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11 Substances Researched for Osteogenic
NameACCKFocus
Melatonin215Locked
Horsetail15Locked
Fucoidan12Locked
Kefir12Locked
Milk: Fermented12Locked
Pomegranate Peel12Locked
Resveratrol22Locked
Rice: Black 12Locked
Alpha-Lipoic Acid11Locked
Berberine11Locked
Catechin 11Locked

View the Evidence:
45 Abstracts with Osteogenic Research

[+]

Low-intensity pulse ultrasound stimulation could accelerate fracture healing of the distal radius and promote local bone formation.Oct 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Cir Bras. 2014 Nov ;29(11):765-70. PMID: 25424299
Article Published Date : Oct 31, 2014
Study Type : Human Study
Additional Links
Diseases : Bone Fractures
Therapeutic Actions : Ultrasound therapy
Pharmacological Actions : Osteogenic
Additional Keywords : Significant Treatment Outcome
[+]

one-year treatment with melatonin increased bone mineral density at femoral neck in a dose-dependent manner, while high dose melatonin increased vBMD in the spine.Jun 02, 2015

Pubmed Data : J Pineal Res. 2015 Jun 3. Epub 2015 Jun 3. PMID: 26036434
Article Published Date : Jun 02, 2015
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Bone Fractures, Osteopenia, Osteoporosis
Pharmacological Actions : Osteogenic
Additional Keywords : Dose Response, Significant Treatment Outcome
[+]

Yoga appears to raise bone mineral density in the spine and the femur safely.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Top Geriatr Rehabil. 2016 Apr ;32(2):81-87. Epub 2015 Nov 5. PMID: 27226695
Article Published Date : Mar 31, 2016
Study Type : Human Study
Additional Links
Diseases : Osteoporosis
Therapeutic Actions : Yoga
Pharmacological Actions : Osteogenic, Osteoprotective
[+]

Horsetail extracts elicited inductive effects on human osteoblasts while inhibiting activity of S. aureus.Jul 31, 2012

Pubmed Data : Cell Prolif. 2012 Aug ;45(4):386-96. Epub 2012 Jun 1. PMID: 22672309
Article Published Date : Jul 31, 2012
Study Type : Human In Vitro
Additional Links
Substances : Horsetail
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Osteogenic
Additional Keywords : Plant Extracts
[+]

Melatonin has prospects for treating osteoporosis caused by inflammatory factors.Jun 05, 2016

Pubmed Data : J Pineal Res. 2016 Jun 6. Epub 2016 Jun 6. PMID: 27265199
Article Published Date : Jun 05, 2016
Study Type : Human In Vitro
Additional Links
Substances : Melatonin
Diseases : Inflammation, Osteoporosis: Inflammation Induced
Pharmacological Actions : Anti-Inflammatory Agents, Osteogenic, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Quercetin stimulates bone marrow mesenchymal stem cell differentiation through an estrogen receptor-mediated pathway.Jan 01, 2018

Pubmed Data : Biomed Res Int. 2018 ;2018:4178021. Epub 2018 Mar 15. PMID: 29736392
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Quercetin
Pharmacological Actions : Estrogen Receptor Modulators, Osteogenic, Osteoprotective , Regenerative
Additional Keywords : Bone Regeneration
[+]

Radix astragalus isoflavones exhibit osteogenic activity.Jan 01, 2018

Pubmed Data : Phytother Res. 2018 Jan ;32(1):115-124. Epub 2017 Oct 18. PMID: 29044703
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Astragalus
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic
[+]

Resveratrol enhances adipose-derived stem cell differentiation to chondrocytes in vitro.Jan 01, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Pharm Bull. 2020 Jan ;10(1):88-96. Epub 2019 Dec 11. PMID: 32002366
Article Published Date : Jan 01, 2020
Study Type : Human In Vitro
Additional Links
Substances : Resveratrol
Pharmacological Actions : Osteogenic
Additional Keywords : Bone Regeneration
[+]

The results of the present study suggested that vitamin K2 targets miR-133a to regulate osteogenesis.Apr 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 May ;15(5):2473-2480. Epub 2017 Mar 9. PMID: 28447758
Article Published Date : Apr 30, 2017
Study Type : Human In Vitro
Additional Links
Substances : Vitamin K2
Diseases : Osteonecrosis, Osteoporosis
Pharmacological Actions : MicroRNA modulator, Osteogenic
[+]

Antrodia camphorata extract could promote osteogenesis and prevent bone loss.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:2617868. Epub 2016 Apr 10. PMID: 27143981
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Antrodia camphorata
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic, Osteoprotective
Additional Keywords : Bone Regeneration, Plant Extracts
[+]

