Chemosensitizer

Name	AC	CK
Curcumin	95	108
Resveratrol	32	37
EGCG (Epigallocatechin gallate)	16	23
Ginsenosides	16	23
Vitamin C	18	23
Genistein	15	22
Melatonin	16	21
Quercetin	18	21
Silibinin	5	18
Shikonin	12	16
Sulforaphane	13	16
Beta-Elemene	14	14
Fucoidan	5	14
Pterostilbene	5	14
Wogonin	6	13
Tanshinone IIA	11	12
Capsaicin	6	11
Amurensin G	2	10
Caffeine	1	10
Catechin	5	10
Ginseng	2	10
Berberine	9	9
Flavonoids	8	9
Green Tea	4	9
Thymoquinone	5	9
Ursolic Acid	5	9
Gingerol	3	8
Indole-3-Carbinol	5	8
Astragaloside	7	7
Emodin	6	7
Gynostemma	2	7
Honokiol	7	7
Vitamin D	6	7
6-Shogaol	2	6
Cucurbitacin B	5	6
Piperine	2	6
Antrodia camphorata	1	5
Astaxanthin	4	5
Bee Venom	5	5
Betulinic acid	4	5
Carotenoids	4	5
Deguelin	4	5
Demethoxycurcumin	4	5
Garlic	1	5
Huaier (Trametes robiniophila murr)	1	5
Luteolin	4	5
Mangiferin	3	5
Panax Notoginseng	1	5
Panaxadiol	1	5
Parthenolide	5	5
Vitamin E: Gamma-tocotrienol	5	5
White Mulberry	1	5
Bisdemethoxycurcumin	3	4
Cannabidiol	3	4
Ellagic Acid	3	4
Fucoxanthin	4	4
Ginger	3	4
Gold (nanoparticles)	3	4
Lotus	4	4
Mistletoe	3	4
Naringenin	4	4
Nobiletin	4	4
Oleuropein	3	4
Paprika	3	4
Reishi Mushroom	3	4
Triptolide	4	4
beta-Carotene	4	4
Apigenin	3	3
Baicalein	2	3
Beta-Caryophyllene	2	3
Bufalin	3	3
Caffeic acid phenethyl ester	3	3
Cannabinoids	2	3
Chrysanthemum Indicum	2	3
Crocin	3	3
DHA (Docosahexaenoic Acid)	3	3
Diosgenin	2	3
Genipin	2	3
Hesperidin	2	3
Isoliquiritigenin	2	3
Lupeol	2	3
Lycopene	2	3
Phenethyl isothiocyanate	2	3
Piperlongumine	2	3
Pomegranate	2	3
Puerarin	2	3
Stilbenes	2	3
Tea	2	3
Theaflavins	3	3
Tocotrienol: Delta	3	3
Tripterygium wilfordii	3	3
Vitamin E	3	3
Vitamin K	3	3
Xanthohumol	3	3
Alpha-Lipoic Acid	2	2
Alpinia galanga	1	2
Apple	1	2
Broccoli	1	2
Cannabinoids: Synthetic	1	2
Chinese Skullcap	2	2
Cholesterol	1	2
Chrysin	2	2
Cinnamic acid	1	2
Crocetin	2	2
Curcuminoids	1	2
Dimethyl trisulfide (DMTS)	1	2
Fenugreek	1	2
Fisetin	2	2
Gallic Acid	2	2
Ginkgo biloba	2	2
Ginseng (Korean)	2	2
Kahweol	2	2
