Abstract Title:

Therapeutic effect of yoga in patients with hypertension with reference to GST gene polymorphism.

Abstract Source:

J Altern Complement Med. 2013 Mar ;19(3):243-9. Epub 2012 Oct 12. PMID: 23062021

Abstract Author(s):

Kanupriya Dhameja, Savita Singh, M D Mustafa, K P Singh, Basu Dev Banerjee, Mukul Agarwal, Rafat S Ahmed

Article Affiliation:

Kanupriya Dhameja


BACKGROUND: Hypertension, a chronic medical condition of increased blood pressure, is a serious public health problem. Environmental and genetic risk factors are known to predispose to hypertension. The present study was designed to investigate the association of glutathione S-transferase (GST) gene polymorphism with oxidative stress in hypertensive patients and the possible beneficial effect of yoga on them.

MATERIALS AND METHODS: Sixty (60) hypertensive individuals, between 30 and 60 years of age, were divided into two groups of 30 each. The yoga group was subjected to 50-60 minutes of yogic practices daily for 42 days, while the control group included the remaining 30 age- and sex-matched hypertensive individuals. GST gene polymorphism was analyzed using multiple allele specific polymerase chain reaction, and oxidative stress parameters were assessed biochemically.

RESULTS: Assessment of blood pressure showed a statistically significant though modest reduction (p<0.05) in the yoga group as compared to the control group. Malondialdehyde was observed to be significantly low (p<0.05), while antioxidant capacity in the form of GST showed an increasing trend and ferric-reducing ability of plasma was significantly increased (p<0.05) in the subjects who practiced yoga.

CONCLUSIONS: In conclusion, yoga has been found to decrease blood pressure as well as the levels of oxidative stress in patients with hypertension.

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