Acetylcholinesterase Inhibitor

Name	AC	CK
Sage	1	10
Black Pepper	1	2
Broccoli	1	2
Chokeberry	1	2
Curcumin	1	2
Evodia ruteacarpa	1	2
Ginkgo biloba	1	2
Kiwifruit	1	2
Licorice	1	2
Melatonin	1	2
Noni	1	2
Nutmeg	1	2
Vitamin C	1	2
Agrimony	1	1
Bacopa	1	1
Cannabis	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Devils Claw	1	1
Green Tea	1	1
Muira Puama	1	0
Schisandra	1	0

[+]

After supplementation of MetS patients with A. melanocarpa extract, a decrease in acetylcholinesterase activity and oxidative stress was noted.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Res Int. 2018 ;2018:5670145. Epub 2018 Mar 26. PMID: 29780825

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Chokeberry

Diseases : Metabolic Syndrome X

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants

Additional Keywords : Plant Extracts

[+]

Sage has cholinesterase inhibiting properties which improve mood and cognitive performance.Apr 01, 2006

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Pubmed Data : Neuropsychopharmacology. 2006 Apr;31(4):845-52. PMID: 16205785

Article Published Date : Apr 01, 2006

Study Type : Human Study

Additional Links

Substances : Sage

Diseases : Cognitive Decline/Dysfunction, Mood Disorders

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Oligonol has strong preventative potential in diabetes mellitus and in Alzheimer's disease.Feb 29, 2016

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Pubmed Data : Arch Pharm Res. 2016 Mar ;39(3):409-20. Epub 2016 Jan 2. PMID: 26724817

Article Published Date : Feb 29, 2016

Study Type : Human In Vitro

Additional Links

Substances : Lychee

Diseases : Alzheimer's Disease, Diabetes Mellitus: Type 2

Pharmacological Actions : Acetylcholinesterase Inhibitor, Alpha-glucosidase inhibitor

Additional Keywords : Dose Response, Proanthocyanidins

[+]

A combined plant extract WS-5 could be applied as a natural product therapy with a focus on neuroinflammation-related neurodegenerative disorders.Dec 31, 2018

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:5160293. Epub 2019 Apr 1. PMID: 31057649

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Ginger, Turmeric

Diseases : Alzheimer's Disease, Neurodegenerative Diseases

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments.Jul 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Sci Biotechnol. 2018 Aug ;27(4):1193-1200. Epub 2018 Apr 4. PMID: 30263850

Article Published Date : Jul 31, 2018

Study Type : Animal Study

Additional Links

Substances : Ginseng (Korean), Kudzu

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

A. arguta might be considered possible substance to prevent neurodegeneration through AChE inhibition and strong antioxidant activity.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:876484. Epub 2015 Oct 21. PMID: 26576196

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Kiwifruit

Diseases : Amnesia: Drug-Induced, Brain: Oxidative Stress, Neurodegenerative Diseases

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

An extract of broccoli leaves could be used as a natural resource for ameliorating Aβ1-42-induced learning and memory impairment.May 03, 2016

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Pubmed Data : J Agric Food Chem. 2016 May 4 ;64(17):3353-61. Epub 2016 Apr 22. PMID: 27079470

Article Published Date : May 03, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Broccoli

Diseases : Learning disorders, Memory Disorders

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Ascorbic acid ameliorates behavioural deficits and neuropathological alterations in rat model of Alzheimer's disease.Feb 05, 2017

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Pubmed Data : Environ Toxicol Pharmacol. 2017 Feb 6 ;50:200-211. Epub 2017 Feb 6. PMID: 28192749

Article Published Date : Feb 05, 2017

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents

[+]

Beneficial effects of Urtica dioica on scopolamine-induced memory impairment.May 09, 2018

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Pubmed Data : Drug Chem Toxicol. 2018 May 10:1-9. Epub 2018 May 10. PMID: 29745257

Article Published Date : May 09, 2018

Study Type : Animal Study

Additional Links

Substances : Nettle

Diseases : Brain: Oxidative Stress, Memory Disorders: Drug-Induced

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

Centella asiatica attenuated the cognitive deficits in rats by restoring cholinergic function, attenuating oxidative stress.Mar 29, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxics. 2019 Mar 30 ;7(2). Epub 2019 Mar 30. PMID: 30935005

Article Published Date : Mar 29, 2019

Study Type : Animal Study

Additional Links

Substances : Gotu Kola

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents

Additional Keywords : Natural Substances Versus Drugs

[+]

Chokeberry extract has potential as a therapeutic agent for the prevention and treatment of neurodegenerative diseases.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:6145926. Epub 2016 Apr 30. PMID: 27239211

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Chokeberry

Diseases : Alzheimer's Disease, Memory Disorders: Drug-Induced, Neurodegenerative Diseases

Pharmacological Actions : Acetylcholinesterase Inhibitor

Additional Keywords : Plant Extracts

[+]

Coconut leaf extract metabolites could decrease amyloid-β1-42 aggregation.Apr 20, 2017

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Pubmed Data : Biomedicines. 2017 Apr 21 ;5(2). Epub 2017 Apr 21. PMID: 28536360

Article Published Date : Apr 20, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Coconut

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Cucurbita maxima seed oil may exert antiamnesic activity which may be attributed to the inhibition of AChE and inflammation.Aug 31, 2014

