Heme oxygenase-1 up-regulation

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30 Substances Researched for Heme oxygenase-1 up-regulation
NameACCKFocus
Pine Bark Extract110Locked
Curcumin58Locked
Garlic: Aged26Locked
Chokeberry15Locked
EGCG (Epigallocatechin gallate)35Locked
Quercetin24Locked
Heme oxygenase-123Locked
Alpha-Lipoic Acid12Locked
Berberine12Locked
Green Tea12Locked
Melatonin22Locked
Nigella sativa (aka Black Seed)12Locked
Olive Oil12Locked
Propolis: Bee12Locked
Pterostilbene12Locked
Sulforaphane22Locked
Vitamin C12Locked
6-Shogaol11Locked
Avenanthramides11Locked
Camel Milk 11Locked
Ferulic acid11Locked
Ginkgo biloba11Locked
Horseradish11Locked
Lotus 11Locked
Luteolin11Locked
Moringa oleifera11Locked
Oats11Locked
Phellinus Linteus11Locked
Prunella vulgaris.11Locked
Pycnogenol (Pine Bark)11Locked

View the Evidence:
314 Abstracts with Heme oxygenase-1 up-regulation Research

[+]

Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1.Mar 31, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arterioscler Thromb Vasc Biol. 2008 Apr ;28(4):739-45. Epub 2008 Jan 17. PMID: 18202320
Article Published Date : Mar 31, 2008
Study Type : Human Study
Additional Links
Diseases : Endothelial Dysfunction, Hemodialysis, Inflammation
Therapeutic Actions : Thermal Therapy: Far-Infrared
Pharmacological Actions : Heme oxygenase-1 up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Omega-3 fatty acids decrease oxidative stress and inflammation in macrophages from patients with small abdominal aortic aneurysmSep 09, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Sep 10 ;9(1):12978. Epub 2019 Sep 10. PMID: 31506475
Article Published Date : Sep 09, 2019
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Aneurysm: Aortic
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pine bark extract significantly prolonged the lag time of LDL oxidation.Dec 31, 2014

Pubmed Data : Nutr Res. 2015 Jan ;35(1):56-64. Epub 2014 Oct 20. PMID: 25458248
Article Published Date : Dec 31, 2014
Study Type : Human Study, In Vitro Study
Additional Links
Substances : Pine Bark Extract
Diseases : Atherosclerosis, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation
Additional Keywords : Plant Extracts
[+]

Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression in human endothelial cells.Jan 31, 2016

Pubmed Data : Nutr Res. 2016 Feb ;36(2):143-9. Epub 2015 Oct 24. PMID: 26507778
Article Published Date : Jan 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Garlic: Aged
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Carnosic acid attenuates cartilage degeneration in human articular chondrocytes.Jul 04, 2018

Pubmed Data : Eur J Pharmacol. 2018 Jul 5 ;830:1-8. Epub 2018 Apr 17. PMID: 29678719
Article Published Date : Jul 04, 2018
Study Type : Human In Vitro
Additional Links
Substances : Carnosic Acid
Diseases : Osteoarthritis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Osteoprotective
[+]

Chokeberry extract may protect endothelial progenitor cells against angiotensin II-induced dysfunction.Dec 14, 2015

Pubmed Data : Phytomedicine. 2015 Dec 15 ;22(14):1238-46. Epub 2015 Nov 10. PMID: 26655406
Article Published Date : Dec 14, 2015
Study Type : Human In Vitro
Additional Links
Substances : Chokeberry
Diseases : Coronary Artery Disease, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Punicalagin protects human retinal pigment epithelium cells from ultraviolet radiation-induced oxidative damage.Jun 01, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Jun 2 ;9(6). Epub 2020 Jun 2. PMID: 32498245
Article Published Date : Jun 01, 2020
Study Type : Human In Vitro
Additional Links
Substances : Punicalagin
Diseases : Eye Damage, Photooxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes.Dec 12, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Dec 13 ;7(50):83720-83726. PMID: 27863411
Article Published Date : Dec 12, 2016
Study Type : Human In Vitro
Additional Links
Substances : Sesamin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Nrf2 activation, Postaglandin PGE2 downregulation
[+]

Myricetin ameliorates sepsis-associated acute lung injury in a murine sepsis model.May 26, 2020

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 May 27. Epub 2020 May 27. PMID: 32458011
Article Published Date : May 26, 2020
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Lung Injury: Acute, Sepsis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

6-Shogaol can alleviate allergic dermatitis-like skin lesions.Oct 31, 2016

Pubmed Data : Toxicol Appl Pharmacol. 2016 Nov 1 ;310:51-59. Epub 2016 Aug 22. PMID: 27562088
Article Published Date : Oct 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Dermatitis
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Heme oxygenase-1 up-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

6-Shogaol protects against ischemic acute kidney injury by modulating NFκB and heme oxygenase-1 pathways.Jul 16, 2019

Pubmed Data : Am J Physiol Renal Physiol. 2019 Jul 17. Epub 2019 Jul 17. PMID: 31313953
Article Published Date : Jul 16, 2019
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Renoprotective
[+]

Acetyl-11-keto-β-boswellic acid ameliorates cognitive deficits and reduces amyloid-β levels.Mar 31, 2020

Pubmed Data : Free Radic Biol Med. 2020 Apr ;150:96-108. Epub 2020 Feb 25. PMID: 32109514
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Acteoside reduces HMGB1 release and may be beneficial for the treatment of sepsis.Mar 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cells. 2013 Apr ;35(4):348-54. Epub 2013 Apr 4. PMID: 23563799
Article Published Date : Mar 31, 2013
Study Type : Animal Study
Additional Links
Substances : Verbascoside
Diseases : Sepsis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nitric Oxide Inhibitor, Nrf2 activation
[+]

Allicin has powerful protective effects against ischemia/hypoxia-induced cell apoptosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:3207973. Epub 2018 Apr 16. PMID: 29849702
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Allicin
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Superoxide Dismutase Up-regulation
[+]

Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-κB pathways in traumatic brain injury.Jan 31, 2019

Pubmed Data : Mol Biol Rep. 2019 Feb ;46(1):241-250. Epub 2018 Nov 8. PMID: 30406889
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Brain: Oxidative Stress, Inflammation, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

Alpha-lipoic acid has ameliorative effects on the oxidative stress of a high fat diet. Aug 03, 2016

Pubmed Data : Free Radic Res. 2016 Aug 4:1-10. Epub 2016 Aug 4. PMID: 27383289
Article Published Date : Aug 03, 2016
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : High Fat Diet, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, NF-E2-Related Factor-2 (Nrf2) Modulator
[+]

Ameliorative effect of Ecklonia cava polyphenol extract on renal inflammation.May 16, 2017

Pubmed Data : J Agric Food Chem. 2017 May 17 ;65(19):3811-3818. Epub 2017 May 5. PMID: 28459555
Article Published Date : May 16, 2017
Study Type : Animal Study
Additional Links
Substances : Polyphenols, Seaweed: Brown
Diseases : Kidney Damage, Obesity, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Anti-allergic rhinitis activity of α-lipoic acid via balancing Th17/Treg expression and enhancing Nrf2/HO-1 pathway signaling.Jul 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 Jul 27 ;10(1):12528. Epub 2020 Jul 27. PMID: 32719431
Article Published Date : Jul 26, 2020
Study Type : Animal Study
Additional Links
Diseases : Allergic Rhinitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Immunomodulatory: Th17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Apigenin has good hepatoprotective effects and potential as a promising therapeutic agent for acute liver failure in clinical application.Jan 10, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jan 11 ;68:171-178. Epub 2019 Jan 11. PMID: 30641432
Article Published Date : Jan 10, 2019
Study Type : Animal Study
Additional Links
Substances : Apigenin, Chrysin, Luteolin
Diseases : Liver Failure: Acute
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Malondialdehyde Down-regulation, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway.Aug 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Sep ;105:1283-1290. Epub 2018 Jun 22. PMID: 30021365
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : High Fructose Diet, Insulin Resistance, Metabolic Syndrome X
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Arctigenin exerts protective effects against myocardial infarction.Feb 28, 2018

Pubmed Data : Mol Med Rep. 2018 Mar ;17(3):4839-4845. Epub 2018 Jan 10. PMID: 29328478
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Arctigenin
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation
Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Arctigenin, Myocardial Infarction
[+]

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jun 26 ;74:105712. Epub 2019 Jun 26. PMID: 31254954
Article Published Date : Jun 25, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astaxanthin ameliorates the lipopolysaccharides-induced subfertility.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dose Response. 2019 Jul-Sep;17(3):1559325819878537. Epub 2019 Sep 25. PMID: 31598118
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Infertility: Male, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antioxidants, Fertility Agents: Male, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astaxanthin from haematococcus pluvialis ameliorates the chemotherapeutic drug doxorubicin induced liver injury. May 13, 2020

Pubmed Data : Food Funct. 2020 May 14. Epub 2020 May 14. PMID: 32405635
Article Published Date : May 13, 2020
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Astaxanthin protects ochratoxin -induced lung injury in mice through the Nrf2/NF-κB pathway.Sep 16, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxins (Basel). 2019 Sep 17 ;11(9). Epub 2019 Sep 17. PMID: 31533259
Article Published Date : Sep 16, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Lung Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Astragaloside IV ameliorates preeclampsia-induced oxidative stress.Sep 13, 2020

Pubmed Data : Am J Physiol Endocrinol Metab. 2020 Sep 14. Epub 2020 Sep 14. PMID: 32924527
Article Published Date : Sep 13, 2020
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Oxidative Stress, Pre-Eclampsia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astragaloside IV attenuates myocardial ischemia-reperfusion injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:9137654. Epub 2019 Jun 24. PMID: 31341538
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:4625912. Epub 2019 Jun 11. PMID: 31285785
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Atractylodes macrocephala or Taraxacum herba extracts can be considered natural agents that can prevent inflammatory bowel disease relapse.Sep 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gut Liver. 2017 Sep 15 ;11(5):655-666. PMID: 28651306
Article Published Date : Sep 14, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bai Zhu, Dandelion
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts, Risk Reduction, Superiority of Natural Substances versus Drugs
[+]

Attenuation of inflammatory pain by puerarin.Jul 31, 2018

Pubmed Data : Int Immunopharmacol. 2018 Aug ;61:306-316. Epub 2018 Jun 15. PMID: 29909234
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Bacopa monniera extract mitigates isoproterenol-induced cardiac stress.Nov 21, 2019

Pubmed Data : Arch Physiol Biochem. 2019 Nov 22:1-11. Epub 2019 Nov 22. PMID: 31755309
Article Published Date : Nov 21, 2019
Study Type : Animal Study
Additional Links
Substances : Bacopa
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Isoproterenol
[+]

Berberine can ameliorate tubulointerstitial fibrosis in diabetic nephropathy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 ;17(8). Epub 2016 Aug 12. PMID: 27529235
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetes Mellitus: Type 1, Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity.Jul 26, 2019

Pubmed Data : Inflammopharmacology. 2019 Jul 27. Epub 2019 Jul 27. PMID: 31352642
Article Published Date : Jul 26, 2019
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Sepsis
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation, Vasodilator Agents
[+]

Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury.Aug 31, 2016

Pubmed Data : Int Immunopharmacol. 2016 Sep ;38:324-31. Epub 2016 Jun 23. PMID: 27344638
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Caffeic acid phenethyl ester could be considered as a promising neuroprotective agent against progressive neurodegenerative diseases.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Dis. 2018 Aug ;9(4):605-622. Epub 2018 Aug 1. PMID: 30090650
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Physiol Pharmacol. 2018 Jan ;22(1):101-110. Epub 2017 Dec 22. PMID: 29302217
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-10 upregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Caffeic acid phenethyl ester, Heme oxygenase-1 up-regulation, Ischemia
[+]

Cardio protective role of wogonin loaded nanoparticle against isoproterenol induced myocardial infarction.Nov 09, 2019

Pubmed Data : Colloids Surf B Biointerfaces. 2019 Nov 10:110635. Epub 2019 Nov 10. PMID: 31744760
Article Published Date : Nov 09, 2019
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Carnosic acid attenuates cadmium induced nephrotoxicity.Nov 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Nov 18 ;24(22). Epub 2019 Nov 18. PMID: 31752142
Article Published Date : Nov 17, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
Problem Substances : Cadmium
[+]

Centella asiatica extract prevents visual impairment by promoting the production of rhodopsin in the retina.May 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2020 Jun ;14(3):203-217. Epub 2020 Jan 28. PMID: 32528628
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Gotu Kola
Diseases : Eye Diseases, Glaucoma, Macular Degeneration
Pharmacological Actions : Antioxidants, Cytoprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Cinnamaldehyde ameliorates high-glucose-induced oxidative stress and cardiomyocyte injury.Jun 30, 2019

Pubmed Data : J Cardiovasc Pharmacol. 2019 Jul ;74(1):30-37. PMID: 31274840
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Cinnamaldehyde
Diseases : Cardiomyopathy, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:1583098. Epub 2017 Mar 15. PMID: 28396714
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Cinnamon
Diseases : High Fat Diet, Hyperlipidemia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hypolipidemic, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Coenzyme Q10 attenuated placental inflammatory and oxidative stress, thereby protecting against preeclampsia.Jul 21, 2020

Pubmed Data : Microcirculation. 2020 Jul 22:e12651. Epub 2020 Jul 22. PMID: 32697403
Article Published Date : Jul 21, 2020
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Pre-Eclampsia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Risk Reduction
[+]

Coenzyme Q10 has a coloprotective effect against experimentally induced ulcerative colitis.Jan 02, 2017

Pubmed Data : Inflammopharmacology. 2017 Jan 3. Epub 2017 Jan 3. PMID: 28050757
Article Published Date : Jan 02, 2017
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Glutathione Upregulation , Heme oxygenase-1 up-regulation, Malondialdehyde Down-regulation, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Crocetin alleviates myocardial ischemia/reperfusion injury.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Feb ;21(2):641-648. Epub 2019 Dec 17. PMID: 31974615
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Crocetin was an effective agent in attenuating the adjuvant-induced arthritis rats in a concentration-dependent manner.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1341. Epub 2018 Dec 12. PMID: 30618728
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation
Additional Keywords : Dose Response
[+]

Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis.Aug 25, 2019

Pubmed Data : Life Sci. 2019 Aug 26:116794. Epub 2019 Aug 26. PMID: 31465731
Article Published Date : Aug 25, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin has a role in attenuation of induced ulcerative colitis in rats.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Feb ;110:389-399. Epub 2018 Dec 5. PMID: 30530041
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Ulcerative Colitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation
[+]

Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity through heme oxygenase-1 induction.May 31, 2014

Pubmed Data : Otol Neurotol. 2014 Jun ;35(5):e169-77. PMID: 24608370
Article Published Date : May 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin, Heme oxygenase-1
Diseases : Ebola Virus Infections
Pharmacological Actions : Heme oxygenase-1 inducer, Heme oxygenase-1 up-regulation
[+]

Curcumin administration can limit the poisonous impacts of deltamethrin.Sep 30, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Oct ;33(10):e22386. Epub 2019 Aug 27. PMID: 31454128
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Pyrethroid Insecticide Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
Problem Substances : Deltamethrin
[+]

Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production.Dec 31, 2017

Pubmed Data : Clin Exp Pharmacol Physiol. 2018 Jan ;45(1):84-93. Epub 2017 Oct 3. PMID: 28853207
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Influenza A, Pneumonia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor
[+]

Curcumin exerts a protective effect on doxorubicin-induced nephrotic syndrome.Dec 23, 2019

Pubmed Data : J Ethnopharmacol. 2019 Dec 24 ;250:112502. Epub 2019 Dec 24. PMID: 31881321
Article Published Date : Dec 23, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Curcumin pretreatment is a promising adjuvant strategy for stem cells transplantation in myocardial restoration. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Stem Cells Int. 2015 ;2015:638153. Epub 2015 May 5. PMID: 26074974
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Ischemia: Myocardial, Oxidative Stress
Pharmacological Actions : Angiogenesis Inducing Agents, Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation
Additional Keywords : Mesenchymal Stem Cells
[+]

Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity.Jan 31, 2020

Pubmed Data : Chin J Nat Med. 2020 Feb ;18(2):103-113. PMID: 32172946
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Dandelion , Polyphenols
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Dibenzoylmethane protects against carbon tetrachloride induced acute liver injury.Oct 31, 2017

Pubmed Data : AAPS J. 2017 Nov ;19(6):1703-1714. Epub 2017 Aug 21. PMID: 28828752
Article Published Date : Oct 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Dibenzoylmethane (DBM)
Diseases : Chemically-Induced Liver Damage, Liver Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Dietary hydrolyzed jujube extract can reduce benzo(a)pyrene-induced lung inflammation.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2020 Aug 1 ;9(8). Epub 2020 Aug 1. PMID: 32752184
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cytoprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Plant Extracts
Problem Substances : Benzo(a)pyrene
[+]

Dietary puerarin supplementation alleviates oxidative stress in the small intestines.Apr 06, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Animals (Basel). 2020 Apr 7 ;10(4). Epub 2020 Apr 7. PMID: 32272553
Article Published Date : Apr 06, 2020
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Diosmetin protects against ischemia/reperfusion-induced acute kidney injury.Jan 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Surg Res. 2017 06 15 ;214:69-78. Epub 2017 Mar 6. PMID: 28624062
Article Published Date : Jan 14, 2017
Study Type : Animal Study
Additional Links
Substances : Diosmetin
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Ecklonia cava ethanol extract has potential therapeutic effects for the alleviation of periodontal disease.May 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 May 22 ;11(5). Epub 2019 May 22. PMID: 31121899
Article Published Date : May 21, 2019
Study Type : Animal Study
Additional Links
Substances : Phlorotannins, Seaweed: Brown
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.Nov 30, 2019

Pubmed Data : J Bioenerg Biomembr. 2019 Dec ;51(6):393-402. Epub 2019 Nov 25. PMID: 31768722
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

EGCG could be useful for the prevention and treatment of rheumatoid arthritis and other inflammatory disorders.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm (Lond). 2015 ;12:53. Epub 2015 Sep 15. PMID: 26379475
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Green Tea
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Immunomodulatory, NF-E2-Related Factor-2 (Nrf2) Modulator
[+]

EGCG decreased the arthritis index and showed protective effects against joint destruction in collagen-induced arthritis mice.Mar 07, 2016

Pubmed Data : J Leukoc Biol. 2016 Mar 8. Epub 2016 Mar 8. PMID: 26957211
Article Published Date : Mar 07, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Heme oxygenase-1 up-regulation, Immunomodulatory: Th17 downregulation, NF-E2-Related Factor-2 (Nrf2) Modulator, STAT3 Inhibitor
[+]

EGCG has an antiarthritic effect by regulating the oxidative-antioxidant balance and cytokine levels.Nov 18, 2019

Pubmed Data : Biotechnol Appl Biochem. 2019 Nov 19. Epub 2019 Nov 19. PMID: 31746064
Article Published Date : Nov 18, 2019
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Immunomodulatory: Th17 downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Electroacupuncture attenuates limb ischemia-reperfusion-induced lung injury.Dec 31, 2019

Pubmed Data : J Surg Res. 2020 02 ;246:170-181. Epub 2019 Oct 4. PMID: 31590030
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Liver Injury: Ischemia/reperfusion
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Electroacupuncture improves locomotor function by regulating expression of inflammation and oxidative stress-related proteins in mice with spinal cord injury.Nov 24, 2019

Pubmed Data : Zhen Ci Yan Jiu. 2019 Nov 25 ;44(11):781-6. PMID: 31777225
Article Published Date : Nov 24, 2019
Study Type : Animal Study
Additional Links
Diseases : Inflammation, Oxidative Stress, Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Electroacupuncture intervention may increase testosterone level of the aged rats.Aug 24, 2019

Pubmed Data : Zhen Ci Yan Jiu. 2019 Aug 25 ;44(8):566-70. PMID: 31475489
Article Published Date : Aug 24, 2019
Study Type : Animal Study
Additional Links
Diseases : Aging, Testosterone: Too Low
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Emodin protects against acute pancreatitis-associated lung injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2020 ;14:1971-1982. Epub 2020 May 21. PMID: 32546964
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Lung Injury: Acute, Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Evaluation of the protective effect of olive leaf extract on cisplatin-induced testicular damage.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8487248. Epub 2018 Apr 26. PMID: 30013722
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats.Dec 30, 2019

Pubmed Data : Environ Sci Pollut Res Int. 2019 Dec 31. Epub 2019 Dec 31. PMID: 31889292
Article Published Date : Dec 30, 2019
Study Type : Animal Study
Additional Links
Substances : Ferulic acid
Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Methotrexate
[+]

Ferulic acid protects against methotrexate nephrotoxicity.Jul 31, 2019

Pubmed Data : Food Funct. 2019 Aug 1 ;10(8):4593-4607. Epub 2019 Jul 10. PMID: 31289794
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Ferulic acid
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Formononetin could improve the cognitive function by inhibiting neuroinflammation.Aug 06, 2019

Pubmed Data : CNS Neurol Disord Drug Targets. 2019 Aug 7. Epub 2019 Aug 7. PMID: 31389320
Article Published Date : Aug 06, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Alzheimer's Disease, Brain Inflammation , High Fat Diet
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fucoidan inhibits lipopolysaccharide-induced acute lung injury.May 31, 2020

Pubmed Data : Arch Pharm Res. 2020 Jun ;43(6):646-654. Epub 2020 Jun 13. PMID: 32533502
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fucoxanthin could be a novel adjuvant for preventing exacerbations associated with skin inflammation as well as protecting skin against UV radiation.Oct 09, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2018 Oct 10 ;16(10). Epub 2018 Oct 10. PMID: 30308980
Article Published Date : Oct 09, 2018
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Erythema, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation, Photoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fucoxanthin could be exploited as a therapeutic target for protecting neurons from cerebral ischemic/reperfusion injury.Sep 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 Oct ;106:1484-1489. Epub 2018 Jul 24. PMID: 30119223
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Cerebral Ischemia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Gastrodin alleviates Tourette syndrome via Nrf-2/HO-1/HMGB1/NF-кB pathway.Aug 29, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Aug 30:e22389. Epub 2019 Aug 30. PMID: 31468582
Article Published Date : Aug 29, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Tourette Syndrome
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Gastrodin could be of importance for the treatment of Parkinson's disease.Aug 31, 2014

