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Article Publish Status: FREE
Abstract Title:

Xanthohumol, a prenylated flavonoid from hops (L.), protects rat tissues against oxidative damage after acute ethanol administration.

Abstract Source:

Toxicol Rep. 2014 ;1:726-733. Epub 2014 Sep 16. PMID: 28962286

Abstract Author(s):

Carmen Pinto, Juan J Cestero, Beatriz Rodríguez-Galdón, Pedro Macías

Article Affiliation:

Carmen Pinto

Abstract:

Ethanol-mediated free radical generation is directly involved in alcoholic liver disease. In addition, chronic alcohol bingeing also induces pathological changes and dysfunction in multi-organs. In the present study, the protective effect of xanthohumol (XN) on ethanol-induced damage was evaluated by determining antioxidative parameters and stress oxidative markers in liver, kidney, lung, heart and brain of rats. An acute treatment (4 g/kg b.w.) of ethanol resulted in the depletion of superoxide dismutase, catalase and glutathione S-transferase activities and reduced glutathione content. This effect was accompanied by the increased activity of tissue damage marker enzymes (glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and lactate dehydrogenase) and a significant increase in lipid peroxidation and hydrogen peroxide concentrations. Pre-treatment with XN protected rat tissues from ethanol-induced oxidative imbalance and partially mitigated the levels to nearly normal levels in all tissues checked. This effect was dose dependent, suggesting that XN reduces stress oxidative and protects rat tissues from alcohol-induced injury.

Study Type : Animal Study

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