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Article Publish Status: FREE
Abstract Title:

Two infants with tuberculid associated with Kawasaki disease.

Abstract Source:

Hum Vaccin Immunother. 2016 11 ;12(11):2772-2776. Epub 2016 Jul 19. PMID: 27435523

Abstract Author(s):

Hiroko Yamada, Haruka Ohta, Shunji Hasegawa, Yoshihiro Azuma, Masanari Hasegawa, Ryo Kadoya, Noriko Ohbuchi, Yuji Ohnishi, Seigo Okada, Madoka Hoshide, Shouichi Ohga

Article Affiliation:

Hiroko Yamada

Abstract:

Bacille de Calmette et Guerin (BCG) is the only licensed tuberculosis vaccine to prevent severe tuberculosis. The adverse events of BCG vaccination, including local reactions, lymphadenitis, osteomyelitis, tuberculid, and disseminated infection, have been reported. Two infants presented erythema at the inoculation site of BCG after the resolution of Kawasaki disease (K). They received BCG vaccination 1 week and 6 weeks before the Konset, respectively. Intravenous immunoglobulin improved the Kactivity, however the skin rash of BCG inoculation site extended to the face and extremities days 24 and 10 after the Konset, respectively. Both bacteriological study and interferon-γ release assay were negative for Mycobacterium tuberculosis infection. These patients were diagnosed as having tuberculid after K. The skin lesions gradually disappeared without antibiotic therapy over 2 months. The development of tuberculid in these patients might be associated with the remnant immune activation of K.

Study Type : Human: Case Report
Additional Links
Anti Therapeutic Actions : Vaccination: All : CK(6351) : AC(662)

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