Kidney Fibrosis

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10 Substances Researched for Kidney Fibrosis
NameACCKFocus
Curcumin48Locked
Amygdalin12Locked
Bee Venom12Locked
Berberine12Locked
Cordyceps sinensis12Locked
Nigella sativa (aka Black Seed)12Locked
Traditional Chinese Medicine: Wen-pi-tang-Hab-Wu-ling-san 12Locked
Tripterygium wilfordii12Locked
Triptolide12Locked
Vitamin D12Locked
2 Problem Substances Researched for Kidney Fibrosis
NameACCKFocus
Fructose12Locked
Sodium Nitrate12Locked

View the Evidence:
66 Abstracts with Kidney Fibrosis Research

[+]

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2017 Dec ;12(6):479-487. PMID: 29204176
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants
Additional Keywords : Anti-Fibrotic, Antioxidants, Kidney Fibrosis, thymoquinone
[+]

Amygdalin is a potent antifibrotic agent that may have therapeutic potential for patients with fibrotic kidney diseases.Apr 30, 2013

Pubmed Data : Mol Med Rep. 2013 May ;7(5):1453-7. Epub 2013 Mar 22. PMID: 23525378
Article Published Date : Apr 30, 2013
Study Type : Animal Study
Additional Links
Substances : Amygdalin
Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis
Pharmacological Actions : Antiproliferative , Renoprotective
[+]

Arctigenin could protect the kidney from unilateral ureteral obstruction induced injury and fibrogenesis.Jun 30, 2017

Pubmed Data : Phytomedicine. 2017 Jul 1 ;30:28-41. Epub 2017 Mar 10. PMID: 28545667
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Arctigenin
Diseases : Kidney Fibrosis, Obstructive Nephropathy
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Asiatic acid and naringenin may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis.Nov 09, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Nov 10 ;6(35):36984-97. PMID: 26474462
Article Published Date : Nov 09, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid, Naringenin
Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.Feb 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Feb 19. Epub 2019 Feb 19. PMID: 30816496
Article Published Date : Feb 18, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Astaxanthin promotes Nrf2/ARE signalling to inhibit high glucose induced renal fibrosis in GMCs.Apr 04, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2018 Apr 5 ;16(4). Epub 2018 Apr 5. PMID: 29621130
Article Published Date : Apr 04, 2018
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective
Additional Keywords : Antioxidants, Astaxanthin, Diabetic Nephropathy, Kidney Fibrosis, Nrf2 activation, Renoprotective
[+]

Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment.Jun 02, 2019

Pubmed Data : Biochim Biophys Acta Gen Subj. 2019 Jun 3. Epub 2019 Jun 3. PMID: 31170498
Article Published Date : Jun 02, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Astragaloside IV attenuates renal fibrosis through repressing epithelial-to-mesenchymal transition.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2019 ;11(8):5029-5038. Epub 2019 Aug 15. PMID: 31497219
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator, Renoprotective
[+]

Astragaloside IV improves renal function and fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:2431-2442. Epub 2018 Aug 6. PMID: 30122901
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Chronic Kidney Disease (CKD), Diabetic Complications, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Astragaloside IV inhibits excessive mesangial cell proliferation and renal fibrosis caused by diabetic nephropathy.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Oct ;18(4):3053-3061. Epub 2019 Aug 14. PMID: 31572545
Article Published Date : Sep 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Bee venom may be a useful therapeutic agent for the prevention of fibrosis that characterizes progression of chronic kidney disease.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxins (Basel). 2015 Jun ;7(6):1917-28. Epub 2015 May 29. PMID: 26035488
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Bee Venom
Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Gene Expression Regulation
[+]

Berberine can ameliorate tubulointerstitial fibrosis in diabetic nephropathy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 ;17(8). Epub 2016 Aug 12. PMID: 27529235
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetes Mellitus: Type 1, Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Bisdemethoxycurcumin protects against renal fibrosis.Mar 14, 2019

