Bcl-2 protein down-regulation

Name	AC	CK
Curcumin	16	19
Ginsenosides	12	14
Thymoquinone	7	13
Cucurbitacin B	5	10
Melatonin	7	10
Piperine	2	10
Parthenolide	5	9
Kahweol	4	8
Apigenin	3	7
Beta-Elemene	7	7
Ginger	5	7
Tanshinone IIA	6	7
Fermented Foods and Beverages	2	6
Fucoidan	6	6
Pterostilbene	4	6
Brown Rice	1	5
Chaga Mushroom (Inonotus obliquus)	1	5
Curcumin: Degradiation byproducts	1	5
Feverfew	1	5
Homeopathic Medicine: All	4	5
Mangosteen	1	5
Neem	1	5
Paeoniflorin	4	5
Pumpkin	1	5
Resveratrol	4	5
Tetrahydrocurcumin	1	5
Turmeric	4	5
Verbascoside	1	5
Astaxanthin	3	4
Baicalein	2	4
Blueberry	2	4
Carnosic Acid	3	4
Huaier (Trametes robiniophila murr)	4	4
Ligustrazine	2	4
Myricetin	4	4
Phloretin	3	4
Quercetin	3	4
Sulforaphane	4	4
Asiatic Acid	2	3
Berberine	3	3
Chrysin	2	3
Crocin	3	3
D-Limonene	3	3
Deguelin	2	3
Ellagic Acid	2	3
Ginkgo biloba	3	3
Ginseng (Korean)	2	3
Grape Seed Extract	2	3
Indole-3-Carbinol	2	3
Lichens	2	3
Lotus	3	3
Piceatannol	3	3
Silibinin	3	3
Tomato	2	3
Toona sinensis	2	3
Vitamin C	3	3
Zerumbone	3	3
Amygdalin	1	2
Arugula	1	2
Bai Zhu	1	2
Bee Venom	1	2
Berbamine	1	2
Bromelain	2	2
Buckwheat	1	2
Bufalin	2	2
Caffeine	1	2
Cinnamon	1	2
Curcumol	1	2
Daisy	1	2
Demethoxycurcumin	2	2
Diosgenin	1	2
Diosmin	1	2
Fisetin	1	2
Garlic	1	2
Grape	1	2
Helenalin	2	2
Honokiol	1	2
Hydrogen Water	1	2
Kefir	2	2
Lactobacillus rhamnosus GG	1	2
Long Pepper	1	2
Lupeol	1	2
Mistletoe	1	2
Modified Arabinoxylan Rice Bran (MGN-3)	1	2
Pine Bark Extract	2	2
Polyphenols	1	2
Pomegranate	1	2
Probiotics	1	2
Prunella vulgaris	1	2
Reishi Mushroom	1	2
Sesamol	1	2
Shiitake Mushroom	1	2
Soursop	2	2
Stilbenes	1	2
Strawberry	1	2
Vanillin	1	2
Vitamin K	1	2
Wogonin	2	2
2-Methoxyestradiol	1	1
6-Shogaol	1	1
Amygdalin (laetrile)	1	1
Arnica	1	1
Artemisinin	1	1
Bee Propolis	1	1
Benzyl isothiocyanate	1	1
Beta-sesquiphellandrene	1	1
Bisdemethoxycurcumin	1	1
Bitter Melon	1	1
Cafestol	1	1
Caffeic acid phenethyl ester	1	1
Cannabinoids: Synthetic	1	1
Capsaicin	1	1
Carrot	1	1
Celery seed	1	1
Chickpea	1	1
Chlorella (Algae)	1	1
Chrysanthemum Indicum	1	1
Clinacanthus nutans	1	1
Cordyceps sinensis	1	1
Cryptomeria japonica	1	1
EGCG (Epigallocatechin gallate)	1	1
Eucalyptus	1	1
Evodiamine	1	1
Flax Straw	1	1
Gallic Acid	1	1
Genistein	1	1
Gingerol	1	1
Gold (nanoparticles)	1	1
Graviola	1	1
Guggul	1	1
Gymnema Sylvestre	1	1
Hesperidin	1	1
Holy Basil	1	1
Hyperforin	1	1
Isoflavones	1	1
Isoliquiritigenin	1	1
Kaempferol	1	1
Lemongrass	1	1
Litchi	1	1
Lithospermum erythrorhizon	1	1
Luteolin	1	1
Lycopene	1	1
Magnolol	1	1
Maitake Mushroom	1	1
Mangiferin	1	1
Mango Seed	1	1
Moringa oleifera	1	1
Mulberry	1	1
Mushrooms: All	1	1
Nettle	1	1
Nexrutine (Phellodendrom)	1	1
Nigella sativa (aka Black Seed)	1	1
Oleanolic acid	1	1
Oleocanthal	1	1
Olive Oil	1	1
Persimmon	1	1
Phyllanthus emblica	1	1
Polyunsaturated Fatty Acids (PUFAs)	1	1
Psychedelics:All	1	1
Puerarin	1	1
Rhubarb	1	1
Rosemaric Acid	1	1
Rosemary	1	1
Shikonin	1	1
Silver (nanoparticles)	1	1
Sweet Potato	1	1
Syrian rue	1	1
Tetrahydropalmatine	1	1
Thistle	1	1
Turmerones	1	1
Ursolic Acid	1	1
Venom: Toad	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin E: alpha tocopherol	1	1
White Mulberry	1	1
Xanthohumol	1	1

