Heme oxygenase-1 up-regulation

Name	AC	CK
Pine Bark Extract	1	10
Curcumin	5	8
Garlic: Aged	2	6
Chokeberry	1	5
EGCG (Epigallocatechin gallate)	3	5
Quercetin	2	4
Heme oxygenase-1	2	3
Alpha-Lipoic Acid	1	2
Berberine	1	2
Green Tea	1	2
Melatonin	2	2
Nigella sativa (aka Black Seed)	1	2
Olive Oil	1	2
Propolis: Bee	1	2
Pterostilbene	1	2
Sulforaphane	2	2
Vitamin C	1	2
6-Shogaol	1	1
Avenanthramides	1	1
Camel Milk	1	1
Ferulic acid	1	1
Ginkgo biloba	1	1
Horseradish	1	1
Lotus	1	1
Luteolin	1	1
Moringa oleifera	1	1
Oats	1	1
Phellinus Linteus	1	1
Prunella vulgaris.	1	1
Pycnogenol (Pine Bark)	1	1

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Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

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Pubmed Data : Int Immunopharmacol. 2019 Jun 26 ;74:105712. Epub 2019 Jun 26. PMID: 31254954

Article Published Date : Jun 25, 2019

Study Type : Animal Study

Additional Links

Substances : Asiatic Acid

Diseases : Hypertension, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation

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Astaxanthin ameliorates the lipopolysaccharides-induced subfertility.Jun 30, 2019

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Pubmed Data : Dose Response. 2019 Jul-Sep;17(3):1559325819878537. Epub 2019 Sep 25. PMID: 31598118

Article Published Date : Jun 30, 2019

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Infertility: Male, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Antioxidants, Fertility Agents: Male, Heme oxygenase-1 up-regulation, Nrf2 activation

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Astaxanthin from haematococcus pluvialis ameliorates the chemotherapeutic drug doxorubicin induced liver injury. May 13, 2020

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Pubmed Data : Food Funct. 2020 May 14. Epub 2020 May 14. PMID: 32405635

Article Published Date : May 13, 2020

Study Type : Animal Study

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Substances : Astaxanthin

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

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Astaxanthin protects ochratoxin -induced lung injury in mice through the Nrf2/NF-κB pathway.Sep 16, 2019

Pubmed Data : Int Immunopharmacol. 2016 Sep ;38:324-31. Epub 2016 Jun 23. PMID: 27344638

Article Published Date : Aug 31, 2016

Study Type : Animal Study

Additional Links

Substances : Biochanin A

Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Caffeic acid phenethyl ester could be considered as a promising neuroprotective agent against progressive neurodegenerative diseases.Jul 31, 2018

Coenzyme Q10 has a coloprotective effect against experimentally induced ulcerative colitis.Jan 02, 2017

Pubmed Data : J Biochem Mol Toxicol. 2019 Oct ;33(10):e22386. Epub 2019 Aug 27. PMID: 31454128

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Pubmed Data : Stem Cells Int. 2015 ;2015:638153. Epub 2015 May 5. PMID: 26074974

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Ischemia: Myocardial, Oxidative Stress

Pharmacological Actions : Angiogenesis Inducing Agents, Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation

Additional Keywords : Mesenchymal Stem Cells

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Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity.Jan 31, 2020

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Pubmed Data : Chin J Nat Med. 2020 Feb ;18(2):103-113. PMID: 32172946

Article Published Date : Jan 31, 2020

Study Type : Animal Study

Additional Links

Substances : Dandelion , Polyphenols

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

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Dibenzoylmethane protects against carbon tetrachloride induced acute liver injury.Oct 31, 2017

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Pubmed Data : AAPS J. 2017 Nov ;19(6):1703-1714. Epub 2017 Aug 21. PMID: 28828752

Article Published Date : Oct 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Dibenzoylmethane (DBM)

Diseases : Chemically-Induced Liver Damage, Liver Disease

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

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Dietary puerarin supplementation alleviates oxidative stress in the small intestines.Apr 06, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Dec 31. Epub 2019 Dec 31. PMID: 31889292

Ginsenoside Rb1 has beneficial effects on oxidative stress injury in rat spinal cords.Jul 31, 2018

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Pubmed Data : Exp Ther Med. 2018 Aug ;16(2):1079-1086. Epub 2018 Jun 12. PMID: 30116359

Article Published Date : Jul 31, 2018

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Spinal Cord Injuries

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

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Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats.Dec 31, 2018

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Pubmed Data : Pathog Dis. 2013 Feb ;67(1):76-83. Epub 2012 Nov 15. PMID: 23620122

