Results for Cyclooxygenase 2 Inhibitors

Adlay bran ethanolic extract suppressed 1,2-dimethylhydrazine-indued preneoplastic lesions of the colon.

Article Published Date : Jul 13, 2010
Study Type : Animal Study
Additional Links
Substances : Adlay : CK(1) : AC(1)
Diseases : Colon Cancer : CK(1217) : AC(742)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Chemopreventive : CK(4220) : AC(1326), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645)
Additional Keywords : Adlay, Anti-Inflammatory Agents, Chemopreventive, COLON CANCER, Cyclooxygenase 2 Inhibitors, Plant Extracts : CK(11762) : AC(4236)

Curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects.

Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(4844) : AC(2458)
Diseases : Depression : CK(62) : AC(7)
Pharmacological Actions : Antidepressive Agents : CK(2853) : AC(522), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645)
Additional Keywords : Antidepressive Agents, CURCUMIN : CK(2) : AC(1), Cyclooxygenase 2 Inhibitors, depression

Extracts of the fruits of Maqui-berry may provide a potential therapeutic approach for inflammation associated disorders.

Article Published Date : Dec 27, 2016
Study Type : In Vitro Study
Additional Links
Substances : Maqui : CK(14) : AC(5)
Diseases : Inflammation : CK(6531) : AC(1986), Oxidative Stress : CK(6519) : AC(2436)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Antioxidants : CK(14410) : AC(5758), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645)
Additional Keywords : Anti-Inflammatory Agents, Antioxidants : CK(1) : AC(1), Cyclooxygenase 2 Inhibitors, Inflammation : CK(2) : AC(2), Maqui, oxidative stress, Plant Extracts : CK(11762) : AC(4236)

Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.

Article Published Date : Jul 20, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(610) : AC(230), Panax Ginseng : CK(81) : AC(37)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(612) : AC(266)
Pharmacological Actions : Chemoprotective Agents : CK(356) : AC(146), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645), Nitric Oxide Inhibitor : CK(390) : AC(196)
Additional Keywords : Anthocyanins : CK(7) : AC(6), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Panax Ginseng

Phloretin inhibits phorbol ester-induced tumor promotion and expression of cyclooxygenase-2 in mouse skin.

Article Published Date : Feb 29, 2012
Study Type : Animal Study
Additional Links
Substances : Phloretin : CK(96) : AC(46)
Diseases : Skin Cancer : CK(1175) : AC(495)
Pharmacological Actions : Anticarcinogenic Agents : CK(1577) : AC(756), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645), NF-kappaB Inhibitor : CK(2446) : AC(1436)
Additional Keywords : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Phloretin, skin cancer

The combination of β-caryophyllene, baicalin and catechin exerts synergistic suppressive effects on macrophages in vitro.

Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene : CK(2) : AC(1), Catechin : CK(565) : AC(191)
Diseases : Inflammation : CK(6531) : AC(1986)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Antiproliferative : CK(4773) : AC(3450), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645)
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative : CK(65) : AC(52), Beta-Caryophyllene, Catechin, Cyclooxygenase 2 Inhibitors, Inflammation : CK(2) : AC(2), Natural Substance Synergy : CK(844) : AC(392)

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.

Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone : CK(386) : AC(227)
Diseases : Inflammation : CK(6531) : AC(1986)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645), Interleukin-1 beta downregulation : CK(1743) : AC(868), Interleukin-6 Downregulation : CK(3054) : AC(1144), NF-kappaB Inhibitor : CK(2446) : AC(1436), Nitric Oxide Inhibitor : CK(390) : AC(196), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(4357) : AC(1763)
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(2) : AC(2), Interleukin-1 beta downregulation, thymoquinone

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin : CK(108) : AC(63)
Diseases : Diabetic Retinopathy : CK(60) : AC(23)
Pharmacological Actions : Anti-Apoptotic : CK(1620) : AC(932), Anti-Inflammatory Agents : CK(12461) : AC(4729), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin

This report confirms the anti-inflammatory potential of this traditionally employed herbal medicine in vitro.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Justicia gendarussa : CK(1) : AC(1)
Diseases : Inflammation : CK(6531) : AC(1986), Lipopolysaccharide-Induced Toxicity : CK(1105) : AC(650)
Pharmacological Actions : 5-Lipoxygenase Inhibitor : CK(8) : AC(7), Anti-Inflammatory Agents : CK(12461) : AC(4729), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645), Interleukin-6 Downregulation : CK(3054) : AC(1144), NF-kappaB Inhibitor : CK(2446) : AC(1436)
Additional Keywords : 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(2) : AC(2), Interleukin-6 Downregulation, Justicia gendarussa, Lipopolysaccharide-Induced Toxicity, NF-kappaB Inhibitor, Plant Extracts : CK(11762) : AC(4236)

Walnut leaf extract exert protective effects against diabetic retinopathy.

Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Walnut : CK(491) : AC(107)
Diseases : Diabetic Retinopathy : CK(60) : AC(23)
Pharmacological Actions : Anti-Apoptotic : CK(1620) : AC(932), Anti-Inflammatory Agents : CK(12461) : AC(4729), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Walnut

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