Periodontal Diseases

Name	AC	CK
Aloe Vera	4	21
Curcumin	5	15
Bee Propolis	4	13
Holy Basil	3	12
Pomegranate	2	12
Lactobacillus salivarius	2	11
Lycopene	2	11
Melatonin	2	11
Triphala	2	11
Acacia arabica	1	10
Borage Oil	1	10
Chamomile	1	10
Fiber	1	10
Fruit: All	1	10
Homeopathic Medicine: All	1	10
Isoflavones	1	10
Kiwifruit	1	10
Lactobacillus reuteri	1	10
Lettuce	1	10
Sesame Seed Oil	1	10
Soy Protein	1	10
Tomato	1	10
Caffeic acid phenethyl ester	2	6
Resveratrol	3	5
Black Tea	3	4
Probiotics	4	4
Vitamin C	2	4
Apples	2	3
Beta-Caryophyllene	2	3
Grape Seed Extract	2	3
Green Tea	2	3
Astaxanthin	1	2
Beta-glucan	1	2
Cannabinoids: Synthetic	1	2
Eucalyptus	2	2
Fish Oil	1	2
Glycine	1	2
Hops	2	2
Hydrogen Water	1	2
Omega-3 Fatty Acids	1	2
Polyphenols	2	2
Quercetin	1	2
Tea Tree	2	2
Theaflavins	2	2
Allicin	1	1
Apple Polyphenols	1	1
Artichoke	1	1
Baicalein	1	1
Berberine	1	1
Blueberry	1	1
Bromelain	1	1
Clove	1	1
Coenzyme Q10	1	1
Cranberry	1	1
Curry Leaves	1	1
D-Mannose	1	1
EGCG (Epigallocatechin gallate)	1	1
Eugenol	1	1
Genipin	1	1
Genistein	1	1
Goldenseal	1	1
Graviola	1	1
Guava	1	1
Hibiscus sabdariffa	1	1
Lemongrass: Essential Oil	1	1
Loquat Leaves	1	1
Magnesium	1	1
Mangifera indica	1	1
Myricetin	1	1
Neem	1	1
Noni	1	1
Pineapple	1	1
Plantago	1	1
Proanthocyanidins	1	1
Propolis: Bee	1	1
Psychedelics:All	1	1
Sea buckthorn	1	1
Shikonin	1	1
Ubiquinol	1	1
Vitamin D	1	1
White Mulberry	1	1
Wormwood	1	1

Name	AC	CK	Focus
Chlorhexidine gluconate	1	10

Name	AC	CK
Oil Pulling	2	20
Ozone Therapy	2	11
Light-Emitting Diodes (LEDs) Therapy	2	6
Light-Emitting Diode Therapy	1	5
Laser Treatment: Low-Level	2	2

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Environ Res Public Health. 2018 11 27 ;15(12). Epub 2018 Nov 27. PMID: 30486374

Article Published Date : Jan 26, 2018

Pubmed Data : J Am Coll Nutr. 2018 08 ;37(6):479-486. Epub 2018 Mar 20. PMID: 29558323

Article Published Date : Dec 31, 2017

Study Type : Human Study

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Substances : Chicory

Diseases : Oxidative Stress, Periodontal Diseases

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation

Additional Keywords : Plant Extracts

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Curcuma longa extract possess antimicrobial efficacy against the common periodontopathic bacteria.Apr 30, 2019

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Pubmed Data : J Clin Periodontol. 2020 Jan 30. Epub 2020 Jan 30. PMID: 31999847

Article Published Date : Jan 29, 2020

Study Type : Human Study

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Substances : Flavonoids

Diseases : Inflammation, Periodontal Diseases, Periodontal Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation

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Holy basil was found to be equally effective in reducing periodontal indices as chlorhexidine yet with no side effects.Mar 31, 2014

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Pubmed Data : J Ayurveda Integr Med. 2014 Apr ;5(2):109-16. PMID: 24948862

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Pubmed Data : J Indian Soc Pedod Prev Dent. 2008 Mar;26(1):12-7. PMID: 18408265

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Pubmed Data : Atherosclerosis. 2011 Jul 23. Epub 2011 Jul 23. PMID: 21831372

