Article Publish Status: FREE
Abstract Title:

Assessing the Effects of Acute and Chronic Whole Apple Consumption on Biomarkers of Inflammation in Overweight and Obese Adults (P21-011-19).

Abstract Source:

Curr Dev Nutr. 2019 Jun ;3(Suppl 1). Epub 2019 Jun 13. PMID: 31224358

Abstract Author(s):

Danyelle Liddle, Xinjie Lois Lin, Liam Cox, Emily Ward, Krista Power, Amanda Wright, Lindsay Robinson

Article Affiliation:

Danyelle Liddle


Objectives: Systemic low-grade inflammation mechanistically links obesity to impairments in the metabolic processes central to the development of type 2 diabetes and cardiovascular disease. This phenomenon is promoted by digestion of a high-fat meal, whereas whole foods with proposed anti-inflammatory actions, such as apples, may be beneficial. Thus, the current studies aimed to assess the effects of acute and chronic consumption of whole apples on biomarkers of inflammation in overweight and obese adults.

Methods: Overweight or obese adults in otherwise good health were recruited. With= 26 (17 female/9 male; mean age 45.5 ± 3.1 y; mean BMI 34.1 ± 0.2 kg/m), a randomized, crossover trial was conducted to assess the effects of acute (one time) consumption of 3 whole Gala apples (∼200 g) on the 6 h postprandial inflammatory response (e.g., plasma gut-derived lipopolysaccharide (LPS), cytokines) to an oral fat tolerance test (1 g fat/kg body weight). Fasting and 4 h postprandial peripheral blood mononuclear cells (PBMCs) were also isolated from whole blood and stimulated with 10 ng/mL LPS for 24 h to measure secreted cytokines. With= 46 (32 female/14 male; mean age, 46.2 ± 2.2 y; mean BMI 33.5 ± 0.8 kg/m), a parallel-arm, randomized, controlled trial was conducted to assess the effects of chronic (6 week) consumption of 3 whole Gala apples per day (∼200 g) on fasting inflammatory markers.

Results: Acute apple consumption decreased 4 h postprandial unstimulated (IL-1β, granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage inflammatory protein (MIP)-1β, TNF-α) and LPS-stimulated (IL-6, TNF-α) PBMC-secreted inflammatory cytokines ( < 0.05,= 18). Similarly, chronic apple consumption decreased fasting unstimulated (IL-6) and LPS-stimulated (IL-6, INF-γ, TNF-α) PBMC-secreted inflammatory cytokines ( < 0.05;= 16-18/group), as well as plasma IL-6 ( < 0.05,= 22/group).

Conclusions: Both acute and chronic whole apple consumption may be an effective dietary strategy to mitigate the obesity-associated inflammation that precedes and exacerbates metabolic disease risk.

Funding Sources: Ontario Ministry of Agriculture, Food&Rural Affairs; Ontario Apple Growers.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.