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Pubmed Data : Z Naturforsch C. 2014 Sep-Oct;69(9-10):407-17. PMID: 25711042

Article Published Date : Aug 31, 2014

Study Type : Animal Study

Additional Links

Substances : Pumpkin Seeds

Diseases : Amnesia, Inflammation, Oxidative Stress

Pharmacological Actions : Acetylcholinesterase Inhibitor, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substances Versus Drugs, Plant Extracts

[+]

Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats.May 16, 2017

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Pubmed Data : Neurotoxicology. 2017 May 17. Epub 2017 May 17. PMID: 28527659

Article Published Date : May 16, 2017

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Alzheimer's Disease, Cadmium Poisoning

Pharmacological Actions : Acetylcholinesterase Inhibitor

Problem Substances : Cadmium

[+]

Curcumin improves episodic memory in cadmium induced memory impairment.Aug 04, 2016

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Pubmed Data : Metab Brain Dis. 2016 Aug 5. Epub 2016 Aug 5. PMID: 27491636

Article Published Date : Aug 04, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Cadmium Poisoning , Lipid Peroxidation, Memory Disorders

Pharmacological Actions : Acetylcholinesterase Inhibitor, Adenosine deaminase inhibitor, Malondialdehyde Down-regulation

[+]

Curcumin lessens unpredictable chronic mild stress-induced depression and memory deficits by modulating oxidative stress and cholinergic activity.Jun 30, 2019

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Pubmed Data : Pak J Pharm Sci. 2019 Jul ;32(4(Supplementary)):1893-1900. PMID: 31680089

Article Published Date : Jun 30, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Anxiety, Depression

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents

[+]

Curcuminoids (from Turmeric) enhance memory in mice through acetylcholinesterase inhibition. Feb 01, 2009

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Pubmed Data : Pharmacol Biochem Behav. 2009 Feb;91(4):554-9. Epub 2008 Oct 1. PMID: 18930076

Article Published Date : Feb 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Alzheimer's Disease, Memory Disorders, Memory Loss

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Dietary supplementation with walnut kernel or walnut septum extract can maintain the liver and brain health and reduce the risk of age-related diseases.May 13, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2020 May 14 ;9(5). Epub 2020 May 14. PMID: 32423149

Article Published Date : May 13, 2020

Study Type : Animal Study

Additional Links

Substances : Walnut

Diseases : Aging: Brain , Brain: Oxidative Stress

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Hypoglycemic Agents, Neuroprotective Agents

[+]

Effect of essential oils from ginger and turmeric rhizomes on some inflammatory biomarkers in cadmium induced neurotoxicity in rats.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Toxicol. 2018 ;2018:4109491. Epub 2018 Oct 8. PMID: 30402094

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Ginger, Turmeric

Diseases : Cadmium Poisoning

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Essential Oils

Problem Substances : Cadmium

[+]

Evodia rutaecarpa has acetylcholinesterase inhibition and antiamnesic activities which may be useful in the treatment of AlzheimersJan 01, 2010

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Pubmed Data : BMC Cancer. 2010;10:238. Epub 2010 May 26. PMID: 8923803

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Evodia ruteacarpa

Diseases : Alzheimer's Disease, Amnesia

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Extracts of A. princeps orientalis could be an effective treatment against cholinergic dysfunction.Dec 31, 2011

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Pubmed Data : Am J Chin Med. 2012 ;40(5):993-1005. PMID: 22928830

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Japanese mugwort

Diseases : Dementia, Memory Disorders

Pharmacological Actions : Acetylcholinesterase Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Extracts of holy basil could become effective anti-amnesic treatments. Dec 03, 2016

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Pubmed Data : J Ethnopharmacol. 2016 Dec 4 ;193:490-499. Epub 2016 Oct 8. PMID: 27725240

Article Published Date : Dec 03, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Holy Basil

Diseases : Amnesia, Amnesia: Drug-Induced

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Fucoxanthin might exhibit great therapeutic efficacy for the treatment of Alzheimer's disease.Mar 24, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mar Drugs. 2016 Mar 25 ;14(4). Epub 2016 Mar 25. PMID: 27023569

Article Published Date : Mar 24, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fucoxanthin

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

Ginkgo biloba ameloriates aluminum-induced learning and memory deficits in rats. Mar 01, 2006

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Pubmed Data : Chin J Integr Med. 2006 Mar;12(1):37-41. PMID: 16571282

Article Published Date : Mar 01, 2006

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Aluminum Toxicity , Memory Disorders, Memory Loss

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Harmine alkaloids are potential agents to utilize in the management of neurodegenerative disorders.Nov 30, 2013

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Pubmed Data : Pak J Biol Sci. 2013 Dec 1 ;16(23):1687-97. PMID: 24506035

Article Published Date : Nov 30, 2013

Study Type : Animal Study

Additional Links

Substances : Syrian rue

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Apoptotic, Neuroprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Harmine could ameliorate impaired memory by enhancement of cholinergic neurotransmission.Dec 04, 2015

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Pubmed Data : Eur J Pharmacol. 2015 Dec 5 ;768:96-107. Epub 2015 Oct 23. PMID: 26526348

Article Published Date : Dec 04, 2015

Study Type : Animal Study

Additional Links

Substances : Syrian rue

Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

Additional Keywords : Acetylcholinesterase Inhibitor, Alzheimer's disease, Cognitive Decline/Dysfunction, Neuroprotective Agents, Syrian rue