Pubmed Data : Eur J Pharmacol. 2019 Mar 15 ;847:26-31. Epub 2019 Jan 17. PMID: 30660576
Article Published Date : Mar 14, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bisdemethoxycurcumin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

C. sinensis may be a promising agent to combat renal fibrosis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2015 ;7(5):932-40. Epub 2015 May 15. PMID: 26175854
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Cordyceps sinensis
Diseases : Kidney Fibrosis
Pharmacological Actions : Renoprotective
[+]

Calcitriol ameliorates kidney injury through reducing podocytopathy, tubular injury, inflammation and fibrosis.Mar 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Kobe J Med Sci. 2020 Mar 27 ;65(5):E153-E163. Epub 2020 Mar 27. PMID: 32249272
Article Published Date : Mar 26, 2020
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Kidney Damage, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Renoprotective
[+]

Chlorogenic acid attenuates kidney ischemic/reperfusion injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:5423703. Epub 2019 Sep 22. PMID: 31662982
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid
Diseases : Inflammation, Ischemia, Kidney Damage, Kidney Fibrosis
Pharmacological Actions : Renoprotective
[+]

Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model.Nov 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Zhejiang Univ Sci B. 2011 Dec ;12(12):1024-33. PMID: 22135152
Article Published Date : Nov 30, 2011
Study Type : Animal Study
Additional Links
Substances : Medicinal Mushrooms
Diseases : Kidney Failure: Chronic, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
Additional Keywords : Plant Extracts
[+]

Curcumin attenuates renal fibrosis in rat obstructive nephropathy.Feb 01, 2006

Pubmed Data : Urology. 2006 Feb;67(2):440-6. PMID: 16461119
Article Published Date : Feb 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Kidney Fibrosis, Obstructive Nephropathy
Pharmacological Actions : NF-kappaB Inhibitor, Renoprotective
[+]

Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis.Nov 01, 2005

Pubmed Data : Kidney Int. 2005 Nov;68(5):2042-9. PMID: 16221204
Article Published Date : Nov 01, 2005
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Glomerulonephritis, Kidney Fibrosis, Proteinuria
Pharmacological Actions : Anti-Fibrotic, Enzyme Inhibitors, Renoprotective
[+]

Curcumin might be an effective antifibrotic drug in the treatment of chronic kidney disease.Jul 01, 2004

Pubmed Data : Kidney Int. 2004 Jul;66(1):112-20. PMID: 15200418
Article Published Date : Jul 01, 2004
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Kidney Diseases, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Emodin ameliorates renal damage and podocyte injury in a model of diabetic nephropathy.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetes Metab Syndr Obes. 2021 ;14:1253-1266. Epub 2021 Mar 18. PMID: 33776462
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Renoprotective
[+]

Emodin ameliorates tubulointerstitial fibrosis in obstructed kidneys by inhibiting EZH2.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Res Commun. 2021 Jan 1 ;534:279-285. Epub 2020 Dec 4. PMID: 33288199
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Fructose-fed rats exhibit increased inflammation, fibrogenesis and NF-κB activation.Jun 17, 2011

Pubmed Data : Eur J Pharmacol. 2011 Jun 17. Epub 2011 Jun 17. PMID: 21704028
Article Published Date : Jun 17, 2011
Study Type : Animal Study
Additional Links
Diseases : Advanced Glycation End products (AGE), Inflammation, Kidney Damage, Kidney Diseases, Kidney Fibrosis
Problem Substances : Fructose
Adverse Pharmacological Actions : Inflammatory, Nephrotoxic, NF-kappaB up-regulation, Oxidant, Profibrotic
[+]

Gadolinium-based contrast agents: Stimulators of myeloid-induced renal fibrosis and major metabolic disruptors.Jul 14, 2019

