Bcl-2 protein down-regulation

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176 Substances Researched for Bcl-2 protein down-regulation
NameACCKFocus
Curcumin1619Locked
Ginsenosides1214Locked
Thymoquinone713Locked
Cucurbitacin B 510Locked
Melatonin710Locked
Piperine210Locked
Parthenolide59Locked
Kahweol48Locked
Apigenin37Locked
Beta-Elemene77Locked
Ginger57Locked
Tanshinone IIA67Locked
Fermented Foods and Beverages26Locked
Fucoidan66Locked
Pterostilbene46Locked
Brown Rice15Locked
Chaga Mushroom (Inonotus obliquus)15Locked
Curcumin: Degradiation byproducts15Locked
Feverfew15Locked
Homeopathic Medicine: All45Locked
Mangosteen15Locked
Neem15Locked
Paeoniflorin45Locked
Pumpkin15Locked
Resveratrol45Locked
Tetrahydrocurcumin15Locked
Turmeric45Locked
Verbascoside15Locked
Astaxanthin34Locked
Baicalein24Locked
Blueberry24Locked
Carnosic Acid34Locked
Huaier (Trametes robiniophila murr)44Locked
Ligustrazine24Locked
Myricetin44Locked
Phloretin34Locked
Quercetin34Locked
Sulforaphane44Locked
Asiatic Acid23Locked
Berberine33Locked
Chrysin23Locked
Crocin33Locked
D-Limonene33Locked
Deguelin23Locked
Ellagic Acid23Locked
Ginkgo biloba33Locked
Ginseng (Korean)23Locked
Grape Seed Extract23Locked
Indole-3-Carbinol23Locked
Lichens23Locked
Lotus 33Locked
Piceatannol 33Locked
Silibinin33Locked
Tomato23Locked
Toona sinensis 23Locked
Vitamin C33Locked
Zerumbone33Locked
Amygdalin12Locked
Arugula12Locked
Bai Zhu12Locked
Bee Venom12Locked
Berbamine12Locked
Bromelain22Locked
Buckwheat12Locked
Bufalin22Locked
Caffeine12Locked
Cinnamon12Locked
Curcumol12Locked
Daisy12Locked
Demethoxycurcumin22Locked
Diosgenin12Locked
Diosmin 12Locked
Fisetin12Locked
Garlic12Locked
Grape12Locked
Helenalin22Locked
Honokiol12Locked
Hydrogen Water12Locked
Kefir22Locked
Lactobacillus rhamnosus GG12Locked
Long Pepper12Locked
Lupeol12Locked
Mistletoe12Locked
Modified Arabinoxylan Rice Bran (MGN-3)12Locked
Pine Bark Extract22Locked
Polyphenols12Locked
Pomegranate12Locked
Probiotics12Locked
Prunella vulgaris12Locked
Reishi Mushroom12Locked
Sesamol12Locked
Shiitake Mushroom 12Locked
Soursop22Locked
Stilbenes12Locked
Strawberry12Locked
Vanillin12Locked
Vitamin K12Locked
Wogonin22Locked
2-Methoxyestradiol11Locked
6-Shogaol11Locked
Amygdalin (laetrile)11Locked
Arnica11Locked
Artemisinin11Locked
Bee Propolis11Locked
Benzyl isothiocyanate 11Locked
Beta-sesquiphellandrene11Locked
Bisdemethoxycurcumin11Locked
Bitter Melon11Locked
Cafestol11Locked
Caffeic acid phenethyl ester11Locked
Cannabinoids: Synthetic11Locked
Capsaicin11Locked
Carrot11Locked
Celery seed11Locked
Chickpea11Locked
Chlorella (Algae)11Locked
Chrysanthemum Indicum11Locked
Clinacanthus nutans11Locked
Cordyceps sinensis11Locked
Cryptomeria japonica11Locked
EGCG (Epigallocatechin gallate)11Locked
Eucalyptus11Locked
Evodiamine11Locked
Flax Straw11Locked
Gallic Acid11Locked
Genistein11Locked
Gingerol 11Locked
Gold (nanoparticles)11Locked
Graviola 11Locked
Guggul11Locked
Gymnema Sylvestre11Locked
Hesperidin11Locked
Holy Basil11Locked
Hyperforin11Locked
Isoflavones11Locked
Isoliquiritigenin11Locked
Kaempferol11Locked
Lemongrass11Locked
Litchi11Locked
Lithospermum erythrorhizon11Locked
Luteolin11Locked
Lycopene11Locked
Magnolol11Locked
Maitake Mushroom11Locked
Mangiferin11Locked
Mango Seed11Locked
Moringa oleifera11Locked
Mulberry11Locked
Mushrooms: All 11Locked
Nettle11Locked
Nexrutine (Phellodendrom)11Locked
Nigella sativa (aka Black Seed)11Locked
Oleanolic acid11Locked
Oleocanthal11Locked
Olive Oil11Locked
Persimmon 11Locked
Phyllanthus emblica11Locked
Polyunsaturated Fatty Acids (PUFAs)11Locked
Psychedelics:All 11Locked
Puerarin11Locked
Rhubarb11Locked
Rosemaric Acid11Locked
Rosemary11Locked
Shikonin11Locked
Silver (nanoparticles)11Locked
Sweet Potato11Locked
Syrian rue11Locked
Tetrahydropalmatine 11Locked
Thistle11Locked
Turmerones11Locked
Ursolic Acid11Locked
Venom: Toad11Locked
Vitamin E: Gamma-tocotrienol11Locked
Vitamin E: alpha tocopherol11Locked
White Mulberry 11Locked
Xanthohumol11Locked

