Article Publish Status: FREE
Abstract Title:

Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells.

Abstract Source:

Molecules. 2015 ;20(7):12992-3004. Epub 2015 Jul 17. PMID: 26193251

Abstract Author(s):

Chloe D Goldsmith, Quan V Vuong, Elham Sadeqzadeh, Costas E Stathopoulos, Paul D Roach, Christopher J Scarlett

Article Affiliation:

Chloe D Goldsmith


Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200μg/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 μg/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrantfurther investigation into their potential anti-pancreatic cancer benefits.

Study Type : In Vitro Study

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