Pubmed Data : Toxicol Appl Pharmacol. 2019 Jul 15 ;375:32-45. Epub 2019 May 10. PMID: 31082427
Article Published Date : Jul 14, 2019
Study Type : Animal Study
Additional Links
Diseases : Gadolinium Toxicity, Kidney Fibrosis
Problem Substances : Gadolinium
[+]

Ginsenoside-Rg1 protects against renal fibrosis. Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2018 ;41(4):585-591. PMID: 29607931
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Kidney Fibrosis, Obstructive Nephropathy
Pharmacological Actions : Renoprotective
[+]

GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.Dec 20, 2019

Pubmed Data : Chem Biol Interact. 2019 Dec 21:108926. Epub 2019 Dec 21. PMID: 31874164
Article Published Date : Dec 20, 2019
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Hydrogen water can inhibit the development of fibrosis in kidney.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2017 ;40(5):610-615. PMID: 28458345
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Korean red ginseng attenuates hyperglycemia-induced renal inflammation and fibrosis.May 22, 2020

Pubmed Data : J Ethnopharmacol. 2020 May 23 ;254:112693. Epub 2020 Feb 26. PMID: 32112899
Article Published Date : May 22, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Diabetic Nephropathy, Hyperglycemia, Inflammation, Kidney Damage, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Autophagy Up-regulation, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Lactoferrin contributes a renoprotective effect in acute kidney injury and early renal fibrosis.May 07, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceutics. 2020 May 8 ;12(5). Epub 2020 May 8. PMID: 32397266
Article Published Date : May 07, 2020
Study Type : Animal Study
Additional Links
Substances : Lactoferrin
Diseases : Kidney Damage, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
Additional Keywords : Gene Expression Regulation
[+]

Nigella sativa oil ameliorates sodium nitrite-induced nephrotoxicity in animals. Jul 28, 2015

Pubmed Data : Redox Rep. 2015 Jul 29. Epub 2015 Jul 29. PMID: 26221999
Article Published Date : Jul 28, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Kidney Fibrosis, Oxidative Stress, Sodium nitrate toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
Problem Substances : Sodium Nitrate
[+]

Oligo-fucoidan improves diabetes-induced renal fibrosis. Oct 07, 2020

Pubmed Data : Nutrients. 2020 Oct 8 ;12(10). Epub 2020 Oct 8. PMID: 33049944
Article Published Date : Oct 07, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Paeonol delays the progression of diabetic renal fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:512. Epub 2018 May 18. PMID: 29867511
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Nrf2 activation, SIRT1 Activator
[+]

Perilla frutescens sprout extract may be useful for the prevention or treatment of diabetic nephropathy.Feb 07, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Feb 8 ;11(2). Epub 2019 Feb 8. PMID: 30744045
Article Published Date : Feb 07, 2019
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Piceatannol may be a beneficial therapeutic agent for treating renal fibrosis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(11):e0167340. Epub 2016 Nov 30. PMID: 27902771
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Piceatannol
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Polyporus umbellatus protects against renal fibrosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:633566. Epub 2021 Feb 19. PMID: 33679418
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Medicinal Mushrooms
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Pterostilbene alleviates fructose-induced renal fibrosis.Jan 04, 2019

Pubmed Data : Eur J Pharmacol. 2019 Jan 5 ;842:70-78. Epub 2018 Oct 16. PMID: 30336139
Article Published Date : Jan 04, 2019
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : High Fructose Diet, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Pterostilbene alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:1802-1808. Epub 2018 Nov 26. PMID: 30551434
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : Kidney Fibrosis, Nephropathy
Pharmacological Actions : Renoprotective, STAT3 Inhibitor
[+]

Puerarin attenuates renal fibrosis by reducing oxidative stress.Oct 31, 2017

Pubmed Data : Ren Fail. 2017 Nov ;39(1):423-431. PMID: 28335679
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Antioxidants, Renoprotective
[+]

Regulation of Wnt activity by curcumin is a feasible alternative strategy to rescue diabetic renal injury.Feb 29, 2016