Article Published Date : Jul 23, 2011

Study Type : Human Study

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Diseases : Cardiac Mortality , Cardiovascular Diseases, Mortality: All-Cause, Periodontal Diseases

Additional Keywords : Diseases that are Linked

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Pubmed Data : J Periodontol. 2018 Mar ;89(3):351-360. Epub 2018 Mar 12. PMID: 29528486

Article Published Date : Feb 28, 2018

Study Type : Human In Vitro

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Diseases : Periodontal Diseases

Therapeutic Actions : Light-Emitting Diode Therapy

Pharmacological Actions : Regenerative

Additional Keywords : Bone Regeneration

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A case report suggests that mild vitamin C deficiency associated with metabolic syndrome and severe periodontal infection may be associated with the pathogenesis of severe gingival overgrowth.Nov 30, 2014

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Pubmed Data : Clin Case Rep. 2014 Dec ;2(6):286-95. Epub 2014 Sep 4. PMID: 25548632

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Pubmed Data : BMC Complement Altern Med. 2019 Jun 21 ;19(1):145. Epub 2019 Jun 21. PMID: 31226983

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Pubmed Data : J Periodontal Res. 2005 Feb;40(1):43-7. PMID: 15613078

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Quercetin, as found in apples and tea, inhibit significant antimicrobial properties on periodontal pathogens. Dec 02, 2009

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Pubmed Data : Phytother Res. 2009 Dec 2. Epub 2009 Dec 2. PMID: 19957242

Pubmed Data : J Periodontol. 2005 Dec;76(12):2223-9. PMID: 16332233

Article Published Date : Dec 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Apples, Hops

Diseases : Periodontal Diseases, Porphyromonas gingivalis

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Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.Dec 31, 2014

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Pubmed Data : Korean J Physiol Pharmacol. 2015 Jan ;19(1):21-7. Epub 2014 Dec 31. PMID: 25605993

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Pubmed Data : PLoS One. 2015 ;10(11):e0143158. Epub 2015 Nov 18. PMID: 26581041

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Pubmed Data : J Int Oral Health. 2014 Sep ;6(5):96-8. PMID: 25395802

Article Published Date : Aug 31, 2014

Study Type : In Vitro Study

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Substances : Bromelain, Pineapple

Diseases : Periodontal Diseases

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Plant Extracts

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Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1.Feb 19, 2019

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Pubmed Data : Int J Oral Sci. 2019 Feb 20 ;11(1):6. Epub 2019 Feb 20. PMID: 30783082

Article Published Date : Feb 19, 2019

Study Type : In Vitro Study

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Substances : Caffeic acid phenethyl ester

Diseases : Inflammation, Oxidative Stress, Periodontal Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 inducer, NF-kappaB Inhibitor

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Coenzyme Q10 may suppress advanced periodontal inflammation.May 01, 2010

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Pubmed Data : Int Immunopharmacol. 2010 May;10(5):605-10. Epub 2010 Feb 23. PMID: 21189900

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Pubmed Data : J Periodontol. 2015 Oct 8:1-18. Epub 2015 Oct 8. PMID: 26447754

Article Published Date : Oct 07, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Periodontal Diseases

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Dose Response

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D-mannose enhanced immunomodulation of periodontal ligament stem cells.Dec 31, 2017

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Pubmed Data : J Lasers Med Sci. 2020 ;11(1):56-64. Epub 2020 Jan 18. PMID: 32099628

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Pubmed Data : BMC Oral Health. 2019 Oct 26 ;19(1):229. Epub 2019 Oct 26. PMID: 31655580

Article Published Date : Oct 25, 2019

Study Type : In Vitro Study

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Substances : Luteolin

Diseases : Periodontal Diseases

Pharmacological Actions : Wnt/β-catenin signaling pathway modulation

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M. alba stem extract has an anti-bacterial potential against the two putative periodontal pathogens.Dec 31, 2017

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Pubmed Data : Open Dent J. 2018 ;12:265-274. Epub 2018 Mar 30. PMID: 29760819

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : White Mulberry

Diseases : Periodontal Diseases

Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation

Additional Keywords : Plant Extracts

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Magnesium deficiency is associated with periodontal disease. -Oct 01, 2005

