Interleukin-18 down-regulation

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8 Substances Researched for Interleukin-18 down-regulation
NameACCKFocus
Cherry: All Varieties110Locked
Cherry: Bing110Locked
Apigenin12Locked
Modified Arabinoxylan Rice Bran (MGN-3)12Locked
Pomegranate12Locked
Resveratrol12Locked
Curcumin11Locked
Vitamin E: Gamma-tocotrienol11Locked

View the Evidence:
57 Abstracts with Interleukin-18 down-regulation Research

[+]

Far infrared radiation therapy provides an effective treatment modality for patients with chronic lymphedema.May 31, 2017

Pubmed Data : Arch Gynecol Obstet. 2017 Jun ;295(6):1441-1450. Epub 2017 Apr 22. PMID: 28434105
Article Published Date : May 31, 2017
Study Type : Human Study
Additional Links
Diseases : Lymphedema
Therapeutic Actions : Thermal Therapy: Far-Infrared
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-18 down-regulation, Interleukin-2 Downregulation
[+]

Long-term bicycle riding improves the quality of life and reduces the severity of depression in patients suffering from chronic hemodialysis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuropsychiatr Dis Treat. 2017 ;13:91-100. Epub 2016 Dec 28. PMID: 28096677
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Diseases : Hemodialysis
Therapeutic Actions : Exercise: Cycling
Pharmacological Actions : Antidepressive Agents, Interleukin-18 down-regulation, Interleukin-6 Downregulation
[+]

Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans.Feb 28, 2013

Pubmed Data : J Nutr. 2013 Mar ;143(3):340-4. Epub 2013 Jan 23. PMID: 23343675
Article Published Date : Feb 28, 2013
Study Type : Human Study
Additional Links
Substances : Cherry: All Varieties, Cherry: Bing
Diseases : C-Reactive Protein, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Endothelin-1 Inhibitor, Epidermal growth factor receptor (EGFR) inhibitor, Interleukin-18 down-regulation
Additional Keywords : Phytotherapy
[+]

Antitumor and immunomodulatory activities of total flavonoids extract from persimmon leaves in H 22 liver tumor-bearing mice.Jul 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Jul 12 ;8(1):10523. Epub 2018 Jul 12. PMID: 30002398
Article Published Date : Jul 11, 2018
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Persimmon
Diseases : Liver Cancer
Pharmacological Actions : Immunomodulatory, Interleukin-18 down-regulation
Additional Keywords : Plant Extracts
[+]

Apigenin ameliorates HFD-induced NAFLD through regulation of the XO/NLRP3 pathways.Jun 13, 2019

Pubmed Data : J Nutr Biochem. 2019 Jun 14 ;71:110-121. Epub 2019 Jun 14. PMID: 31325892
Article Published Date : Jun 13, 2019
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : High Fat Diet, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Apigenin supplement might provide a basis for developing a new dietary strategy for the prevention of chronic ulcerative colitis.Mar 31, 2016

Pubmed Data : J Nutr Biochem. 2016 Apr ;30:143-52. Epub 2016 Jan 4. PMID: 27012631
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Arctigenin may confer protection against ischemic stroke.Nov 03, 2017

Pubmed Data : Biochem Biophys Res Commun. 2017 Nov 4 ;493(1):821-826. Epub 2017 Sep 6. PMID: 28888980
Article Published Date : Nov 03, 2017
Study Type : Animal Study
Additional Links
Substances : Arctigenin
Diseases : Stroke: Ischemic
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Neuroprotective Agents
[+]

Astragaloside IV attenuates inflammatory response mediated by NLRP-3/calpain-1 is involved in the development of pulmonary hypertension.Dec 07, 2020

Pubmed Data : J Cell Mol Med. 2020 Dec 8. Epub 2020 Dec 8. PMID: 33295020
Article Published Date : Dec 07, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Hypertension: Pulmonary
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Astragaloside IV treatment ameliorated the severity of diabetic nephropathy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:9542165. Epub 2020 Aug 12. PMID: 32855769
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Renoprotective
[+]

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Cir Bras. 2019 ;34(11):e201901104. Epub 2019 Dec 20. PMID: 31859817
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Biochanin A protects against angiotensin II-induced damage of dopaminergic neurons.Jan 11, 2019

Pubmed Data : Behav Pharmacol. 2019 12 ;30(8):700-711. PMID: 31703032
Article Published Date : Jan 11, 2019
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Brain Inflammation , Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Cabbage extracts have a pancreato-protective effect.Jan 19, 2017

