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Abstract Title:

Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice.

Abstract Source:

Neuroscience. 2020 Nov 10 ;448:94-106. Epub 2020 Sep 15. PMID: 32946950

Abstract Author(s):

Xiao-Hong Lin, Xiu-Juan Ye, Qing-Feng Li, Zhuo Gong, Xin Cao, Jian-Hua Li, Shen-Ting Zhao, Xiang-Dong Sun, Xiao-Song He, Ai-Guo Xuan

Article Affiliation:

Xiao-Hong Lin

Abstract:

Neuroinflammation contributes to neuronal death in cerebral ischemia. Urolithin A (UA), a gut microbial metabolite of ellagic acid, has emerged as a potential anti-inflammatory agent. However, its roles and precise mechanisms in stroke remain unknown. Here we found that UA treatment ameliorated infarction, neurological deficit scores, and spatial memory deficits after cerebral ischemia. Furthermore, UA significantly reduced neuron loss and promoted neurogenesis after ischemic stroke. We also found that UA attenuated apoptosis by regulating apoptotic-related proteins. Meanwhile, UA treatment inhibited glial activation via affecting inflammatory signaling pathways, specifically by enhancing cerebral AMPK and IκBa activation while decreasing the activation of Akt, P65NFκB, ERK, JNK, and P38MAPK. Our findings reveal a key role of UA against ischemic stroke through modulating apoptosis and neuroinflammation in mice.

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