Pubmed Data : Neurochem Int. 2014 Sep ;75:79-88. Epub 2014 Jun 14. PMID: 24932697
Article Published Date : Aug 31, 2014
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Genipin attenuates dextran sulfate sodium-induced colitis via suppressing inflammatory and oxidative responses.Oct 22, 2019

Pubmed Data : Inflammopharmacology. 2019 Oct 23. Epub 2019 Oct 23. PMID: 31646411
Article Published Date : Oct 22, 2019
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Genipin inhibited LPS-induced inflammatory response by activating Nrf2 signalling pathway in BV2 microglia.Sep 30, 2017

Pubmed Data : Neurochem Res. 2017 Oct ;42(10):2769-2776. Epub 2017 May 11. PMID: 28497344
Article Published Date : Sep 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Nrf2 activation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Genistein exerted antioxidant effects on myocardial injury in diabetic rats.Aug 27, 2019

Pubmed Data : Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019 Aug 28 ;44(8):850-856. PMID: 31570670
Article Published Date : Aug 27, 2019
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Diabetic Complications
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Geraniol protects against oxidative stress-induced apoptosis in hepatic ischemia-reperfusion injury.Sep 30, 2020

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 Oct ;393(10):1849-1858. Epub 2020 May 16. PMID: 32417955
Article Published Date : Sep 30, 2020
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginger extract ameliorates bisphenol A induced disruption in thyroid hormones synthesis and metabolism.Nov 02, 2019

Pubmed Data : Sci Total Environ. 2019 Nov 3:134664. Epub 2019 Nov 3. PMID: 31757552
Article Published Date : Nov 02, 2019
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Bisphenol Toxicity
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Bisphenol A
[+]

Ginsenoside Rb1 has beneficial effects on oxidative stress injury in rat spinal cords.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Aug ;16(2):1079-1086. Epub 2018 Jun 12. PMID: 30116359
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetes Metab Syndr Obes. 2019 ;12:1091-1103. Epub 2019 Jul 10. PMID: 31372019
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2, Diabetic Complications
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ginsenoside Rg1 may be a promising agent for prevention against acute liver injury.Jun 10, 2018

Pubmed Data : Int Immunopharmacol. 2018 Jun 11 ;61:266-276. Epub 2018 Jun 11. PMID: 29902710
Article Published Date : Jun 10, 2018
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetes. Jan 04, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Pharmacol. 2020 Jan 5 ;866:172801. Epub 2019 Nov 16. PMID: 31738935
Article Published Date : Jan 04, 2020
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Nrf2 activation
[+]

Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis-induced atherosclerosis.Jan 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pathog Dis. 2013 Feb ;67(1):76-83. Epub 2012 Nov 15. PMID: 23620122
Article Published Date : Jan 31, 2013
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Atherosclerosis, Porphyromonas gingivalis
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, MicroRNA modulator
Additional Keywords : Gene Expression Regulation
[+]

Gypenoside attenuates renal ischemia/reperfusion injury in mice.Mar 31, 2016

Pubmed Data : Exp Ther Med. 2016 Apr ;11(4):1499-1505. Epub 2016 Jan 29. PMID: 27073472
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Gynostemma
Diseases : Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Renoprotective
[+]

Hawthorn extract could have protective effects in ovariectomized rats.May 12, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 May 13 ;8(5). Epub 2016 May 13. PMID: 27187458
Article Published Date : May 12, 2016
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Ovariectomy-Induced Changes, Plant Extracts
[+]

Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EXCLI J. 2019 ;18:723-745. Epub 2019 Aug 29. PMID: 31611754
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

High dose of ascorbic acid may be useful in the treatment of sepsis, at least, by activation of Nrf2/HO-1 signals.Jun 14, 2015

Pubmed Data : Biochem Pharmacol. 2015 Jun 15 ;95(4):279-89. Epub 2015 Apr 17. PMID: 25896849
Article Published Date : Jun 14, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
Additional Keywords : Significant Treatment Outcome
[+]

High-dose vitamin C alleviates pancreatic injury.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2020 Jul ;8(14):852. PMID: 32793696
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Pancreatitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Pancreato Protective Agents
[+]

Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway.Jul 31, 2018

Pubmed Data : J Surg Res. 2018 Aug ;228:238-246. Epub 2018 Apr 11. PMID: 29907217
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Hydrogen-rich water protects against inflammatory bowel disease in mice.Feb 27, 2017

Pubmed Data : World J Gastroenterol. 2017 Feb 28 ;23(8):1375-1386. PMID: 28293084
Article Published Date : Feb 27, 2017
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Inflammatory Bowel Diseases, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hydroxytyrosol acetate supplements might provide a basis for developing a new dietary strategy for the prevention of rheumatoid arthritis.Sep 17, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Sep 18. Epub 2015 Sep 18. PMID: 26382723
Article Published Date : Sep 17, 2015
Study Type : Animal Study
Additional Links
Substances : Olive Oil
Diseases : Oxidative Stress, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Hyperbaric oxygen has a neuroprotective role in traumatic brain injury.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genet Mol Res. 2016 ;15(1). Epub 2016 Jan 29. PMID: 26909929
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Anti-Apoptotic, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Increased HO-1 expression, along with suppressed oxidative stress as well as reduced hepatic fat accumulation and fibrotic changes, contribute to the beneficial effects of curcumin.Sep 30, 2014

Pubmed Data : Can J Physiol Pharmacol. 2014 Oct ;92(10):805-12. Epub 2014 Aug 11. PMID: 25211173
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Fatty Liver, High Fat Diet, Metabolic Diseases
Pharmacological Actions : Heme oxygenase-1 up-regulation
[+]

Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2017 ;9(12):5653-5661. Epub 2017 Dec 15. PMID: 29312517
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, MicroRNA modulator, Neuroprotective Agents
[+]

Indole-3-carbinol derivative DIM mitigates carbon tetrachloride-induced acute liver injury.Mar 16, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Mar 17 ;21(6). Epub 2020 Mar 17. PMID: 32192079
Article Published Date : Mar 16, 2020
Study Type : Animal Study
Additional Links
Diseases : Liver Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Indole-3-carbinol enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin.Jun 24, 2018

Pubmed Data : Chem Biol Interact. 2018 Jun 25 ;290:19-36. Epub 2018 May 15. PMID: 29775573
Article Published Date : Jun 24, 2018
Study Type : Animal Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Breast Cancer, Oxidative Stress
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Antioxidants, Apoptotic, Chemosensitizer, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Krill oil might be a new candidate for treatment of iron overload-induced toxicity.Jan 31, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2020 Feb ;27(4):3950-3961. Epub 2019 Dec 10. PMID: 31823254
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Krill
Diseases : Iron Overload, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Lavender oil and especially linalool could be a potential agent for improving cognitive impairment in Alzheimer's disease.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:7426538. Epub 2017 Apr 26. PMID: 28529531
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Lavender, Lavender: Essential Oil
Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Alzheimer's disease, Antioxidants, Cognitive Decline/Dysfunction, lavender, Lavender: Essential Oil
Problem Substances : Aluminum
[+]

Linagliptin and indole-3-carbinol combination might represent a beneficial therapeutic modality for amelioration of polycystic ovarian syndrome.Jul 31, 2017

Pubmed Data : Chem Biol Interact. 2017 Aug 1 ;273:190-199. Epub 2017 Jun 13. PMID: 28619389
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Polycystic Ovary Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-10 downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lonicera caerulea L. polyphenols alleviate oxidative stress-induced intestinal environment imbalance and lipopolysaccharide-induced liver injury.Apr 05, 2020

Pubmed Data : Mol Nutr Food Res. 2020 Apr 6:e1901315. Epub 2020 Apr 6. PMID: 32250024
Article Published Date : Apr 05, 2020
Study Type : Animal Study
Additional Links
Substances : Blue Honeysuckle
Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Low-level laser therapy has an important anti-inflammatory action in acute lung inflammation.Sep 19, 2016

Pubmed Data : J Biophotonics. 2016 Sep 20. Epub 2016 Sep 20. PMID: 27649282
Article Published Date : Sep 19, 2016
Study Type : Animal Study
Additional Links
Diseases : Experimental Lung Inflammation
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation
[+]

Lutein and zeaxanthin isomers may attenuate photo-oxidative retinal damage.Aug 12, 2019

Pubmed Data : Biochem Biophys Res Commun. 2019 Aug 13 ;516(1):163-170. Epub 2019 Jun 13. PMID: 31204054
Article Published Date : Aug 12, 2019
Study Type : Animal Study
Additional Links
Substances : Lutein, Zeaxanthin
Diseases : Eye Damage, Photooxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Luteolin may suppress experimental colitis through the Nrf2 signaling pathway.Aug 24, 2016

Pubmed Data : Int Immunopharmacol. 2016 Aug 25 ;40:24-31. Epub 2016 Aug 25. PMID: 27569028
Article Published Date : Aug 24, 2016
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Luteolin protects against testicular injury induced by lead acetate.May 31, 2020

Pubmed Data : IUBMB Life. 2020 Jun 1. Epub 2020 Jun 1. PMID: 32478470
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Lead Poisoning, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Lead
[+]

Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway.Aug 15, 2018

Pubmed Data : Aging (Albany NY). 2018 Aug 16. Epub 2018 Aug 16. PMID: 30115814
Article Published Date : Aug 15, 2018
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Lycopene exerts protective effects against Atrazine induced toxicity in rat adrenal cortex.Apr 21, 2016

Pubmed Data : Environ Sci Pollut Res Int. 2016 Apr 22. Epub 2016 Apr 22. PMID: 27102619
Article Published Date : Apr 21, 2016
Study Type : Animal Study
Additional Links
Diseases : Pesticide Toxicity
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Problem Substances : Pesticides
[+]

Magnolol might be used as a potential treatment for alcoholic liver damage.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:1459. Epub 2019 Dec 5. PMID: 31920652
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Mangiferin alleviates arsenic induced oxidative lung injury.Feb 11, 2019

Pubmed Data : Food Chem Toxicol. 2019 Feb 12 ;126:41-55. Epub 2019 Feb 12. PMID: 30769048
Article Published Date : Feb 11, 2019
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Arsenic Poisoning
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Arsenic
[+]

Melatonin ameliorated sodium fluoride-induced testicular metabolic stress.Dec 10, 2019

Pubmed Data : Biol Trace Elem Res. 2019 Dec 11. Epub 2019 Dec 11. PMID: 31828722
Article Published Date : Dec 10, 2019
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
Problem Substances : Sodium Fluoride
[+]

Myricetin may be a potential candidate for mitigating motor defects and demyelination.Oct 11, 2016

Pubmed Data : Food Funct. 2016 Oct 12 ;7(10):4332-4342. PMID: 27713953
Article Published Date : Oct 11, 2016
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Demyelinating Diseases
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Myristica fragrans kernels prevent paracetamol-induced hepatotoxicity.Feb 24, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Feb 25 ;20(4). Epub 2019 Feb 25. PMID: 30823534
Article Published Date : Feb 24, 2019
Study Type : Animal Study
Additional Links
Substances : Nutmeg
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Naringenin exerts anti-arthritic effects by downregulating NF-κB and activating the Nrf-2/HO-1 pathway.Sep 30, 2017

