Acetylcholinesterase Inhibitor

Name	AC	CK
Chokeberry	3	13
Sage	1	10
Curcumin	5	8
Huperzine	5	8
Syrian rue	4	7
Ginger	4	6
Turmeric	4	6
Lychee	1	5
Ginkgo biloba	2	4
Naringenin	2	4
Schisandra	3	4
Vitamin C	2	4
Citrus naringin	2	3
Aloe Vera	1	2
Black Pepper	1	2
Broccoli	1	2
Celery Oil	1	2
Coconut	1	2
Corn: Purple	1	2
Evodia ruteacarpa	1	2
Flaxseed Oil	1	2
Fucoxanthin	1	2
Ginseng (Korean)	1	2
Gotu Kola	1	2
Hibiscus sabdariffa	1	2
Holy Basil	1	2
Japanese mugwort	1	2
Kiwifruit	1	2
Kudzu	1	2
Lavender	1	2
Lemon	1	2
Licorice	1	2
Melatonin	1	2
Moringa oleifera	1	2
Myricetin	1	2
Nettle	1	2
Nigella sativa (aka Black Seed)	1	2
Noni	1	2
Nutmeg	1	2
Perilla	1	2
Phloretin	1	2
Polyphenols	2	2
Prickly Pear Cactus	1	2
Propolis: Bee	1	2
Prunella vulgaris	1	2
Pumpkin Seeds	1	2
Radish	1	2
Selenium	1	2
Valerian	1	2
Walnut	1	2
Agrimony	1	1
Apple Polyphenols	1	1
Asiatic Acid	1	1
Bacopa	1	1
Bael	1	1
Banana	1	1
Berberine	1	1
Bisdemethoxycurcumin	1	1
Cannabis	1	1
Carpolobia lutea	1	1
Carvacrol	1	1
Chrysin	1	1
Cinnamon	1	1
Culinary Herbs and Spices	1	1
Curcuminoids	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Demethoxycurcumin	1	1
Devils Claw	1	1
Flavonoids	1	1
Fucoidan	1	1
Goji	1	1
Green Tea	1	1
Guduchi	1	1
Hemp Seed	1	1
Hesperidin	1	1
Honeysuckle	1	1
Kaempferol	1	1
Lichens	1	1
Lotus	1	1
Mushrooms: All	1	1
Parsley	1	1
Piperine	1	1
Piperlongumine	1	1
Plum	1	1
Reishi Mushroom	1	1
Rutin	1	1
Saffron	1	1
Salvia miltiorrhiza	1	1
Shallot	1	1
White Mulberry	1	1
Muira Puama	1	0

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After supplementation of MetS patients with A. melanocarpa extract, a decrease in acetylcholinesterase activity and oxidative stress was noted.Dec 31, 2017

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Pubmed Data : Biomed Res Int. 2018 ;2018:5670145. Epub 2018 Mar 26. PMID: 29780825

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Chokeberry extract has potential as a therapeutic agent for the prevention and treatment of neurodegenerative diseases.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Additional Keywords : Essential Oils

Problem Substances : Cadmium

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Pubmed Data : Eur J Pharmacol. 2015 Dec 5 ;768:96-107. Epub 2015 Oct 23. PMID: 26526348

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Pubmed Data : J Clin Diagn Res. 2015 Apr ;9(4):FF01-4. Epub 2015 Apr 1. PMID: 26023568

Article Published Date : Mar 31, 2015

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Pubmed Data : J Neurosci Res. 2012 Feb ;90(2):508-17. Epub 2011 Oct 17. PMID: 22002568

Article Published Date : Jan 31, 2012

Study Type : Transgenic Animal Study

Additional Links

Substances : Huperzine

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Neuroprotective Agents

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This result indicated an important role for A. graveolens extract in preventing age-associated decline in cognitive function associated with depression.Jun 30, 2017

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Pubmed Data : J Nat Med. 2017 Jul ;71(3):492-505. Epub 2017 Feb 15. PMID: 28205135