Lignans	2	2
Long Pepper	1	2
Lutein	2	2
Modified Arabinoxylan Rice Bran (MGN-3)	2	2
Myricetin	2	2
Nettle	2	2
Pantothenic Acid (Vitamin B-5)	1	2
Phloretin	2	2
Piceatannol	1	2
Polyphenols	2	2
Rosemaric Acid	2	2
Rutin	2	2
Shiitake Mushroom	1	2
Soy	1	2
Sprouts	1	2
Sweet Orange	1	2
Tangeretin	2	2
Urolithin A	1	2
Zeaxanthin	1	2
Acerola	1	1
Adlay	1	1
Aloe Vera	1	1
Andrographis	1	1
Andrographolide	1	1
Antheraxanthin	1	1
Apple: Golden Delicious	1	1
Arctigenin	1	1
Artemisinin	1	1
Artesunate	1	1
Ashwagandha	1	1
Asiatic Acid	1	1
Beet	1	1
Biochanin A	1	1
Bioflavonoids	1	1
Birch	1	1
Bloodroot	1	1
Broccoli Sprouts	1	1
Bromelain	1	1
Burdock	1	1
Cafestol	1	1
Camptothecin	1	1
Canthaxanthin	1	1
Capsorubin	1	1
Carnosic Acid	1	1
Carnosol	1	1
Chlorogenic Acid	1	1
Citrus naringin	1	1
Cleistocalyx Operculatus	1	1
Coenzyme Q10	1	1
Cranberry	1	1
DIM (3,3'-diindolylmethane)	1	1
Damnacanthal	1	1
Dandelion	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Dopa bean	1	1
EPA (Eicosapentaenoic Acid)	1	1
Erucin	1	1
Eugenol	1	1
Farnesiferol A	1	1
Fennel	1	1
Fermented Foods and Beverages	1	1
Ferula Persica	1	1
Ferula Szowitsiana	1	1
Flavan-3-ols	1	1
Flaxseed	1	1
Flaxseed Oil	1	1
Folic Acid	1	1
Galbanic Acid	1	1
Geraniol	1	1
Glucosamine	1	1
Guarana	1	1
Hedyotis corymbosa	1	1
Hedyotiscone A	1	1
Honey	1	1
Japanese Raisin Tree	1	1
Kaempferol	1	1
Lactobacillus paracasei	1	1
Lactobacillus plantarum	1	1
Lactobacillus rhamnosus GG	1	1
Licorice	1	1
Ligustrazine	1	1
Lion's Mane (Hericium Erinaceus)	1	1
Lobelia	1	1
Loquat	1	1
Maca	1	1
Milk: Fermented	1	1
Nexrutine (Phellodendrom)	1	1
Nicotinamide	1	1
Omega-3 Fatty Acids	1	1
Oolong tea	1	1
Orange	1	1
Phellinus Linteus	1	1
Phyllanthus emblica	1	1
Red Sage	1	1
Rhubarb	1	1
Riboflavin (Vitamin B-2)	1	1
Rice Bran	1	1
Rosemary	1	1
Saffron	1	1
Sakuranetin	1	1
Silymarin	1	1
Tabebuia	1	1
Thyme	1	1
Tocotrienol: Gamma	1	1
Tocotrienols	1	1
Turmeric	1	1
Vitamin A	1	1
Vitamin K2	1	1
Vitex negundo	1	1
Wheat Grass	1	1
Zinc	1	1