Pubmed Data : J Cell Biochem. 2019 03 ;120(3):3736-3746. Epub 2018 Sep 19. PMID: 30229997

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Oridonin

Diseases : Esophageal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation

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Overall results indicate Gymnema sylvestre to have significant anticancer effect on A375 cells.Aug 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Anticancer Drugs. 2013 Feb ;24(2):140-9. PMID: 23069790

Article Published Date : Jan 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Paeoniflorin

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

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Paeoniflorin modulates multidrug resistance of a human gastric cancer cell line via the inhibition of NF-κB activation.Jan 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Protective effects of chronic green tea consumption on age-related neurodegeneration.Jan 01, 2012

Click here to read the entire abstract

Pubmed Data : Curr Pharm Des. 2012 ;18(1):4-14. PMID: 22211685

Click here to read the entire abstract

Pubmed Data : J Nutr. 2006 Nov ;136(11):2715-21. PMID: 17056790

Article Published Date : Nov 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Quercetin

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2014 ;37(8):1366-72. Epub 2014 Jun 11. PMID: 24920239

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest

[+]

Tetrahydropalmatine protects against gamma-radiation induced damage to human endothelial cells.Jul 03, 2010

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Pubmed Data : Life Sci. 2010 Jul 3;87(1-2):55-63. Epub 2010 May 26. PMID: 20562023

Article Published Date : Jul 03, 2010

Study Type : In Vitro Study

Additional Links

Substances : Tetrahydropalmatine

Diseases : Oxidative Stress, Radiation Induced Illness

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Radioprotective

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These results demonstrate that phloretin exerts potent chemo-preventive activity in human glioblastoma cells through the generation of ROS.May 31, 2016

Click here to read the entire abstract

Pubmed Data : J Neurooncol. 2016 Jun ;128(2):217-23. Epub 2016 Mar 16. PMID: 26983952

Article Published Date : May 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Phloretin

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Chemopreventive

[+]

These results extend the understanding of the anti-tumor mechanism of diosmetin.Jun 21, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Apoptosis. 2009 Nov ;14(11):1378-86. PMID: 19768546

Article Published Date : Oct 31, 2009

Study Type : In Vitro Study

Additional Links

Substances : Kahweol

Diseases : Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

[+]

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2018 Jan 24 ;66(3):602-612. Epub 2018 Jan 16. PMID: 29276946

Click here to read the entire abstract

Pubmed Data : J Neurooncol. 2012 Apr ;107(2):307-14. Epub 2011 Dec 11. PMID: 22160627

Article Published Date : Mar 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Glioblastoma