Black rice extract is a potentially useful ingredient to protect against age related osteoporosis and diet induced obesity.Dec 31, 2014

Pubmed Data : Food Funct. 2015 Jan ;6(1):265-75. Epub 2014 Nov 27. PMID: 25428526
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Rice: Black
Diseases : Obesity, Osteoarthritis
Pharmacological Actions : Osteogenic
Additional Keywords : Anti-Obesity Agents, Gene Expression Regulation
[+]

Co-administrated puerarin and zinc can partially reverse OVX-induced bone loss.Nov 30, 2016

Pubmed Data : Life Sci. 2016 Dec 1 ;166:20-26. Epub 2016 Sep 30. PMID: 27697446
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Puerarin, Zinc
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic, Osteoprotective
Additional Keywords : bone loss, Osteoporosis, Ovariectomy-Induced Changes, Puerarin, zinc
[+]

Consumption of pomegranate peel extract may be effective in preventing the bone loss.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2015 ;7(11):9265-84. Epub 2015 Nov 11. PMID: 26569295
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Pomegranate Peel
Diseases : Osteoarthritis
Pharmacological Actions : Osteogenic
Additional Keywords : Plant Extracts
[+]

Effects of concurrent use of royal jelly with hydroxyapatite on bone healing.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2020 Jul ;6(7):e04547. Epub 2020 Jul 30. PMID: 32775723
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Royal Jelly
Diseases : Bone Fractures
Pharmacological Actions : Osteogenic
[+]

Fermentation improves calcium bioavailability in Moringa oleifera leaves and prevents bone loss in calcium-deficient rats.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2020 Jul ;8(7):3692-3703. Epub 2020 May 25. PMID: 32724632
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages, Moringa oleifera
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic
[+]

Guava fruit extract and its triterpene constituents have osteoanabolic effect.Mar 07, 2017

Pubmed Data : J Nutr Biochem. 2017 Mar 8 ;44:22-34. Epub 2017 Mar 8. PMID: 28343085
Article Published Date : Mar 07, 2017
Study Type : Animal Study
Additional Links
Substances : Guava
Diseases : Osteopenia
Pharmacological Actions : Osteogenic, Wnt/β-catenin signaling pathway modulation
[+]

Kaempferol promotes bone formation in part via the mTOR signaling pathway.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Dec ;20(6):5197-5207. Epub 2019 Oct 16. PMID: 31638215
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic
[+]

Kaempferol stimulates WNT/β-catenin signaling pathway to induce differentiation of osteoblasts.Aug 30, 2019

Pubmed Data : J Nutr Biochem. 2019 Aug 31 ;74:108228. Epub 2019 Aug 31. PMID: 31678747
Article Published Date : Aug 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Osteoarthritis
Pharmacological Actions : Osteogenic, Wnt/β-catenin signaling pathway modulation
[+]

Kefir has a protective effect against bone loss, deterioration of trabecular microarchitecture, and biomechanical dysfunction.Jan 31, 2015

Pubmed Data : Osteoporos Int. 2015 Feb ;26(2):589-99. Epub 2014 Oct 3. PMID: 25278298
Article Published Date : Jan 31, 2015
Study Type : Animal Study
Additional Links
Substances : Kefir, Milk: Fermented
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic
Additional Keywords : Significant Treatment Outcome
[+]

Lepidium sativum extract that accelerated bone healing by increasing osteoblastic proliferation.Jan 31, 2020

Pubmed Data : J Family Med Prim Care. 2020 Feb ;9(2):812-818. Epub 2020 Feb 28. PMID: 32318426
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Garden Cress (Lepidium sativum)
Diseases : Bone Fractures
Pharmacological Actions : Osteogenic
[+]

Low intensity pulsed ultrasound may be a promising modality for the treatment of early stage steroid associated osteonecrosis.Apr 30, 2015

Pubmed Data : Clin Orthop Relat Res. 2015 May ;473(5):1830-9. Epub 2015 Mar 4. PMID: 25736917
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Diseases : Fractures: Bone, Lipopolysaccharide-Induced Toxicity
Therapeutic Actions : Ultrasound therapy
Pharmacological Actions : Osteogenic
[+]

Mate tea increases bone area and osteocyte density in the alveolar socket healing on day 28 after tooth extraction.Oct 13, 2017