Pubmed Data : Pharmacol Rep. 2017 Oct ;69(5):1021-1029. Epub 2017 Apr 13. PMID: 28943290
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Arthritis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Neuroprotective effect of ginsenoside Rb-1 on a rat model of Alzheimer's disease.Aug 17, 2020

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2020 Aug 18 ;100(31):2462-2466. PMID: 32819064
Article Published Date : Aug 17, 2020
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Nigella sativa oil might be beneficial for controlling hypertension.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clinics (Sao Paulo). 2015 Nov ;70(11):751-7. PMID: 26602523
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Heme oxygenase-1 up-regulation
Additional Keywords : Natural Substances Versus Drugs
[+]

Oligonol can be applied during maintenance therapy of inflammatory bowel disease to prevent relapse.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Physiol Pharmacol. 2018 Jun ;69(3). Epub 2018 Aug 22. PMID: 30149369
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Oligonol
Diseases : Inflammatory Bowel Diseases, Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Risk Reduction
[+]

Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage.Apr 02, 2020

Pubmed Data : Metab Brain Dis. 2020 Apr 3. Epub 2020 Apr 3. PMID: 32246322
Article Published Date : Apr 02, 2020
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Subarachnoid hemorrhage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Paeoniflorin improves acute lung injury in sepsis.Aug 31, 2020

Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2020 Sep ;51(5):664-669. PMID: 32975081
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol alleviated acute alcohol-induced liver injury.May 31, 2018

Pubmed Data : Environ Toxicol Pharmacol. 2018 Jun ;60:110-117. Epub 2018 Apr 22. PMID: 29704732
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Alcoholic Liver Disease, Chemically-Induced Liver Damage, Lipid Peroxidation
Pharmacological Actions : Heme oxygenase-1 up-regulation, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation
[+]

Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-κB pathways.Jan 14, 2017

Pubmed Data : Eur J Pharmacol. 2017 Jan 15 ;795:84-93. Epub 2016 Dec 6. PMID: 27940053
Article Published Date : Jan 14, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Epirubicin
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Paeonol pretreatment attenuates cerebral ischemic injury.Sep 30, 2014

Pubmed Data : Brain Res Bull. 2014 Oct ;109:61-7. Epub 2014 Oct 5. PMID: 25286445
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Stroke: Ischemic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Malondialdehyde Down-regulation, Neuroprotective Agents, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Peoniflorin activates Nrf2/ARE pathway to alleviate the Abeta(1-42)-induced hippocampal neuron injuryJul 31, 2013

Pubmed Data : Yao Xue Xue Bao. 2013 Aug ;48(8):1353-7. PMID: 24187848
Article Published Date : Jul 31, 2013
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Malondialdehyde Down-regulation, Nrf2 activation
[+]

Perillaldehyde ameliorates aspergillus fumigatus keratitis.Jun 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Invest Ophthalmol Vis Sci. 2020 Jun 3 ;61(6):51. PMID: 32579678
Article Published Date : Jun 02, 2020
Study Type : Animal Study
Additional Links
Substances : Perillaldehyde
Diseases : Aspergillosis, Inflammation, Keratitis
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Piceatannol treatment results in significant protection against cadmium-induced testicular dysfunctions.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2019 ;13:2811-2824. Epub 2019 Aug 13. PMID: 31496657
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Piceatannol
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Cadmium
[+]

Piper Nigrum extract improves OVA-induced nasal epithelial barrier dysfunction via activating Nrf2/HO-1 signaling.Dec 29, 2019

Pubmed Data : Cell Immunol. 2019 Dec 30:104035. Epub 2019 Dec 30. PMID: 32051090
Article Published Date : Dec 29, 2019
Study Type : Animal Study
Additional Links
Substances : Black Pepper
Diseases : Allergic Rhinitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Pre-administration of hydrogen-rich water protects against lipopolysaccharide-induced sepsis and attenuates liver injury.Dec 31, 2016

Pubmed Data : Shock. 2017 07 ;48(1):85-93. PMID: 27918369
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Lipopolysaccharide-Induced Toxicity, Oxidative Stress, Sepsis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pre-treatment with astaxanthin has a protective effect and is a safe therapeutic treatment for ischemia-reperfusion injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(11):e0187810. Epub 2017 Nov 9. PMID: 29121675
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Hypoxia, Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Protective effect of lactobacillus plantarum on alcoholic liver injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2019 ;14(9):e0222339. Epub 2019 Sep 11. PMID: 31509586
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Lactobacillus plantarum
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Protective role of luteolin against bisphenol A-induced renal toxicity.May 14, 2019

Pubmed Data : IUBMB Life. 2019 May 15. Epub 2019 May 15. PMID: 31091348
Article Published Date : May 14, 2019
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Bisphenol Toxicity, Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
Problem Substances : Bisphenol A
[+]

Protective role of wogonin against cadmium induced testicular toxicity.Sep 30, 2020

Pubmed Data : Life Sci. 2020 Oct 1 ;258:118192. Epub 2020 Aug 8. PMID: 32781062
Article Published Date : Sep 30, 2020
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Testicular Injury: Cadmium-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
Problem Substances : Cadmium
[+]

Pterocarpus marsupium has a protective effect on acetic acid-induced ulcerative colitis in rats.Jul 31, 2015

Pubmed Data : Inflammopharmacology. 2015 Aug ;23(4):195-201. Epub 2015 May 20. PMID: 25991550
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Pterocarpus marsupium
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation
Additional Keywords : Plant Extracts
[+]

Pterostilbene 4′-β-glucoside attenuates LPS-induced acute lung injury via induction of heme oxygenase-1.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:2747018. Epub 2018 Oct 23. PMID: 30425781
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation
[+]

Pterostilbene induces Nrf2/HO-1 and potentially regulates NF-κB and JNK-Akt/mTOR signaling in ischemic brain injury.Apr 30, 2020

Pubmed Data : 3 Biotech. 2020 May ;10(5):192. Epub 2020 Apr 4. PMID: 32269897
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : Brain Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pterostilbene prevents LPS-induced early pulmonary fibrosis by suppressing oxidative stress, inflammation and apoptosis in vivo.May 06, 2020

Pubmed Data : Food Funct. 2020 May 7. Epub 2020 May 7. PMID: 32377661
Article Published Date : May 06, 2020
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : Lipopolysaccharide-Induced Toxicity, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Pterostilbene treatment attenuates cerebral IRI by reducing IR-induced mitochondrial oxidative damage through the activation of HO-1 signaling.May 15, 2015

Pubmed Data : Mol Neurobiol. 2015 May 16. Epub 2015 May 16. PMID: 25983033
Article Published Date : May 15, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Brain: Oxidative Stress, Brain Edema, Cerebral Ischemia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents
[+]

Puerarin had hypoglycemic effects and that it prevented cataract development and progression in diabetic rats.Jun 02, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Jun 3. Epub 2019 Jun 3. PMID: 31173182
Article Published Date : Jun 02, 2019
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Diabetes: Cataract
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hypoglycemic Agents, Interleukin-1 beta downregulation, Nrf2 activation
[+]

Quercetin may be a useful dietary factor for protecting against obesity-induced steatohepatitis.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2016 Dec ;10(6):623-628. Epub 2016 Sep 9. PMID: 27909560
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Fatty Liver, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Hepatoprotective, NF-E2-Related Factor-2 (Nrf2) Modulator
[+]

Quercetin may be useful in protecting against obesity-induced hepatosteatosis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2015 ;12:33. Epub 2015 Oct 6. PMID: 26445592
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Mitochondrial Dysfunction , Obesity, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Quercetin protected mice from D-galactose-induced cognitive functional impairment and neuronal cell apoptosis.Jul 26, 2017

Pubmed Data : Biochem Biophys Res Commun. 2017 Jul 27. Epub 2017 Jul 27. PMID: 28757412
Article Published Date : Jul 26, 2017
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Aging: Brain , Cognitive Decline/Dysfunction
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis.Aug 19, 2015

Pubmed Data : Arch Biochem Biophys. 2015 Aug 20 ;583:150-157. Epub 2015 Aug 20. PMID: 26297952
Article Published Date : Aug 19, 2015
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Arthritis, C-Reactive Protein, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Red propolis protects kidney against acute ischemic renal failure.Aug 14, 2015

Pubmed Data : Phytomedicine. 2015 Aug 15 ;22(9):787-95. Epub 2015 Apr 12. PMID: 26220625
Article Published Date : Aug 14, 2015
Study Type : Animal Study
Additional Links
Substances : Propolis: Bee
Diseases : Ischemia, Kidney Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Renoprotective
[+]

Red raspberry extract protects the skin against UVB-induced damage with antioxidative and anti-inflammatory properties.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:9529676. Epub 2019 Jan 6. PMID: 30723535
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Raspberry
Diseases : Ultraviolet Radiation Induced Damage
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Resveratrol induces HO-1 expression and prevents dopaminergic cell death.Jan 21, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2014 Jan 22 ;15(1):1625-46. Epub 2014 Jan 22. PMID: 24451142
Article Published Date : Jan 21, 2014
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Heme oxygenase-1 up-regulation, Neuroprotective Agents
[+]

Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2018 Dec ;13(12):2119-2128. PMID: 30323140
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Rosemaric Acid
Diseases : Stroke: Ischemic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects against noise-induced injury.Jul 31, 2015

Pubmed Data : Free Radic Biol Med. 2015 Aug ;85:269-81. Epub 2015 Apr 30. PMID: 25936352
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Rosemaric Acid
Diseases : Hearing Loss: Noise-Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Selenium-rich yeast protects against aluminum-induced peroxidation of lipide and inflammation in mice liver.Oct 03, 2018

Pubmed Data : Biometals. 2018 Oct 4. Epub 2018 Oct 4. PMID: 30288658
Article Published Date : Oct 03, 2018
Study Type : Animal Study
Additional Links
Substances : Selenium, Yeast
Diseases : Aluminum Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Hepatoprotective, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Aluminum
[+]

Short-term administration of astaxanthin attenuates retinal changes in diet-induced diabetic psammomys obesus.Aug 31, 2018

Pubmed Data : Curr Eye Res. 2018 Sep ;43(9):1177-1189. Epub 2018 Jul 20. PMID: 30028214
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Diabetes Mellitus: Type 2, Diabetic Complications
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation
[+]

Strawberry leaf extract may be a potential drug candidate for the treatment of diabetes-associated cognitive impairment.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Aging Neurosci. 2020 ;12:201. Epub 2020 Jul 23. PMID: 32792939
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Strawberry
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Neuroprotective Agents, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Study on the mechanism of curcumin regulating lung injury induced by outdoor fine particulate matter.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2019 ;2019:8613523. Epub 2019 Aug 21. PMID: 31530996
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation
[+]

Sulforaphane protects against skeletal muscle dysfunction in spontaneous type 2 diabetic Db/Db mice. May 19, 2020

Pubmed Data : Life Sci. 2020 May 20 ;255:117823. Epub 2020 May 20. PMID: 32445760
Article Published Date : May 19, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Musculoskeletal Diseases
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Tartary buckwheat flavonoids ameliorate high fructose-induced insulin resistance and oxidative stress.Jul 16, 2017

Pubmed Data : Food Funct. 2017 Jul 17. Epub 2017 Jul 17. PMID: 28714504
Article Published Date : Jul 16, 2017
Study Type : Animal Study
Additional Links
Substances : Buckwheat, Flavonoids
Diseases : High Fructose Diet, Insulin Resistance
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Antioxidants, Buckwheat, Flavonoids, High Fructose Diet, Insulin Resistance
[+]