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Pubmed Data : J Dent Res. 2005 Oct;84(10):937-41. PMID: 16183794

Article Published Date : Oct 01, 2005

Study Type : Commentary

Additional Links

Substances : Magnesium

Diseases : Periodontal Diseases

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Marshmallow root, arnica, and witch hazel display good antibacterial activity against periodontal bacteria.Jun 01, 2003

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Pubmed Data : Phytother Res. 2003 Jun ;17(6):599-604. PMID: 12820224

Article Published Date : Jun 01, 2003

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Pubmed Data : PLoS One. 2015 ;10(6):e0131758. Epub 2015 Jun 29. PMID: 26121135

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Myricetin

Diseases : Inflammation, Periodontal Diseases

Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Matrix metalloproteinase-3 (MMP-3) inhibitor, NF-kappaB Inhibitor

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New evidences of antibacterial effects of cranberry against periodontal pathogens.Feb 23, 2020

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Pubmed Data : Mediators Inflamm. 2015 ;2015:137357. Epub 2015 Apr 30. PMID: 26063967

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Diseases : Alzheimer's Disease, Periodontal Diseases

Additional Keywords : Risk Factors

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Possible involvement of vitamin C in periodontal disease-diabetes mellitus association.Feb 19, 2020

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Pubmed Data : Nutrients. 2020 Feb 20 ;12(2). Epub 2020 Feb 20. PMID: 32093297

Article Published Date : Feb 19, 2020

Study Type : Review

Additional Links

Substances : Vitamin C

Diseases : Periodontal Diseases

Pharmacological Actions : Antioxidants

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The maintenance of periodontal health could be enhanced by emphasizing the habit of drinking green tea in periodontitis patients.Aug 30, 2015

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Pubmed Data : Infect Disord Drug Targets. 2015 Aug 31. Epub 2015 Aug 31. PMID: 26321324

Article Published Date : Aug 30, 2015

Study Type : Review

Additional Links

Substances : Green Tea, Polyphenols

Diseases : Periodontal Diseases

Pharmacological Actions : Antimicrobial

Additional Keywords : Mouthwash

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The mechanistic activity of Chinese skullcap may make it a useful herb for treating periodontal disease.Jun 01, 2018

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Pubmed Data : Complement Ther Med. 2018 Jun ;38:11-18. Epub 2018 Mar 26. PMID: 29857875

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This review has focused on several beneficial properties of probiotics.Jul 31, 2016

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Pubmed Data : J Indian Soc Periodontol. 2016 Mar-Apr;20(2):145-50. PMID: 27143825

Article Published Date : Feb 29, 2016

Study Type : In Vitro Study

Additional Links

Substances : Holy Basil

Diseases : Periodontal Diseases

Pharmacological Actions : Antimicrobial

Additional Keywords : Natural Substances Versus Drugs, Plant Extracts

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Visible blue light and curcumin could be considered as a potential treatment for gram-negative periodontal pathogens.Mar 30, 2015

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Pubmed Data : Laser Ther. 2015 Mar 31 ;24(2):103-11. PMID: 26246690

Article Published Date : Mar 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Periodontal Diseases

Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy

Pharmacological Actions : Anti-Bacterial Agents, Photosensitizing Agents

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Vitamin C administration may provide a potentially effective technique in periodontal therapy.Dec 31, 2014

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Pubmed Data : Mol Med Rep. 2015 Jan ;11(1):242-8. Epub 2014 Oct 21. PMID: 25333298

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress, Periodontal Diseases, Periodontitis

Pharmacological Actions : Antioxidants

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Vitamin D could modulate the inflammatory response in periodontal tissues. Nov 30, 2015

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Pubmed Data : Inflammation. 2015 Dec ;38(6):2252-8. PMID: 26156812

Article Published Date : Nov 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Vitamin D

Diseases : Periodontal Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor

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Lactobacillus reuteri may help to combat inflammation in the oral cavity.Feb 01, 2009

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Pubmed Data : Acta Odontol Scand. 2009 Feb;67(1):19-24. PMID: 18985460

Article Published Date : Feb 01, 2009

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Diseases : Periodontal Diseases

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View the Evidence: 148 Abstracts with Periodontal Diseases Research