View the Evidence:
393 Abstracts with Bcl-2 protein down-regulation Research

[+]

Oleocanthal had a remarkable and selective activity on human melanoma cells.Jun 06, 2016

Pubmed Data : Nutr Cancer. 2016 Jun 7:1-5. Epub 2016 Jun 7. PMID: 27266366
Article Published Date : Jun 06, 2016
Study Type : In Vitro Study
Additional Links
Substances : Oleocanthal, Olive Oil
Diseases : Melanoma
Pharmacological Actions : Bcl-2 protein down-regulation, Cytotoxic
Additional Keywords : Selective Cytotoxicity
[+]

Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2016 Apr ;13(4):3342-8. Epub 2016 Feb 16. PMID: 26935490
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemotherapeutic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Oridonin induces apoptosis in human nasopharyngeal carcinoma cells involving ROS generation.Dec 31, 2016

Pubmed Data : Folia Biol (Praha). 2017 ;63(4):155-163. PMID: 29256858
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Oridonin-induced mitochondria-dependent apoptosis in esophageal cancer cells.Dec 31, 2018

Pubmed Data : J Cell Biochem. 2019 03 ;120(3):3736-3746. Epub 2018 Sep 19. PMID: 30229997
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Overall results indicate Gymnema sylvestre to have significant anticancer effect on A375 cells.Aug 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2013 Sep ;12(5):433-41. Epub 2013 Apr 24. PMID: 23615751
Article Published Date : Aug 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Gymnema Sylvestre
Diseases : Melanoma, Skin Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Plant Extracts
[+]

P. vulgaris L has marked anti- uterine myoma activity.Jun 17, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2020 Jun 18 ;20(1):189. Epub 2020 Jun 18. PMID: 32552673
Article Published Date : Jun 17, 2020
Study Type : In Vitro Study
Additional Links
Substances : Prunella vulgaris
Diseases : Myoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Survivin Down-Regulation
[+]

Paeoniflorin exerts neuroprotective effects against glutamate‑induced PC12 cellular cytotoxicity by inhibiting apoptosis.Aug 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2017 Sep ;40(3):825-833. Epub 2017 Jul 20. PMID: 28731183
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Neuroprotective Agents
[+]

Paeoniflorin has a promising therapeutic potential in for osteosarcoma.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Apr ;17(4):5095-5101. Epub 2018 Jan 22. PMID: 29363721
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cell cycle arrest
[+]

Paeoniflorin inhibits IL-1β-induced chondrocyte apoptosisMar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Apr ;17(4):6194-6200. Epub 2018 Feb 26. PMID: 29484390
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Interleukin-1 beta downregulation
[+]

Paeoniflorin may be a promising agent in the treatment of liver cancer.Jan 31, 2013