[+]

Hibiscus represents a promising safe agent that can be repurposed for Alzheimer's disease.Jul 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2020 Aug ;128:110303. Epub 2020 May 29. PMID: 32480228

Article Published Date : Jul 31, 2020

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa

Diseases : Alzheimer’s disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Inflammatory Agents, Neuroprotective Agents

[+]

Huperzine-A contributed to the healing process in rats for damage occurring both in the brain and in the neuro-muscular system.Aug 31, 2017

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Pubmed Data : Life Sci. 2017 Sep 1 ;184:47-57. Epub 2017 Jul 12. PMID: 28709849

Article Published Date : Aug 31, 2017

Study Type : Animal Study

Additional Links

Substances : Huperzine

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

Intranasal administration of nasal gel huperzine A may represent a safe and noninvasive therapeutic strategy for the treatment of Alzheimer's disease.Mar 31, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neuropsychopharmacology. 2011 Apr ;36(5):1073-89. Epub 2011 Feb 2. PMID: 21289607

Article Published Date : Mar 31, 2011

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Huperzine

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Wnt/β-catenin signaling pathway modulation

[+]

Lavandula stoechas is a very potent antioxidant and attenuates dementia.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2018 ;9:1375. Epub 2018 Nov 23. PMID: 30532710

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Lavender

Diseases : Dementia

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Malondialdehyde Down-regulation

[+]

Lemon essential oil ameliorates age-associated cognitive dysfunction.May 10, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Aging (Albany NY). 2020 May 11 ;12(9):8622-8639. Epub 2020 May 11. PMID: 32392535

Article Published Date : May 10, 2020

Study Type : Animal Study

Additional Links

Substances : Lemon

Diseases : Aging, Cognitive Decline/Dysfunction

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

Additional Keywords : Essential Oils

[+]

Licorice (Glycyrrhiza glabra), Nutmega (Myristica fragrans), and vitamin C (ascorbic acid) have acetylcholinesterase-inhibiting associated with improved memory and learning. activity. Jun 01, 2006

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Pubmed Data : J Med Food. 2006 Summer;9(2):281-3. PMID: 16822217

Article Published Date : Jun 01, 2006

Study Type : Animal Study

Additional Links

Substances : Licorice, Nutmeg, Vitamin C

Diseases : Memory Disorders

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Myricetin is a potential multifunctional treatment for Alzheimer's disease.Jan 18, 2017

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Pubmed Data : Biochem Biophys Res Commun. 2017 08 19 ;490(2):336-342. Epub 2017 Jun 12. PMID: 28619513

Article Published Date : Jan 18, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Myricetin

Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Memory Disorders

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

Naringenin attenuates social defeat stress induced neurobehavioral deficits.Aug 31, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Sep ;105:714-723. Epub 2018 Jun 12. PMID: 29906750

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Social Behavior

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

Naringenin may play a role in enhancing neuroprotective and cognition functions.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2020 ;15(1):e0227631. Epub 2020 Jan 16. PMID: 31945778

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents

[+]

Naringin treatment may be useful to reduce wood smoke-induced oxidative stress and related ocular and pulmonary damage.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Curr Ther Res Clin Exp. 2020 ;92:100586. Epub 2020 Apr 20. PMID: 32419878

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Air Pollution Linked Toxicity, Lung Injury: Smoke-Induced

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Inflammatory Agents, Antioxidants

[+]

Natural acetylcholinesterase Inhibitors could be useful in toxoplasma gondii induced memory impairment. Mar 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Parasitol. 2016 Apr-Jun;11(2):177-185. PMID: 28096851

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Cognitive Decline/Dysfunction, Toxoplasma gondii Infection

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Neuroprotective and memory-enhancing effect of the combined extract of purple waxy corn cob and pandan in ovariectomized rats.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:5187102. Epub 2017 Jul 9. PMID: 28770022

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Corn: Purple

Diseases : Menopausal Syndrome

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

Additional Keywords : Ovariectomy-Induced Changes

[+]

Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats.Oct 30, 2019

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Pubmed Data : Neurotoxicology. 2019 Oct 31 ;76:99-110. Epub 2019 Oct 31. PMID: 31678059

Article Published Date : Oct 30, 2019

Study Type : Animal Study

Additional Links

Substances : Selenium

Diseases : Arsenic Poisoning

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

Problem Substances : Arsenic

[+]

Noni may have a protective effect against memory impairment. Nov 15, 2011

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Pubmed Data : J Ethnopharmacol. 2011 Nov 15. Epub 2011 Nov 15. PMID: 22107832

Article Published Date : Nov 15, 2011

Study Type : Animal Study

Additional Links

Substances : Noni

Diseases : Memory Disorders

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Peganum harmala extracts exert beneficial effect on learning and memory processes in mice with scopolamine-induced memory impairment.May 22, 2017

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Pubmed Data : J Ethnopharmacol. 2017 May 23 ;204:95-106. Epub 2017 Apr 23. PMID: 28442406

Article Published Date : May 22, 2017

Study Type : Animal Study

Additional Links

Substances : Syrian rue

Diseases : Alzheimer's Disease, Memory Disorders

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Phloretin has nootropic, neuroprotective and neurotrophic activities in scopolamine induced memory impaired mice.Jul 31, 2015

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Pubmed Data : Pharmacol Biochem Behav. 2015 Aug ;135:182-91. Epub 2015 Jun 10. PMID: 26071678