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Evidence from cohort studies suggests that patients with periodontal disease are at increased risk of developing lung cancer.Sep 30, 2016

"Tooth brushing, oil pulling and tissue regeneration: A review of holistic approaches to oral health."Mar 31, 2011

A large increase of fruit intake had a favourable effect on periodontal status in some respects, despite the high sugar contents.Dec 31, 2017

A toothpaste/mouthwash containing Carica papaya leaf extract has beneficial effects on interdental gingival bleeding.Jan 26, 2018

Adverse oral health and cognitive decline: the health, aging and body composition study.Jan 31, 2013

Aloe vera gel can improve periodontal disease.Jul 01, 2011

Antibiotics are no more effective than placebo in improving the clinical and microbiological condition of patients with periodontal disease. Jul 01, 1999

Association of endodontic infection with detection of an initial lesion to the cardiovascular system.Nov 30, 2011

Borage oil may provide benefits in the treatment of adult periodontitis.Mar 01, 2003

Both Acacia arabica gel and powder may be useful herbal formulations for chemical plaque control in subjects with gingivitis.Aug 31, 2012

Chicory leaf extract as an adjunct nutritional approach with nonsurgical periodontal therapy may be helpful in controlling periodontal status.Dec 31, 2017

Curcuma longa extract possess antimicrobial efficacy against the common periodontopathic bacteria.Apr 30, 2019

Curcumin is comparable to chlorhexidine as an anti-inflammatory mouthwash. Thus, it can be considered as an effective adjunct to mechanical periodontal therapy.Dec 31, 2012

Dental homeopathy had positive outcomes in the frequently treated conditions such as pericoronitis, periodontal abscess, periodontal infection, reversible pulpitis, sensitive cementum, and decay.Mar 31, 2007

Dietary nitrate consumption may be a useful adjunct in the control of chronic gingivitis.Jun 30, 2016

Higher flavonoid intake is associated with lower IL-1β.Jan 29, 2020

Holy basil was found to be equally effective in reducing periodontal indices as chlorhexidine yet with no side effects.Mar 31, 2014

Kiwifruit consumption reduces gingival inflammation.Feb 28, 2018

Lactobacillus salivarius is therapeutic in the improvement/maintenance of periodontal disease. Oct 01, 2008

Low vitamin C was associated with higher periodontal disease stage.Jul 27, 2020

Lycopene is a promising treatment modality as an adjunct to full mouth SRP of the oral cavity in patients with moderate periodontal disease.Oct 31, 2013

Lycopene with green tea extract may prove to be a promising adjunctive prophylactic and therapeutic modality in the treatment of gingivitis patients.Dec 31, 2018

Maternal periodontal disease is associated with an increased risk for preeclampsia.Feb 01, 2003

Melatonin can modulate the inflammatory actions in periodontal patients.Nov 30, 2015

Oil pulling with sesame seed oil significantly reduces Steptococcus mutans in plaque and saliva of children. Mar 01, 2008

Oral probiotics in the management of gingivitis in diabetic patients.Mar 31, 2017

Ozone therapy resulted in the reduction of inflammation and normalization of local blood circulation in the periodontal tissues.Dec 31, 2016

Periodontal disease is associated with increased cardiovascular and all-cause mortality.Jul 23, 2011

Periodontal disease was associated with increased risk of postmenopausal breast cancer.Dec 31, 2015

Periodontal disease was associated with low whole-grain intake.Oct 25, 2016

Periodontitis might be associated with increased cancer risk.Jul 11, 2017

Pomegranate and chamomile plant extracts had antimicrobial and anti-inflammatory properties similar to that of chlorhexidine 0.12%.Jan 31, 2014

Propolis has significant antimicrobial activity in the treatment of peridontitis.Jul 01, 2005

Soy and isoflavone intake may decrease the likelihood of periodontal disease.Jan 01, 2008

Sudarshan Kriya Pranayama can be considered as an adjunct to treatment modality in patients with periodontal disease.Aug 31, 2018

These findings show that e-cigarettes may be harmful to oral health.Jan 08, 2019

These results suggest a potential role of oral health in colorectal carcinogenesis.Jan 31, 2017