Pubmed Data : Anticancer Drugs. 2013 Feb ;24(2):140-9. PMID: 23069790
Article Published Date : Jan 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Paeoniflorin modulates multidrug resistance of a human gastric cancer cell line via the inhibition of NF-κB activation.Jan 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2012 Feb ;5(2):351-6. Epub 2011 Nov 1. PMID: 22051979
Article Published Date : Jan 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Cancers: Multi-Drug Resistant, Gastric Cancer
Pharmacological Actions : Bcl-2 protein down-regulation, Multidrug Resistance Gene Modulators, NF-kappaB Inhibitor
[+]

Paeonol could be a promising treatment of hepatocellular carcinoma.Apr 27, 2008

Pubmed Data : Eur J Pharmacol. 2008 Apr 28 ;584(2-3):246-52. Epub 2008 Feb 15. PMID: 18329639
Article Published Date : Apr 27, 2008
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis.Mar 26, 2013

Pubmed Data : J Ethnopharmacol. 2013 Mar 27 ;146(2):543-51. Epub 2013 Jan 26. PMID: 23357312
Article Published Date : Mar 26, 2013
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Cholesterol: Oxidation, Lipid Peroxidation
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, NF-kappaB Inhibitor
[+]

Parthenolide induces apoptosis and autophagy-mediated growth inhibition in HeLa cells.Jul 31, 2016

Pubmed Data : Biotechnol Lett. 2016 Aug ;38(8):1251-60. Epub 2016 Apr 21. PMID: 27099069
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Parthenolide induces apoptosis in colitis-associated colon cancer.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2015 May ;9(5):2135-2142. Epub 2015 Mar 6. PMID: 26137027
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation
[+]

Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells.Jan 05, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2014 Jan 6 ;33:3. Epub 2014 Jan 6. PMID: 24387758
Article Published Date : Jan 05, 2014
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Phloretin exhibits an anticancer effect and enhances the anticancer ability of cisplatin on non-small cell lung cancer cell lines.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2016 Feb ;48(2):843-53. Epub 2015 Dec 21. PMID: 26692364
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Phloretin
Diseases : Cancer Metastasis, Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Piceatannol can be considered to be a promising anticancer agent for colorectal cancer.Sep 25, 2014

Pubmed Data : Biochem Biophys Res Commun. 2014 Sep 26 ;452(3):775-81. Epub 2014 Sep 8. PMID: 25218158
Article Published Date : Sep 25, 2014
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, MicroRNA modulator
[+]

Piceatannol enhances cisplatin sensitivity in ovarian cancer.Aug 15, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2013 Aug 16 ;288(33):23740-50. Epub 2013 Jul 5. PMID: 23833193
Article Published Date : Aug 15, 2013
Study Type : In Vitro Study
Additional Links
Substances : Piceatannol
Diseases : Cancers: Drug Resistant, Chemotherapy-Induced Toxicity: Cisplatin, Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Pinus massoniana bark extract inhibited proliferation, induces apoptosis and causes cell cycle arrest in HeLa cells.Oct 31, 2008

Pubmed Data : Phytother Res. 2008 Nov ;22(11):1472-6. PMID: 18803251
Article Published Date : Oct 31, 2008
Study Type : In Vitro Study
Additional Links
Substances : Pine Bark Extract
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
Additional Keywords : Plant Extracts
[+]

Pinus massoniana bark proanthocyanidins exert anti-tumor effects on ovarian cancer cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(11):e0142157. Epub 2015 Nov 5. PMID: 26539720
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Pine Bark Extract
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Proanthocyanidins
[+]

Protective effects of chronic green tea consumption on age-related neurodegeneration.Jan 01, 2012

Pubmed Data : Curr Pharm Des. 2012 ;18(1):4-14. PMID: 22211685
Article Published Date : Jan 01, 2012
Study Type : Review
Additional Links
Substances : Catechin , Polyphenols, Tea
Diseases : Aging, Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Antioxidants, Bcl-2 protein down-regulation, Brain-derived neurotrophic factor modulator, Chelating Agents, Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

Psorinum 6× triggered apoptosis in A549 cells.Feb 29, 2016

Pubmed Data : J Integr Med. 2016 Mar ;14(2):143-53. PMID: 26988436
Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Pterostilbene can facilitate apoptosis of glioma cells, and inhibit their proliferation and invasion via mediating apoptotic/anti-apoptotic homeostasis.Dec 31, 2015