[+]

"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

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Pubmed Data : Expert Opin Ther Targets. 2016 Jan ;20(1):7-18. Epub 2015 Dec 15. PMID: 26568207

Article Published Date : Dec 31, 2015

Study Type : Animal Study, Human In Vitro

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Diseases : Esophageal Cancer

Pharmacological Actions : Adenosine Monophosphate (AMP)-activated Protein Kinase (AMPK, Anti-metastatic, Apoptotic, Chemosensitizer

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Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression.Dec 31, 2017

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Pubmed Data : Fitoterapia. 2018 Jan ;124:42-48. Epub 2017 Oct 12. PMID: 29031537

Article Published Date : Dec 31, 2017

Study Type : Human In Vitro

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Substances : Silibinin

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Colon Cancer

Pharmacological Actions : Chemosensitizer, Glucose transporter-1 (GLUT1) expression down-regulation

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

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The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

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Pubmed Data : Ann N Y Acad Sci. 2012 Jul ;1259:95-103. PMID: 22758641

Article Published Date : Jun 30, 2012

Study Type : Insect Study

Additional Links

Substances : Quercetin

Diseases : Chronic Lymphocytic Leukemia, Leukemia

Pharmacological Actions : Chemosensitizer

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20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.Dec 31, 2018

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Pubmed Data : Cancer Sci. 2019 Jan ;110(1):389-400. Epub 2018 Dec 14. PMID: 30431207

Article Published Date : Dec 31, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Ginsenosides

Diseases : Cancers: Drug Resistant, Glioblastoma

Pharmacological Actions : Anti-metastatic, Chemosensitizer

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6-Gingerol is a potent inducer of p53 reactivation in HPV positive cervical cancer cells through proteasome inhibition.Nov 24, 2015

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Baicalein reversed the resistance of human A549 lung adenocarcinoma cells to cisplatin.May 31, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Jun ;90:677-685. Epub 2017 Apr 14. PMID: 28415048

Article Published Date : May 31, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Baicalein

Diseases : Cancers: Drug Resistant, Lung Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

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Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.Apr 18, 2004

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Pubmed Data : Br J Cancer. 2004 Apr 19 ;90(8):1672-8. PMID: 15083202

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Pubmed Data : Med Sci Monit. 2019 Jun 1 ;25:4068-4075. Epub 2019 Jun 1. PMID: 31152143

Article Published Date : May 31, 2019

Study Type : Animal Study

Additional Links

Substances : Celastrol

Diseases : Liver Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Sorafenib

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Cholesterol derived from LDL acts as a chemosensitizer in multidrug resistant lymphoblastic leukemia cells.Oct 01, 2007

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Pubmed Data : Biochem Cell Biol. 2007 Oct;85(5):638-46. PMID: 17901905

Article Published Date : Oct 01, 2007

Study Type : Animal Study

Additional Links

Substances : Cholesterol

Diseases : Acute lymphoblastic leukemia (ALL), Cancers: Multi-Drug Resistant, Leukemia: T-cell acute Lymphoblastic

Pharmacological Actions : Chemosensitizer

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Chrysanthemum indicum could enhance the anti-cancer activity of bleomycin and reduce the its induced pulmonary injury in H22 tumor-bearing mice.Feb 23, 2017

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Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Dose Response

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Curcumin is a potent chemosensitizer to improve the therapeutic index of paclitaxel.Jul 13, 2011

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Pubmed Data : Oncogene. 2011 Jul 14 ;30(28):3139-52. Epub 2011 Feb 14. PMID: 21317920

Article Published Date : Jul 13, 2011

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Cervical Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer, NF-kappaB Inhibitor

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

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Curcumin may act synergistically with the chemotherapeutic regimen FOLFOX in gastric cancer in vitro and in vivo.Dec 31, 2015

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Pubmed Data : Oncol Res. 2016 ;23(1):29-34. PMID: 26802648

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:2951428. Epub 2019 Jul 17. PMID: 31391857

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Dandelion , Lemongrass

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Natural Substance/Drug Synergy, Selective Cytotoxicity

[+]

Deguelin may represent a novel and effective chemo-agent against head and neck squamous cell carcinoma.Dec 31, 2012

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Mangiferin shows synergistic anticancer activity with cisplatin.Dec 31, 2017

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Pubmed Data : J Cell Physiol. 2019 Aug ;234(10):17392-17404. Epub 2019 Feb 20. PMID: 30790292

Article Published Date : Jul 31, 2019

Study Type : Animal Study, In Vitro Study

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Substances : Flavonoids

Diseases : Glioma

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Temozolomide

[+]

Paeonol reversed paclitaxel resistance in MCF-7/PTX cells by downregulating the activity of the SET/PP2A/Akt pathway.Jun 30, 2015

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Pubmed Data : Biosci Rep. 2018 Dec 21 ;38(6). Epub 2018 Dec 11. PMID: 30420490

Article Published Date : Dec 20, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Shikonin

