Wnt/β-catenin signaling pathway modulation

Name	AC	CK
Curcumin	9	16
Bee Propolis	1	2
Caffeic acid phenethyl ester	1	2
EGCG (Epigallocatechin gallate)	1	2
Grape Seed Extract	1	2
Resveratrol	1	2
Sulforaphane	2	2
Theaflavins	1	2
Thymoquinone	1	2
Broccoli	1	1
Broccoli Sprouts	1	1
Chlorophyllin	1	1
Ellagic Acid	1	1
Ginger	1	1
Honey	1	1
Luteolin	1	1
Pomegranate	1	1
Quercetin	1	1
Silymarin	1	1
Urolithin A	1	1

[+]

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Oral curcumin intake could inhibit androgen receptor expression and probably PSA activity.Aug 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Treadmill exercise alleviates Alzheimer disease-associated memory loss by increasing neurogenesis.Jul 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Exerc Rehabil. 2016 Aug ;12(4):276-83. Epub 2016 Aug 31. PMID: 27656623

Article Published Date : Jul 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Alzheimer's Disease, Diabetic Complications

Therapeutic Actions : Exercise

Pharmacological Actions : Neurogenesis, Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation

[+]

Treatment with curcumin alleviates sublesional bone loss following spinal cord injury in rats.Aug 19, 2015

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2015 Aug 20 ;765:209-216. Epub 2015 Aug 20. PMID: 26300394

Article Published Date : Aug 19, 2015

Study Type : Animal Study

Additional Links

Diseases : Spinal Cord Injuries

Pharmacological Actions : MicroRNA modulator, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation

[+]

Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/β-catenin pathway.Jul 24, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Exp Clin Cancer Res. 2015 Jul 25 ;34:71. Epub 2015 Jul 25. PMID: 26205949

Click here to read the entire abstract

Pubmed Data : Lasers Med Sci. 2018 Apr ;33(3):637-645. Epub 2018 Feb 21. PMID: 29468283

Article Published Date : Mar 31, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Alopecia

Therapeutic Actions : Light-Emitting Diode Therapy

Pharmacological Actions : Wnt/β-catenin signaling pathway modulation

Additional Keywords : Hair Regeneration

[+]

An ellagic acid derivative efficiently inhibits colon cancer cell growth through a mechanism involving WNT16.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : J Pharmacol Exp Ther. 2015 May ;353(2):433-44. Epub 2015 Mar 10. PMID: 25758919

Berberine protected C17.2 NSCs from oxidative damage then induced them to differentiate into neurons.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Cell Neurosci. 2019 ;13:395. Epub 2019 Sep 3. PMID: 31551713

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Brain: Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation

[+]

Beta-elemene increases chemosensitivity to 5-fluorouracil in colorectal carcinoma cells.Jul 31, 2018

Click here to read the entire abstract

Pubmed Data : J Cell Biochem. 2018 Aug ;119(8):7032-7039. Epub 2018 May 8. PMID: 29737579

Pubmed Data : Cancer Sci. 2019 Jul 19. Epub 2019 Jul 19. PMID: 31325197

Article Published Date : Jul 18, 2019

Study Type : In Vitro Study

Additional Links

Substances : Delphinidin

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Anticarcinogenic Agents, Chemoprotective Agents, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation

[+]

Diallyl trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.Dec 14, 2017

Pubmed Data : Mol Med Rep. 2018 May ;17(5):7265-7273. Epub 2018 Mar 16. PMID: 29568950

Article Published Date : Apr 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Wnt/β-catenin signaling pathway modulation

[+]

Ginkgetin suppresses the growth of medulloblastoma.Mar 28, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nat Prod Bioprospect. 2015 Mar 29. Epub 2015 Mar 29. PMID: 25821199

Article Published Date : Mar 28, 2015

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Medulloblastoma

Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation

[+]

