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Abstract Title:

Ursolic acid potentiated oxaliplatin to induce apoptosis in colorectal cancer RKO cells.

Abstract Source:

Pharmazie. 2020 Jun 1 ;75(6):246-249. PMID: 32539919

Abstract Author(s):

Jia -Lu Zheng, Shuang-Shuang Wang, Ke-Ping Shen, Xiao-Wei Huang, Miao Li, Lei Chen, Xiao Peng, Hong-Mei An, Bing Hu

Article Affiliation:

Jia -Lu Zheng

Abstract:

Ursolic acid (UA) is found in multiple anticancer herbs and has shown anticancer effects in colorectal cancer (CRC) cells. The present study aimed to observe the effects of a combination of UA and oxaliplatin (Oxa), a frequently used chemotherapeutic drug in CRC, on human CRC RKO cells. The results showed that UA and Oxa synergistically inhibited the proliferation of RKO cells. A combination of UA and Oxa induced apoptosis in RKO cells and increased the activities of caspase-3, caspase-8, and caspase-9. Z-VAD-FMK, a caspase inhibitor, significantly antagonized UA- and Oxa-activated caspase-3, caspase-8, and caspase-9 and induced apoptosis. In addition, UA and Oxa downregulated the expression of X-linked inhibitor of apoptosis (XIAP) and Survivin in RKO cells. These observations suggested that a combination of UA and Oxa elicited synergistically anticancer effects in RKO cells and provided new evidence for potential application of UA and Oxa for CRC treatment.

Study Type : In Vitro Study

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