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Phloretin

Diseases : Alzheimer's Disease, Memory Disorders

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Brain-derived neurotrophic factor modulator, Catalase Up-Regulation, Neuroprotective Agents, Nootropic Agents, Superoxide Dismutase Up-regulation

[+]

Piper nigrum significantly improved learning and memory deficits associated with aluminium chloride and also showed the anticholinesterase activity with prevention of nerve degeneration.Mar 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Diagn Res. 2015 Apr ;9(4):FF01-4. Epub 2015 Apr 1. PMID: 26023568

Article Published Date : Mar 31, 2015

Study Type : Animal Study

Additional Links

Substances : Black Pepper

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents

Additional Keywords : Prevention

Problem Substances : Aluminum Chloride

[+]

Radish leaves may have preventive effects against memory deficits related to Alzheimer's disease.Jul 31, 2018

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Pubmed Data : J Med Food. 2018 Aug ;21(8):769-776. PMID: 30110203

Article Published Date : Jul 31, 2018

Study Type : Animal Study

Additional Links

Substances : Radish

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

Repeated administration of Nigella sativa oil may exert memory enhancing effects against restrained stress.Aug 31, 2017

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Pubmed Data : Pak J Pharm Sci. 2017 Sep ;30(5(Supplementary)):2039-2046. PMID: 29105641

Article Published Date : Aug 31, 2017

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Memory Disorders

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents

[+]

Schisandra chinensis extract may be a potential therapeutic candidate for Alzheimer's disease.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:2804849. Epub 2020 Feb 20. PMID: 32148536

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Schisandra

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Malondialdehyde Down-regulation, Neuroprotective Agents

[+]

Schisanhenol improves learning and memory in scopolamine-treated mice.Jan 31, 2019

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Pubmed Data : Int J Neurosci. 2019 Feb ;129(2):110-118. Epub 2018 Oct 30. PMID: 30033800

Article Published Date : Jan 31, 2019

Study Type : Animal Study

Additional Links

Substances : Schisandra

Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Memory Disorders, Memory Disorders: Drug-Induced

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

Sesquiterpenes and a monoterpenoid with acetylcholinesterase inhibitory activity from Valeriana officinalis.Mar 31, 2016

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Pubmed Data : Fitoterapia. 2016 Apr ;110:142-9. Epub 2016 Mar 11. PMID: 26976216

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Substances : Valerian

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

The current study highlights P. vulgaris L. as an anti-dementia dietary supplement.Jan 17, 2017

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Pubmed Data : J Agric Food Chem. 2017 Jan 18 ;65(2):291-300. Epub 2017 Jan 3. PMID: 28001065

Article Published Date : Jan 17, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Prunella vulgaris

Diseases : Dementia

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation

[+]

The study concludes that a macerated ethanolic extract of Indian propolis has anti-Alzheimer potential in rats.Jul 03, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Jul 4 ;93:543-553. Epub 2017 Jul 4. PMID: 28686968

Article Published Date : Jul 03, 2017

Study Type : Animal Study

Additional Links

Substances : Propolis: Bee

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Brain-derived neurotrophic factor modulator, Neuroprotective Agents

Additional Keywords : Acetylcholinesterase Inhibitor, Alzheimer's disease, Propolis: Bee

[+]

These findings may provide adequate evidence for the clinical and experimental benefits gained from huperzine A treatment.Jan 31, 2012

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Pubmed Data : J Neurosci Res. 2012 Feb ;90(2):508-17. Epub 2011 Oct 17. PMID: 22002568

Article Published Date : Jan 31, 2012

Study Type : Transgenic Animal Study

Additional Links

Substances : Huperzine

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

This result indicated an important role for A. graveolens extract in preventing age-associated decline in cognitive function associated with depression.Jun 30, 2017

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Pubmed Data : J Nat Med. 2017 Jul ;71(3):492-505. Epub 2017 Feb 15. PMID: 28205135

Article Published Date : Jun 30, 2017

Study Type : Animal Study

Additional Links

Substances : Celery Oil

Diseases : Aging: Brain , Cognitive Decline/Dysfunction, Depression

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Zinc exhibits anti-amnesiac activity in mice. Jun 03, 2008

Click here to read the entire abstract

Pubmed Data : Behav Brain Res. 2008 Jun 3;189(2):381-6. Epub 2008 Feb 5. PMID: 18336929

Article Published Date : Jun 03, 2008

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Amnesia

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Antibacterial and in vitro antidementia effects of chokeberry leaf extracts.Aug 31, 2020

Click here to read the entire abstract

Pubmed Data : Food Sci Biotechnol. 2020 Sep ;29(9):1295-1300. Epub 2020 May 22. PMID: 32802569

Article Published Date : Aug 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Chokeberry

Diseases : Dementia

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Bacterial Agents, Neuroprotective Agents

[+]

A review of the antitumour, antimicrobial, antioxidant and antiacetylcholinesterase effect of Ganoderma lucidum terpenoids and polysaccharides.Mar 12, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2018 Mar 13 ;23(3). Epub 2018 Mar 13. PMID: 29534044

Article Published Date : Mar 12, 2018

Study Type : Review

Additional Links

Substances : Reishi Mushroom

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antimicrobial, Antioxidants, Antiproliferative

[+]

A. marmelos is a significant source of polyphenolic compounds with potential AChE inhibitory property and antioxidant activity.Feb 28, 2014