Pubmed Data : Am J Transl Res. 2016 ;8(12):5211-5218. Epub 2016 Dec 15. PMID: 28077996
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Glioma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Pterostilbene has cytotoxic, anti-proliferative and antioxidant properties relevant to the treatment of breast and prostate cancer.Jun 01, 2010

Pubmed Data : Toxicol In Vitro. 2010 Jun;24(4):1215-28. Epub 2010 Feb 10. PMID: 20152895
Article Published Date : Jun 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Breast Cancer, Prostate Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Stilbenes
[+]

Quercetin exhibits an inhibitory effect in a human hepatoma cell line.Nov 01, 2006

Pubmed Data : J Nutr. 2006 Nov ;136(11):2715-21. PMID: 17056790
Article Published Date : Nov 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Radiation protection and radiosensitization of EGCG were associated with apoptosis regulated by miR-34a/Sirt1/p53 signaling pathway.Sep 04, 2019

Pubmed Data : Food Chem Toxicol. 2019 Sep 5 ;133:110807. Epub 2019 Sep 5. PMID: 31494133
Article Published Date : Sep 04, 2019
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, MicroRNA modulator, Radioprotective, Radiosensitizer
[+]

Resveratrol induces programmed cell death in human nasopharyngeal carcinoma cells.Mar 01, 2011

Pubmed Data : J Cell Physiol. 2011 Mar;226(3):720-8. PMID: 20717957
Article Published Date : Mar 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Stilbenes
[+]

Resveratrol inhibited the proliferation of pancreatic cancer cells by inducing programmed cell death. Nov 01, 2010

Pubmed Data : Phytother Res. 2010 Nov;24(11):1637-44. PMID: 21031621
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
Additional Keywords : Stilbenes
[+]

Resveratrol inhibits proliferation and induces apoptosis of A549 cells.Oct 31, 2015

Pubmed Data : Cell Biochem Biophys. 2015 Nov ;73(2):527-31. PMID: 27352348
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Non-Small-Cell Lung Carcinoma
Pharmacological Actions : Apoptotic, Bax/Bcl2 Ratio: Decrease, Bcl-2 protein down-regulation
Additional Keywords : Dose Response
[+]

Rheum palmatum extract exerts anti-hepatocellular carcinoma effects by inhibiting signal transducer and activator of transcription 3 signaling.Mar 24, 2019

Pubmed Data : J Ethnopharmacol. 2019 Mar 25 ;232:62-72. Epub 2018 Dec 13. PMID: 30553869
Article Published Date : Mar 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : Rhubarb
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cyclin D1 Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor, Survivin Down-Regulation
Additional Keywords : Plant Extracts
[+]

Rosmarinic acid combined with adriamycin induces apoptosis in HepG2 and Bel-7402 cells.Nov 03, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Nov 4 ;24:7898-7908. Epub 2018 Nov 4. PMID: 30391993
Article Published Date : Nov 03, 2018
Study Type : In Vitro Study
Additional Links
Substances : Rosemaric Acid
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Safflower polysaccharide inhibits the proliferation and metastasis of MCF-7 breast cancer cell.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Jun ;11(6):4611-6. Epub 2015 Feb 6. PMID: 25673029
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Safflower
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Bcl-2 protein down-regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Polysaccharides
[+]

Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2015 Oct ;34(4):1659-66. Epub 2015 Aug 6. PMID: 26251956
Article Published Date : Sep 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Kefir
Diseases : Breast Cancer, Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Selective Cytotoxicity
[+]

Shikonin can sensitize esophageal cancer cells to paclitaxel-treatment.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2019 Sep ;18(3):3195-3201. Epub 2019 Jul 25. PMID: 31452796
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Esophageal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Shikonin exhibited its anti-tumor activity against HGC-27 cells through inhibiting cell growth and promoting apoptosis by targeting mitochondrial-related signaling pathway.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2015 Apr-Jun;11(42):250-6. PMID: 25829762
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lithospermum erythrorhizon, Shikonin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation
[+]

Shikonin induces cell death by inhibiting glycolysis in human testicular cancer I-10 and seminoma TCAM-2 cells.Sep 29, 2020