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation

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View the Evidence: 405 Abstracts with Bcl-2 protein down-regulation Research

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Myricetin induces apoptosis of human anaplastic thyroid cancer cells.Dec 31, 2016

Myricetin induces cell death of human colon cancer cells.Jan 31, 2014

Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis.Oct 07, 2009

Neferine-induced apoptosis is dependent on the suppression of Bcl-2 expression via downregulation of p65 in renal cancer cells.Jun 11, 2019

Neuroprotective effects of lotus seedpod procyanidins on extremely low frequency electromagnetic field-induced neurotoxicity.Jul 31, 2016

Nexrutine treatment also significantly inhibited invasion of androgen-independent prostate cancer cells.Feb 28, 2010

Nimbolide epigenetically regulates autophagy and apoptosis in breast cancer.Aug 31, 2018

O. stamineus extracts are able to inhibit proliferation and induced apoptosis of uterine fibroid cells.Oct 25, 2018

Oleanolic acid produces its anti-tumor effect via induction of cell cycle arrest and apoptosis.Nov 30, 2015

Oleocanthal had a remarkable and selective activity on human melanoma cells.Jun 06, 2016

Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells.Mar 31, 2016

Oridonin induces apoptosis in human nasopharyngeal carcinoma cells involving ROS generation.Dec 31, 2016

Oridonin-induced mitochondria-dependent apoptosis in esophageal cancer cells.Dec 31, 2018

Overall results indicate Gymnema sylvestre to have significant anticancer effect on A375 cells.Aug 31, 2013

P. vulgaris L has marked anti- uterine myoma activity.Jun 17, 2020

Paeoniflorin exerts neuroprotective effects against glutamate‑induced PC12 cellular cytotoxicity by inhibiting apoptosis.Aug 31, 2017

Paeoniflorin has a promising therapeutic potential in for osteosarcoma.Mar 31, 2018

Paeoniflorin inhibits IL-1β-induced chondrocyte apoptosisMar 31, 2018

Paeoniflorin may be a promising agent in the treatment of liver cancer.Jan 31, 2013

Paeoniflorin modulates multidrug resistance of a human gastric cancer cell line via the inhibition of NF-κB activation.Jan 31, 2012

Paeonol could be a promising treatment of hepatocellular carcinoma.Apr 27, 2008

Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis.Mar 26, 2013

Parthenolide induces apoptosis and autophagy-mediated growth inhibition in HeLa cells.Jul 31, 2016

Parthenolide induces apoptosis in colitis-associated colon cancer.Apr 30, 2015

Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells.Jan 05, 2014

Phloretin exhibits an anticancer effect and enhances the anticancer ability of cisplatin on non-small cell lung cancer cell lines.Jan 31, 2016

Piceatannol can be considered to be a promising anticancer agent for colorectal cancer.Sep 25, 2014

Piceatannol enhances cisplatin sensitivity in ovarian cancer.Aug 15, 2013

Pinus massoniana bark extract inhibited proliferation, induces apoptosis and causes cell cycle arrest in HeLa cells.Oct 31, 2008

Pinus massoniana bark proanthocyanidins exert anti-tumor effects on ovarian cancer cells.Dec 31, 2014

Protective effects of chronic green tea consumption on age-related neurodegeneration.Jan 01, 2012

Psorinum 6× triggered apoptosis in A549 cells.Feb 29, 2016

Pterostilbene can facilitate apoptosis of glioma cells, and inhibit their proliferation and invasion via mediating apoptotic/anti-apoptotic homeostasis.Dec 31, 2015

Pterostilbene has cytotoxic, anti-proliferative and antioxidant properties relevant to the treatment of breast and prostate cancer.Jun 01, 2010

Quercetin exhibits an inhibitory effect in a human hepatoma cell line.Nov 01, 2006

Radiation protection and radiosensitization of EGCG were associated with apoptosis regulated by miR-34a/Sirt1/p53 signaling pathway.Sep 04, 2019

Resveratrol induces programmed cell death in human nasopharyngeal carcinoma cells.Mar 01, 2011