Click here to read the entire abstract

Pubmed Data : Psychogeriatrics. 2014 Mar ;14(1):1-10. PMID: 24646308

Article Published Date : Feb 28, 2014

Study Type : In Vitro Study

Additional Links

Substances : Bael

Diseases : Alzheimer's Disease, Lipid Peroxidation

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

AChE inhibition by the methanolic extract of T. cordifolia was probably due to the synergism of the isoquinoline alkaloids.Nov 17, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2019 Nov 18 ;24(22). Epub 2019 Nov 18. PMID: 31752124

Article Published Date : Nov 17, 2019

Study Type : In Vitro Study

Additional Links

Substances : Guduchi

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Adjunctive treatment with huperzine A was associated with a faster resolution of the cognitive symptoms that frequently accompany major depressive disorder.Apr 24, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Shanghai Arch Psychiatry. 2016 Apr 25 ;28(2):64-71. PMID: 27605862

Article Published Date : Apr 24, 2016

Study Type : Review

Additional Links

Substances : Huperzine

Diseases : Depression, Depressive Disorder

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Agrimony has acetylcholinesterase inhibitory properties. Jan 01, 2007

Click here to read the entire abstract

Pubmed Data : Molecules. 2007;12(9):2130-9. Epub 2007 Sep 3. PMID: 17962731

Article Published Date : Jan 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Agrimony

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

An ethyl acetate soluble fraction of the roots of Harpagophytum procumbens was found to inhibit AChE activity.Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Arch Pharm Res. 2014 ;37(9):1124-9. Epub 2013 Dec 28. PMID: 24374905

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Devils Claw

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Cholinesterase Inhibitors

Additional Keywords : Plant Extracts

[+]

Antioxidant, cholinesterase inhibition activities and essential oil analysis of Nelumbo nucifera seeds.May 31, 2016

Click here to read the entire abstract

Pubmed Data : Nat Prod Res. 2016 Jun ;30(11):1335-8. Epub 2015 Jul 27. PMID: 26212099

Article Published Date : May 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids, Lotus

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants

Additional Keywords : Essential Oils

[+]

Bacopa is an acetylcholinesterase inhibitor, neuroprotective, and has antioxidant effects. Aug 05, 2008

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2008 Aug 5. [Epub ahead of print] PMID: 18755259

Article Published Date : Aug 05, 2008

Study Type : In Vitro Study

Additional Links

Substances : Bacopa

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents

[+]

Carpolobia lutea possesses anti-AChE activity and beneficial antioxidant capacity indicative of its potential development as a treatment of Alzheimer's.Nov 30, 2017

Click here to read the entire abstract

Pubmed Data : Pharm Biol. 2017 Dec ;55(1):1875-1883. PMID: 28629287

Article Published Date : Nov 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Carpolobia lutea

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants

Additional Keywords : Dose Response

[+]

Curcumin and piperine demonstrated promising neuroprotective effects.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Aging Neurosci. 2019 ;11:206. Epub 2019 Aug 27. PMID: 31507403

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Curcuminoids have anti-cholinesterase and anti-diabetic activities.Mar 12, 2017

Click here to read the entire abstract

Pubmed Data : Nat Prod Res. 2017 Mar 13:1-4. Epub 2017 Mar 13. PMID: 28287280

Article Published Date : Mar 12, 2017

Study Type : In Vitro Study

Additional Links

Substances : Bisdemethoxycurcumin, Curcuminoids, Demethoxycurcumin, Turmeric

Diseases : Alzheimer's Disease, Diabetes Mellitus: Type 2

Pharmacological Actions : Acetylcholinesterase Inhibitor, Alpha-glucosidase inhibitor , Antioxidants

[+]

Effect of Salvia miltiorrhiza on acetylcholinesterase: Enzyme kinetics and interaction mechanism merging with molecular docking analysis.May 21, 2019

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2019 May 22 ;135:303-313. Epub 2019 May 22. PMID: 31128195

Article Published Date : May 21, 2019

Study Type : In Vitro Study

Additional Links

Substances : Salvia miltiorrhiza

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Fruiting body extracts of T. pubescens demonstrated antioxidant related anti-diabetes, anti-dementia and anti-inflammatory activities.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2016 ;21(5). Epub 2016 May 16. PMID: 27196881

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Mushrooms: All

Diseases : Dementia, Diabetes Mellitus: Type 2, Inflammation

Pharmacological Actions : Acetylcholinesterase Inhibitor, Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Huperzine A is documented to be a promising agent for the treatment of Alzheimer's disease due to its potent acetylcholinesterase inhibitory activity.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Pak J Pharm Sci. 2017 Jan ;30(1 Suppl):235-239. PMID: 28625948

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Huperzine

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor

Additional Keywords : Plant Extracts

[+]

Inhibitory effect of asiatic acid on acetylcholinesterase.Feb 14, 2012

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2012 Feb 15 ;19(3-4):311-6. Epub 2011 Nov 23. PMID: 22112723

Article Published Date : Feb 14, 2012

Study Type : In Vitro Study

Additional Links

Substances : Asiatic Acid

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Kinetics of acetylcholinesterase inhibition by hemp seed protein-derived peptides.Jun 30, 2019

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2019 Jul ;43(7):e12897. Epub 2019 May 15. PMID: 31353736

Article Published Date : Jun 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Hemp Seed