Ginsenoside Rh2 inhibits proliferation and migration of medulloblastoma Daoy by down-regulation of microRNA-31.Jul 31, 2018

Click here to read the entire abstract

Pubmed Data : J Cell Biochem. 2018 Aug ;119(8):6527-6534. Epub 2018 Apr 19. PMID: 29377269

Article Published Date : Jul 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Medulloblastoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation

[+]

Green tea polyphenols protect PC12 cells against H2O2-induced damages by upregulating lncRNA MALAT1.Dec 31, 2018

Pubmed Data : J Cell Biochem. 2018 Sep 11. Epub 2018 Sep 11. PMID: 30203502

Article Published Date : Sep 10, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Kidney Cancer

Pharmacological Actions : Anti-metastatic, NF-kappaB Inhibitor, Wnt/β-catenin signaling pathway modulation

[+]

Noni leaf extract might be a novel alternative medicine for bone and periodontal regeneration in patients with periodontal diseases.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : J Med Food. 2018 Jan ;21(1):57-69. Epub 2017 Oct 5. PMID: 28981378

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

[+]

These findings indicate that Z-ajoene from garlic may be a potential chemotherapeutic agent.Feb 05, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2020 Feb 6 ;25(3). Epub 2020 Feb 6. PMID: 32041324

Article Published Date : Feb 05, 2020

Study Type : In Vitro Study

Additional Links

Substances : Garlic

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Chemotherapeutic, Wnt/β-catenin signaling pathway modulation

[+]

These results demonstrate that Notoginsenoside R1 promotes growth of cultured cortical neurons.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : CNS Neurol Disord Drug Targets. 2018 ;17(7):547-556. PMID: 29992896

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Panax Notoginseng

Pharmacological Actions : Neurogenesis, Wnt/β-catenin signaling pathway modulation

[+]

These studied flavonoids significantly enhances doxorubicin-mediated cell death.Nov 25, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Cancer. 2018 Nov 26 ;18(1):1168. Epub 2018 Nov 26. PMID: 30477461

Article Published Date : Nov 25, 2018

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate), Flavonoids, Quercetin, Rutin, Theaflavins

Diseases : Cancers: Multi-Drug Resistant

Pharmacological Actions : Chemosensitizer, Chemotherapeutic, Wnt/β-catenin signaling pathway modulation

[+]

This article focuses on the effects of sulforaphane on CSCs and self-renewal pathways.Jul 31, 2013

Click here to read the entire abstract

Pubmed Data : Future Oncol. 2013 Aug ;9(8):1097-103. PMID: 23902242

Click here to read the entire abstract

Pubmed Data : Toxicol In Vitro. 2015 Aug ;29(5):1107-15. Epub 2015 Apr 21. PMID: 25910917

Article Published Date : Jul 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Urolithin A

Diseases : Liver Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Chemopreventive, Superoxide Dismutase Up-regulation, Tumor Suppressor Protein p53 Upregulation, Wnt/β-catenin signaling pathway modulation

[+]

Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell lineDec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2018 ;12:1303-1310. Epub 2018 May 18. PMID: 29849451

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation

Wnt/β-catenin signaling pathway modulation jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 115 Abstracts with Wnt/β-catenin signaling pathway modulation Research

Limited to Members Only

Currently Available Sorting Options

Light-emitting diodes have a potential to stimulate human dermal papilla cell proliferation.Nov 30, 2017

Resveratrol may represent a new interesting therapeutic approach, in order to affect glioma stem cell proliferation and motility.Dec 31, 2016

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

Arctigenin attenuates tumor metastasis of hepatocellular carcinoma.Dec 31, 2018

Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway.Jul 31, 2019

Berberine combined with HMQ1611 exhibited potential antitumor activities against human liver cancer in vitro and in vivo.Dec 17, 2018

Caffeic acid phenethyl ester may be a potential therapeutic agent for patients with advanced PCa.May 14, 2016

