Results for Chemoprotective Agents

A short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicity

Article Published Date : Dec 12, 2016
Study Type : Human Study
Additional Links
Substances : Magnesium : CK(2196) : AC(275)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(612) : AC(266)
Pharmacological Actions : Chemoprotective Agents : CK(356) : AC(146)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Magnesium : CK(10) : AC(1)

Combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy.

Article Published Date : Nov 23, 2016
Study Type : Animal Study
Additional Links
Substances : Lycopene : CK(550) : AC(128), Rosmarinic acid : CK(47) : AC(26)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(54) : AC(28)
Pharmacological Actions : Chemoprotective Agents : CK(356) : AC(146), Renoprotective : CK(1308) : AC(593)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Gentamicin, lycopene, Renoprotective, Rosmarinic acid

Egyptian sweet orange hesperidin ameliorates the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.

Article Published Date : Mar 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hesperidin : CK(375) : AC(148), Sweet Orange : CK(28) : AC(6)
Diseases : Ehrlich carcinoma : CK(17) : AC(9)
Pharmacological Actions : Chemoprotective Agents : CK(356) : AC(146), Chemosensitizer : CK(772) : AC(577)
Additional Keywords : Chemoprotective Agents, Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(91) : AC(61), Ehrlich carcinoma, Hesperidin, Sweet Orange

Folic acid may be a novel therapeutic approach to attenuate doxorubicin induced cardiomyopathy.

Article Published Date : Jun 12, 2017
Study Type : Animal Study
Additional Links
Substances : Folic Acid : CK(900) : AC(135)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(296) : AC(149)
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758), Cardioprotective : CK(3412) : AC(1032), Chemoprotective Agents : CK(356) : AC(146)
Additional Keywords : Antioxidants : CK(1) : AC(1), Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, folic acid

Ginsenosides Rk2 and Rh3 have kidney protective effects of against cisplatin.

Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides : CK(1024) : AC(597)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(612) : AC(266)
Pharmacological Actions : Chemoprotective Agents : CK(356) : AC(146), Renoprotective : CK(1308) : AC(593)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Ginsenosides Rk3 and Rh4 protect the kidney from cisplatin-induced oxidative injury.

Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides : CK(1024) : AC(597)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(612) : AC(266)
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758), Chemoprotective Agents : CK(356) : AC(146), Renoprotective : CK(1308) : AC(593)
Additional Keywords : Antioxidants : CK(1) : AC(1), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Honey can decrease the side effects of chemotherapy on reproductive system and prevent sterility.

Article Published Date : May 22, 2018
Study Type : Animal Study
Additional Links
Substances : Honey : CK(784) : AC(188)
Diseases : Chemotherapy and Radiation Toxicity : CK(1796) : AC(457)
Pharmacological Actions : Chemoprotective Agents : CK(356) : AC(146)
Additional Keywords : Chemoprotective Agents, Chemotherapy and Radiation Toxicity, Honey : CK(1) : AC(1)

Melatonin could be used as an adjuvant agent with rapamycin in head and neck cancers.

Article Published Date : Dec 15, 2017
Study Type : In Vitro Study
Additional Links
Substances : Melatonin : CK(1399) : AC(461)
Diseases : Head and Neck Cancer : CK(374) : AC(85)
Pharmacological Actions : Chemoprotective Agents : CK(356) : AC(146), Chemotherapeutic : CK(397) : AC(152)
Additional Keywords : Chemoprotective Agents, Chemotherapeutic, Head and Neck Cancer, melatonin, Natural Substance/Drug Synergy : CK(352) : AC(142)

Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin.

Article Published Date : Sep 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(153) : AC(108)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(296) : AC(149)
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729), Cardioprotective : CK(3412) : AC(1032), Chemoprotective Agents : CK(356) : AC(146)
Additional Keywords : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents, Lotus

Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy.

Article Published Date : Mar 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(153) : AC(108)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(612) : AC(266)
Pharmacological Actions : Autophagy Up-regulation : CK(296) : AC(197), Chemoprotective Agents : CK(356) : AC(146)
Additional Keywords : Autophagy Up-regulation, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Lotus

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(934) : AC(279), Thymoquinone : CK(386) : AC(227)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(612) : AC(266)
Pharmacological Actions : Chemoprotective Agents : CK(356) : AC(146)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

Nigella sativa oil may help prevent the accompanying gastrointestinal dysfunction in cisplatin chemotherapy.

Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(934) : AC(279)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(612) : AC(266)
Pharmacological Actions : Chemoprotective Agents : CK(356) : AC(146), Gastroprotective : CK(534) : AC(228)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Gastroprotective, Nigella sativa (aka Black Seed)

Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.

Article Published Date : Jul 20, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(610) : AC(230), Panax Ginseng : CK(81) : AC(37)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(612) : AC(266)
Pharmacological Actions : Chemoprotective Agents : CK(356) : AC(146), Cyclooxygenase 2 Inhibitors : CK(1114) : AC(645), Nitric Oxide Inhibitor : CK(390) : AC(196)
Additional Keywords : Anthocyanins : CK(7) : AC(6), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Panax Ginseng

Phloretin has an anti-apoptotic effect on cisplatin-induced apoptosis in HEI-OC1 auditory cells.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Phloretin : CK(96) : AC(46)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(612) : AC(266)
Pharmacological Actions : Anti-Apoptotic : CK(1620) : AC(932), Chemoprotective Agents : CK(356) : AC(146), Heme oxygenase-1 inducer : CK(8) : AC(5)
Additional Keywords : Anti-Apoptotic, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Heme oxygenase-1 inducer, Phloretin

Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(1649) : AC(947)
Diseases : Lung Cancer : CK(1741) : AC(742), Melanoma : CK(584) : AC(306)
Pharmacological Actions : Anti-metastatic : CK(1284) : AC(927), Chemoprotective Agents : CK(356) : AC(146), Chemosensitizer : CK(772) : AC(577)
Additional Keywords : Anti-metastatic, Chemoprotective Agents, Chemosensitizer, lung cancer, melanoma, RESVERATROL

These results highlight the protective effects of tangeretin against cisplatin-induced acute hepatic injury.

Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Tangeretin : CK(38) : AC(24)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(612) : AC(266)
Pharmacological Actions : Anti-Apoptotic : CK(1620) : AC(932), Anti-Inflammatory Agents : CK(12461) : AC(4729), Antioxidants : CK(14410) : AC(5758), Chemoprotective Agents : CK(356) : AC(146)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants : CK(1) : AC(1), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin

This study suggests the use of neferine for amelioration of doxorubicin -mediated cardiotoxicity.

Article Published Date : Jul 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(153) : AC(108)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(296) : AC(149)
Pharmacological Actions : Cardioprotective : CK(3412) : AC(1032), Chemoprotective Agents : CK(356) : AC(146)
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Lotus

Zingiber officinale Roscoe ameliorates anticancer antibiotic doxorubicin-induced acute cardiotoxicity.

Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Ginger : CK(1125) : AC(318)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(296) : AC(149)
Pharmacological Actions : Cardioprotective : CK(3412) : AC(1032), Chemoprotective Agents : CK(356) : AC(146)
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Ginger

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