Pubmed Data : Nat Prod Res. 2017 Jan 20:1-4. Epub 2017 Jan 20. PMID: 28107794
Article Published Date : Jan 19, 2017
Study Type : Animal Study
Additional Links
Substances : Cabbage
Diseases : Alcohol Toxicity , Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Pancreato Protective Agents
Additional Keywords : Alcohol Toxicity, Anti-Inflammatory Agents, Antioxidants, Cabbage, Pancreatitis, Plant Extracts
[+]

Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats.Dec 31, 2018

Pubmed Data : Int Immunopharmacol. 2019 Jan ;66:215-223. Epub 2018 Nov 22. PMID: 30472522
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Celastrol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Electro-acupuncture alleviates chronic unpredictable stress-induced depressive- and anxiety-like behaviour and neuroinflammation.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Mol Neurosci. 2018 ;11:149. Epub 2018 May 31. PMID: 29946236
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Brain Inflammation , Depression
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-18 down-regulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Emodin alleviated pancreatic and intestinal mucosa injury in experimental severe acute pancreatitis.Aug 14, 2017

Pubmed Data : Hepatobiliary Pancreat Dis Int. 2017 Aug 15 ;16(4):431-436. PMID: 28823375
Article Published Date : Aug 14, 2017
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Emodin attenuates severe acute pancreatitis via antioxidant and anti-inflammatory activity.Nov 30, 2019

Pubmed Data : Inflammation. 2019 Dec ;42(6):2129-2138. PMID: 31605249
Article Published Date : Nov 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Emodin
Diseases : Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-18 down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Galactooligosaccharides protects against DSS-induced murine colitis.Jan 31, 2020

Pubmed Data : Life Sci. 2020 Feb 1 ;242:117220. Epub 2019 Dec 24. PMID: 31881230
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Galactooligosaccharides
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, interleukin-13 down-regulation, Interleukin-18 down-regulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Gastrodin is anti-inflammatory as it effectively suppresses inflammasome in oxygen-glucose-deprivation-stimulated astrocytes.Jun 18, 2019

Pubmed Data : Neuromolecular Med. 2019 Jun 19. Epub 2019 Jun 19. PMID: 31218587
Article Published Date : Jun 18, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-18 down-regulation, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Ginsenoside Rg1 can inhibit inflammatory reaction, regulate lipid metabolism, and alleviate liver injury in NAFLD.May 18, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ACS Omega. 2020 May 19 ;5(19):10878-10890. Epub 2020 May 5. PMID: 32455208
Article Published Date : May 18, 2020
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, Interleukin-18 down-regulation, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Ginsenoside Rg1 may have protective effects on neuroinflammation and neuronal injury induced by chronic glucocorticoids exposure.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2017 Oct ;40(4):1134-1142. Epub 2017 Aug 9. PMID: 28849171
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
Problem Substances : Dexamethasone
[+]

Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetes. Jan 04, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Pharmacol. 2020 Jan 5 ;866:172801. Epub 2019 Nov 16. PMID: 31738935
Article Published Date : Jan 04, 2020
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Nrf2 activation
[+]

Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury.Jun 11, 2019

Pubmed Data : Food Funct. 2019 Jun 12. Epub 2019 Jun 12. PMID: 31187838
Article Published Date : Jun 11, 2019
Study Type : Animal Study
Additional Links
Substances : Green Tea, Polyphenols
Diseases : Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Gypenosides improve diabetic cardiomyopathy by inhibiting ROS‐mediated NLRP3 inflammasome activation.Dec 31, 2017

Pubmed Data : J Cell Mol Med. 2018 09 ;22(9):4437-4448. Epub 2018 Jul 11. PMID: 29993180
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Gynostemma
Diseases : Cardiomyopathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
Additional Keywords : Plant Extracts
[+]

Intermittent fasting attenuates inflammasome activity in ischemic stroke.Jun 30, 2014

Pubmed Data : Exp Neurol. 2014 Jul ;257:114-9. Epub 2014 May 5. PMID: 24805069
Article Published Date : Jun 30, 2014
Study Type : Animal Study
Additional Links
Diseases : Stroke: Ischemic
Therapeutic Actions : Fasting/Caloric Restriction
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

LED therapy can attenuate neuroinflammatory responses and tissue damage following ischemic stroke.Feb 05, 2017

Pubmed Data : J Biophotonics. 2017 Feb 6. Epub 2017 Feb 6. PMID: 28164443
Article Published Date : Feb 05, 2017
Study Type : Animal Study
Additional Links
Diseases : Stroke: Ischemic
Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Mangiferin inhibits hippocampal NLRP3 inflammasome and exerts antidepressant effects.Apr 12, 2017