Pubmed Data : Am J Med Sci. 2016 Mar ;351(3):286-95. PMID: 26992258
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Wnt/β-catenin signaling pathway modulation
[+]

Resveratrol is a potential therapeutic agent for preventing renal fibrosis.Aug 26, 2019

Pubmed Data : Br J Pharmacol. 2019 Aug 27. Epub 2019 Aug 27. PMID: 31454852
Article Published Date : Aug 26, 2019
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Rosa roxburghii fruit freeze-dried powder could effectively prevent renal fibrosis and injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:4946580. Epub 2019 Aug 20. PMID: 31531112
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Rose
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Renoprotective
Additional Keywords : Plant Extracts
[+]

Silibinin enhances anti-renal fibrosis effect of MK-521 via downregulation of TGF-β signaling pathway.Jan 17, 2020

Pubmed Data : Hum Cell. 2020 Jan 18. Epub 2020 Jan 18. PMID: 31953678
Article Published Date : Jan 17, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

These results demonstrate that Astragaloside IV protects against the progression of renal fibrosis.Dec 31, 2016

Pubmed Data : Int Immunopharmacol. 2017 Jan ;42:18-24. Epub 2016 Nov 14. PMID: 27855303
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Inflammation, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

These results provide new insight into the anti-fibrotic mechanism of asiatic acid.Nov 07, 2019

Pubmed Data : Acta Pharmacol Sin. 2019 Nov 8. Epub 2019 Nov 8. PMID: 31705123
Article Published Date : Nov 07, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

These results suggest that Tanshinone IIA suppresses renal fibrosis and inflammation.Apr 30, 2015

Pubmed Data : Int Immunopharmacol. 2015 May ;26(1):4-12. Epub 2015 Mar 2. PMID: 25744602
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Inflammation, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Treatment with rhubarb extracts may represent as an effective therapy for chronic kidney disease associated with fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1029. Epub 2018 Sep 13. PMID: 30271345
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Rhubarb
Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Triptolide showed a protective effect against renal fibrosis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:814089. Epub 2015 Sep 14. PMID: 26451157
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Tripterygium wilfordii, Triptolide
Diseases : Kidney Diseases, Kidney Fibrosis
Pharmacological Actions : MicroRNA modulator, Renoprotective
[+]

Vitamin D reduces kidney fibrosis through inhibition of fibroblast activation.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Kobe J Med Sci. 2016 ;62(2):E38-44. Epub 2016 Jul 5. PMID: 27578035
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Renoprotective
[+]

Wen-pi-tang-Hab-Wu-ling-san reduces ureteral obstructive renal fibrosis by the reduction of oxidative stress, inflammation, and TGF-beta/Smad2/3 signaling.Feb 01, 2010

Pubmed Data : Food Chem Toxicol. 2010 Feb;48(2):522-9. Epub 2009 Nov 11. PMID: 19913069
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Traditional Chinese Medicine: Wen-pi-tang-Hab-Wu-ling-san
Diseases : Kidney Fibrosis, Obstructive uropathy, Oxidative Stress
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Zinc supplementation inhibits the high glucose‑induced EMT of peritoneal mesothelial cells by activating the Nrf2 antioxidant pathway.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Jul ;20(1):655-663. Epub 2019 May 22. PMID: 31115566
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Zinc
Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis
Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective
[+]

Apoptotic and antihepatofibrotic effect of honokiol via activation of GSK3β and suppression of Wnt/β-catenin pathway in hepatic stellate cells.Aug 09, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytother Res. 2020 Aug 10. Epub 2020 Aug 10. PMID: 32776713
Article Published Date : Aug 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Renoprotective
[+]

Combined melatonin and poricoic acid A inhibits renal fibrosis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ther Adv Chronic Dis. 2019 ;10:2040622319869116. Epub 2019 Aug 14. PMID: 31452866
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
Additional Keywords : Polysaccharides
[+]

