Kidney Damage

Name	AC	CK
Curcumin	9	17
Sodium Bicarbonate	1	10
Melatonin	3	6
Quercetin	3	6
Sesamol	3	6
Nigella sativa (aka Black Seed)	3	5
Resveratrol	3	5
EGCG (Epigallocatechin gallate)	2	4
Pomegranate	2	4
Thymoquinone	2	3
Vitamin C	2	3
Anthocyanins	1	2
Arginine	1	2
Baicalein	1	2
Carotenoids	1	2
Crocin	1	2
Date Seeds	1	2
Garlic	1	2
Ginger	1	2
Grape Seed Extract	1	2
Krill	1	2
Lycopene	1	2
Mangiferin	1	2
Mangosteen	1	2
Naringenin	1	2
Nordihydroguaiaretic acid (NDGA)	1	2
Palm Oil	1	2
Proanthocyanidins	1	2
Propolis: Bee	1	2
Sweet Potato: Purple	1	2
Tetrahydrocurcumin	1	2
Tocotrienols	1	2
Berberine	1	1
Sulforaphane	1	1
Turmeric	1	1

Name	AC	CK
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	20
Zoledronic Acid	2	11
Acyclovir	1	10
Artificial Sweeteners	1	10
Artificially Sweetened Beverages	1	10
Aspartame	1	10
High Fructose Corn Syrup	1	10
Paraphenylenediamine (Hair Dye Ingredient)	1	10
Pesticides	1	10
Sugary soda	1	10
Fructose	2	4
Varenicline (trade name Chantix)	1	3
2,4-Dichlorophenoxyacetic acid	1	2
Diclofenac	1	2
Monosodium Glutamate (MSG)	1	2
Sodium hexametaphosphate	1	2
Titanium Dioxide	1	2
Uranium	1	2
Bisphenol A	1	1
Bisphosphonates	1	1
Fluoride	1	1
Glyphosate	1	1
Ibandronate	1	1
Pamidronate	1	1
Sodium Fluoride	1	1
Statin Drugs	1	1

Name	AC	CK	Focus
Nanotechnology	1	2

Adverse Pharmacological Actions : Nephrotoxic

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Lower dietary magnesium intake was independently associated with greater odds of rapid kidney function decline.Oct 21, 2016

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Pubmed Data : Am J Nephrol. 2016 Oct 22 ;44(5):381-387. Epub 2016 Aug 22. PMID: 27771720

Article Published Date : Oct 21, 2016

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Kidney Damage, Magnesium Deficiency

Pharmacological Actions : Renoprotective

Additional Keywords : Risk Factors

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Sodium bicarbonate reduces the incidence of contrast-induced acute kidney injury.Jan 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicine (Baltimore). 2016 Feb ;95(7):e2715. PMID: 26886610

Pubmed Data : Int Urol Nephrol. 2018 Jan 24. Epub 2018 Jan 24. PMID: 29368247

Article Published Date : Jan 23, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astaxanthin

Diseases : Kidney Damage

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Renoprotective

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Adverse Pharmacological Actions : Inflammatory, Renotoxic

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Chicory can be used as an alternative for alleviating renal dysfunction in hyperuricaemia.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:1764212. Epub 2018 Dec 2. PMID: 30622589

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Chicory

Diseases : Hyperuricemia, Kidney Damage

Pharmacological Actions : Renoprotective, Uricosuric Agents

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Chlorogenic acid attenuates kidney ischemic/reperfusion injury.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Phytother Res. 2016 Jun 9. Epub 2016 Jun 9. PMID: 27279282

Article Published Date : Jun 08, 2016

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Kidney Damage, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

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Crocin has anti-inflammatory and protective effects in ischemia-reperfusion induced renal injuries.Jun 30, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Cell Physiol. 2020 May 21. Epub 2020 May 21. PMID: 32437012

