formula containing berberine, chlorogenic acid, and tocotrienols was found to improve a large number of metabolic and liver parameters in overweight subjects.Mar 28, 2015

Berberine Capsule was effective in improving blood lipid level in mild hyperlipidemia patients.May 31, 2016

Berberine containing quadruple therapy could be used for Helicobacter pylori eradication.Jul 31, 2017

Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.Aug 31, 2019

Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.Dec 10, 2018

Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.Feb 01, 2007

Berberine is a potent oral hypoglycemic agent with benefical effects on lipid metabolism, comparable in efficacy to metformin. May 01, 2008

Berberine is efficacious for the treatment of atrial fibrillation.Dec 31, 2016

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.Oct 06, 2009

Berberine possesses potential lipid-regulating, antiarthritis, and synovial hyperplasia inhibition activities against rheumatoid arthritis.Dec 31, 2018

Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy.Aug 31, 2018

Berberine was safe and effective in reducing the risk of recurrence of colorectal adenoma.Jan 07, 2020

Dry extracts of artichoke and berberine have beneficial effects in hypercholesterolemic patients.Feb 14, 2019

Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women. Dec 19, 2009

Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders.Feb 29, 2020

The combined application of berberine in patients with metabolic syndrome can effectively regulate blood glucose and blood lipid of patients.Mar 31, 2019

Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

Berberine induced apoptosis and DNA damage in human osteosarcoma lines that were treated.Sep 30, 2014

Berberine may serve as a potential therapeutic option for patients with psoriasis.Mar 19, 2019

These results suggest that berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokine profile in human preadipocytes and metabolic syndrome patients.Mar 07, 2012

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

Berberine improves neointima formation in a rat model.May 01, 2006

A berberine derivative attenuates cardiac failure. Feb 01, 2010

A relatively low dose berberine exhibited strong neuroprotective activity against 6-OHDA-induced neurotoxicity in PC12 cells.Nov 03, 2016

Administration of Berberis vulgaris could ameliorate neurotoxicity induced by beta amyloid. Jul 04, 2015

Ameliorating effects of berberine on MK-801-induced cognitive and motor impairments in a neonatal rat model of schizophrenia.May 15, 2019

Ameliorative effect of berberine on neonatally induced type 2 diabetic neuropathy.Jun 30, 2019

Anti-inflammation associated protective mechanism of berberine and its derivatives on attenuating pentylenetetrazole-induced seizures.Jan 05, 2020

Anti-influenza activity of berberine improves prognosis by reducing viral replication in mice.Oct 10, 2018

Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis.Aug 20, 2018

Autologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment.Nov 30, 2020

Berbamine induces programmed cell death in human liver cancer cells and inhibits tumor growth in mice. Jan 01, 2009

Berberine (a major constituent of goldenseal) has significant cholesterol-lowering action Dec 01, 2004

Berberine activates apoptosis to suppress triple-negative breast cancer cells.Aug 17, 2017

Berberine alleviated doxorubicin induced cardiotoxicity via inhibition of the metabolism of doxorubicin and reduced accumulation of doxorubicinol selectively in hearts.May 12, 2015

Berberine alleviates adipose tissue fibrosis.May 27, 2018

Berberine alleviates amyloid-beta pathogenesis.Mar 14, 2019

Berberine alleviates amyloid-beta pathology in the brain of APP/PS1 transgenic mice.Jun 30, 2018

Berberine alleviates dextran sodium sulfate-induced colitis.May 31, 2017

Berberine alleviates disease symptoms in mouse models mimicking the symptoms of IBS-D. Dec 31, 2014

Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS.Oct 07, 2018

Berberine alleviates hepatic lipid accumulation.Mar 01, 2018

Berberine alleviates hyperglycemia by targeting hepatic glucokinase.May 28, 2019

Berberine alleviates monosodium glutamate induced postnatal metabolic disorders associated vascular endothelial dysfunction.Feb 18, 2020

Berberine alleviates NASH and its predisposing factors.Feb 29, 2016

Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3.Mar 07, 2019

Berberine alleviates oxidative stress in islets of diabetic mice.Apr 23, 2017

Berberine alleviates oxidative stress in rats with osteoporosis.Oct 21, 2017

Berberine alleviates paclitaxel-induced neuropathy.May 31, 2019

Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder.Feb 28, 2018

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.Nov 25, 2019

Berberine ameliorates collagen-induced arthritis in rats by facilitating the generation of butyrate and adjusting the intestinal hypoxia and nitrate supply.Aug 18, 2019

Berberine ameliorates colonic damage accompanied with the modulation of dysfunctional bacteria and functions in ulcerative colitis rats.Jan 31, 2020

Berberine ameliorates diabetic nephropathy.Mar 30, 2018

Berberine ameliorates diabetic neuropathy.Nov 08, 2017

Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels.Oct 16, 2018

Berberine ameliorates high-fat diet-induced non-alcoholic fatty liver disease.Jan 31, 2019

Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process.Jan 02, 2017

Berberine ameliorates MCAO induced cerebral ischemia-reperfusion injury.Jan 21, 2018

Berberine ameliorates myocardial ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis.Jan 24, 2016

Berberine ameliorates non alcoholic fatty liver disease and related metabolic disorders.Dec 31, 2014

Berberine ameliorates NSAIDs-induced intestinal injury by the repair of enteric nervous system.Sep 12, 2019

Berberine

View the Evidence:
518 Abstracts with Berberine Research