Diseases : Neurodegenerative Diseases

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Lichen depsides and depsidones showed neuroactive properties in vitro, suggesting their potential to treat CNS disorders.Nov 14, 2016

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2016 Nov 15 ;23(12):1527-1534. Epub 2016 Aug 31. PMID: 27765373

Article Published Date : Nov 14, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lichens

Diseases : Central Nervous System Diseases

Pharmacological Actions : Acetylcholinesterase Inhibitor

Additional Keywords : Gene Expression Regulation

[+]

M. acuminata leaf is rich in bioactive flavonoids with relatively high antioxidative, antidiabetic, and anti-inflammatory activities.Jan 02, 2020

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2020 Jan 3:e13137. Epub 2020 Jan 3. PMID: 31899556

Article Published Date : Jan 02, 2020

Study Type : In Vitro Study

Additional Links

Substances : Banana, Kaempferol, Rutin

Diseases : Alzheimer's Disease, Diabetes Mellitus: Type 2, Inflammation

Pharmacological Actions : 15-Lipoxygenase (15-LOX) Inhibitor, Acetylcholinesterase Inhibitor, Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Anti-Inflammatory Agents, Enzyme Inhibitors

[+]

New cholinesterase inhibitory constituents from Lonicera quinquelocularis.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2014 ;9(4):e94952. Epub 2014 Apr 14. PMID: 24733024

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Honeysuckle

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Cholinesterase Inhibitors

[+]

P. harmala had inhibitory activities on acetylcholinesterase and butyrylcholinesterase.Jun 19, 2015

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2015 Jun 20 ;168:279-86. Epub 2015 Apr 8. PMID: 25862961

Article Published Date : Jun 19, 2015

Study Type : In Vitro Study

Additional Links

Substances : Syrian rue

Pharmacological Actions : Acetylcholinesterase Inhibitor

Additional Keywords : Acetylcholinesterase Inhibitor, Syrian rue

[+]

Piperlongumine B and analogs are promising and selective inhibitors for acetylcholinesterase.Aug 01, 2017

Click here to read the entire abstract

Pubmed Data : Eur J Med Chem. 2017 Aug 2 ;139:222-231. Epub 2017 Aug 2. PMID: 28802122

Article Published Date : Aug 01, 2017

Study Type : In Vitro Study

Additional Links

Substances : Piperlongumine

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Possible role of common spices as a preventive and therapeutic agent for Alzheimer's disease.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Prev Med. 2017 ;8:5. Epub 2017 Feb 7. PMID: 28250905

Article Published Date : Dec 31, 2016

Study Type : Review

Additional Links

Substances : Cinnamon, Culinary Herbs and Spices, Ginger, Saffron, Turmeric

Diseases : Alzheimer's Disease, Dementia

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Inflammatory Agents

[+]

Potential application of Prunus armeniaca L. and P. domestica L. leaf essential oils as antioxidant and of cholinesterases inhibitors.Dec 20, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2018 Dec 21 ;8(1). Epub 2018 Dec 21. PMID: 30577585

Article Published Date : Dec 20, 2018

Study Type : In Vitro Study

Additional Links

Substances : Plum

Diseases : Alzheimer's Disease, Neurodegenerative Diseases

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents

Additional Keywords : Essential Oils

[+]

Protective effect of fucoidan extract from Ecklonia cava on hydrogen peroxide-induced neurotoxicity.Nov 08, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Microbiol Biotechnol. 2017 Nov 9. Epub 2017 Nov 9. PMID: 29121706

Article Published Date : Nov 08, 2017

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Hydrogen Peroxide Induced Toxicity

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

Tea polyphenols inhibit AChE as well as BChE and enhance the cholinergic neurotransmission by prolonging the time.Mar 20, 2016

Click here to read the entire abstract

Pubmed Data : CNS Neurol Disord Drug Targets. 2016 Mar 21. Epub 2016 Mar 21. PMID: 26996169

Article Published Date : Mar 20, 2016

Study Type : In Vitro Study

Additional Links

Substances : Green Tea

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Cholinesterase Inhibitors

[+]

THC appears to be superior as a Abeta aggregation to currently approved drugs prescribed for the treatment of Alzheimer's disease. Oct 31, 2006

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Pharm. 2006 Nov-Dec;3(6):773-7. PMID: 17140265

Article Published Date : Oct 31, 2006

Study Type : In Vitro Study

Additional Links

Substances : Cannabis, Delta-tetrahydrocannabinol (THC)

Pharmacological Actions : Acetylcholinesterase Inhibitor

Additional Keywords : Superiority of Natural Substances versus Drugs

[+]

The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzymes.Nov 30, 2017

Click here to read the entire abstract

Pubmed Data : J Biochem Mol Toxicol. 2017 Dec ;31(12). Epub 2017 Sep 13. PMID: 28902458

Article Published Date : Nov 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Carvacrol, Chrysin, Citrus naringin, Ginger, Hesperidin, Polyphenols

Diseases : Hypoglycemia

Pharmacological Actions : Acetylcholinesterase Inhibitor, Alpha-glucosidase inhibitor , Hypoglycemic Agents

[+]

The root bark of M. alba and its active compounds might be promising candidates for preventive and therapeutic agents for Alzheimer's disease.Jan 15, 2017