AChE inhibition by the methanolic extract of T. cordifolia was probably due to the synergism of the isoquinoline alkaloids.Nov 17, 2019

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Pubmed Data : Molecules. 2019 Nov 18 ;24(22). Epub 2019 Nov 18. PMID: 31752124

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Pubmed Data : Front Aging Neurosci. 2019 ;11:206. Epub 2019 Aug 27. PMID: 31507403

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Pubmed Data : Molecules. 2016 ;21(5). Epub 2016 May 16. PMID: 27196881

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Mushrooms: All

Diseases : Dementia, Diabetes Mellitus: Type 2, Inflammation

Pharmacological Actions : Acetylcholinesterase Inhibitor, Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts

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Huperzine A is documented to be a promising agent for the treatment of Alzheimer's disease due to its potent acetylcholinesterase inhibitory activity.Dec 31, 2016

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Pubmed Data : Pak J Pharm Sci. 2017 Jan ;30(1 Suppl):235-239. PMID: 28625948

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Pubmed Data : J Food Biochem. 2020 Jan 3:e13137. Epub 2020 Jan 3. PMID: 31899556

Article Published Date : Jan 02, 2020

Study Type : In Vitro Study

Additional Links

Substances : Banana, Kaempferol, Rutin

Diseases : Alzheimer's Disease, Diabetes Mellitus: Type 2, Inflammation

Pharmacological Actions : 15-Lipoxygenase (15-LOX) Inhibitor, Acetylcholinesterase Inhibitor, Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Anti-Inflammatory Agents, Enzyme Inhibitors

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New cholinesterase inhibitory constituents from Lonicera quinquelocularis.Dec 31, 2013

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Pubmed Data : PLoS One. 2014 ;9(4):e94952. Epub 2014 Apr 14. PMID: 24733024

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Honeysuckle

Diseases : Alzheimer's Disease

Pharmacological Actions : Acetylcholinesterase Inhibitor, Cholinesterase Inhibitors

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P. harmala had inhibitory activities on acetylcholinesterase and butyrylcholinesterase.Jun 19, 2015

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Pubmed Data : J Ethnopharmacol. 2015 Jun 20 ;168:279-86. Epub 2015 Apr 8. PMID: 25862961

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Pubmed Data : Int J Prev Med. 2017 ;8:5. Epub 2017 Feb 7. PMID: 28250905

Article Published Date : Dec 31, 2016

Study Type : Review

Additional Links

Substances : Cinnamon, Culinary Herbs and Spices, Ginger, Saffron, Turmeric

Diseases : Alzheimer's Disease, Dementia

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Inflammatory Agents

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Potential application of Prunus armeniaca L. and P. domestica L. leaf essential oils as antioxidant and of cholinesterases inhibitors.Dec 20, 2018

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Pubmed Data : Antioxidants (Basel). 2018 Dec 21 ;8(1). Epub 2018 Dec 21. PMID: 30577585

Article Published Date : Dec 20, 2018

Study Type : In Vitro Study

Additional Links

Substances : Plum

Diseases : Alzheimer's Disease, Neurodegenerative Diseases

Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents

Additional Keywords : Essential Oils

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Protective effect of fucoidan extract from Ecklonia cava on hydrogen peroxide-induced neurotoxicity.Nov 08, 2017

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View the Evidence: 101 Abstracts with Acetylcholinesterase Inhibitor Research

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After supplementation of MetS patients with A. melanocarpa extract, a decrease in acetylcholinesterase activity and oxidative stress was noted.Dec 31, 2017

Sage has cholinesterase inhibiting properties which improve mood and cognitive performance.Apr 01, 2006

Oligonol has strong preventative potential in diabetes mellitus and in Alzheimer's disease.Feb 29, 2016

A combined plant extract WS-5 could be applied as a natural product therapy with a focus on neuroinflammation-related neurodegenerative disorders.Dec 31, 2018

A diet containing a mixture of P. montana and red ginseng extracts reversed learning and memory impairments.Jul 31, 2018