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2020 Sep 30 ;40(9):1288-1294. PMID: 32990238
Article Published Date : Sep 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Testicular Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Bcl-2 protein down-regulation
[+]

silibinin induced autophagic cell death through ROS-dependent mitochondrial dysfunction and ATP depletion involving BNIP3 in MCF7 cells. May 31, 2015

Pubmed Data : Oncol Rep. 2015 Jun ;33(6):2711-8. Epub 2015 Apr 17. PMID: 25891311
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Breast Cancer
Pharmacological Actions : Autophagy Up-regulation, Bcl-2 protein down-regulation
[+]

Silibinin-induces programmed cell death in breast cancer. Jan 01, 2011

Pubmed Data : Cancer Invest. 2011 Jan ;29(1):12-20. PMID: 21166494
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-8 activation
[+]

Sodium selenite and ginsenoside Rh2 combination may be effective treatment for human colorectal carcinoma.Dec 31, 2015

Pubmed Data : Arch Iran Med. 2016 Jan ;19(1):23-9. PMID: 26702744
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Sodium Selenite
[+]

Sulforaphane has a chemopreventive effect in colon cancer cells. Apr 30, 2012

Pubmed Data : Chin J Physiol. 2012 Apr 30 ;55(2):134-44. PMID: 22559738
Article Published Date : Apr 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Chemopreventive
[+]

Sulforaphane has potent apoptosis inducing effects and invasion inhibiting effects against U251 glioblastoma cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Springerplus. 2016 ;5:235. Epub 2016 Feb 29. PMID: 27026929
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Glioblastoma
Pharmacological Actions : Anti-metastatic, Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Survivin Down-Regulation
[+]

Sulforaphane with EGCG can inhibit both paclitaxel-sensitive and resistant ovarian cancer cells.Mar 09, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Cell Res. 2013 Mar 10 ;319(5):697-706. Epub 2013 Jan 16. PMID: 23333498
Article Published Date : Mar 09, 2013
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Sulforaphane
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Telomerase Inhibitor
Additional Keywords : Isothiocyanates
[+]

Synergistic antitumor effect of 5-fluorouracil in combination with parthenolide in human colorectal cancer.Jul 27, 2013

Pubmed Data : Cancer Lett. 2013 Jul 28 ;335(2):479-86. Epub 2013 Mar 16. PMID: 23507557
Article Published Date : Jul 27, 2013
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Cancers: Drug Resistant, Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines.Jul 31, 2018

Pubmed Data : Mol Med Rep. 2018 Aug ;18(2):1835-1841. Epub 2018 Jun 5. PMID: 29901126
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Gastric Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Synergistic effect of combining paeonol and cisplatin on apoptotic induction of human hepatoma cell lines.May 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharmacol Sin. 2007 Jun ;28(6):869-78. PMID: 17506946
Article Published Date : May 31, 2007
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Tanshinone IIA can inhibit the proliferation of K562 cells.Apr 30, 2014

Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 May ;45(3):410-3. PMID: 24941807
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Tanshinone IIA enhances chemosensitivity of colon cancer cells by suppressing nuclear factor-κB.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Mar ;11(3):1085-1089. Epub 2016 Jan 12. PMID: 26998041
Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Bcl-2 protein down-regulation, Chemosensitizer, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Tanshinone IIA induces apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2014 ;37(8):1366-72. Epub 2014 Jun 11. PMID: 24920239
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Tetrahydropalmatine protects against gamma-radiation induced damage to human endothelial cells.Jul 03, 2010

Pubmed Data : Life Sci. 2010 Jul 3;87(1-2):55-63. Epub 2010 May 26. PMID: 20562023
Article Published Date : Jul 03, 2010
Study Type : In Vitro Study
Additional Links
Substances : Tetrahydropalmatine
Diseases : Oxidative Stress, Radiation Induced Illness
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Radioprotective
[+]

The combination of berberine and d-limonene exerted synergistic anticancer effects on MGC803 cells by cell-cycle arrest, ROS production, and apoptosis induction.Aug 31, 2014