Cinnamaldehyde enhances apoptotic effect of oxaliplatin and reverses epithelial-mesenchymal transition and stemnness in hypoxic colorectal cancer cells.Jul 11, 2019

Curcumin affects β-catenin pathway in HSCs and might suggest a possible new explanation for the effects of curcumin on HSC activation and liver fibrosis.Oct 31, 2014

Curcumin may be a potential therapeutic agent for the treatment of glucocorticoid induced osteoporosis.Dec 10, 2015

Curcumin nanoparticles may offer a therapeutic approach to treating neurodegenerative diseases by enhancing brain self-repair mechanisms.Jan 27, 2014

Curcumin provides neuroprotection against BPA-mediated impaired neurogenesis via activation of the Wnt/β-catenin signaling pathway.May 11, 2015

Effect of electroacupuncture at Wnt/β-catenin signaling pathway on inhibiting cartilage degeneration in rats with knee osteoarthritis.Oct 11, 2019

Ellagic acid may be used in functional foods or medicines to help treat nerve dysfunction, neurodegenerative disease and aging.Oct 28, 2016

Epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways.Aug 20, 2015

Gastrodin treatment markedly preserved the Wnt/β-Catenin signalling pathway, which could promote neurogenesis and provide neuroprotection brain injury.May 31, 2019

Geraniol represents a valuable asset against colitis alone or in combination with the conventional anti-colitic therapies.Aug 31, 2015

Ginsenoside Rb1 ameliorates chronic kidney disease-associated vascular calcification by inhibiting the Wnt/β-catenin pathway.Aug 18, 2019

Ginsenoside Rg1 could exert its therapeutic effects on intestinal intestinal ischemia/reperfusion injury.Jan 01, 2016

Guava fruit extract and its triterpene constituents have osteoanabolic effect.Mar 07, 2017

Hesperidin has a prophylactic effect against hepatocarcinogenesis.Jul 24, 2017

Intranasal administration of nasal gel huperzine A may represent a safe and noninvasive therapeutic strategy for the treatment of Alzheimer's disease.Mar 31, 2011

Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma.Aug 04, 2019

Kaempferol stimulates WNT/β-catenin signaling pathway to induce differentiation of osteoblasts.Aug 30, 2019

Micellar curcumin in combination with cisplatin can be a promising strategy for treatment of pediatric hepatocellular carcinoma.Oct 18, 2015

Oral curcumin intake could inhibit androgen receptor expression and probably PSA activity.Aug 31, 2015

Panax notoginseng ameliorated albuminuria and podocyte epithelial-mesenchymal transition in diabetic rats.Dec 31, 2019

Quercetin improves blood-brain barrier dysfunction in rats with cerebral ischemia reperfusion via Wnt signaling pathway.Dec 31, 2018

Regulation of Wnt activity by curcumin is a feasible alternative strategy to rescue diabetic renal injury.Feb 29, 2016

Resveratrol and grape seed extract combination eliminates colon CSCs in vivo and in vitro.Dec 31, 2015

Salvia miltiorrhiza protects against diabetic nephropathy.Nov 01, 2018

Sesamin promotes osteoblastic differentiation and protects rats from osteoporosis.Jul 16, 2019

These findings suggest crocin as a promising complementary antimetastatic herbal medicine for treatment of triple-negative breast cancer.Oct 22, 2018

These results suggest that electro-acupuncture therapy may promote spinal cord recovery following injury.Jun 18, 2017

This study revealed that cotreatment of cardamonin and 5-FU could strongly potentiate the antitumor activity of 5-FU.May 16, 2019

Treadmill exercise alleviates Alzheimer disease-associated memory loss by increasing neurogenesis.Jul 31, 2016

Treatment with curcumin alleviates sublesional bone loss following spinal cord injury in rats.Aug 19, 2015

Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/β-catenin pathway.Jul 24, 2015