Tetramethylpyrazine ameliorates rotenone-induced Parkinson’s disease.Aug 31, 2017

Pubmed Data : Mol Neurobiol. 2017 Sep ;54(7):4866-4878. Epub 2016 Aug 11. PMID: 27514753
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Ligustrazine
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

The anti-diabetic and anti-diabetic nephritic effects of crocin were related to its modulation of oxidative stress-mediated NF-κB signalling.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:541. Epub 2020 Apr 30. PMID: 32425787
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Hypoglycemic Agents, NF-kappaB Inhibitor, Renoprotective, Superoxide Dismutase Up-regulation
[+]

The effect of rutin and hesperidin on the expression of Nrf2- and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachlorideDec 31, 2015

Pubmed Data : Vopr Pitan. 2016 ;85(5):28-35. PMID: 29381299
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Hesperidin, Rutin
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Antioxidants, Calcium Carbonate, Gene Expression Regulation, Heme oxygenase-1 up-regulation, Hesperidin, Nrf2 activation, Rutin
Problem Substances : Calcium Carbonate
[+]

The influence of separate and combined supplementation with curcumin and quercetin on the protective capacity in rats.Dec 31, 2016

Pubmed Data : Vopr Pitan. 2017 ;86(2):14-22. Epub 2017 Feb 27. PMID: 30645874
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin, Quercetin
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Natural Substance Synergy
[+]

The polysaccharide from Inonotus obliquus protects mice from Toxoplasma gondii-induced liver injury.Mar 14, 2019

Pubmed Data : Int J Biol Macromol. 2019 Mar 15 ;125:1-8. Epub 2018 Nov 13. PMID: 30445083
Article Published Date : Mar 14, 2019
Study Type : Animal Study
Additional Links
Substances : Chaga Mushroom (Inonotus obliquus)
Diseases : Liver Damage, Toxoplasma gondii Infection
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Interleukin-4 downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Polysaccharides
[+]

The present study suggested that sulforaphane exerted a therapeutic effect in the atopic dermatitis.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Aug ;20(2):1761-1771. Epub 2019 Jun 20. PMID: 31257541
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Atopic Dermatitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

The protective effect of glycyrrhizin on hepatic ischemia-reperfusion injury in rats and possible related signal pathway.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Sep ;23(9):1232-1238. PMID: 32963746
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

The protective role of lutein on isoproterenol-induced cardiac failure.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2019 Dec ;57(1):529-535. PMID: 31411934
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Lutein
Diseases : Heart Failure
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Isoproterenol
[+]

These findings provide the possible mechanism of the anti-neuroinflammatory properties of Petatewalide B.May 31, 2018

Pubmed Data : Immunopharmacol Immunotoxicol. 2018 Jun ;40(3):232-241. Epub 2018 Feb 12. PMID: 29433360
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Butterbur
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

These findings suggest that crocetin ameliorates arsenic trioxide-induced hepatic injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2020 ;14:1921-1931. Epub 2020 May 19. PMID: 32546959
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Arsenic Trioxide
[+]

These findings suggest that paeoniflorin alleviate the acute inflammation in mice brain damage induced by lipopolysaccharide.Jun 30, 2015

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2015 Jul ;40(14):2871-5. PMID: 26666042
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

These findings suggest that taraxasterol possesses the potential protective effects against ethanol-induced liver injury.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8284107. Epub 2018 Sep 23. PMID: 30344887
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Dandelion
Diseases : Alcohol Toxicity , Liver Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results showed that grape seed polyphenols could attenuate cadmium induced prostatic deficits.Jun 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jul ;91:707-713. Epub 2017 May 9. PMID: 28499242
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Polyphenols
Diseases : Cadmium Poisoning
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, MicroRNA modulator, Nrf2 activation
Additional Keywords : Antioxidants, Cadmium Poisoning, Grape Seed Extract, Heme oxygenase-1 up-regulation, POLYPHENOLS
[+]

These results suggest ligustrazine has therapeutic potential for arthritis.Aug 31, 2019

Pubmed Data : Arch Pharm Res. 2019 Sep ;42(9):824-831. Epub 2018 Nov 17. PMID: 30448958
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Ligustrazine
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

These results support the potential of resveratrol to suppress periodontitis-mediated tissue damages.Dec 31, 2015

Pubmed Data : Acta Biomater. 2016 Jan ;29:398-408. Epub 2015 Oct 20. PMID: 26497626
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Arthritis, Lipopolysaccharide-Induced Toxicity, Osteoporosis, Periodontal Diseases, Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

This data for the first time confirmed the protective effects of isoliquiritigenin on acute pancreatitis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:7161592. Epub 2018 Apr 26. PMID: 29854090
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Oxidative Stress, Pancreatitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Pancreato Protective Agents
[+]

This review aims to summarize an overview on the neuroprotective effects of andrographolide and exemplifies the essential mechanisms involved.Jul 26, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Jul 27 ;18(8). Epub 2017 Jul 27. PMID: 28749412
Article Published Date : Jul 26, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Stroke
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
Additional Keywords : Andrographolide, Anti-Inflammatory Agents, Antioxidants, stroke
[+]

This study demonstrates that tanshinone IIA alleviates neuropathic pain.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Kaohsiung J Med Sci. 2018 Aug ;34(8):428-437. Epub 2018 Apr 27. PMID: 30041760
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Diabetic Neuropathy, Neuropathic Pain
Pharmacological Actions : Heme oxygenase-1 up-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

Thymol exhibited beneficial effects on HFD-induced cognitive deficits through improving hippocampal insulin resistance.Oct 19, 2016

Pubmed Data : Metab Brain Dis. 2016 Oct 20. Epub 2016 Oct 20. PMID: 27761760
Article Published Date : Oct 19, 2016
Study Type : Animal Study
Additional Links
Substances : Thymol
Diseases : Cognitive Decline/Dysfunction, High Fat Diet, Insulin Resistance
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity.Feb 04, 2020

Pubmed Data : J Drug Target. 2020 Feb 5:1-10. Epub 2020 Feb 5. PMID: 31983246
Article Published Date : Feb 04, 2020
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Thymoquinone attenuated brain injury induced by status epilepticus via an anti-oxidative pathway.Dec 31, 2016

Pubmed Data : Transl Neurosci. 2017 Jan ;8:9-14. Epub 2017 Mar 25. PMID: 28400978
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Seizures
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Thymoquinone can be developed as a potential therapeutic modularity in bleomycin-induced lung fibrosis for human use.Feb 12, 2020

Pubmed Data : Exp Lung Res. 2020 Feb 13:1-11. Epub 2020 Feb 13. PMID: 32053036
Article Published Date : Feb 12, 2020
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model.Dec 31, 2018

Pubmed Data : Toxicol Appl Pharmacol. 2019 09 1 ;378:114617. Epub 2019 Jun 6. PMID: 31176653
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(4):e0196405. Epub 2018 Apr 25. PMID: 29694408
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Vitexins
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation
[+]

Xanthohumol attenuates cisplatin-induced nephrotoxicity.Jun 11, 2018

Pubmed Data : Int Immunopharmacol. 2018 Jun 12 ;61:277-282. Epub 2018 Jun 12. PMID: 29906742
Article Published Date : Jun 11, 2018
Study Type : Animal Study
Additional Links
Substances : Xanthohumol
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Zinc has a protective effect on spinal cord injury by inhibiting oxidative damage and nlrp3 inflammation.Jan 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life Sci. 2020 Jan 22:117351. Epub 2020 Jan 22. PMID: 31981629
Article Published Date : Jan 21, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Zinc
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2019 ;14(12):e0226769. Epub 2019 Dec 26. PMID: 31877176
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

COVID-19 and heme oxygenase: novel insight into the disease and potential therapies.Jun 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Stress Chaperones. 2020 Jun 4. Epub 2020 Jun 4. PMID: 32500379
Article Published Date : Jun 03, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Melatonin, Resveratrol
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents, Heme oxygenase-1 up-regulation
[+]

Zinc and the modulation of Nrf2 in human neuroblastoma cells.May 12, 2020

Pubmed Data : Free Radic Biol Med. 2020 May 13. Epub 2020 May 13. PMID: 32416241
Article Published Date : May 12, 2020
Study Type : In Vitro Study
Additional Links
Substances : Zinc
Diseases : Brain: Oxidative Stress, Zinc Deficiency
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

6-S is a novel small molecule activator of Nrf2 in PC12 cells, and suggests that 6-S might be a potential candidate for the prevention of oxidative stress-mediated neurodegenerative disorders.Aug 04, 2015

Pubmed Data : Food Funct. 2015 Aug 5 ;6(8):2813-23. Epub 2015 Jul 14. PMID: 26169810
Article Published Date : Aug 04, 2015
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

A review of the promising therapeutic potential of pterostilbene.Jul 26, 2016

Pubmed Data : Eur J Pharmacol. 2016 Jul 27 ;789:229-243. Epub 2016 Jul 27. PMID: 27475678
Article Published Date : Jul 26, 2016
Study Type : Review
Additional Links
Substances : Pterostilbene
Diseases : Cancers: All, Cardiovascular Diseases, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Aged citrus peel (Chenpi) prevents acetaminophen-induced Hepatotoxicity by epigenetically regulating Nrf2 pathway.Dec 31, 2018

Pubmed Data : Am J Chin Med. 2019 ;47(8):1833-1851. Epub 2019 Dec 3. PMID: 31795743
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Citrus Peel
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Aged red garlic extract may enhance anti-inflammatory effects by controlling other anti-inflammatory signals as well as regulation of NF-κB.Mar 31, 2015

Pubmed Data : J Med Food. 2015 Apr ;18(4):439-45. Epub 2015 Jan 13. PMID: 25584924
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Garlic: Aged
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor
[+]

Alleviated oxidative damage by Taraxacum officinale.Jul 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Jul 18 ;9(7). Epub 2019 Jul 18. PMID: 31323756
Article Published Date : Jul 17, 2019
Study Type : In Vitro Study
Additional Links
Substances : Dandelion
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation
[+]

Allyl isothiocyanate treatment alleviates chronic obstructive pulmonary disease.Feb 14, 2020

Pubmed Data : Life Sci. 2020 Feb 15 ;243:117291. Epub 2020 Jan 9. PMID: 31927049
Article Published Date : Feb 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Chronic Obstructive Pulmonary Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Amelioration of cyclosporine-induced testicular toxicity by carvedilol and/or alpha-lipoic acid.Feb 12, 2020

Pubmed Data : Clin Exp Pharmacol Physiol. 2020 Feb 13. Epub 2020 Feb 13. PMID: 32052493
Article Published Date : Feb 12, 2020
Study Type : In Vitro Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Drug-Induced Toxicity: Cyclosporine, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Cyclosporine
[+]

Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits.Nov 13, 2018

Pubmed Data : Psychopharmacology (Berl). 2018 Nov 14. Epub 2018 Nov 14. PMID: 30426184
Article Published Date : Nov 13, 2018
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Anthocyanins from Hibiscus syriacus L. inhibit oxidative stress-mediated apoptosis by activating the Nrf2/HO-1 signalling pathway.Jan 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Jan 3 ;9(1). Epub 2020 Jan 3. PMID: 31947843
Article Published Date : Jan 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins, Hibiscus
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Anti-inflammatory action of methanol extract of Carthamus tinctorius involves in heme oxygenase-1 induction.Jan 26, 2011