Pubmed Data : J Med Food. 2014 Sep ;17(9):955-62. Epub 2014 Jul 21. PMID: 25045784
Article Published Date : Aug 31, 2014
Study Type : Plant Study
Additional Links
Substances : Berberine, D-Limonene
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation
Additional Keywords : Dose Response, Natural Substance Synergy, Plant Extracts
[+]

The combination of cinobufacini and doxorubicin increases apoptosis of hepatocellular carcinoma cells.Dec 31, 2016

Pubmed Data : Am J Chin Med. 2017 ;45(7):1537-1556. Epub 2017 Sep 25. PMID: 28946772
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Venom: Toad
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

The current study demonstrated that licochalcone C may be a potential adjuvant therapeutic agent for bladder cancer.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Nov ;12(5):7623-8. Epub 2015 Sep 22. PMID: 26397392
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Licorice
Diseases : Bladder Cancer, Lymphoma: B-Cell
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

The cytotoxic and apoptotic effects of nobiletin on bladder cancer cells are associated with endoplasmic reticulum stress and mitochondrial dysfunction.Aug 07, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Aug 8 ;24(16). Epub 2019 Aug 8. PMID: 31398899
Article Published Date : Aug 07, 2019
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation
[+]

The effects of thymoquinone on viability, and anti-apoptotic factors in prostate cancer cells.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Pharm Bull. 2019 Aug ;9(3):490-496. Epub 2019 Aug 1. PMID: 31592099
Article Published Date : Jul 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation
[+]

The findings demonstrated that ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells.Jan 31, 2016

Pubmed Data : Oncol Rep. 2016 Feb ;35(2):1034-40. Epub 2015 Nov 16. PMID: 26573608
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, STAT3 Inhibitor
[+]

The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells.Dec 31, 2014

Pubmed Data : Int J Oncol. 2015 ;46(6):2670-8. Epub 2015 Apr 16. PMID: 25892545
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Mulberry
Diseases : Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
[+]

The present data suggests a potential clinical impact of wogonin for ovarian cancer patients.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2017 ;2017:9381513. Epub 2017 Oct 18. PMID: 29181409
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation, Vascular Endothelial Growth Factor Inhibitors
[+]

The present study demonstrated the anti-proliferative and apoptotic activities of crocin against both sensitive and resistant cervical cancer cells.Jul 28, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jul 29 ;94:307-316. Epub 2017 Jul 29. PMID: 28763753
Article Published Date : Jul 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation
[+]

The present study demonstrated the potential anticancer effects of apigenin on glioma cells.Jun 29, 2016

Pubmed Data : Mol Med Rep. 2016 Jun 30. Epub 2016 Jun 30. PMID: 27430517
Article Published Date : Jun 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, MicroRNA modulator
Additional Keywords : Dose Response
[+]

The results of this study show the anti-proliferative effects of ascorbic acid against leukemic cells.Dec 31, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2007 Jan-Feb;27(1A):289-98. PMID: 17352246
Article Published Date : Dec 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Acute T cell Leukemias, Human T-cell leukemia virus type I (HTLV-I)
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

The study identified the potential chemopreventive agent among the bioactive compounds of Annona muricata.Dec 03, 2017

Pubmed Data : Apoptosis. 2017 Dec 4. Epub 2017 Dec 4. PMID: 29204721
Article Published Date : Dec 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Soursop
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Mar ;17(3):4299-4306. Epub 2018 Jan 18. PMID: 29363722
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Suppressor Protein p53 Upregulation, Wnt/β-catenin signaling pathway modulation
[+]

Therapeutic implications of Nigella sativa against cancer metastasis.Aug 31, 2016

Pubmed Data : Pak J Pharm Sci. 2016 Sep ;29(5(Suppl)):1881-1884. PMID: 28476718
Article Published Date : Aug 31, 2016
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cancer Metastasis, Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors
[+]

These findings indicate that puerarin may act as a chemopreventive and chemotherapeutic agent in colon cancer cells.Jul 07, 2006

Pubmed Data : Cancer Lett. 2006 Jul 8 ;238(1):53-60. Epub 2005 Aug 1. PMID: 16055262
Article Published Date : Jul 07, 2006
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemopreventive, Chemotherapeutic
[+]

These findings suggest that Lonicera japonica has a potent anti-parkinsonism effects.Feb 29, 2012