Article Published Date : Jan 31, 2013

Study Type : Animal Study

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Substances : EGCG (Epigallocatechin gallate)

Diseases : Atherosclerosis, Porphyromonas gingivalis

Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, MicroRNA modulator

Additional Keywords : Gene Expression Regulation

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Gypenoside attenuates renal ischemia/reperfusion injury in mice.Mar 31, 2016

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Pubmed Data : Exp Ther Med. 2016 Apr ;11(4):1499-1505. Epub 2016 Jan 29. PMID: 27073472

Article Published Date : Mar 31, 2016

Study Type : Animal Study

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Substances : Gynostemma

Diseases : Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Renoprotective

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Hawthorn extract could have protective effects in ovariectomized rats.May 12, 2016

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Pubmed Data : Environ Sci Pollut Res Int. 2020 Feb ;27(4):3950-3961. Epub 2019 Dec 10. PMID: 31823254

Article Published Date : Jan 31, 2020

Study Type : Animal Study

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Substances : Krill

Diseases : Iron Overload, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

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Lavender oil and especially linalool could be a potential agent for improving cognitive impairment in Alzheimer's disease.Dec 31, 2016

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Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:7426538. Epub 2017 Apr 26. PMID: 28529531

Article Published Date : Dec 31, 2016

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Pubmed Data : Aging (Albany NY). 2018 Aug 16. Epub 2018 Aug 16. PMID: 30115814

Article Published Date : Aug 15, 2018

Study Type : Animal Study

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Substances : Lycopene

Diseases : Aging, Oxidative Stress

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

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Lycopene exerts protective effects against Atrazine induced toxicity in rat adrenal cortex.Apr 21, 2016

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Pubmed Data : Environ Sci Pollut Res Int. 2016 Apr 22. Epub 2016 Apr 22. PMID: 27102619

Article Published Date : Apr 21, 2016

Study Type : Animal Study

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Diseases : Pesticide Toxicity

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation

Problem Substances : Pesticides

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Pubmed Data : Drug Des Devel Ther. 2019 ;13:2811-2824. Epub 2019 Aug 13. PMID: 31496657

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Piceatannol

Diseases : Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

Problem Substances : Cadmium

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Piper Nigrum extract improves OVA-induced nasal epithelial barrier dysfunction via activating Nrf2/HO-1 signaling.Dec 29, 2019

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Pubmed Data : Cell Immunol. 2019 Dec 30:104035. Epub 2019 Dec 30. PMID: 32051090

Article Published Date : Dec 29, 2019

Study Type : Animal Study

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Substances : Black Pepper

Diseases : Allergic Rhinitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

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Pubmed Data : Nutr Res Pract. 2016 Dec ;10(6):623-628. Epub 2016 Sep 9. PMID: 27909560

Article Published Date : Nov 30, 2016

Study Type : Animal Study

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Substances : Quercetin

Diseases : Fatty Liver, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Hepatoprotective, NF-E2-Related Factor-2 (Nrf2) Modulator

[+]

Quercetin may be useful in protecting against obesity-induced hepatosteatosis.Dec 31, 2014

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Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:9529676. Epub 2019 Jan 6. PMID: 30723535

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Pubmed Data : Curr Eye Res. 2018 Sep ;43(9):1177-1189. Epub 2018 Jul 20. PMID: 30028214

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Diabetes Mellitus: Type 2, Diabetic Complications

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation

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Study on the mechanism of curcumin regulating lung injury induced by outdoor fine particulate matter.Dec 31, 2018

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Pubmed Data : Vopr Pitan. 2017 ;86(2):14-22. Epub 2017 Feb 27. PMID: 30645874

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Quercetin

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

Additional Keywords : Natural Substance Synergy

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The polysaccharide from Inonotus obliquus protects mice from Toxoplasma gondii-induced liver injury.Mar 14, 2019

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8284107. Epub 2018 Sep 23. PMID: 30344887

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Dandelion

Diseases : Alcohol Toxicity , Liver Damage

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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These results showed that grape seed polyphenols could attenuate cadmium induced prostatic deficits.Jun 30, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Jul ;91:707-713. Epub 2017 May 9. PMID: 28499242

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Pubmed Data : Int J Mol Sci. 2017 Jul 27 ;18(8). Epub 2017 Jul 27. PMID: 28749412

Article Published Date : Jul 26, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Andrographolide

Diseases : Stroke

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation

Additional Keywords : Andrographolide, Anti-Inflammatory Agents, Antioxidants, stroke