Diseases : Cancers: Drug Resistant, Non-Small-Cell Lung Carcinoma

Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic

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These results suggest that the combination of SK and gemcitabine may be a promising chemotherapy regimen for pancreatic cancer.Dec 31, 2016

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Pubmed Data : Am J Transl Res. 2017 ;9(12):5507-5517. Epub 2017 Dec 15. PMID: 29312502

Article Published Date : Dec 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Shikonin

Diseases : Pancreatic Cancer

Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemotherapeutic Synergy: Gemcitabine

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These results suggested that quercetin and cisplatin synergistically increased cellular toxicity in breast cancer cells.Jun 30, 2019

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Pubmed Data : J Ethnopharmacol. 2019 Oct 5 ;242:111699. Epub 2019 Apr 18. PMID: 31005632

Article Published Date : Oct 04, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Formononetin, Isoflavones

Diseases : Gliomas

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Temozolomide

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This study highlights the potential therapeutic usefulness of curcumin as an adjunct in patients with chemoresistant advanced CRC. Feb 28, 2015

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Pubmed Data : Carcinogenesis. 2015 Mar ;36(3):355-67. Epub 2015 Feb 4. PMID: 25653233

A comprehensive review of the benefits of neferine.Feb 26, 2018

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Pubmed Data : Neuromolecular Med. 2020 Feb 21. Epub 2020 Feb 21. PMID: 32086739

Article Published Date : Feb 20, 2020

Study Type : In Vitro Study

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Substances : Allicin

Diseases : Glioblastoma

Pharmacological Actions : Chemosensitizer, MicroRNA modulator

Additional Keywords : Chemotherapeutic Synergy: Temozolomide

[+]

Aloe-emodin enhances tamoxifen cytotoxicity in breast cancer cells.Feb 22, 2017

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Pubmed Data : Am J Chin Med. 2017 Feb 23:1-14. Epub 2017 Feb 23. PMID: 28231748

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Pubmed Data : Int J Oncol. 2017 Feb ;50(2):468-476. Epub 2017 Jan 2. PMID: 28101573

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Pubmed Data : Anticancer Drugs. 2017 Jul 7. Epub 2017 Jul 7. PMID: 28692436

Article Published Date : Jul 06, 2017

Study Type : In Vitro Study

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Substances : Andrographolide

Diseases : Lung Cancer

Pharmacological Actions : Autophagy Inhibitors, Chemosensitizer, Chemotherapeutic

Additional Keywords : Andrographolidem, Autophagy Inhibitors, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin, lung cancer

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Anti-cancer and ototoxicity characteristics of the curcuminoids, CLEFMA and EF24, in combination with cisplatin.Oct 28, 2019

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Pubmed Data : J Pharm Pharmacol. 2017 Jun ;69(6):743-752. Epub 2017 Mar 7. PMID: 28266023

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Pubmed Data : J Thorac Dis. 2020 Jul ;12(7):3715-3724. PMID: 32802451

Article Published Date : Jun 30, 2020

Study Type : In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Apoptotic, Autophagy Inhibitors, Chemosensitizer

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Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib.Mar 31, 2017

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Pubmed Data : Tumour Biol. 2017 Apr ;39(4):1010428317697555. PMID: 28443459

Beta-elemene enhances susceptibility to cisplatin in resistant ovarian carcinoma cells.Aug 31, 2013

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Pubmed Data : Int J Oncol. 2013 Sep ;43(3):721-8. Epub 2013 Jun 28. PMID: 23817665

Article Published Date : Aug 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Cancers: Drug Resistant, Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

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Betulinic acid could induce colorectal cancer cell death by inducing apoptosis.Oct 04, 2017

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Pubmed Data : Cell Death Dis. 2017 Oct 5 ;8(10):e3087. Epub 2017 Oct 5. PMID: 28981110

Article Published Date : Oct 04, 2017

Study Type : In Vitro Study

Additional Links

Substances : Betulinic acid

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic, Chemosensitizer

[+]

Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signalingDec 31, 2018

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Pubmed Data : Apoptosis. 2017 Jul 4. Epub 2017 Jul 4. PMID: 28677094

Article Published Date : Jul 03, 2017

Study Type : In Vitro Study

Additional Links

Substances : Bisdemethoxycurcumin

Diseases : Cancers: Multi-Drug Resistant, Lung Cancer

Pharmacological Actions : Chemosensitizer

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Bisdemethoxycurcumin partially offsets the chemoresistance induced by gemcitabine and produces apoptosis in PANC-1 cells.Nov 09, 2016

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Capsaicin potentiates the vitamin D3-induced and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia cells. May 25, 2001

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Pubmed Data : Eur J Pharmacol. 2001 May 25;420(2-3):83-90. PMID: 11408028

Article Published Date : May 25, 2001

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin, Vitamin D

Diseases : Promyelocytic leukemia

Pharmacological Actions : Chemosensitizer, Enzyme Inhibitors

Additional Keywords : Drug-Plant-Vitamin Synergies, Natural Substance Synergy

[+]

Cardamonin reduces chemotherapy resistance of colon cancer cells.May 31, 2018

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Pubmed Data : EBioMedicine. 2019 Nov 14. Epub 2019 Nov 14. PMID: 31735550

Article Published Date : Nov 13, 2019

Study Type : In Vitro Study

Additional Links

Substances : Celastrol

Diseases : Glioma

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Carboplatin

[+]

Chemo-sensitization resulting from fasting may in fact be an effect of enhanced immune surveillance.Dec 31, 2015

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Pubmed Data : J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18789628. PMID: 30051721

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Lung Cancer

Pharmacological Actions : Chemosensitizer, Hypoxia-inducible factor-1 (HIF-1) inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

Chrysanthemulide A induces apoptosis in human osteosarcoma cells.Dec 16, 2018

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Pubmed Data : J Cell Physiol. 2018 Dec 17. Epub 2018 Dec 17. PMID: 30556589

Article Published Date : Dec 16, 2018

Study Type : In Vitro Study

Additional Links

Substances : Chrysanthemum Indicum

Diseases : Osteosarcoma

Pharmacological Actions : Apoptotic, Chemosensitizer

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Chrysin-induced ERK1/2 phosphorylation enhances the sensitivity of human hepatocellular carcinoma cells to sorafenib.Jan 31, 2019

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Combined treatment with N-acetylcysteine and gefitinib overcomes drug resistance to gefitinib in NSCLC cell line.Dec 30, 2019

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Pubmed Data : Int J Mol Sci. 2020 Apr 16 ;21(8). Epub 2020 Apr 16. PMID: 32316312

Article Published Date : Apr 15, 2020

Study Type : In Vitro Study

Additional Links

Substances : Garlic

Diseases : Colon Cancer

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Oxaliplatin

[+]

Cranberry flavonols and PACs possess cytotoxic properties against ovarian cancer cells. Apr 30, 2015

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Pubmed Data : Transl Lung Cancer Res. 2015 Dec ;4(6):775-83. PMID: 26798587

Article Published Date : Nov 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Crocin

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Dose Response

[+]

Cucurbitacin B alone or in combination with imatinib mesylate synergistically inhibited cell proliferation and induced apoptosis.Dec 31, 2015

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Pubmed Data : Anticancer Agents Med Chem. 2016 ;16(6):747-54. PMID: 26863882

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Breast Cancer, Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Chemothapeutic Synergy: Imatinib, Dose Response

[+]

Cucurbitacin B is a promising chemosensitizer for the cisplatin-resistant ovarian cancer.Dec 31, 2015

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Pubmed Data : Tumour Biol. 2016 Jan ;37(1):685-98. Epub 2015 Aug 5. PMID: 26242260

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Cancers: Drug Resistant, Ovarian Cancer

Pharmacological Actions : Chemosensitizer

[+]

Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in Ramos cells.Feb 19, 2017

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Pubmed Data : Leuk Lymphoma. 2017 Feb 20:1-13. Epub 2017 Feb 20. PMID: 28278714

Article Published Date : Feb 19, 2017

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Leukemia: Acute promyelocytic leukemia

Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic

Problem Substances : Arsenic Trioxide

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"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer."Feb 28, 2011

Caffeine potentiates chemotherapy for metastatic osteosarcoma.Sep 01, 2009

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Amurensin G augmented the cytotoxic and apoptotic effects of TRAIL in TRAIL resistant leukemic cells.Jul 31, 2012

Amurensin G. was a potent SIRT1 Inhibitor which led to the down regulation of multidrug resistance.Oct 31, 2010

An ethanolic extract of T. camphoratus treatment further enhanced the tumor suppression efficiency of cisplatin and doxorubicin.Dec 31, 2014

Calebin A potentiates the effect of 5-FU and TNF-β against human colorectal cancer cells.Mar 30, 2020

Capsaicin inhibits 5-FU-induced autophagy and rendering Cholangiocarcinoma cells more susceptible to 5-FU-induced apoptosis.Dec 31, 2014

Epigenetic upregulation of metallothionein 2A by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel.Jan 21, 2016

Ginsenoside 20(S)-Rh2 has therapeutic potential for the treatment with colorectal cancer.Dec 23, 2016

Ginsenoside-Rb1 targets chemotherapy-resistant ovarian cancer stem cells.Nov 03, 2016

Huaier may be a potential drug for the treatment of cancers caused by aberrant mTOR signaling.Mar 31, 2016

Melatonin in combination with sorafenib synergistically inhibits proliferation and induces apoptosis in human liver cancer cells.Feb 07, 2017

Morus alba flavonoid extract and doxorubicin induce a dose dependent cell death in HT-29 cell line.Mar 30, 2016

Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.May 08, 2012

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.Nov 07, 2016

Silibinin may be a potentially useful therapeutic agent and chemosensitizer for esophageal cancer.Dec 31, 2015

Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression.Dec 31, 2017

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.Oct 31, 2016

Thymoquinone intensified temozolomide-induced apoptosis in U87MG cells.Apr 20, 2017

Ursolic acid could affect the proliferation and apoptosis of human ovarian cancer stem-like cells and it is a potent anti-ovarian cancer agent.Oct 31, 2015

Wogonin could increase doxorubicin sensitivity in human breast cancer cells.Dec 31, 2014

This reports on the synergistic effects of vitamin C with sorafenib against liver cancers. May 31, 2016

Emodin reverses 5-Fu resistance in human colorectal cancer via downregulation of PI3K/Akt signaling pathway.Dec 31, 2019

"Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia."Jun 30, 2012

20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.Dec 31, 2018

6-Gingerol is a potent inducer of p53 reactivation in HPV positive cervical cancer cells through proteasome inhibition.Nov 24, 2015

A combination therapy using silibinin and doxorubicin may show a better therapeutic efficacy in patients with HCC.Jun 30, 2016

A variety of carotenoids induce reduce resistance to chemotherapy in multidrug resistant lymphoma and human breast cancer cell lines. Mar 01, 2004

Adjuvant mistletoe therapy should be considered as an auspicious treatment option for glioma patients.Dec 31, 2017

An apple oligogalactan enhances the growth inhibitory effect of 5-fluorouracil on colorectal cancer.Jun 04, 2017

Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice.Dec 31, 2015

Anti-neoplastic effect of mangiferin on human ovarian adenocarcinoma OVCAR8 cells.Dec 31, 2018

Antineoplaston A10 works synergistically with conventional chemotherapy in human liver cancer transplanted to animals.May 01, 1992

Apigenin could inhibit the growth of cisplatin-resistant colon cancer cells in vitro and in vivo.Feb 28, 2019

Artesunate promotes sensitivity to sorafenib in hepatocellular carcinoma.Oct 28, 2019