Pubmed Data : Clin Oral Investig. 2017 Oct 14. Epub 2017 Oct 14. PMID: 29032403
Article Published Date : Oct 13, 2017
Study Type : Animal Study
Additional Links
Substances : Yerba Mate
Diseases : Tooth Extraction: Wisdom
Pharmacological Actions : Osteogenic
[+]

Melatonin rescues osteoporosis by upregulating bone marrow mesenchymal stem cells osteogenic ability.Jan 02, 2020

Pubmed Data : Br J Pharmacol. 2020 Jan 3. Epub 2020 Jan 3. PMID: 31900938
Article Published Date : Jan 02, 2020
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Osteoarthritis
Pharmacological Actions : Osteogenic
[+]

Melatonin treatment is an efficient and practical strategy to improve in vitro expansion of BMMSCs for tissue engineering and cytotherapy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Theranostics. 2016 ;6(11):1899-917. Epub 2016 Aug 8. PMID: 27570559
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic, Regenerative
Additional Keywords : Mesenchymal Stem Cells
[+]

Mushroom extracts decrease bone resorption and improve bone formation.Dec 31, 2015

Pubmed Data : Int J Med Mushrooms. 2016 ;18(7):559-69. PMID: 27649725
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Maitake Mushroom, Oyster Mushroom, Shiitake Mushroom
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic, Osteoprotective
Additional Keywords : Plant Extracts
[+]

Puerarin has a stimulatory effect on bone formation.Sep 30, 2012

Pubmed Data : Chin Med J (Engl). 2012 Oct ;125(20):3646-53. PMID: 23075718
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : Isoflavones
Diseases : Osteoarthritis
Pharmacological Actions : Osteogenic
[+]

Puerarin might be beneficial as a promising candidate drug for the prevention and treatment of bacteria-induced bone destruction disease.Dec 31, 2015

Pubmed Data : Biol Pharm Bull. 2016 ;39(12):2028-2035. PMID: 27904045
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Interleukin-1 beta downregulation, Osteogenic, Osteoprotective , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Puerarin stimulates osteogenic differentiation and bone formation.Mar 08, 2018

Pubmed Data : Curr Mol Med. 2018 Mar 9 ;17(7):488-496. PMID: 29256352
Article Published Date : Mar 08, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic
[+]

Spirulina enhances bone modelling in growing male rats by regulating growth-related hormones.Apr 23, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Apr 24 ;12(4). Epub 2020 Apr 24. PMID: 32344533
Article Published Date : Apr 23, 2020
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Bone Diseases, Hormones: Insufficient Levels
Pharmacological Actions : Osteogenic
[+]

Systemic administration of stinging nettle may be effective in accelerating new bone formation and reducing inflammation.Aug 31, 2016

Pubmed Data : Arch Oral Biol. 2016 Sep ;69:13-8. Epub 2016 May 7. PMID: 27209059
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Nettle
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Osteogenic
Additional Keywords : Anti-Inflammatory Agents, Inflammation. nettle, Osteogenic, Plant Extracts
[+]

The sulfated polysaccharide fucoidan stimulates osteogenic differentiation of human adipose-derived stem cells, indicating it may it may be a potential candidate for promoting bone regeneration.Aug 09, 2012

Pubmed Data : Stem Cells Dev. 2012 Aug 10 ;21(12):2204-11. Epub 2011 Dec 19. PMID: 22050637
Article Published Date : Aug 09, 2012
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Bone Destructive Diseases: Over-Active Osteoclasts, Bone Fractures, Hip Fracture, Osteoporosis
Pharmacological Actions : Osteogenic
Additional Keywords : Bone Regeneration
[+]

These findings suggest that gastrodin alleviated glucocorticoid-induced osteoporosis.Feb 19, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Feb 20 ;9(14):11528-11540. Epub 2018 Jan 3. PMID: 29545917
Article Published Date : Feb 19, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Osteoporosis
Pharmacological Actions : Antioxidants, Osteogenic
[+]

Vitamin C reverses bone loss in an osteopenic rat model of osteoporosis.Mar 11, 2019

Pubmed Data : Int J Vitam Nutr Res. 2019 Mar 12:1-8. Epub 2019 Mar 12. PMID: 30859904
Article Published Date : Mar 11, 2019
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Osteoporosis
Pharmacological Actions : Antioxidants, Osteogenic, Osteoprotective
Additional Keywords : Ovariectomy-Induced Changes
[+]

A delphinidin enriched maqui berry extract can be a promising natural agent for the prevention of bone loss in osteopenic conditions.Sep 09, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Sep 10 ;8(9). Epub 2019 Sep 10. PMID: 31509995
Article Published Date : Sep 09, 2019
Study Type : In Vitro Study
Additional Links
Substances : Delphinidin, Maqui
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic, Osteoprotective
[+]