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This study demonstrates that tanshinone IIA alleviates neuropathic pain.Jul 31, 2018

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Pubmed Data : J Med Food. 2015 Apr ;18(4):439-45. Epub 2015 Jan 13. PMID: 25584924

Article Published Date : Mar 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Garlic: Aged

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor

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Alleviated oxidative damage by Taraxacum officinale.Jul 17, 2019

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Pubmed Data : Psychopharmacology (Berl). 2018 Nov 14. Epub 2018 Nov 14. PMID: 30426184

Article Published Date : Nov 13, 2018

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

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Anthocyanins from Hibiscus syriacus L. inhibit oxidative stress-mediated apoptosis by activating the Nrf2/HO-1 signalling pathway.Jan 02, 2020

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Pubmed Data : J Biomed Biotechnol. 2012 ;2012:782642. Epub 2012 Feb 27. PMID: 22570534

Article Published Date : Dec 31, 2011

Study Type : In Vitro Study

Additional Links

Substances : Camel Milk

Diseases : Cancers: All, Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Chemopreventive, Heme oxygenase-1 up-regulation, MicroRNA modulator

Additional Keywords : Gene Expression Regulation

Problem Substances : Polycyclic aromatic hydrocarbon

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Chlorogenic acid promoted the Nrf2/HO-1 anti-oxidative pathway by activating p21 to prevent Dex-induced mitochondrial apoptosis in osteoblastic cells.Apr 16, 2019

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Pubmed Data : Clin Exp Pharmacol Physiol. 2015 May ;42(5):520-9. PMID: 25739561

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Asthma, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation

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Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway.Dec 31, 2018

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Pubmed Data : PLoS One. 2019 ;14(5):e0216711. Epub 2019 May 21. PMID: 31112588

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Immunomodulatory, Nrf2 activation, Superoxide Dismutase Up-regulation

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Curcumin inhibits appoptosin induced apoptosis in SH-SY5Y cells by upregulating the expression of HO-1.Apr 30, 2015

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Pubmed Data : Acta Pharmacol Sin. 2015 May ;36(5):544-52. Epub 2015 Apr 20. PMID: 25891083

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Apoptotic, Heme oxygenase-1 up-regulation

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Diosmetin alleviates lipopolysaccharide-induced acute lung injury. Feb 28, 2018

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:1128-1134. Epub 2018 Aug 27. PMID: 30257325

Article Published Date : Oct 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Eriodictyol

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation

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Eriodictyol protects endothelial cells against oxidative stress-induced cell death.Jun 25, 2015

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Pubmed Data : Int J Mol Sci. 2015 Jun 26 ;16(7):14526-39. Epub 2015 Jun 26. PMID: 26132561

Article Published Date : Jun 25, 2015

Study Type : In Vitro Study

Additional Links

Substances : Eriodictyol

Diseases : Cardiovascular Diseases, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation

[+]

Ferulic acid protects against lead acetate-induced inhibition of neurite outgrowth.Nov 25, 2015

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Pubmed Data : Mol Neurobiol. 2015 Nov 26. Epub 2015 Nov 26. PMID: 26611834

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Pubmed Data : Antioxidants (Basel). 2019 Sep 26 ;8(10). Epub 2019 Sep 26. PMID: 31561418

H. erinaceus may be considered as a potent antiangiogenesis candidate to treat diseases with impaired inflammation and cancer.Dec 31, 2015

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Pubmed Data : Neurotox Res. 2019 May 10. Epub 2019 May 10. PMID: 31076999

Article Published Date : May 09, 2019

Study Type : In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Hydrogen Peroxide Induced Toxicity

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation

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Nelumbo nucifera leaves protect against hydrogen peroxide-induced hepatic damage.May 31, 2015

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Pubmed Data : Food Funct. 2015 Jun ;6(6):1911-8. PMID: 25962859

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Jun 14. Epub 2019 Jun 14. PMID: 31197431

Article Published Date : Jun 13, 2019

Study Type : In Vitro Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation

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Poria cocos polysaccharides may be a promising candidate for the therapy of atherosclerosis.Jan 12, 2020

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Pubmed Data : Int Immunopharmacol. 2020 Jan 13 ;80:106173. Epub 2020 Jan 13. PMID: 31945610

Article Published Date : Jan 12, 2020

Study Type : In Vitro Study

Additional Links

Substances : Poria cocos

Diseases : Atherosclerosis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

Additional Keywords : Polysaccharides

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Pretreatment with curcumin induces Nrf2 and an antioxidant response that may play an important role in the protective effect of this antioxidant against hemin-induced neuronal death.Dec 31, 2012