Click here to read the entire abstract

Pubmed Data : Arch Pharm Res. 2017 Jan 16. Epub 2017 Jan 16. PMID: 28093699

Article Published Date : Jan 15, 2017

Study Type : In Vitro Study

Additional Links

Substances : White Mulberry

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

[+]

These findings may help to rationalize the wide use of Persian shallot for the treatment of inflammatory disorders.May 27, 2014

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2014 May 28 ;154(1):176-82. Epub 2014 Apr 8. PMID: 24721027

Article Published Date : May 27, 2014

Study Type : In Vitro Study

Additional Links

Substances : Shallot

Diseases : Inflammation

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors

[+]

This research presents a systematic study on wolfberry polyphenols, including their bioactivities. Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Food Chem. 2017 Jan 1 ;214:644-54. Epub 2016 Jul 19. PMID: 27507521

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Goji, Polyphenols

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants

[+]

This review examines the efficacy of curcumin to treat Alzheimer's disease.May 16, 2017

Click here to read the entire abstract

Pubmed Data : J Alzheimers Dis. 2017 May 17. Epub 2017 May 17. PMID: 28527218

Article Published Date : May 16, 2017

Study Type : Review

Additional Links

Substances : Curcumin

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anticholesteremic Agents, Neuroprotective Agents

[+]

Muira Puama's anticholinesterase activity may be responsible for its traditional therapeutic role associated with cognition.Jun 01, 2003

Click here to read the entire abstract

Pubmed Data : Pharmacol Biochem Behav. 2003 Jun;75(3):645-50. PMID: 12895682

Article Published Date : Jun 01, 2003

Additional Links

Substances : Muira Puama

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor

[+]

Schisandra inhibits the acetylcholinesterase enzyme, which may explain its positive effect on memory. Jun 01, 2007

Click here to read the entire abstract

Pubmed Data : Arch Pharm Res. 2007 Jun;30(6):685-90. PMID: 17679544

Article Published Date : Jun 01, 2007

Additional Links

Substances : Schisandra

Pharmacological Actions : Acetylcholinesterase Inhibitor

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View the Evidence: 87 Abstracts with Acetylcholinesterase Inhibitor Research

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After supplementation of MetS patients with A. melanocarpa extract, a decrease in acetylcholinesterase activity and oxidative stress was noted.Dec 31, 2017

Sage has cholinesterase inhibiting properties which improve mood and cognitive performance.Apr 01, 2006

Oligonol has strong preventative potential in diabetes mellitus and in Alzheimer's disease.Feb 29, 2016

A combined plant extract WS-5 could be applied as a natural product therapy with a focus on neuroinflammation-related neurodegenerative disorders.Dec 31, 2018

A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments.Jul 31, 2018

A. arguta might be considered possible substance to prevent neurodegeneration through AChE inhibition and strong antioxidant activity.Dec 31, 2014

An extract of broccoli leaves could be used as a natural resource for ameliorating Aβ1-42-induced learning and memory impairment.May 03, 2016

Ascorbic acid ameliorates behavioural deficits and neuropathological alterations in rat model of Alzheimer's disease.Feb 05, 2017

Beneficial effects of Urtica dioica on scopolamine-induced memory impairment.May 09, 2018

Centella asiatica attenuated the cognitive deficits in rats by restoring cholinergic function, attenuating oxidative stress.Mar 29, 2019

Chokeberry extract has potential as a therapeutic agent for the prevention and treatment of neurodegenerative diseases.Dec 31, 2015

Coconut leaf extract metabolites could decrease amyloid-β1-42 aggregation.Apr 20, 2017

Cucurbita maxima seed oil may exert antiamnesic activity which may be attributed to the inhibition of AChE and inflammation.Aug 31, 2014

Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats.May 16, 2017

Curcumin improves episodic memory in cadmium induced memory impairment.Aug 04, 2016

Curcumin lessens unpredictable chronic mild stress-induced depression and memory deficits by modulating oxidative stress and cholinergic activity.Jun 30, 2019

Curcuminoids (from Turmeric) enhance memory in mice through acetylcholinesterase inhibition. Feb 01, 2009

Dietary supplementation with walnut kernel or walnut septum extract can maintain the liver and brain health and reduce the risk of age-related diseases.May 13, 2020

Effect of essential oils from ginger and turmeric rhizomes on some inflammatory biomarkers in cadmium induced neurotoxicity in rats.Dec 31, 2017

Evodia rutaecarpa has acetylcholinesterase inhibition and antiamnesic activities which may be useful in the treatment of AlzheimersJan 01, 2010

Extracts of A. princeps orientalis could be an effective treatment against cholinergic dysfunction.Dec 31, 2011

Extracts of holy basil could become effective anti-amnesic treatments. Dec 03, 2016

Fucoxanthin might exhibit great therapeutic efficacy for the treatment of Alzheimer's disease.Mar 24, 2016

Ginkgo biloba ameloriates aluminum-induced learning and memory deficits in rats. Mar 01, 2006

Harmine alkaloids are potential agents to utilize in the management of neurodegenerative disorders.Nov 30, 2013

Harmine could ameliorate impaired memory by enhancement of cholinergic neurotransmission.Dec 04, 2015

Hibiscus represents a promising safe agent that can be repurposed for Alzheimer's disease.Jul 31, 2020

Huperzine-A contributed to the healing process in rats for damage occurring both in the brain and in the neuro-muscular system.Aug 31, 2017

Intranasal administration of nasal gel huperzine A may represent a safe and noninvasive therapeutic strategy for the treatment of Alzheimer's disease.Mar 31, 2011