A. arguta might be considered possible substance to prevent neurodegeneration through AChE inhibition and strong antioxidant activity.Dec 31, 2014

Allium hookeri extracts improve scopolamine-induced cognitive impairment.Aug 22, 2021

An extract of broccoli leaves could be used as a natural resource for ameliorating Aβ1-42-induced learning and memory impairment.May 03, 2016

Anxiolytic and memory enhancing potential of aloe vera and flax seed oil Oct 31, 2020

Ascorbic acid ameliorates behavioural deficits and neuropathological alterations in rat model of Alzheimer's disease.Feb 05, 2017

Beneficial effects of Urtica dioica on scopolamine-induced memory impairment.May 09, 2018

Centella asiatica attenuated the cognitive deficits in rats by restoring cholinergic function, attenuating oxidative stress.Mar 29, 2019

Chokeberry extract has potential as a therapeutic agent for the prevention and treatment of neurodegenerative diseases.Dec 31, 2015

Co-administration of EGb 761 and donepezil exerted better anti-amnestic effect.Dec 24, 2020

Coconut leaf extract metabolites could decrease amyloid-β1-42 aggregation.Apr 20, 2017

Cucurbita maxima seed oil may exert antiamnesic activity which may be attributed to the inhibition of AChE and inflammation.Aug 31, 2014

Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats.May 16, 2017

Curcumin improves episodic memory in cadmium induced memory impairment.Aug 04, 2016

Curcumin lessens unpredictable chronic mild stress-induced depression and memory deficits by modulating oxidative stress and cholinergic activity.Jun 30, 2019

Curcuminoids (from Turmeric) enhance memory in mice through acetylcholinesterase inhibition. Feb 01, 2009

Dietary supplementation with walnut kernel or walnut septum extract can maintain the liver and brain health and reduce the risk of age-related diseases.May 13, 2020

Effect of essential oils from ginger and turmeric rhizomes on some inflammatory biomarkers in cadmium induced neurotoxicity in rats.Dec 31, 2017

Evodia rutaecarpa has acetylcholinesterase inhibition and antiamnesic activities which may be useful in the treatment of AlzheimersJan 01, 2010

Extracts of A. princeps orientalis could be an effective treatment against cholinergic dysfunction.Dec 31, 2011

Extracts of holy basil could become effective anti-amnesic treatments. Dec 03, 2016

Fucoxanthin might exhibit great therapeutic efficacy for the treatment of Alzheimer's disease.Mar 24, 2016

Ginkgo biloba ameloriates aluminum-induced learning and memory deficits in rats. Mar 01, 2006

Harmine alkaloids are potential agents to utilize in the management of neurodegenerative disorders.Nov 30, 2013

Harmine could ameliorate impaired memory by enhancement of cholinergic neurotransmission.Dec 04, 2015

Hibiscus represents a promising safe agent that can be repurposed for Alzheimer's disease.Jul 31, 2020

Huperzine-A contributed to the healing process in rats for damage occurring both in the brain and in the neuro-muscular system.Aug 31, 2017

Intranasal administration of nasal gel huperzine A may represent a safe and noninvasive therapeutic strategy for the treatment of Alzheimer's disease.Mar 31, 2011

Kolaviron inhibits acetylcholinesterase activities in the hippocampus and striatum.Mar 31, 2013

Lavandula stoechas is a very potent antioxidant and attenuates dementia.Dec 31, 2017

Lemon essential oil ameliorates age-associated cognitive dysfunction.May 10, 2020

Licorice (Glycyrrhiza glabra), Nutmega (Myristica fragrans), and vitamin C (ascorbic acid) have acetylcholinesterase-inhibiting associated with improved memory and learning. activity. Jun 01, 2006

Long-term consumption of M. oleifera-supplemented diets shows strong protection against hippocampal degeneration and improves neurocognition.Mar 25, 2021

Long-term consumption of M. oleifera-supplemented diets shows strong protection against oxidative stress and hippocampal degeneration.Mar 25, 2021

Myricetin is a potential multifunctional treatment for Alzheimer's disease.Jan 18, 2017