Cordyceps Sinensis inhibits the epithelial-mesenchymal transition and protects against renal fibrosis in diabetic nephropathy.Nov 13, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Nov 14 ;24(22). Epub 2019 Nov 14. PMID: 31739543
Article Published Date : Nov 13, 2019
Study Type : In Vitro Study
Additional Links
Substances : Cordyceps sinensis
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Diosgenin has the potential to inhibit high glucose-induced renal tubular fibrosis possibly through EMT pathway.Apr 30, 2014

Pubmed Data : Exp Cell Res. 2014 May 1 ;323(2):255-62. Epub 2014 Feb 10. PMID: 24525371
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Diosgenin
Diseases : Kidney Failure, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

EGCG targeted Notch to attenuate renal fibrosis.Nov 17, 2020

Pubmed Data : Food Funct. 2020 Nov 18 ;11(11):9686-9695. PMID: 33057539
Article Published Date : Nov 17, 2020
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Emodin in combination with HGF may serve as a new possibility for treatment of renal fibrosis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2020 ;14:3567-3575. Epub 2020 Sep 3. PMID: 32943844
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Emodin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Fucoxanthin is a potential therapeutic strategy for diabetic nephropathy.Dec 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2019 Dec 12 ;17(12). Epub 2019 Dec 12. PMID: 31842414
Article Published Date : Dec 11, 2019
Study Type : In Vitro Study
Additional Links
Substances : Fucoxanthin
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants
[+]

Ginsenoside Rb1 could be applied in the treatment of patients with chronic kidney disease.Jul 10, 2020

Pubmed Data : Int J Biol Macromol. 2020 Jul 11 ;163:996-1009. Epub 2020 Jul 11. PMID: 32659400
Article Published Date : Jul 10, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Hydroxysafflor yellow A had a protective effect against fibrosis in renal cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(4):e0153409. Epub 2016 Apr 18. PMID: 27088510
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Safflower
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Melatonin prevents TGF-β1-stimulated transdifferentiation of fibroblasts to myofibroblasts.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Jan 1 ;9(1). Epub 2020 Jan 1. PMID: 31906396
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Nicotinamide mononucleotide attenuates renal interstitial fibrosis after acute kidney injury.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2021 ;12:649547. Epub 2021 Mar 23. PMID: 33833691
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Nicotinamide adenine dinucleotide (NADH)
Diseases : Ischemia, Kidney Damage, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Oleanolic acid may be a promising therapeutic agent in the treatment of renal fibrosis.Jul 03, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2018 Jul 4 ;18(1):205. Epub 2018 Jul 4. PMID: 29973206
Article Published Date : Jul 03, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Fibrosis, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Pterostilbene attenuated renal interstitial fibrosis by mediating MMT by regulating transcriptional activity of CXCL10.Dec 31, 2019

Pubmed Data : Am J Chin Med. 2020 ;48(7):1715-1729. Epub 2020 Nov 5. PMID: 33148003
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Kidney Fibrosis, Renal tubulointerstitial fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Renoprotective effect and mechanism of polysaccharide from Polyporus umbellatus sclerotia on renal fibrosis.May 14, 2019

Pubmed Data : Carbohydr Polym. 2019 May 15 ;212:1-10. Epub 2019 Feb 12. PMID: 30832835
Article Published Date : May 14, 2019
Study Type : Review
Additional Links
Substances : Zhu Ling Mushroom
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
Additional Keywords : Polysaccharides
[+]

Salvianolic acid B attenuates renal interstitial fibrosis.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Aug ;22(2):1325-1334. Epub 2020 Jun 15. PMID: 32626974
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
Additional Keywords : Dose Response
[+]

Wogonin ameliorates renal inflammation and fibrosis in diabetic nephropathy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2020 ;14:4135-4148. Epub 2020 Oct 8. PMID: 33116403
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor

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