Pubmed Data : J Ethnopharmacol. 2011 Jan 27 ;133(2):524-30. Epub 2010 Oct 20. PMID: 20969944
Article Published Date : Jan 26, 2011
Study Type : In Vitro Study
Additional Links
Substances : Safflower
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Anti-inflammatory effect of ginsenoside Rg5 in lipopolysaccharide-stimulated BV2 microglial cells.May 07, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2013 May 8 ;14(5):9820-33. Epub 2013 May 8. PMID: 23698769
Article Published Date : May 07, 2013
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Brain: Microglial Activation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Apigenin protected against lipopolysaccharide induced endometritis.Jun 18, 2018

Pubmed Data : Microb Pathog. 2018 Jun 19 ;123:139-143. Epub 2018 Jun 19. PMID: 29928944
Article Published Date : Jun 18, 2018
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Endometritis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Apigenin protects renal tubular epithelial cells against high glucose-induced injury through suppression of oxidative stress and inflammation.Jul 15, 2019

Pubmed Data : Med Sci Monit. 2019 Jul 16 ;25:5280-5288. Epub 2019 Jul 16. PMID: 31309931
Article Published Date : Jul 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Apocynin may present as a promising candidate for in vivo evaluation of a therapeutic agent for inflammation-associated renal disorders.Aug 03, 2017

Pubmed Data : Int J Mol Med. 2017 Aug 4. Epub 2017 Aug 4. PMID: 28791341
Article Published Date : Aug 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Apocynin
Diseases : Inflammation, Kidney Failure, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Astaxanthin ameliorates cardiomyocyte apoptosis after coronary microembolization.Nov 29, 2018

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2018 Nov 30. Epub 2018 Nov 30. PMID: 30506291
Article Published Date : Nov 29, 2018
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Cardiac Failure, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astaxanthin might inhibit oxidative stress and inflammatory responses by activating the Nrf2-ARE signalling pathway.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:748. Epub 2018 Jul 10. PMID: 30042685
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
[+]

Astragaloside IV inhibits H9c2 cardiomyocyte injury induced by hypoxia-reoxygenation.Mar 12, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2019 Mar 13. Epub 2019 Mar 13. PMID: 30867343
Article Published Date : Mar 12, 2019
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Hypoxia, Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation
[+]

Astragaloside IV may be a promising candidate for the treatment of lead developmental neurotoxicity.May 31, 2017

Pubmed Data : Biochim Biophys Acta. 2017 Jun ;1863(6):1195-1203. Epub 2017 Mar 14. PMID: 28315454
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Lead Poisoning
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents
[+]

Astragaloside IV prevents oxidized low-density lipoprotein-induced endothelial cell injury.Mar 21, 2019

Pubmed Data : Med Sci Monit. 2019 Mar 22 ;25:2132-2140. Epub 2019 Mar 22. PMID: 30901320
Article Published Date : Mar 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Endothelial Dysfunction, Lipid Peroxidation
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Astragaloside IV suppresses inflammatory response via suppression of NF-κB, and MAPK signalling in human bronchial epithelial cells.Feb 13, 2020

Pubmed Data : Arch Physiol Biochem. 2020 Feb 14:1-10. Epub 2020 Feb 14. PMID: 32057253
Article Published Date : Feb 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Nrf2 activation
[+]

Berberine enhances the radiosensitivity of hepatoma cells by Nrf2 pathway.May 31, 2019

Pubmed Data : Front Biosci (Landmark Ed). 2019 Jun 1 ;24:1190-1202. Epub 2019 Jun 1. PMID: 31136975
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Liver Cancer
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Radiosensitizer
[+]

Berberine significantly inhibits atherosclerotic disease development by regulating lipid homeostasis and suppressing macrophage foam cell formation.Dec 31, 2019

Pubmed Data : J Cardiovasc Pharmacol. 2020 Jan ;75(1):45-53. PMID: 31895879
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Atherosclerosis
Pharmacological Actions : Anticholesteremic Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Betulinic acid alleviates myocardial hypoxia/reoxygenation injury.Nov 04, 2018

Pubmed Data : Eur J Pharmacol. 2018 Nov 5 ;838:53-59. Epub 2018 Aug 17. PMID: 30125567
Article Published Date : Nov 04, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Hypoxia, Myocardial Ischemia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Bisdemethoxycurcumin possessed favorable cardioprotection in a Nrf2/HO-1-dependent manner.Sep 15, 2019

Pubmed Data : Chem Res Toxicol. 2019 Sep 16 ;32(9):1871-1879. Epub 2019 Aug 22. PMID: 31402651
Article Published Date : Sep 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bisdemethoxycurcumin
Diseases : Cardiovascular Diseases
Pharmacological Actions : Anti-Apoptotic, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Black currants are a suitable target for further investigation as an anti-photoaging agent.May 15, 2018

Pubmed Data : Photochem Photobiol. 2018 May 16. Epub 2018 May 16. PMID: 29768726
Article Published Date : May 15, 2018
Study Type : In Vitro Study
Additional Links
Substances : Black Currant
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Nrf2 activation, Photoprotective
[+]

Black radish extract mediates a hepatoprotective effect on carbon tetrachloride-induced hepatic injury.Aug 31, 2018

Pubmed Data : J Med Food. 2018 Sep ;21(9):866-875. Epub 2018 Aug 1. PMID: 30067118
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Radish
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Blueberry anthocyanins can protect retinal cells from diabetes-induced oxidative stress and inflammation.Nov 08, 2016

Pubmed Data : J Neuroimmunol. 2016 Nov 9. Epub 2016 Aug 9. PMID: 27847126
Article Published Date : Nov 08, 2016
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins, Blueberry
Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 1, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Camel milk could protect against or decrease the deleterious effects of many environmental toxicants and carcinogens such as PAHs.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomed Biotechnol. 2012 ;2012:782642. Epub 2012 Feb 27. PMID: 22570534
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Camel Milk
Diseases : Cancers: All, Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Chemopreventive, Heme oxygenase-1 up-regulation, MicroRNA modulator
Additional Keywords : Gene Expression Regulation
Problem Substances : Polycyclic aromatic hydrocarbon
[+]

Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis.Sep 13, 2020

Pubmed Data : Environ Toxicol Pharmacol. 2020 Sep 14 ;80:103494. Epub 2020 Sep 14. PMID: 32942000
Article Published Date : Sep 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Chlorogenic acid promoted the Nrf2/HO-1 anti-oxidative pathway by activating p21 to prevent Dex-induced mitochondrial apoptosis in osteoblastic cells.Apr 16, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Free Radic Biol Med. 2019 Apr 17 ;137:1-12. Epub 2019 Apr 17. PMID: 31004750
Article Published Date : Apr 16, 2019
Study Type : In Vitro Study
Additional Links
Substances : Chlorogenic Acid
Diseases : Osteoporosis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Dexamethasone
[+]

Citric acid treatment enhanced the anti-inflammatory activity of wheat germ extract.Jul 09, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Jul 10 ;9(7). Epub 2017 Jul 10. PMID: 28698513
Article Published Date : Jul 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Citric Acid , Fermented Foods and Beverages, Wheat Germ
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-10 upregulation, Interleukin-12 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Citrus flavonoids suppress IL-5 and ROS through distinct pathways in PMA/ionomycin-induced EL-4 cells.Jan 13, 2020

Pubmed Data : Food Funct. 2020 Jan 14. Epub 2020 Jan 14. PMID: 31932824
Article Published Date : Jan 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Hesperidin
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents, Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-5 downregulation, Nrf2 activation
[+]

Coenzyme Q10 may be considered as a potential effective therapeutic for the treatment of spinal cord injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2019 ;11(10):6544-6552. Epub 2019 Oct 15. PMID: 31737205
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Coenzyme Q10
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Consumption of alpha-lipoic acid-rich foods may prevent the development of H. pylori-associated gastric diseases.Oct 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Oct 19 ;11(10). Epub 2019 Oct 19. PMID: 31635029
Article Published Date : Oct 18, 2019
Study Type : In Vitro Study
Additional Links
Substances : Alpha Linolenic Acid
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-8 downregulation, Nrf2 activation
[+]

Consumption of cashew nuts inhibits oxidative stress.Sep 25, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Sep 26 ;25(19). Epub 2020 Sep 26. PMID: 32993187
Article Published Date : Sep 25, 2020
Study Type : In Vitro Study
Additional Links
Substances : Cashew
Diseases : Ischemia, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Crocetin attenuates sepsis-induced cardiac dysfunction.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2020 ;11:514. Epub 2020 Jun 9. PMID: 32581829
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin ameliorates arsenic trioxide‑induced cardiotoxicity.Sep 09, 2020

Pubmed Data : Biomed Pharmacother. 2020 Sep 10 ;131:110713. Epub 2020 Sep 10. PMID: 32920515
Article Published Date : Sep 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Cardiotoxicity: Chemotherapy-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Arsenic Trioxide
[+]

Curcumin ameliorates asthmatic airway inflammation.Apr 30, 2015

Pubmed Data : Clin Exp Pharmacol Physiol. 2015 May ;42(5):520-9. PMID: 25739561
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Asthma, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
[+]

Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2019 ;14(5):e0216711. Epub 2019 May 21. PMID: 31112588
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Immunomodulatory, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Curcumin inhibits appoptosin induced apoptosis in SH-SY5Y cells by upregulating the expression of HO-1.Apr 30, 2015

Pubmed Data : Acta Pharmacol Sin. 2015 May ;36(5):544-52. Epub 2015 Apr 20. PMID: 25891083
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Heme oxygenase-1 up-regulation
[+]

Diosmetin alleviates lipopolysaccharide-induced acute lung injury. Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2018 Mar 1 ;26(2):157-166. PMID: 28365974
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Diosmetin
Diseases : Acute Respiratory Distress Syndrome, Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ecklonia cava extract containing dieckol suppresses RANKL-induced osteoclastogenesis.Jan 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2019 Jan 28 ;29(1):11-20. PMID: 30518021
Article Published Date : Jan 27, 2019
Study Type : In Vitro Study
Additional Links
Substances : Seaweed: Brown
Diseases : Osteoarthritis, Oxidative Stress
Pharmacological Actions : Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Osteoprotective
Additional Keywords : Plant Extracts
[+]

EGCG is a possible therapeutic agent for preventing Aβ-induced inflammatory neurodegeneration.Nov 27, 2015

Pubmed Data : Eur J Pharmacol. 2015 Nov 28 ;770:16-24. Epub 2015 Nov 28. PMID: 26643169
Article Published Date : Nov 27, 2015
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Alzheimer's Disease, Brain Inflammation , Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-E2-Related Factor-2 (Nrf2) Modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction.Nov 30, 2019

Pubmed Data : Daru. 2019 Dec ;27(2):721-733. Epub 2019 Nov 18. PMID: 31736017
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid
Diseases : Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Eriodictyol induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression.Apr 30, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Invest Ophthalmol Vis Sci. 2009 May ;50(5):2398-406. Epub 2008 Dec 30. PMID: 19117929
Article Published Date : Apr 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Eriodictyol
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Gene Expression Regulation
[+]