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Pubmed Data : Toxicol Appl Pharmacol. 2020 Apr 19 ;397:115014. Epub 2020 Apr 19. PMID: 32320792

Article Published Date : Apr 18, 2020

Study Type : In Vitro Study

Additional Links

Substances : Rosemaric Acid

Diseases : Spinal Cord Injuries

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation

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Royal jelly might be a promising functional food to delay inflammatory progress by influencing the microglia function.Dec 31, 2017

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Pubmed Data : Mediators Inflamm. 2018 ;2018:7834381. Epub 2018 Apr 8. PMID: 29849495

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Pubmed Data : Antioxidants (Basel). 2019 Nov 21 ;8(12). Epub 2019 Nov 21. PMID: 31766492

Article Published Date : Nov 20, 2019

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Synergism between luteolin and sulforaphane in anti-inflammation.Sep 11, 2018

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Pubmed Data : Food Funct. 2018 Sep 12. Epub 2018 Sep 12. PMID: 30206627

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Pubmed Data : Iran J Basic Med Sci. 2019 Feb ;22(2):179-186. PMID: 30834084

Article Published Date : Jan 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tangeretin

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Tanshinone IIA suppresses cholesterol accumulation in human macrophages.Jan 31, 2014

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Pubmed Data : Neurobiol Aging. 2016 Feb ;38:1-10. Epub 2015 Oct 23. PMID: 26827637

Article Published Date : Jan 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation

[+]

These data provide the molecular mechanism to understand the cellular antioxidant activity of fisetin.Feb 14, 2019

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Pubmed Data : PLoS One. 2016 ;11(3):e0152236. Epub 2016 Mar 29. PMID: 27023634

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Hepatitis C

Pharmacological Actions : Antiviral Agents, Heme oxygenase-1 up-regulation, MicroRNA modulator

Additional Keywords : Dose Response

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These results suggest a potential therapeutic application of paeoniflorin on vitiligo.Dec 31, 2019

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View the Evidence: 288 Abstracts with Heme oxygenase-1 up-regulation Research

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Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1.Mar 31, 2008

Omega-3 fatty acids decrease oxidative stress and inflammation in macrophages from patients with small abdominal aortic aneurysmSep 09, 2019

Pine bark extract significantly prolonged the lag time of LDL oxidation.Dec 31, 2014

Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression in human endothelial cells.Jan 31, 2016

Carnosic acid attenuates cartilage degeneration in human articular chondrocytes.Jul 04, 2018

Chokeberry extract may protect endothelial progenitor cells against angiotensin II-induced dysfunction.Dec 14, 2015

Punicalagin protects human retinal pigment epithelium cells from ultraviolet radiation-induced oxidative damage.Jun 01, 2020

Sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes.Dec 12, 2016

6-Shogaol can alleviate allergic dermatitis-like skin lesions.Oct 31, 2016

6-Shogaol protects against ischemic acute kidney injury by modulating NFκB and heme oxygenase-1 pathways.Jul 16, 2019

Acetyl-11-keto-β-boswellic acid ameliorates cognitive deficits and reduces amyloid-β levels.Mar 31, 2020

Acteoside reduces HMGB1 release and may be beneficial for the treatment of sepsis.Mar 31, 2013

Allicin has powerful protective effects against ischemia/hypoxia-induced cell apoptosis.Dec 31, 2017

Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-κB pathways in traumatic brain injury.Jan 31, 2019

Alpha-lipoic acid has ameliorative effects on the oxidative stress of a high fat diet. Aug 03, 2016

Ameliorative effect of Ecklonia cava polyphenol extract on renal inflammation.May 16, 2017

Apigenin has good hepatoprotective effects and potential as a promising therapeutic agent for acute liver failure in clinical application.Jan 10, 2019

Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway.Aug 31, 2018

Arctigenin exerts protective effects against myocardial infarction.Feb 28, 2018

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Astaxanthin ameliorates the lipopolysaccharides-induced subfertility.Jun 30, 2019

Astaxanthin from haematococcus pluvialis ameliorates the chemotherapeutic drug doxorubicin induced liver injury. May 13, 2020

Astaxanthin protects ochratoxin -induced lung injury in mice through the Nrf2/NF-κB pathway.Sep 16, 2019

Astragaloside IV attenuates myocardial ischemia-reperfusion injury.Dec 31, 2018

Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy.Dec 31, 2018

Atractylodes macrocephala or Taraxacum herba extracts can be considered natural agents that can prevent inflammatory bowel disease relapse.Sep 14, 2017