Triphala mouthwash (herbal) is an effective antiplaque agent like 0.2% chlorhexidine.May 31, 2014

Acemannan could be a candidate biomolecule for periodontal tissue regeneration.Mar 31, 2014

Aloe vera gel at optimum concentration could be used as an antiseptic for prevention of dental caries and periodontal diseases. Jan 01, 2012

Caffeic acid phenethyl ester could be effective for treating of periodontal diseases.Nov 06, 2016

Dose-dependent green tea effect on decrease of inflammation in human oral gingival epithelial keratinocytes.Oct 23, 2019

LED irradiation promoted elastin gene expression more in elderly than in younger adults.Mar 31, 2016

These findings suggest that LED may be a useful tool for periodontal tissue regeneration.Feb 28, 2018

A case report suggests that mild vitamin C deficiency associated with metabolic syndrome and severe periodontal infection may be associated with the pathogenesis of severe gingival overgrowth.Nov 30, 2014

Severe gingivitis associated with ascorbic acid-deficiency in a pediatric patient.May 14, 2019

A combination of astaxanthin and fish oil supplementation alters antioxidant enzyme profile of dental pulp tissue.May 06, 2012

Antimicrobial activity of red wine and oenological extracts against periodontal pathogens in a validated oral biofilm model.Jun 20, 2019

Beta glucan inhibits experimental periodontal disease possibly through steering the T helper Th1/Th2 balance towards Th1 and T regulatory responses. Apr 01, 2005

Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats, indicating its potential therapeutic value.Jan 17, 2011

Dietary omega-3 fatty acids consumption is inversely related to alveolar bone loss in a rat model of periodontitis. Apr 01, 2009

Drinking hydrogen-rich water is proposed to have anti-aging effects on periodontal oxidative damage.Jul 01, 2014

Glycine nhibits ligature-induced periodontal disease in rats.Feb 01, 2005

Green tea extract rich in epigallocatechin gallate impairs alveolar bone loss.Nov 30, 2020

Luteolin successfully improved periodontal health in a ligature-induced experimental periodontitis.May 21, 2019

Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration.Mar 12, 2019

Oral supplementation with p-coumaric acid protects mice against diabetes-associated spontaneous destruction of periodontal tissue.Nov 30, 2019

Pomegranate glycolic extract had antimicrobial action against P. gingivalis in vivo.Dec 31, 2015

Quercetin, as found in apples and tea, inhibit significant antimicrobial properties on periodontal pathogens. Dec 02, 2009

Resveratrol partially reversed the effects of smoking and infection on alveolar bone loss in a rat model of periodontal disease. Nov 01, 2006

Severe magnesium deficiency compromises systemic bone mineral density and aggravates inflammatory bone resorption.Nov 25, 2019

Systemic administration of Morus nigra significantly inhibited the regional alveolar bone resorption and contributes to periodontal healing.Aug 31, 2019

The results showed that β-caryophyllene has antimicrobial activity against the proliferation of dog's dental plaque-forming bacteria.Sep 30, 2016

The results suggest anti-inflammatory activities of grape seed extract on periodontitis. Feb 28, 2017

These results support the potential of resveratrol to suppress periodontitis-mediated tissue damages.Dec 31, 2015

This study demonstrates anti-inflammatory, osteoprotective, and prohomeostatic effects of HU-308 in oral tissues of rats.May 31, 2016

This review is an attempt to assess the antimicrobial efficacy of 10 plant extracts on dental caries and plaque microorganisms.Jun 30, 2015

A. sativum bulb can be effectively used to treat periodontal and dental caries infections.May 31, 2020

Allicin may have therapeutic value for controlling oral pathogens.May 06, 2011

Aloe barbadensis can play a significant role in dentistry in treatment of lichen planus, oral submucous fibrosis, recurrent aphthous stomatitis, alveolar osteitis, periodontitis.Mar 31, 2015

Antibacterial and antibiofilm activities of eugenol from Syzygium aromaticum leaf against periodontal pathogen Porphyromonas gingivalis.Nov 30, 2017

Antimicrobial activity of honey in periodontal disease: a systematic review.Jan 15, 2020

Periodontal Diseases

View the Evidence:
148 Abstracts with Periodontal Diseases Research