Xanthohumol protects against Azoxymethane-induced colorectal cancer.Nov 11, 2019

20(S)-ginsenoside Rh2 inhibits the proliferation and induces the apoptosis of KG-1a cells through the Wnt/β-catenin signaling pathway.Jun 30, 2016

A comparative study on anti-invasion, antimigration, and anti-adhesion effects of the bioactive carotenoids of saffron on 4T1 breast cancer cells.Jul 31, 2018

A review of targeting oncogenic transcription factors by polyphenols.Jan 03, 2018

A review of the possible use of Punica granatum in cancer therapy.May 01, 2018

A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway.Jan 28, 2019

Acanthopanax senticosus polysaccharide suppressed the proliferation and metastasis of the human non-small cell lung cancer NCI-H520 cells.Jul 22, 2019

Activation of Wnt/β-catenin signaling is involved in hair growth-promoting effect of 655-nm red light and LED.Mar 31, 2018

An ellagic acid derivative efficiently inhibits colon cancer cell growth through a mechanism involving WNT16.Apr 30, 2015

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.Oct 14, 2013

Apigenin was noted to upregulate miR-520b and miR-101 in different cancers to inhibit tumor growth. Oct 01, 2018

Atractylodes macrocephala can inhibit the proliferation and invasion of hepatocellular carcinoma cells.Oct 29, 2019

Baicalein may represent a potential candidate for periodontitis therapy.May 31, 2017

Benzyl isothiocyanate inhibits breast cancer cell tumorigenesisDec 31, 2014

Berbamine suppresses cell proliferation and promotes apoptosis in ovarian cancer.Apr 25, 2018

Berberine accelerates odontoblast differentiation by Wnt/β-catenin activation.Mar 31, 2019

Berberine encapsulated PEG-coated liposomes attenuate Wnt1/β-catenin signaling in rheumatoid arthritis via miR-23a activation.Feb 13, 2020

Berberine promotes osteogenic differentiation of mesenchymal stem cells with therapeutic potential in periodontal regeneration.Feb 14, 2019

Berberine protected C17.2 NSCs from oxidative damage then induced them to differentiate into neurons.Dec 31, 2018

Beta-elemene increases chemosensitivity to 5-fluorouracil in colorectal carcinoma cells.Jul 31, 2018

CBD suppresses pro-inflammatory signalling and may be a potential new candidate for Alzheimer's disease therapy.Sep 30, 2017

Coumestrol modulates Akt and Wnt/β-catenin signaling during the attenuation of adipogenesis.Dec 06, 2016

Curcumin exhibits a neuroprotective effect through the classical wnt signaling pathway.Nov 30, 2014

Curcumin inhibits cell viability and increases apoptosis of SW620 human colon adenocarcinoma cells.Oct 03, 2019

Curcumin inhibits the growth via Wnt/β-catenin pathway in non-small-cell lung cancer cells.Oct 31, 2018

Deep-sea water has some promise in improving cancer survival by preventing tumor metastasis.Oct 31, 2013

Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway.Oct 31, 2009

Delphinidin is a potent inhibitor of Wnt/β-catenin signaling in prostate cancer cells.May 31, 2016

Delphinidin suppresses breast carcinogenesis through HOTAIR/microRNA-34a axis.Jul 18, 2019

Diallyl trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.Dec 14, 2017

Dietary compound proanthocyanidins from Chinese bayberry leaves attenuate chemotherapy-resistant ovarian cancer stem cell traits.Jan 23, 2018

Ganoderic acid A inhibits the proliferation, viability, and intracellular ROS of pancreatic cancer RIN-5F cells.Aug 21, 2016

Ganoderma lucidum exerts an anticancer effect on human osteosarcoma cells.Dec 31, 2018

Gastrodin attenuates proliferation and inflammatory responses in activated microglia through Wnt/β-catenin signaling pathway.Aug 14, 2019

Wnt/β-catenin signaling pathway modulation

View the Evidence:
115 Abstracts with Wnt/β-catenin signaling pathway modulation Research