Pubmed Data : Food Chem Toxicol. 2012 Mar ;50(3-4):797-807. Epub 2011 Dec 28. PMID: 22227216
Article Published Date : Feb 29, 2012
Study Type : In Vitro Study
Additional Links
Substances : Honeysuckle
Diseases : Brain: Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

These findings suggest that mango kernel extract has potential to be developed into a therapeutic mixture for treatment of breast cancers.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 ;15:45. Epub 2015 Mar 9. PMID: 25881293
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Mango Seed
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Redox Modulator
Additional Keywords : Dose Response
[+]

These results demonstrate that phloretin exerts potent chemo-preventive activity in human glioblastoma cells through the generation of ROS.May 31, 2016

Pubmed Data : J Neurooncol. 2016 Jun ;128(2):217-23. Epub 2016 Mar 16. PMID: 26983952
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Phloretin
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Chemopreventive
[+]

These results extend the understanding of the anti-tumor mechanism of diosmetin.Jun 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2019 Jun 22 ;25:4639-4647. Epub 2019 Jun 22. PMID: 31228347
Article Published Date : Jun 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Diosmetin
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

These results highlight the NF-κB inhibitor helenalin as a promising chemotherapeutic agent to overcome Bcl-2-induced cell death resistance.Aug 31, 2011

Pubmed Data : Biochem Pharmacol. 2011 Sep 1 ;82(5):453-63. Epub 2011 Jun 2. PMID: 21669190
Article Published Date : Aug 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Helenalin
Diseases : Breast Cancer, Cancers: All, Pancreatic Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemotherapeutic, NF-kappaB Inhibitor
[+]

These results indicate that beta-elemene inhibits growth and induces apoptosis of human glioma cells in vitro.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2014 ;15(23):10407-12. PMID: 25556484
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Glioma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

These results show the activity of kahweol to modulate multiple components in apoptotic response of human leukemia cells.Oct 31, 2009

Pubmed Data : Apoptosis. 2009 Nov ;14(11):1378-86. PMID: 19768546
Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Kahweol
Diseases : Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

These results suggest a potential benefit of isoliquiritigenin for cervical cancer prevention and treatment.Oct 31, 2013

Pubmed Data : Planta Med. 2013 Nov ;79(17):1628-35. Epub 2013 Nov 8. PMID: 24214831
Article Published Date : Oct 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemopreventive, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Phytotherapy
[+]

This present study is shows the effect of ellagic acid in inhibiting human prostate cancer cell growth.Jun 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2011 Jul ;4(7):550-5. PMID: 21803307
Article Published Date : Jun 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

This review describes the anti-cancer properties, molecular targets, and the apoptotic effects of guggulsterone.Nov 11, 2015

Pubmed Data : Curr Pharm Des. 2015 Nov 12. Epub 2015 Nov 12. PMID: 26561056
Article Published Date : Nov 11, 2015
Study Type : Review
Additional Links
Substances : Guggul
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Apoptotic, Bcl-2 protein down-regulation, Chemopreventive, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, Survivin Down-Regulation, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Gene Expression Regulation
[+]

This study demonstrates the therapeutic potential and action mechanism of cirsimaritin for the prevention and treatment of type 1 diabetes mellitus.Jun 30, 2017

Pubmed Data : J Pharm Pharmacol. 2017 Jul ;69(7):875-883. Epub 2017 Apr 11. PMID: 28397263
Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thistle
Diseases : Diabetes Mellitus: Type 1: Prevention, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Pancreato Protective Agents
[+]

This study highlights the chemo-preventive and chemo-sensitizing role of curcumin in leukemia cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2016 ;17(8):3865-9. PMID: 27644631
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

This study revealed the efficiency of hesperetin against human skin carcinoma cells.Dec 31, 2014

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2015 ;61(6):92-9. Epub 2015 Oct 30. PMID: 26518900
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Hesperidin
Diseases : Skin Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, P21 Activation
[+]

This study showed the functions of shogaol as a sensitizing agent to induce cell death of TRAIL-resistant colon cancer cells.Jun 10, 2015

Pubmed Data : Tumour Biol. 2015 Jun 11. Epub 2015 Jun 11. PMID: 26063410
Article Published Date : Jun 10, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ginger
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Survivin Down-Regulation
Additional Keywords : Plant Extracts
[+]

