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Article Publish Status: FREE
Abstract Title:

Ursolic acid prevents doxorubicin-induced cardiac toxicity in mice through eNOS activation and inhibition of eNOS uncoupling.

Abstract Source:

J Cell Mol Med. 2019 Mar ;23(3):2174-2183. Epub 2019 Jan 4. PMID: 30609217

Abstract Author(s):

Haiman Mu, Haiwen Liu, Jiayi Zhang, Jianhua Huang, Chen Zhu, Yue Lu, Yueping Shi, Yi Wang

Article Affiliation:

Haiman Mu

Abstract:

In addition to the known antitumour effects of ursolic acid (UA), increasing evidence indicates that this molecule plays a role in cardiac protection. In this study, the effects of ursolic acid on the heart in mice treated with doxorubicin (DOX) were assessed. The results showed that ursolic acid improved left ventrical fractional shortening (LVFS) and left ventrical ejection fraction (LVEF) of the heart, increased nitrogen oxide (NO) levels, inhibited reactive oxygen species (ROS) production and decreased cardiac apoptosis in mice treated with doxorubicin. Mechanistically, ursolic acid increased AKT and endothelial nitric-oxide synthase (eNOS) phosphorylation levels, and enhanced eNOS expression, while inhibiting doxorubicin induced eNOS uncoupling through NADPH oxidase 4 (NOX4) down-regulation. These effects of ursolic acid resulted in heart protection from doxorubicin-induced injury. Therefore, ursolic acid may be considered a potential therapeutic agent for doxorubicin-associated cardiac toxicity in clinical practice.

Study Type : Animal Study

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Sayer Ji
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