Article Published Date : May 20, 2020

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Aging, Kidney Damage

Pharmacological Actions : Renoprotective

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Diosmetin protects against ischemia/reperfusion-induced acute kidney injury.Jan 14, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int Urol Nephrol. 2015 Jun 28. Epub 2015 Jun 28. PMID: 26122117

Article Published Date : Jun 27, 2015

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Kidney Damage, Kidney Diseases

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Renoprotective

Additional Keywords : Significant Treatment Outcome

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Diseases : DNA damage, Ehrlich carcinoma, Kidney Damage

Pharmacological Actions : Renoprotective

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Green tea polyphenols ameliorate the early renal damage induced by a high-fat diet.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmaceutics. 2020 May 8 ;12(5). Epub 2020 May 8. PMID: 32397266

Article Published Date : May 07, 2020

Study Type : Animal Study

Additional Links

Substances : Lactoferrin

Diseases : Kidney Damage, Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Renoprotective

Additional Keywords : Gene Expression Regulation

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Ligustrazine ameliorates acute kidney injury through downregulation of NOD2‑mediated inflammation.Jan 09, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Pak J Pharm Sci. 2014 May ;27(3):505-10. PMID: 24811809

Pomegranate juice was proved to be a potential hepato-renal protective agent against liver and kidney damage induced by copper oxide nanoparticles.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Nanomedicine. 2019 ;14:8905-8922. Epub 2019 Nov 15. PMID: 31814719

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Kidney Dis. 2016 May ;10(3):135-43. PMID: 27225721

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Kidney Damage

Pharmacological Actions : Renoprotective

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Proanthocyanidin-rich date seed extract protects against chemically induced hepatorenal toxicity.Feb 28, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Trace Elem Med Biol. 2020 Jan ;57:126407. Epub 2019 Sep 18. PMID: 31570250

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Iron Overload, Kidney Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Renoprotective

Additional Keywords : Proanthocyanidins

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Purple sweet potato anthocyanin can exert renal protection by inhibiting ROS in high fat diet. Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Nov 12 ;10(11). Epub 2018 Nov 12. PMID: 30424556

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Pharmacol Rep. 2017 Mar 14 ;69(4):648-657. Epub 2017 Mar 14. PMID: 28521173

Pubmed Data : Sci Total Environ. 2019 Nov 16 ;706:135522. Epub 2019 Nov 16. PMID: 31864998

Article Published Date : Nov 15, 2019

Study Type : Review

Additional Links

Diseases : Air Pollution Linked Toxicity, Chronic Kidney Disease (CKD), Kidney Damage

Additional Keywords : Risk Factors

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An overview on renoprotective effects of thymoquinone.May 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Kidney Dis (Basel). 2018 Jun ;4(2):74-82. Epub 2018 Feb 14. PMID: 29998122

Article Published Date : May 31, 2018

Study Type : Review

Additional Links

Substances : Thymoquinone

Diseases : Diabetic Nephropathy, Kidney Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

[+]

Berberine has excellent pharmacological potential to prevent kidney damage.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(11):14486-92. Epub 2015 Nov 1. PMID: 26823767

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Ursolic acid is a potential anti-inflammatory natural compound for treating acute kidney injury by inducing autophagy.Jul 10, 2019

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Pubmed Data : Cytokine. 2019 Jul 11 ;123:154726. Epub 2019 Jul 11. PMID: 31302461

Article Published Date : Jul 10, 2019

Study Type : In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Kidney Damage

Pharmacological Actions : Anti-Inflammatory Agents, Autophagy Up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Vitamin C can decrease aristolochic acid induced increases in H2O2 levels and caspase 3 activity to attenuate aristolochic acid induced cell cytotoxicity.Aug 02, 2015

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Pubmed Data : Mol Med Rep. 2015 Aug 3. Epub 2015 Aug 3. PMID: 26239057

Article Published Date : Aug 02, 2015

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Hydrogen Peroxide Induced Toxicity, Kidney Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Caspase-3 Inhibition, Renoprotective

Additional Keywords : Aristolochic Acid

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View the Evidence: 159 Abstracts with Kidney Damage Research