Lavandula stoechas is a very potent antioxidant and attenuates dementia.Dec 31, 2017

Lemon essential oil ameliorates age-associated cognitive dysfunction.May 10, 2020

Licorice (Glycyrrhiza glabra), Nutmega (Myristica fragrans), and vitamin C (ascorbic acid) have acetylcholinesterase-inhibiting associated with improved memory and learning. activity. Jun 01, 2006

Myricetin is a potential multifunctional treatment for Alzheimer's disease.Jan 18, 2017

Naringenin attenuates social defeat stress induced neurobehavioral deficits.Aug 31, 2018

Naringenin may play a role in enhancing neuroprotective and cognition functions.Dec 31, 2019

Naringin treatment may be useful to reduce wood smoke-induced oxidative stress and related ocular and pulmonary damage.Dec 31, 2019

Natural acetylcholinesterase Inhibitors could be useful in toxoplasma gondii induced memory impairment. Mar 31, 2016

Neuroprotective and memory-enhancing effect of the combined extract of purple waxy corn cob and pandan in ovariectomized rats.Dec 31, 2016

Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats.Oct 30, 2019

Noni may have a protective effect against memory impairment. Nov 15, 2011

Peganum harmala extracts exert beneficial effect on learning and memory processes in mice with scopolamine-induced memory impairment.May 22, 2017

Phloretin has nootropic, neuroprotective and neurotrophic activities in scopolamine induced memory impaired mice.Jul 31, 2015

Piper nigrum significantly improved learning and memory deficits associated with aluminium chloride and also showed the anticholinesterase activity with prevention of nerve degeneration.Mar 31, 2015

Radish leaves may have preventive effects against memory deficits related to Alzheimer's disease.Jul 31, 2018

Repeated administration of Nigella sativa oil may exert memory enhancing effects against restrained stress.Aug 31, 2017

Schisandra chinensis extract may be a potential therapeutic candidate for Alzheimer's disease.Dec 31, 2019

Schisanhenol improves learning and memory in scopolamine-treated mice.Jan 31, 2019

Sesquiterpenes and a monoterpenoid with acetylcholinesterase inhibitory activity from Valeriana officinalis.Mar 31, 2016

The current study highlights P. vulgaris L. as an anti-dementia dietary supplement.Jan 17, 2017

The study concludes that a macerated ethanolic extract of Indian propolis has anti-Alzheimer potential in rats.Jul 03, 2017

These findings may provide adequate evidence for the clinical and experimental benefits gained from huperzine A treatment.Jan 31, 2012

This result indicated an important role for A. graveolens extract in preventing age-associated decline in cognitive function associated with depression.Jun 30, 2017

Zinc exhibits anti-amnesiac activity in mice. Jun 03, 2008

Antibacterial and in vitro antidementia effects of chokeberry leaf extracts.Aug 31, 2020

A review of the antitumour, antimicrobial, antioxidant and antiacetylcholinesterase effect of Ganoderma lucidum terpenoids and polysaccharides.Mar 12, 2018

A. marmelos is a significant source of polyphenolic compounds with potential AChE inhibitory property and antioxidant activity.Feb 28, 2014

AChE inhibition by the methanolic extract of T. cordifolia was probably due to the synergism of the isoquinoline alkaloids.Nov 17, 2019

Adjunctive treatment with huperzine A was associated with a faster resolution of the cognitive symptoms that frequently accompany major depressive disorder.Apr 24, 2016

Agrimony has acetylcholinesterase inhibitory properties. Jan 01, 2007

An ethyl acetate soluble fraction of the roots of Harpagophytum procumbens was found to inhibit AChE activity.Dec 31, 2013

Antioxidant, cholinesterase inhibition activities and essential oil analysis of Nelumbo nucifera seeds.May 31, 2016

Bacopa is an acetylcholinesterase inhibitor, neuroprotective, and has antioxidant effects. Aug 05, 2008

Carpolobia lutea possesses anti-AChE activity and beneficial antioxidant capacity indicative of its potential development as a treatment of Alzheimer's.Nov 30, 2017

Curcumin and piperine demonstrated promising neuroprotective effects.Dec 31, 2018

Curcuminoids have anti-cholinesterase and anti-diabetic activities.Mar 12, 2017

Effect of Salvia miltiorrhiza on acetylcholinesterase: Enzyme kinetics and interaction mechanism merging with molecular docking analysis.May 21, 2019

Fruiting body extracts of T. pubescens demonstrated antioxidant related anti-diabetes, anti-dementia and anti-inflammatory activities.Dec 31, 2015

Huperzine A is documented to be a promising agent for the treatment of Alzheimer's disease due to its potent acetylcholinesterase inhibitory activity.Dec 31, 2016

Inhibitory effect of asiatic acid on acetylcholinesterase.Feb 14, 2012

Kinetics of acetylcholinesterase inhibition by hemp seed protein-derived peptides.Jun 30, 2019

Lichen depsides and depsidones showed neuroactive properties in vitro, suggesting their potential to treat CNS disorders.Nov 14, 2016

M. acuminata leaf is rich in bioactive flavonoids with relatively high antioxidative, antidiabetic, and anti-inflammatory activities.Jan 02, 2020

Acetylcholinesterase Inhibitor

View the Evidence:
87 Abstracts with Acetylcholinesterase Inhibitor Research