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Abstract Title:

Failure of a Single Varicella Vaccination to Protect Children With Cancer From Life-Threatening Breakthrough Varicella.

Abstract Source:

Pediatr Infect Dis J. 2015 Sep ;34(9):1027-9. PMID: 25955833

Abstract Author(s):

James Kelley, Debra Tristram, Masaki Yamada, Charles Grose

Article Affiliation:

James Kelley

Abstract:

We report 2 children with life-threatening breakthrough varicella. Both had received 1 varicella vaccination before onset of cancer. Despite treatment with intravenous acyclovir, 1 child died of disseminated varicella. Because similar fatal cases have been reported, high-risk immunocompromised children with 1 varicella vaccination may warrant the same varicella prophylaxis as immunocompromised children who have never been vaccinated.

Study Type : Human: Case Report
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1307) : AC(596)
Anti Therapeutic Actions : Vaccination: All : CK(6351) : AC(662)

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Sayer Ji
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