Pubmed Data : Behav Pharmacol. 2017 Apr 13. Epub 2017 Apr 13. PMID: 28410265
Article Published Date : Apr 12, 2017
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

MGN-3 and its hydrolysate significantly alleviated D-galactosamine induced hepatitis in rats.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Biotechnol Biochem. 2012 ;76(5):942-6. Epub 2012 May 7. PMID: 22738964
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Modified Arabinoxylan Rice Bran (MGN-3)
Diseases : Chemically-Induced Liver Damage, Hepatitis
Pharmacological Actions : Hepatoprotective, Interleukin-18 down-regulation
[+]

Pomegranate juice can be potentially used for the treatment of inflammatory bowel disease.Jun 27, 2016

Pubmed Data : Mol Cell Biochem. 2016 Jun 28. Epub 2016 Jun 28. PMID: 27352379
Article Published Date : Jun 27, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Procyanidin B2 prevents lupus nephritis development in mice by inhibiting NLRP3 inflammasome activation.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Innate Immun. 2018 Jul ;24(5):307-315. Epub 2018 Jun 6. PMID: 29874961
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Procyanidin B2
Diseases : Lupus Nephritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Procyanidin B2 protects rats from paraquat-induced acute lung injury.Sep 30, 2018

Pubmed Data : Immunobiology. 2018 Oct ;223(10):555-561. Epub 2018 Jul 6. PMID: 30025709
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Procyanidin B2
Diseases : Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
Problem Substances : Paraquat
[+]

Protective effect of ginsenoside metabolite compound K against diabetic nephropathy.Sep 30, 2018

Pubmed Data : Int Immunopharmacol. 2018 Oct ;63:227-238. Epub 2018 Aug 11. PMID: 30107367
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Renoprotective
[+]

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation.Mar 06, 2020

Pubmed Data : Pharmacol Res. 2020 Mar 7 ;155:104746. Epub 2020 Mar 7. PMID: 32156650
Article Published Date : Mar 06, 2020
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Renoprotective
[+]

Puerarin has the capability of inhibiting vascular calcification in uremic rats by inhibiting inflammation.Jul 14, 2019

Pubmed Data : Eur J Pharmacol. 2019 Jul 15 ;855:235-243. Epub 2019 May 11. PMID: 31085237
Article Published Date : Jul 14, 2019
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Vascular Calcification
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db miceJan 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2020 Jan 30. Epub 2020 Jan 30. PMID: 32000299
Article Published Date : Jan 29, 2020
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Diabetic Complications, Encephalopathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Red raspberries suppress NLRP3 inflammasome and attenuate metabolic abnormalities in diet-induced obese mice.Nov 01, 2017

Pubmed Data : J Nutr Biochem. 2017 Nov 2 ;53:96-103. Epub 2017 Nov 2. PMID: 29202274
Article Published Date : Nov 01, 2017
Study Type : Animal Study
Additional Links
Substances : Raspberry
Diseases : Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Resveratrol prevents inflammation-dependent hepatic melanoma metastasis.Jan 01, 2011

Pubmed Data : J Transl Med. 2011 ;9:59. Epub 2011 May 12. PMID: 21569399
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Inflammation, Liver Cancer, Liver Cancer: Metastatic, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Antiproliferative , Interleukin-18 down-regulation, Vascular Cell Adhesion Molecule-1 Inhibitor
[+]

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injuryFeb 08, 2017

Pubmed Data : Int Immunopharmacol. 2017 Feb 9 ;45:74-78. Epub 2017 Feb 9. PMID: 28189971
Article Published Date : Feb 08, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Tetramethylpyrazine ameliorates experimental autoimmune encephalomyelitis by modulating the inflammatory response.Jul 31, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 Aug 1. Epub 2018 Aug 1. PMID: 30078676
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ligustrazine
Diseases : Multiple Sclerosis
Pharmacological Actions : Interleukin-10 upregulation, Interleukin-17 downregulation, Interleukin-18 down-regulation
[+]

The present findings indicated that ursolic acid may be a possible therapeutic agent against diabetic nephropathy.Oct 31, 2018

Pubmed Data : Mol Med Rep. 2018 Nov ;18(5):4675-4681. Epub 2018 Sep 3. PMID: 30221655
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ursolic Acid
Diseases : Diabetic Nephropathy, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The study is the first to demonstrate strong effects of cyanidin-3-O-glucosideto alleviate DSS-induced colonic damage.Aug 19, 2019