Eriodictyol inhibits high glucose-induced oxidative stress and inflammation in retinal ganglial cells.Mar 31, 2019

Pubmed Data : J Cell Biochem. 2019 Apr ;120(4):5644-5651. Epub 2018 Oct 14. PMID: 30317656
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Eriodictyol
Diseases : Diabetic Retinopathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-8 downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Eriodictyol inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes.Oct 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:1128-1134. Epub 2018 Aug 27. PMID: 30257325
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Eriodictyol
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Eriodictyol protects endothelial cells against oxidative stress-induced cell death.Jun 25, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2015 Jun 26 ;16(7):14526-39. Epub 2015 Jun 26. PMID: 26132561
Article Published Date : Jun 25, 2015
Study Type : In Vitro Study
Additional Links
Substances : Eriodictyol
Diseases : Cardiovascular Diseases, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation
[+]

Ferulic acid protects against lead acetate-induced inhibition of neurite outgrowth.Nov 25, 2015

Pubmed Data : Mol Neurobiol. 2015 Nov 26. Epub 2015 Nov 26. PMID: 26611834
Article Published Date : Nov 25, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ferulic acid
Diseases : Lead Poisoning
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents
Problem Substances : Lead
[+]

Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines.Jul 31, 2018

Pubmed Data : Food Chem Toxicol. 2018 Aug 1 ;120:528-535. Epub 2018 Aug 1. PMID: 30076913
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Heme oxygenase-1 up-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Nrf2 activation
[+]

Flavonoids derived from Abelmoschus esculentus attenuates UV-B induced cell damage.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2016 May ;12(Suppl 2):S129-38. Epub 2016 May 11. PMID: 27279697
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Okra
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Photoprotective
[+]

Formononetin may represent an effective adjuvant that can prevent methotrexate nephrotoxicity.Sep 25, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Sep 26 ;8(10). Epub 2019 Sep 26. PMID: 31561418
Article Published Date : Sep 25, 2019
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Methotrexate
[+]

Fucoidan attenuates oxidative stress by regulating the gene expression superoxide dismutase 1 and heme oxygenase 1. Sep 30, 2016

Pubmed Data : Mol Med Rep. 2016 Oct ;14(4):3255-60. Epub 2016 Aug 11. PMID: 27513069
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Fucoxanthin has anti-neuroinflammatory effects.Jan 31, 2017

Pubmed Data : Neurochem Res. 2017 Feb ;42(2):667-677. Epub 2016 Dec 8. PMID: 27933547
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fucoxanthin
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway.May 08, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 May 9 ;8(19):32147-32156. PMID: 28389632
Article Published Date : May 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gastrodin
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginnalin A from Acer tataricum exhibits a colorectal cancer chemoprevention effect.May 22, 2018

Pubmed Data : Food Funct. 2018 May 23 ;9(5):2809-2819. PMID: 29693091
Article Published Date : May 22, 2018
Study Type : In Vitro Study
Additional Links
Substances : Maple
Diseases : Colorectal Cancer
Pharmacological Actions : Antioxidants, Chemopreventive, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ginseng and heme oxygenase-1: The link between an old herb and a new protective system.Oct 16, 2019

Pubmed Data : Fitoterapia. 2019 Oct 17 ;139:104370. Epub 2019 Oct 17. PMID: 31629872
Article Published Date : Oct 16, 2019
Study Type : Review
Additional Links
Substances : Ginseng
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Glutathione induced immune-stimulatory activity.Sep 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Sep 18 ;8(9). Epub 2019 Sep 18. PMID: 31540482
Article Published Date : Sep 17, 2019
Study Type : In Vitro Study
Additional Links
Substances : Glutathione
Diseases : Bacterial Infections
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Immunostimulatory, Nrf2 activation
[+]

H. erinaceus may be considered as a potent antiangiogenesis candidate to treat diseases with impaired inflammation and cancer.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:8257238. Epub 2015 Dec 28. PMID: 26823953
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus)
Diseases : Cancers: All, Inflammation
Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hesperetin suppresses inflammatory responses in lipopolysaccharide-induced RAW 264.7 cells.May 31, 2016

Pubmed Data : Inflammation. 2016 Jun ;39(3):964-73. PMID: 26994999
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Hesperidin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Horseradish root extracts had an anti-inflammatory action. Dec 01, 2015

Pubmed Data : Food Funct. 2015 Dec 2 ;6(12):3778-88. PMID: 26411988
Article Published Date : Dec 01, 2015
Study Type : In Vitro Study
Additional Links
Substances : Horseradish
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

In this review, all the available data on the chemistry, mechanisms of neuroprotection and clinical impacts of Ginkgolide B are critically discussed.Jun 09, 2015

Pubmed Data : Curr Top Med Chem. 2015 Jun 10. Epub 2015 Jun 10. PMID: 26059355
Article Published Date : Jun 09, 2015
Study Type : Review
Additional Links
Substances : Ginkgo biloba
Diseases : Stroke: Attenuation/Recovery , Stroke: Ischemic
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Lignans from Opuntia ficus-indica seeds protect rat primary hepatocytes and HepG2 cells against ethanol-induced oxidative stress.Dec 31, 2016

Pubmed Data : Biosci Biotechnol Biochem. 2017 Jan ;81(1):181-183. Epub 2016 Sep 22. PMID: 27885940
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Prickly Pear Cactus
Diseases : Alcohol Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective
[+]

Lotus root might potentially improve neural function through the stimulation of BDNF production in glial cells.May 08, 2017

Pubmed Data : J Diet Suppl. 2017 May 9:1-13. Epub 2017 May 9. PMID: 28485986
Article Published Date : May 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Pharmacological Actions : Brain-derived neurotrophic factor modulator, Heme oxygenase-1 up-regulation
Additional Keywords : Brain-derived neurotrophic factor modulator, Heme oxygenase-1 up-regulation, Lotus, Plant Extracts
[+]

Lotus seedpod proanthocyanidins protect against neurotoxicity after methyl-mercuric chloride injury.Nov 14, 2019

Pubmed Data : Ecotoxicol Environ Saf. 2019 Nov 15 ;183:109560. Epub 2019 Aug 14. PMID: 31421536
Article Published Date : Nov 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Proanthocyanidins
Problem Substances : Mercury
[+]

Luteolin inhibits viral-induced inflammatory response in RAW264.7 cells Mar 22, 2016

Pubmed Data : Free Radic Biol Med. 2016 Mar 23. Epub 2016 Mar 23. PMID: 27016074
Article Published Date : Mar 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Luteolin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Nitric Oxide Inhibitor, Nrf2 activation
[+]

Lycopene alleviates hepatic hypoxia/reoxygenation injury.Jul 31, 2020

Pubmed Data : J Interferon Cytokine Res. 2020 Aug ;40(8):406-417. PMID: 32813603
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lycopene
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lycopene suppresses the activation of TNFα-induced signalling pathways through the upregulation of Nrf2-mediated HO-1 expression.Apr 19, 2017

Pubmed Data : Int J Mol Med. 2017 Apr 20. Epub 2017 Apr 20. PMID: 28440398
Article Published Date : Apr 19, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lycopene
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

M. oleifera leaves are good sources of natural antioxidant with isoquercetin as an active compound. Jul 31, 2015

Pubmed Data : Planta Med. 2015 Aug ;81(12-13):1084-9. Epub 2015 Jul 10. PMID: 26166137
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Moringa oleifera
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Superoxide Dismutase Up-regulation
[+]

Mangiferin attenuates LPS/D-GalN-induced acute liver injury by promoting HO-1 in kupffer cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2020 ;11:285. Epub 2020 Feb 25. PMID: 32158448
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin
Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Melatonin could be a useful treatment aid in ebola infections. Mar 31, 2015

Pubmed Data : J Med Virol. 2015 Apr ;87(4):537-43. Epub 2015 Jan 21. PMID: 25611054
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Melatonin
Diseases : Ebola Virus Infections, Inflammation, Septic Shock
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Heme oxygenase-1 up-regulation
Additional Keywords : Cytokines
[+]

Melatonin might have therapeutic utility in mastitis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(5):e0178525. Epub 2017 May 25. PMID: 28542575
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Lipopolysaccharide-Induced Toxicity, Mastitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
[+]

Melatonin significantly induces the activation of phase-2 antioxidative enzymes via the Nrf2 pathway.Apr 26, 2016

Pubmed Data : J Pineal Res. 2016 Apr 27. Epub 2016 Apr 27. PMID: 27117941
Article Published Date : Apr 26, 2016
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Oxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Myricetin possesses the therapeutic potential on osteoarthritis.Jul 16, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jul 17 ;75:105742. Epub 2019 Jul 17. PMID: 31325727
Article Published Date : Jul 16, 2019
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

N-acetylcysteine provides cytoprotection in murine oligodendrocytes through heme oxygenase-1 activity.Jul 22, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2020 Jul 23 ;8(8). Epub 2020 Jul 23. PMID: 32717964
Article Published Date : Jul 22, 2020
Study Type : In Vitro Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective, Heme oxygenase-1 up-regulation, Neuroprotective Agents
[+]

Naringenin exerts anti-inflammatory effects in paraquat-treated SH-SY5Y cells.Feb 05, 2018

Pubmed Data : Neurochem Res. 2018 Feb 6. Epub 2018 Feb 6. PMID: 29411263
Article Published Date : Feb 05, 2018
Study Type : In Vitro Study
Additional Links
Substances : Naringenin
Diseases : Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Naringenin, Pesticide Toxicity
[+]

Naringenin inhibit the hydrogen peroxide-induced SH-SY5Y cells injury through Nrf2/HO-1 pathway.May 09, 2019

Pubmed Data : Neurotox Res. 2019 May 10. Epub 2019 May 10. PMID: 31076999
Article Published Date : May 09, 2019
Study Type : In Vitro Study
Additional Links
Substances : Naringenin
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Nelumbo nucifera leaves protect against hydrogen peroxide-induced hepatic damage.May 31, 2015

Pubmed Data : Food Funct. 2015 Jun ;6(6):1911-8. PMID: 25962859
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Neochlorogenic acid inhibits against LPS-activated inflammatory responsesAug 31, 2018

Pubmed Data : Environ Toxicol Pharmacol. 2018 Sep ;62:1-10. Epub 2018 Jun 8. PMID: 29908432
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Honeysuckle
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Neuroprotective effect of Annona muricata-derived polysaccharides in neuronal HT22 cell damage induced by hydrogen peroxide.Jan 20, 2020

Pubmed Data : Biosci Biotechnol Biochem. 2020 Jan 21:1-12. Epub 2020 Jan 21. PMID: 31960754
Article Published Date : Jan 20, 2020
Study Type : In Vitro Study
Additional Links
Substances : Soursop
Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Hydrogen Peroxide Induced Toxicity, Parkinson's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

Neuroprotective effects of astaxanthin against oxygen and glucose deprivation damage.Jun 20, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2020 Jun 21. Epub 2020 Jun 21. PMID: 32567157
Article Published Date : Jun 20, 2020
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Oat avenanthramides induce heme oxygenase-1 expression via Nrf2-mediated signaling in HK-2 cells.Sep 01, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Sep 2. Epub 2015 Sep 2. PMID: 26331632
Article Published Date : Sep 01, 2015
Study Type : In Vitro Study
Additional Links
Substances : Avenanthramides, Oats
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Dose Response
[+]