Attenuation of inflammatory pain by puerarin.Jul 31, 2018

Bacopa monniera extract mitigates isoproterenol-induced cardiac stress.Nov 21, 2019

Berberine can ameliorate tubulointerstitial fibrosis in diabetic nephropathy.Dec 31, 2015

Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity.Jul 26, 2019

Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury.Aug 31, 2016

Caffeic acid phenethyl ester could be considered as a promising neuroprotective agent against progressive neurodegenerative diseases.Jul 31, 2018

Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice.Dec 31, 2017

Cardio protective role of wogonin loaded nanoparticle against isoproterenol induced myocardial infarction.Nov 09, 2019

Carnosic acid attenuates cadmium induced nephrotoxicity.Nov 17, 2019

Cinnamaldehyde ameliorates high-glucose-induced oxidative stress and cardiomyocyte injury.Jun 30, 2019

Cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress.Dec 31, 2016

Coenzyme Q10 has a coloprotective effect against experimentally induced ulcerative colitis.Jan 02, 2017

Crocetin alleviates myocardial ischemia/reperfusion injury.Jan 31, 2020

Crocetin was an effective agent in attenuating the adjuvant-induced arthritis rats in a concentration-dependent manner.Dec 31, 2017

Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis.Aug 25, 2019

Crocin has a role in attenuation of induced ulcerative colitis in rats.Jan 31, 2019

Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity through heme oxygenase-1 induction.May 31, 2014

Curcumin administration can limit the poisonous impacts of deltamethrin.Sep 30, 2019

Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production.Dec 31, 2017

Curcumin exerts a protective effect on doxorubicin-induced nephrotic syndrome.Dec 23, 2019

Curcumin pretreatment is a promising adjuvant strategy for stem cells transplantation in myocardial restoration. Dec 31, 2014

Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity.Jan 31, 2020

Dibenzoylmethane protects against carbon tetrachloride induced acute liver injury.Oct 31, 2017

Dietary puerarin supplementation alleviates oxidative stress in the small intestines.Apr 06, 2020

Diosmetin protects against ischemia/reperfusion-induced acute kidney injury.Jan 14, 2017

Ecklonia cava ethanol extract has potential therapeutic effects for the alleviation of periodontal disease.May 21, 2019

Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.Nov 30, 2019

EGCG could be useful for the prevention and treatment of rheumatoid arthritis and other inflammatory disorders.Dec 31, 2014

EGCG decreased the arthritis index and showed protective effects against joint destruction in collagen-induced arthritis mice.Mar 07, 2016

EGCG has an antiarthritic effect by regulating the oxidative-antioxidant balance and cytokine levels.Nov 18, 2019

Electroacupuncture attenuates limb ischemia-reperfusion-induced lung injury.Dec 31, 2019

Electroacupuncture improves locomotor function by regulating expression of inflammation and oxidative stress-related proteins in mice with spinal cord injury.Nov 24, 2019

Electroacupuncture intervention may increase testosterone level of the aged rats.Aug 24, 2019

Evaluation of the protective effect of olive leaf extract on cisplatin-induced testicular damage.Dec 31, 2017

Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats.Dec 30, 2019

Ferulic acid protects against methotrexate nephrotoxicity.Jul 31, 2019

Formononetin could improve the cognitive function by inhibiting neuroinflammation.Aug 06, 2019

Fucoidan inhibits lipopolysaccharide-induced acute lung injury.May 31, 2020

Fucoxanthin could be a novel adjuvant for preventing exacerbations associated with skin inflammation as well as protecting skin against UV radiation.Oct 09, 2018

Fucoxanthin could be exploited as a therapeutic target for protecting neurons from cerebral ischemic/reperfusion injury.Sep 30, 2018

Gastrodin alleviates Tourette syndrome via Nrf-2/HO-1/HMGB1/NF-кB pathway.Aug 29, 2019

Gastrodin could be of importance for the treatment of Parkinson's disease.Aug 31, 2014

Genipin attenuates dextran sulfate sodium-induced colitis via suppressing inflammatory and oxidative responses.Oct 22, 2019

Genipin inhibited LPS-induced inflammatory response by activating Nrf2 signalling pathway in BV2 microglia.Sep 30, 2017

Genistein exerted antioxidant effects on myocardial injury in diabetic rats.Aug 27, 2019

Ginger extract ameliorates bisphenol A induced disruption in thyroid hormones synthesis and metabolism.Nov 02, 2019

Heme oxygenase-1 up-regulation

View the Evidence:
288 Abstracts with Heme oxygenase-1 up-regulation Research