This study suggests grape seed proanthocyanidin extract as a potential therapeutic agent that could help reduce lymphocyte apoptosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PeerJ. 2017 ;5:e3108. Epub 2017 Mar 21. PMID: 28344907
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract
Diseases : Sepsis
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Inhibition
Additional Keywords : Proanthocyanidins
[+]

Thymoquinone and cisplatin had comparable antitumoric effects on SK-OV-3 cells.Jul 06, 2017

Pubmed Data : Int J Gynecol Cancer. 2017 Jul 7. Epub 2017 Jul 7. PMID: 28692636
Article Published Date : Jul 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells.Jan 09, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mutat Res. 2011 Jan 10 ;706(1-2):28-35. Epub 2010 Oct 30. PMID: 21040738
Article Published Date : Jan 09, 2011
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Breast Cancer, Cancers: Drug Resistant
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Tulsi extracts can effectively induce apoptosis in prostate cancer cells.Jun 30, 2015

Pubmed Data : J Med Food. 2015 Jul ;18(7):776-85. Epub 2015 Feb 18. PMID: 25692494
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Holy Basil
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation
Additional Keywords : Plant Extracts
[+]

Turmeric oil contains ar-turmerone which displays anti-lymphoma properties.Feb 28, 2009

Pubmed Data : BMB Rep. 2009 Feb 28;42(2):96-100. PMID: 19250610
Article Published Date : Feb 28, 2009
Study Type : In Vitro Study
Additional Links
Substances : Turmeric, Turmerones
Diseases : Lymphoma
Pharmacological Actions : Antioxidants, Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Plant Extracts
[+]

Ursolic acid appears to be a potent molecule for the treatment of melanoma.Feb 16, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2019 Feb 17 ;25:1283-1290. Epub 2019 Feb 17. PMID: 30772887
Article Published Date : Feb 16, 2019
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

WIN induces a clear apoptotic effect which was accompanied by up-regulation of the death signaling factors and down regulation of the survival factors.Mar 31, 2009

Pubmed Data : Biochimie. 2009 Apr ;91(4):457-65. Epub 2008 Nov 27. PMID: 19059457
Article Published Date : Mar 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Cannabinoids: Synthetic
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, Survivin Down-Regulation
[+]

Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells.Jan 31, 2012

Pubmed Data : Int Immunopharmacol. 2012 Feb ;12(2):334-41. Epub 2011 Dec 17. PMID: 22182776
Article Published Date : Jan 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Xanthohumol partially inhibited the invasiveness of glioblastoma cells.Oct 31, 2012

Pubmed Data : Phytother Res. 2012 Nov ;26(11):1709-13. Epub 2012 Mar 9. PMID: 22407755
Article Published Date : Oct 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Xanthohumol
Diseases : Glioblastoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Selective Cytotoxicity
[+]

Zerumbone induces apoptosis, cell cycle arrest, and antimigratory effects in SW480 colorectal cancer cells.Jan 23, 2018

Pubmed Data : J Agric Food Chem. 2018 Jan 24 ;66(3):602-612. Epub 2018 Jan 16. PMID: 29276946
Article Published Date : Jan 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Zerumbone
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Plant Extracts
[+]

Zerumbone induces gastric cancer cells apoptosis.Sep 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Oct ;83:740-745. Epub 2016 Jul 29. PMID: 27479192
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Zerumbone
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Zerumbone might have a chemotherapeutic effect on human melanoma cells through mitochondria-mediated pathways.Nov 30, 2016

Pubmed Data : Clin Exp Dermatol. 2016 Dec ;41(8):858-863. Epub 2016 Oct 19. PMID: 27759171
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Zerumbone
Diseases : Melanoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemotherapeutic
[+]

β-elemene reverses the drug resistance of lung cancer A549/DDP cells via the mitochondrial apoptosis pathway.Apr 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2014 May ;31(5):2131-8. Epub 2014 Mar 12. PMID: 24627125
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Βeta-elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells.Mar 31, 2012

Pubmed Data : J Neurooncol. 2012 Apr ;107(2):307-14. Epub 2011 Dec 11. PMID: 22160627
Article Published Date : Mar 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Glioblastoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation

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