Resveratrol inhibited the proliferation of pancreatic cancer cells by inducing programmed cell death. Nov 01, 2010

Resveratrol inhibits proliferation and induces apoptosis of A549 cells.Oct 31, 2015

Rheum palmatum extract exerts anti-hepatocellular carcinoma effects by inhibiting signal transducer and activator of transcription 3 signaling.Mar 24, 2019

Rosmarinic acid combined with adriamycin induces apoptosis in HepG2 and Bel-7402 cells.Nov 03, 2018

Safflower polysaccharide inhibits the proliferation and metastasis of MCF-7 breast cancer cell.May 31, 2015

Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri.Sep 30, 2015

Selenium enrichment improves anti-proliferative effect of oolong tea extract on human hepatoma HuH-7 cells.Dec 31, 2020

Shikonin can sensitize esophageal cancer cells to paclitaxel-treatment.Aug 31, 2019

Shikonin exhibited its anti-tumor activity against HGC-27 cells through inhibiting cell growth and promoting apoptosis by targeting mitochondrial-related signaling pathway.Mar 31, 2015

Shikonin induces cell death by inhibiting glycolysis in human testicular cancer I-10 and seminoma TCAM-2 cells.Sep 29, 2020

silibinin induced autophagic cell death through ROS-dependent mitochondrial dysfunction and ATP depletion involving BNIP3 in MCF7 cells. May 31, 2015

Silibinin-induces programmed cell death in breast cancer. Jan 01, 2011

Sodium selenite and ginsenoside Rh2 combination may be effective treatment for human colorectal carcinoma.Dec 31, 2015

Sulforaphane has a chemopreventive effect in colon cancer cells. Apr 30, 2012

Sulforaphane has potent apoptosis inducing effects and invasion inhibiting effects against U251 glioblastoma cells.Dec 31, 2015

Sulforaphane with EGCG can inhibit both paclitaxel-sensitive and resistant ovarian cancer cells.Mar 09, 2013

Synergistic antitumor effect of 5-fluorouracil in combination with parthenolide in human colorectal cancer.Jul 27, 2013

Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines.Jul 31, 2018

Synergistic effect of combining paeonol and cisplatin on apoptotic induction of human hepatoma cell lines.May 31, 2007

Tanshinone IIA can inhibit the proliferation of K562 cells.Apr 30, 2014

Tanshinone IIA enhances chemosensitivity of colon cancer cells by suppressing nuclear factor-κB.Feb 29, 2016

Tanshinone IIA induces apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis.Dec 31, 2013

Tetrahydropalmatine protects against gamma-radiation induced damage to human endothelial cells.Jul 03, 2010

The antimammary tumor effects of ethanolic extract of propolis from Adamawa region are by apoptosis.Jan 03, 2021

The combination of berberine and d-limonene exerted synergistic anticancer effects on MGC803 cells by cell-cycle arrest, ROS production, and apoptosis induction.Aug 31, 2014

The combination of cinobufacini and doxorubicin increases apoptosis of hepatocellular carcinoma cells.Dec 31, 2016

The current study demonstrated that licochalcone C may be a potential adjuvant therapeutic agent for bladder cancer.Oct 31, 2015

The cytotoxic and apoptotic effects of nobiletin on bladder cancer cells are associated with endoplasmic reticulum stress and mitochondrial dysfunction.Aug 07, 2019

The effects of thymoquinone on viability, and anti-apoptotic factors in prostate cancer cells.Jul 31, 2019

The findings demonstrated that ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells.Jan 31, 2016

The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells.Dec 31, 2014

The present data suggests a potential clinical impact of wogonin for ovarian cancer patients.Dec 31, 2016

The present study demonstrated the anti-proliferative and apoptotic activities of crocin against both sensitive and resistant cervical cancer cells.Jul 28, 2017

The present study demonstrated the potential anticancer effects of apigenin on glioma cells.Jun 29, 2016

The results of this study show the anti-proliferative effects of ascorbic acid against leukemic cells.Dec 31, 2006

View the Evidence:
405 Abstracts with Bcl-2 protein down-regulation Research