Oleocanthal might be a promising natural agent for future treatment of immune-inflammatory diseases.May 14, 2019

Pubmed Data : J Agric Food Chem. 2019 May 15 ;67(19):5552-5559. Epub 2019 May 1. PMID: 31042377
Article Published Date : May 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oleocanthal
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Palbinone from Paeonia suffruticosa protects hepatic cells via up-regulation of heme oxygenase-1.Jan 31, 2014

Pubmed Data : Phytother Res. 2014 Feb ;28(2):308-11. Epub 2013 Apr 18. PMID: 23595773
Article Published Date : Jan 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Peony
Diseases : Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Perillaldehyde is thus potentially useful for managing inflammatory skin diseases or disorders related to oxidative stress.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:9524657. Epub 2018 Feb 14. PMID: 29643980
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Perillaldehyde
Diseases : Atopic Dermatitis, Psoriasis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Petatewalide B alleviates oxygen glucose deprivation/reoxygenation induced neuronal injury.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Jul ;22(1):239-246. Epub 2020 Apr 16. PMID: 32319645
Article Published Date : Jun 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Butterbur
Diseases : Stroke: Ischemic
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Phellinus linteus extract has neuroprotective effects against oxidative stress (H2O2)-induced neuronal cell death.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res. 2016 Jan ;36(1):31-43. Epub 2015 Nov 11. PMID: 26773779
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Phellinus Linteus
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents
Additional Keywords : Dose Response
[+]

Phyllanthin and hypophyllanthin from Phyllanthus amarus ameliorates immune-inflammatory response in ovalbumin-induced asthma.Jan 31, 2019

Pubmed Data : Immunopharmacol Immunotoxicol. 2019 Feb ;41(1):55-67. Epub 2018 Dec 12. PMID: 30541359
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Phyllanthus amarus
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Piceatannol alleviates inflammation and oxidative stress in diabetic cardiomyopathy.Jul 15, 2019

Pubmed Data : Chem Biol Interact. 2019 Jul 16 ;310:108754. Epub 2019 Jul 16. PMID: 31323227
Article Published Date : Jul 15, 2019
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Cardiomyopathy, Diabetic Complications
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells.Aug 31, 2010

Pubmed Data : Arch Biochem Biophys. 2010 Sep 1 ;501(1):142-50. Epub 2010 Jun 15. PMID: 20558128
Article Published Date : Aug 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Chemopreventive, Heme oxygenase-1 up-regulation
[+]

Piceatannol is capable of protecting HT22 neuronal cells against glutamate-induced cell death.Jul 31, 2013

Pubmed Data : Amino Acids. 2013 Aug ;45(2):393-401. Epub 2013 May 28. PMID: 23712764
Article Published Date : Jul 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents
[+]

Piceatannol protects against cisplatin induced nephrotoxicity.Jun 13, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Jun 14. Epub 2019 Jun 14. PMID: 31197431
Article Published Date : Jun 13, 2019
Study Type : In Vitro Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Poria cocos polysaccharides may be a promising candidate for the therapy of atherosclerosis.Jan 12, 2020

Pubmed Data : Int Immunopharmacol. 2020 Jan 13 ;80:106173. Epub 2020 Jan 13. PMID: 31945610
Article Published Date : Jan 12, 2020
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

Pretreatment with curcumin induces Nrf2 and an antioxidant response that may play an important role in the protective effect of this antioxidant against hemin-induced neuronal death.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2013 ;2013:801418. Epub 2013 Dec 22. PMID: 24454990
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Protection of the myocardium against ischemia/reperfusion injury by punicalagin.May 31, 2019

Pubmed Data : Chem Biol Interact. 2019 Jun 1 ;306:152-162. Epub 2019 May 4. PMID: 31063767
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effect of epigallocatechin gallate on endothelial disorders in atherosclerosis.Dec 29, 2019

Pubmed Data : J Cardiovasc Pharmacol. 2019 Dec 30. Epub 2019 Dec 30. PMID: 31895874
Article Published Date : Dec 29, 2019
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Atherosclerosis, Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Prunella vulgaris could be an effective therapeutic candidate against diabetes-associated cardiovascular diseases.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:936463. Epub 2013 Sep 12. PMID: 24159354
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Prunella vulgaris
Diseases : Atherosclerosis, Cardiovascular Diseases, Diabetic Complications
Pharmacological Actions : Antioxidants, Antiproliferative , Heme oxygenase-1 up-regulation, NF-E2-Related Factor-2 (Nrf2) Modulator
Additional Keywords : Plant Extracts
[+]

Puerarin protects against high glucose-induced acute vascular dysfunction.Feb 28, 2009

Pubmed Data : Vascul Pharmacol. 2009 Mar-Apr;50(3-4):110-5. Epub 2008 Nov 24. PMID: 19073281
Article Published Date : Feb 28, 2009
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Endothelial Dysfunction
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation
Additional Keywords : Antioxidants, endothelial dysfunction, Heme oxygenase-1 up-regulation, Puerarin
[+]

Punicalagin protects H9c2 cardiomyocytes from doxorubicin-induced toxicity through activation of Nrf2/HO-1 signaling.Apr 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2019 Apr 23. Epub 2019 Apr 23. PMID: 31015369
Article Published Date : Apr 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Punicalagin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Pycnogenol has potential as a therapeutic agent for the treatment of allergic asthma.Nov 30, 2013

Pubmed Data : Food Chem Toxicol. 2013 Dec ;62:681-6. Epub 2013 Oct 9. PMID: 24120901
Article Published Date : Nov 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Pycnogenol (Pine Bark)
Diseases : Asthma, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Nitric Oxide Inhibitor
Additional Keywords : Plant Extracts
[+]

Quercetin attenuated hydrogen peroxide-induced cell damage via heme oxygenase-1 induction in endothelial cells.Oct 19, 2019

Pubmed Data : Arch Biochem Biophys. 2019 Oct 20:108157. Epub 2019 Oct 20. PMID: 31644887
Article Published Date : Oct 19, 2019
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation
[+]

Red yeast rice protects circulating bone marrow-derived proangiogenic cells against high-glucose-induced senescence and oxidative stress.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:3831750. Epub 2017 May 6. PMID: 28555162
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Red Yeast Rice
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation
[+]

Rosmarinic acid exerts a neuroprotective effect on spinal cord injury.Apr 18, 2020

Pubmed Data : Toxicol Appl Pharmacol. 2020 Apr 19 ;397:115014. Epub 2020 Apr 19. PMID: 32320792
Article Published Date : Apr 18, 2020
Study Type : In Vitro Study
Additional Links
Substances : Rosemaric Acid
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Royal jelly might be a promising functional food to delay inflammatory progress by influencing the microglia function.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2018 ;2018:7834381. Epub 2018 Apr 8. PMID: 29849495
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Royal Jelly
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Inflammation, Lipopolysaccharide-Induced Toxicity, Royal Jelly
[+]

Sambucus nigra L. ameliorates UVB-induced photoaging and inflammatory response in human skin keratinocytes.Sep 10, 2019

Pubmed Data : Cytotechnology. 2019 Sep 11. Epub 2019 Sep 11. PMID: 31512082
Article Published Date : Sep 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Elderberry
Diseases : Inflammation, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Photoprotective
[+]

Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress.May 31, 2019

Pubmed Data : Metab Brain Dis. 2019 Jun ;34(3):853-864. Epub 2019 Mar 27. PMID: 30919246
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Soursop
Diseases : Amnesia: Drug-Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane attenuated the pro-inflammatory state induced by hydrogen peroxide in SH-SY5Y cells.Feb 22, 2018

Pubmed Data : Neurotox Res. 2018 Feb 23. Epub 2018 Feb 23. PMID: 29473125
Article Published Date : Feb 22, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane exerts an anti-neuroinflammatory effect on microglia through JNK/AP-1/NF-κB pathway inhibition and Nrf2/HO-1 pathway activation.Feb 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2019 Feb 22 ;8(2). Epub 2019 Feb 22. PMID: 30813369
Article Published Date : Feb 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-4 upregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane protects cells against lipopolysaccharide-stimulated inflammation in murine macrophages.Nov 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Nov 21 ;8(12). Epub 2019 Nov 21. PMID: 31766492
Article Published Date : Nov 20, 2019
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Synergism between luteolin and sulforaphane in anti-inflammation.Sep 11, 2018

Pubmed Data : Food Funct. 2018 Sep 12. Epub 2018 Sep 12. PMID: 30206627
Article Published Date : Sep 11, 2018
Study Type : In Vitro Study
Additional Links
Substances : Luteolin, Sulforaphane
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
Additional Keywords : Natural Substance Synergy
[+]

T. coreanum exhibits a promising function in preventionof neurodegeneration.Mar 31, 2017

Pubmed Data : Mol Med Rep. 2017 Apr ;15(4):2347-2352. Epub 2017 Feb 22. PMID: 28260050
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Dandelion
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Tangeretin may play an effective protective role in liver injury.Jun 26, 2018

Pubmed Data : J Agric Food Chem. 2018 Jun 27 ;66(25):6317-6325. Epub 2018 Jun 14. PMID: 29871486
Article Published Date : Jun 26, 2018
Study Type : In Vitro Study
Additional Links
Substances : Tangeretin
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Tertiary butyl hydroperoxide
[+]

Tangeretin protects renal tubular epithelial cells against experimental cisplatin toxicity.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2019 Feb ;22(2):179-186. PMID: 30834084
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tangeretin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Tanshinone IIA suppresses cholesterol accumulation in human macrophages.Jan 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Lipid Res. 2014 Feb ;55(2):201-13. Epub 2013 Dec 3. PMID: 24302760
Article Published Date : Jan 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Atherosclerosis, Cholesterol: Oxidation
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

The cytoprotective enzyme heme oxygenase-1 suppresses Ebola virus replication.Nov 30, 2013

Pubmed Data : J Virol. 2013 Dec ;87(24):13795-802. Epub 2013 Oct 9. PMID: 24109237
Article Published Date : Nov 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Heme oxygenase-1
Diseases : Ebola Virus Infections
Pharmacological Actions : Heme oxygenase-1 inducer, Heme oxygenase-1 up-regulation
[+]

The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity.Jan 22, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 Jan 23 ;10(1):1063. Epub 2020 Jan 23. PMID: 31974389
Article Published Date : Jan 22, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Ferulic acid
Diseases : Cancers: Drug Resistant, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Chemosensitizer, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

The phytochemical sulforaphane has a potential application in Alzheimer’s disease therapeutics.Jan 31, 2016

Pubmed Data : Neurobiol Aging. 2016 Feb ;38:1-10. Epub 2015 Oct 23. PMID: 26827637
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

These data provide the molecular mechanism to understand the cellular antioxidant activity of fisetin.Feb 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Feb 15 ;24(4). Epub 2019 Feb 15. PMID: 30781396
Article Published Date : Feb 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

These data support the antioxidant properties' nutraceutical role of Moringa oleifera against titanium dioxide nanoparticles-induced toxicity.May 03, 2018

Pubmed Data : Biol Trace Elem Res. 2018 May 4. Epub 2018 May 4. PMID: 29728821
Article Published Date : May 03, 2018
Study Type : In Vitro Study
Additional Links
Substances : Moringa oleifera
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Titanium Dioxide, Titanium Nanoparticles

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