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A statistically significant elevated AKI risk among traditional NSAID users has been demonstrated in this meta-analysis. Apr 06, 2015

Acyclovir has been associated with kidney and cerebral toxicity. Nov 01, 1999

Consumption of≥2 servings per day of artificially sweetened soda is associated with a 2-fold increased odds for kidney function decline in women.Sep 30, 2010

Lower dietary magnesium intake was independently associated with greater odds of rapid kidney function decline.Oct 21, 2016

Sodium bicarbonate reduces the incidence of contrast-induced acute kidney injury.Jan 31, 2016

Sugary soda consumption is associated with kidney damage. Jan 01, 2008

There is an association between prolonged occupational exposure to paraphenylenediamine (hair-dye) and renal impairment.Jan 01, 2011

These findings support an association between end-stage renal disease and chronic exposure to specific pesticides.Jul 14, 2015

This study provides evidence of a beneficial effect of coffee on kidney function. Dec 01, 2019

Zoledronic acid may cause renal toxicity in 37.7% of patients with multiple myeloma. Jan 01, 2010

Acute kidney injury caused by decompression illness successfully treated with hyperbaric oxygen therapy and temporary dialysis.Sep 11, 2017

Varenicline-associated acute renal failure has been reported.Dec 01, 2008

2,4-Dichlorophenoxyacetic acid exhibits nephrotoxic properties. Nov 01, 2011

6-Shogaol protects against ischemic acute kidney injury by modulating NFκB and heme oxygenase-1 pathways.Jul 16, 2019

A tocotrienol rich fraction of palm oil protects against chemically-induced kidney damage.Jul 30, 2010

Administration of astragaloside containing fluid led to a dramatic improvement in survival following crush syndrome.Sep 03, 2017

Ameliorative effect of Ecklonia cava polyphenol extract on renal inflammation.May 16, 2017

Ameliorative effects of honey, propolis, pollen, and royal jelly mixture against chronic toxicity of sumithion insecticide.Jun 04, 2020

Angelica sinensis pretreatment could effectively guard the liver and kidney of mice from D-galactose-induced injury.Aug 31, 2018

Antioxidant effect of p-coumaric acid on interleukin 1-β and tumor necrosis factor-α in rats with renal ischemic reperfusion.Dec 27, 2019

Apigenin possesses excellent protective effect against 3-MCPD-induced renal injury.Dec 24, 2018

Astaxanthin attenuates contrast agent-induced acute kidney injury in vitro and in vivo.Jan 23, 2018

Astragaloside IV alleviates lipopolysaccharide-induced acute kidney injury.Mar 21, 2017

Baicalein significantly attenuates kidney injury induced by myocardial ischemia and reperfusion.Jan 31, 2016

Bergamot has antioxidant effects against metabolic syndrome induced by a cafeteria diet. Mar 15, 2019

Calcitriol ameliorates kidney injury through reducing podocytopathy, tubular injury, inflammation and fibrosis.Mar 26, 2020

Carnosol protects against renal ischemia-reperfusion injury in rats.Oct 31, 2018

Cell phone exposure 8 hours a day for 20 days produces kidney tissue damage in rats.Jan 01, 2013

Chicory can be used as an alternative for alleviating renal dysfunction in hyperuricaemia.Dec 31, 2017

Chlorogenic acid attenuates kidney ischemic/reperfusion injury.Dec 31, 2018

Chronic monosodium glutamate (MSG) intake causes kidney dysfunction and renal oxidative stress in the animal model.Dec 31, 2013

Comparison of olive leaf, olive oil, palm oil, and omega-3 oil in acute kidney injury induced by sepsis.Dec 31, 2018

Crocin has a renoprotective effects against the development of oxidative stress and inflammation in the kidney of old rats.Jun 08, 2016

Crocin has anti-inflammatory and protective effects in ischemia-reperfusion induced renal injuries.Jun 30, 2017

Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice.Aug 01, 2001

Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA).Apr 01, 2009

Curcumin protects against hepatic and renal injury. Dec 18, 2009

Curcumin protects against ischemia/reperfusion injury in rat kidneys.Jun 01, 2008

Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice.May 20, 2020

Diosmetin protects against ischemia/reperfusion-induced acute kidney injury.Jan 14, 2017

Effect of caffeic acid on ischemia-reperfusion-induced acute renal failure.Mar 13, 2019

Effects of exercise and stevia on renal ischemia/reperfusion injury in rats.Jun 30, 2019

EGCG treatment can decrease renal ischemia-reperfusion injury by suppressing inflammation and cell apoptosis.Jun 27, 2015

Ellagic acid ameliorates renal ischemic-reperfusion injury.Nov 25, 2019

Exposure to a continuous 900-MHz EMF for 1 h daily during middle and late adolescence may cause changes in the female rat kidney at postnatal day 60.Sep 30, 2018

Ferulic acid protects hyperglycemia-induced kidney damage.Dec 31, 2018

Ferulic acid protects lipopolysaccharide-induced acute kidney injury.Mar 31, 2018

Fisetin alleviated kidney inflammation and apoptosis to protect against lipopolysaccharide-induced septic acute kidney injury.Jan 31, 2020

Fructose causes renal damage in an animal model of metabolic syndrome. May 01, 2011

Fructose-fed rats exhibit increased inflammation, fibrogenesis and NF-κB activation.Jun 17, 2011

Garlic powder protects against dichromate-induced oxidative stress and kidney damage.Feb 01, 2008

Genipin ameliorates hypertension-induced renal damage.Jun 30, 2016

Ginger has a protective effect against kidney damage associated with diabetes.Apr 30, 2011

Ginsenoside protects against AKI via activation of HIF 1α and VEGF A in the kidney brain axis.Jan 14, 2020

Grape seed and skin extract alleviates high-fat diet-induced renal lipotoxicity and prevents copper depletion in rat.Feb 28, 2013

Grape seeds proanthocyanidin extract ameliorates Ehrlich solid tumor induced renal tissue and DNA damage in mice.Jun 30, 2019

Green tea polyphenols ameliorate the early renal damage induced by a high-fat diet.Dec 31, 2016

GSSE treatment protected efficiently against all the deleterious effects of diabetes-induced kidney dysfunction.Jul 22, 2016

Hesperidin is a potential therapeutic agent for acute ischemia-induced renal damage.Sep 30, 2019

Hesperidin protects against renal injury induced by ischemia/reperfusion.Feb 29, 2020

Honokiol alleviates sepsis-induced acute kidney injury.Dec 31, 2018

Hypericum Perforatum is protective against acute renal Ischemia/reperfusion injury. Oct 31, 2017

Inflammation and kidney injury attenuated by prior intake of Brazil nuts in the process of ischemia and reperfusion.Sep 30, 2018

Inhibition of inflammatory cytokine expression prevents high-fat diet-induced kidney injury: role of lingonberry supplementation.Dec 31, 2019

Korean red ginseng attenuates hyperglycemia-induced renal inflammation and fibrosis.May 22, 2020

Krill protein concentrate prevents early renal injury and nephrocalcinosis in female rats.Feb 01, 2011

Lactoferrin contributes a renoprotective effect in acute kidney injury and early renal fibrosis.May 07, 2020

Ligustrazine ameliorates acute kidney injury through downregulation of NOD2‑mediated inflammation.Jan 09, 2020

Ligustrazine exhibited protective effects against sepsis-associated acute kidney injury.Nov 15, 2019

Long-term dietary supplementation with L-arginine prevents age-related reduction in renal function.Jun 01, 1997

Luteolin confers renoprotection against ischemia-reperfusion injury.May 13, 2019

Lycium barbarum polysaccharides attenuate kidney injury in sepsis.Dec 27, 2019

Kidney Damage

View the Evidence:
159 Abstracts with Kidney Damage Research