Acemannan could function as a bioactive molecule inducing bone formation by stimulating BMSCs proliferation, differentiation into osteoblasts.Jun 30, 2014

Pubmed Data : Odontology. 2014 Jul ;102(2):310-7. Epub 2013 Aug 12. PMID: 23315202
Article Published Date : Jun 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Aloe Vera
Diseases : Wound Healing: Periodontal
Pharmacological Actions : Osteogenic, Regenerative
Additional Keywords : Polysaccharides
[+]

Annatto-derived tocotrienols enhance osteogenic activity.Jan 01, 2018

Pubmed Data : Drug Des Devel Ther. 2018 ;12:1715-1726. Epub 2018 Jun 13. PMID: 29942115
Article Published Date : Jan 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienols
Pharmacological Actions : Osteogenic, Regenerative
Additional Keywords : Bone Regeneration, Phytotherapy
[+]

Asiatic acid could be a potential candidate for a novel treatment against osteoporosis.Feb 28, 2014

Pubmed Data : Cell Biochem Biophys. 2014 Mar ;68(2):437-42. PMID: 23934183
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic
[+]

Baicalein may represent a potential candidate for periodontitis therapy.May 31, 2017

Pubmed Data : Arch Oral Biol. 2017 Jun ;78:100-108. Epub 2017 Feb 7. PMID: 28222387
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Baicalein
Diseases : Periodontitis
Pharmacological Actions : Osteogenic, Wnt/β-catenin signaling pathway modulation
[+]

Betulinic acid could be an interesting and safe candidate for the treatment of type 2 diabetes and bone diseases.Jul 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Jul 18 ;7(1):5777. Epub 2017 Jul 18. PMID: 28720829
Article Published Date : Jul 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Osteogenic
[+]

Cafestol may be a novel agent for bone diseases.Jun 30, 2015

Pubmed Data : Biofactors. 2015 Jul-Aug;41(4):222-31. Epub 2015 Jul 7. PMID: 26154488
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cafestol, Kahweol
Diseases : Bone Diseases, Osteoarthritis
Pharmacological Actions : MicroRNA modulator, NF-kappaB Inhibitor, Nrf2 activation, Osteogenic, Osteoprotective
Additional Keywords : Dose Response
[+]

Lactoferrin: a biologically active molecule for bone regeneration.Dec 31, 2010

Pubmed Data : Curr Med Chem. 2011 ;18(8):1220-9. PMID: 21291364
Article Published Date : Dec 31, 2010
Study Type : Review
Additional Links
Substances : Lactoferrin
Diseases : Osteoarthritis
Pharmacological Actions : Osteogenic
Additional Keywords : Bone Regeneration
[+]

Resveratrol facilitates in vitro mineralization and in vivo bone regeneration.Feb 01, 2011

Pubmed Data : Acta Biomater. 2011 Feb;7(2):751-8. Epub 2010 Sep 16. PMID: 20849988
Article Published Date : Feb 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Osteoporosis
Pharmacological Actions : Osteogenic, Regenerative
Additional Keywords : Bone Regeneration, Regenerative Substances
[+]

Resveratrol, EGCG, berberine and alpha-lipoic acid may have a beneficial effect on bone health through negatively regulating RANKL.Nov 01, 2010

Pubmed Data : Bone. 2010 Nov;47(5):926-37. Epub 2010 Aug 7. PMID: 20696287
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Alpha-Lipoic Acid, Berberine, Catechin , Resveratrol
Diseases : Osteoporosis
Pharmacological Actions : Apoptotic, Osteogenic, RANK Downregulation
Additional Keywords : Drug: Metformin, Macrophage Colony-Stimulating Factor, Stilbenes
[+]

The role of ginsenoside Rb1 in bone homeostasis.Jun 27, 2020

Pubmed Data : Curr Stem Cell Res Ther. 2020 Jun 28. Epub 2020 Jun 28. PMID: 32598274
Article Published Date : Jun 27, 2020
Study Type : Review
Additional Links
Substances : Ginsenosides
Diseases : Osteoporosis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Osteogenic, Wnt/β-catenin signaling pathway modulation
[+]

These results suggest the therapeutic potential of fucoidan for enhancing bone repair.Jul 15, 2017

Pubmed Data : J Tissue Eng Regen Med. 2017 Jul 16. Epub 2017 Jul 16. PMID: 28714275
Article Published Date : Jul 15, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Pharmacological Actions : Osteogenic
Additional Keywords : Bone Regeneration

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