Ascorbate supplementation might help reduce the severe side effects that arise from BETi therapy by reducing the dosage necessary for treatment.Nov 26, 2017

Ascorbic acid chemosensitizes colorectal cancer cells and synergistically inhibits tumor growth.Dec 31, 2017

Astaxanthin inhibits gemcitabine-resistant human pancreatic cancer progressionOct 31, 2017

Baicalein reversed the resistance of human A549 lung adenocarcinoma cells to cisplatin.May 31, 2017

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells.Apr 18, 2004

Betulinic acid chemosensitizes breast cancer cells.May 24, 2018

Bufalin could be an effective additional treatment to overcome acquired resistance to osimertinib in NSCLC cells.Sep 14, 2019

Celastrol enhances the antitumor activity of sorafenib in liver cancer cells.May 31, 2019

Cholesterol derived from LDL acts as a chemosensitizer in multidrug resistant lymphoblastic leukemia cells.Oct 01, 2007

Chrysanthemum indicum could enhance the anti-cancer activity of bleomycin and reduce the its induced pulmonary injury in H22 tumor-bearing mice.Feb 23, 2017

Cinnamic acid treatment increased the sensitivity of cancer stem cells to chemotherapeutic drugs through apoptosis.Dec 31, 2012

Co-treatments with Uro-A decreased IC50 values for both 5-FU and 5'DFUR and additionally arrested the cell cycle at the G2/M phase.Apr 30, 2015

Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.Jan 11, 2017

Combining ginger extract and doxorubicin revealed a greater efficacy as anticancer therapeutic regimen.Feb 21, 2017

Cucurbitacin B and cisplatin combination treatment may be a potentially useful therapeutic option for individuals diagnosed with laryngeal cancer.Aug 31, 2010

Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity.Feb 19, 2020

Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo.Sep 13, 2010

Curcumin and vitamin D3 enhanced the tumor response to paclitaxel.Oct 15, 2019

Curcumin combined with 5-FU led to the lower cell viability and higher apoptosis than 5-FU treated alone.Sep 30, 2012

Curcumin enhanced the therapeutic response to TMZ in U87MG glioblastoma by enhancing apoptosis.Sep 30, 2014

Curcumin enhances adriamycin-induced human liver-derived hepatoma G2 cell death.Jun 14, 2011

Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma. Oct 01, 2010

Curcumin has a synergistic effect with cisplatin against fibrosarcoma.Mar 01, 1999

Curcumin has anticancer, chemosensitization and radiosensitization effects in prostate cancer.Mar 01, 2007

Curcumin inhibited growth of murine malignant pleural mesothelioma cell-derived tumors in vivo in part by stimulating apoptosis.Oct 31, 2011

Curcumin is a potent chemosensitizer to improve the therapeutic index of paclitaxel.Jul 13, 2011

Curcumin may act synergistically with the chemotherapeutic regimen FOLFOX in gastric cancer in vitro and in vivo.Dec 31, 2015

Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells.Sep 30, 2013

Curcuminoids combined with gefitinib mediated apoptosis and autophagy of human oral cancer.May 01, 2018

Dandelion and lemongrass extracts were able to significantly reduce the tumour burden in prostate cancer xenograft models.Dec 31, 2018

Deguelin may represent a novel and effective chemo-agent against head and neck squamous cell carcinoma.Dec 31, 2012

Diallyl trisulfide potentiates chemotherapeutic efficacy of doxorubicin in experimentally induced mammary carcinoma.Jul 26, 2020

Diallyl trisulfide suppresses tumor growth and potentiates cisplatin efficacy in gastric cancer treatment.Mar 26, 2017

Dietary ellagitannins from pomegranate could alleviate intestinal mucositis in rats induced by 5-FU.Jun 18, 2018

Diosgenin, a compound isolated from fenugreek, has chemosensitizing activity against human liver cancer cells. Jan 04, 2010

Chemosensitizer

View the Evidence:
761 Abstracts with Chemosensitizer Research