Naringenin attenuates social defeat stress induced neurobehavioral deficits.Aug 31, 2018

Naringenin may play a role in enhancing neuroprotective and cognition functions.Dec 31, 2019

Naringin treatment may be useful to reduce wood smoke-induced oxidative stress and related ocular and pulmonary damage.Dec 31, 2019

Natural acetylcholinesterase Inhibitors could be useful in toxoplasma gondii induced memory impairment. Mar 31, 2016

Neuroprotective and memory-enhancing effect of the combined extract of purple waxy corn cob and pandan in ovariectomized rats.Dec 31, 2016

Neuroprotective effects of ethanolic extract from dry Rhodiola rosea L. rhizomes.Jan 31, 2021

Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats.Oct 30, 2019

Noni may have a protective effect against memory impairment. Nov 15, 2011

Opuntia ficus-indica might be promising candidate for treating Alzheimer disease.Sep 30, 2020

P. frutescens leaf exhibits excellent hypoglycemic activity in vitro and in vivo.Feb 02, 2021

Peganum harmala extracts exert beneficial effect on learning and memory processes in mice with scopolamine-induced memory impairment.May 22, 2017

Phloretin has nootropic, neuroprotective and neurotrophic activities in scopolamine induced memory impaired mice.Jul 31, 2015

Piper nigrum significantly improved learning and memory deficits associated with aluminium chloride and also showed the anticholinesterase activity with prevention of nerve degeneration.Mar 31, 2015

Radish leaves may have preventive effects against memory deficits related to Alzheimer's disease.Jul 31, 2018

Repeated administration of Nigella sativa oil may exert memory enhancing effects against restrained stress.Aug 31, 2017

Schisandra chinensis extract may be a potential therapeutic candidate for Alzheimer's disease.Dec 31, 2019

Schisanhenol improves learning and memory in scopolamine-treated mice.Jan 31, 2019

Sesquiterpenes and a monoterpenoid with acetylcholinesterase inhibitory activity from Valeriana officinalis.Mar 31, 2016

The current study highlights P. vulgaris L. as an anti-dementia dietary supplement.Jan 17, 2017

The study concludes that a macerated ethanolic extract of Indian propolis has anti-Alzheimer potential in rats.Jul 03, 2017

These findings may provide adequate evidence for the clinical and experimental benefits gained from huperzine A treatment.Jan 31, 2012

This result indicated an important role for A. graveolens extract in preventing age-associated decline in cognitive function associated with depression.Jun 30, 2017

Zinc exhibits anti-amnesiac activity in mice. Jun 03, 2008

Ziziphus jujuba aqueous extract possesses an antiamnesic effect.Dec 31, 2020

Antibacterial and in vitro antidementia effects of chokeberry leaf extracts.Aug 31, 2020

A review of the antitumour, antimicrobial, antioxidant and antiacetylcholinesterase effect of Ganoderma lucidum terpenoids and polysaccharides.Mar 12, 2018

A. marmelos is a significant source of polyphenolic compounds with potential AChE inhibitory property and antioxidant activity.Feb 28, 2014

AChE inhibition by the methanolic extract of T. cordifolia was probably due to the synergism of the isoquinoline alkaloids.Nov 17, 2019

Adjunctive treatment with huperzine A was associated with a faster resolution of the cognitive symptoms that frequently accompany major depressive disorder.Apr 24, 2016

Agrimony has acetylcholinesterase inhibitory properties. Jan 01, 2007

An ethyl acetate soluble fraction of the roots of Harpagophytum procumbens was found to inhibit AChE activity.Dec 31, 2013

Annurca apple polyphenol extract affects acetyl-cholinesterase and mono-amine oxidase in vitro enzyme activity.Jan 13, 2021

Antioxidant, cholinesterase inhibition activities and essential oil analysis of Nelumbo nucifera seeds.May 31, 2016

Acetylcholinesterase Inhibitor

View the Evidence:
101 Abstracts with Acetylcholinesterase Inhibitor Research