Pubmed Data : Inflamm Bowel Dis. 2019 Aug 20 ;25(9):1510-1521. PMID: 31107535
Article Published Date : Aug 19, 2019
Study Type : Animal Study
Additional Links
Substances : Cyanidin 3-glucoside
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, Interleukin-18 down-regulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:1609-1619. Epub 2018 Jun 12. PMID: 29928110
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Brain Inflammation , Cerebral Hemorrhage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Thymoquinone effectively modulates autophagy, pyroptosis, and pro-inflammatory, making it important in the treatment of sepsis-induced cardiac damage.Oct 19, 2018

Pubmed Data : Inflammation. 2018 Oct 20. Epub 2018 Oct 20. PMID: 30343389
Article Published Date : Oct 19, 2018
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymoquinone reduces spinal cord injury by inhibiting inflammatory response, oxidative stress and apoptosis May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Jun ;15(6):4987-4994. Epub 2018 Apr 16. PMID: 29904397
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Ursolic acid treatment alleviates diabetic kidney injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetes Metab Syndr Obes. 2019 ;12:2597-2608. Epub 2019 Dec 9. PMID: 31849504
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ursolic Acid
Diseases : Diabetes Mellitus: Type 2, Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Renoprotective
[+]

Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3 inflammasome activation.Sep 30, 2019

Pubmed Data : Phytother Res. 2019 Oct ;33(10):2737-2748. Epub 2019 Jul 23. PMID: 31338905
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Coriolus versicolor
Diseases : Cardiomyopathy, Diabetes: Cardiovascular Illness
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Curcumin significantly inhibited the production of pro-inflammatory cytokine IL-18 in E.coli LPS stimulated murine macrophage-like cells.Dec 31, 2014

Pubmed Data : Indian J Clin Biochem. 2015 Jan ;30(1):109-12. Epub 2014 Jul 15. PMID: 25646051
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation
Additional Keywords : Dose Response
[+]

Gamma-tocotrienol inhibits the NLRP3 inflammasome thereby delaying the progression of type 2 diabetes.Dec 31, 2015

Pubmed Data : J Lipid Res. 2016 Jan ;57(1):66-76. Epub 2015 Dec 1. PMID: 26628639
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation
[+]

Hydroxysafflor yellow A protects against myocardial ischemia/reperfusion injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:1170. Epub 2020 Jul 30. PMID: 32848777
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Safflower
Diseases : Inflammation, Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hyperbaric oxygen therapy alleviates the inflammatory response in experimental traumatic brain injury.Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Oct ;16(4):3922-3928. Epub 2017 Jul 24. PMID: 29067455
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : anti-inflammatory, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Loganin's antioxidant effects prevent RSC96 Schwann cell pyroptosis by inhibiting ROS generation and suppressing NLRP3 inflammasome activation.Jan 22, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2020 08 23 ;9(9). Epub 2020 Aug 23. PMID: 32842536
Article Published Date : Jan 22, 2020
Study Type : In Vitro Study
Additional Links
Substances : Dogwood
Diseases : Diabetic Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Naringin may have a therapeutic effect on endothelial injury-related disorders.Mar 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2020 Mar 27 ;40(3). PMID: 32091090
Article Published Date : Mar 26, 2020
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Oridonin attenuates myocardial ischemia/reperfusion injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:7395187. Epub 2020 May 30. PMID: 32565873
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and endoplasmic reticulum stress markers.Sep 03, 2019

Pubmed Data : Am J Reprod Immunol. 2019 Sep 4:e13186. Epub 2019 Sep 4. PMID: 31483910
Article Published Date : Sep 03, 2019
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Polycystic Ovary Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sweet olive flower ethanolic extract could be developed as an agent that suppresses IL-8 secretion to treat chronic inflammatory diseases.Jul 31, 2017

Pubmed Data : J Food Sci. 2017 Aug ;82(8):1792-1798. Epub 2017 Jul 3. PMID: 28671329
Article Published Date : Jul 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Olive
Diseases : Colon Cancer, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation
Additional Keywords : Plant Extracts
[+]

These results provide convincing evidence that α-lipoic acid might inhibit endometriosis progression.Jan 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Jan 8 ;26(2). Epub 2021 Jan 8. PMID: 33430114
Article Published Date : Jan 07, 2021
Study Type : In Vitro Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Endometriosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

This study shows the potential application of nobiletin in the treatment of non alcoholic fatty liver disease.Nov 30, 2018

Pubmed Data : Mol Med Rep. 2018 Dec ;18(6):5815-5822. Epub 2018 Oct 31. PMID: 30387829
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

This work supports berberine as a putative anti-tumor agent targeting glioma cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2019 ;9:364. Epub 2019 May 14. PMID: 31139563
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Glioma
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Interleukin-18 down-regulation, Interleukin-1 beta downregulation

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