Abstract Title:

Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.

Abstract Source:

Bioorg Med Chem. 1995 Oct;3(10):1345-8. PMID: 8564400

Abstract Author(s):

K Chen, Q Shi, T Fujioka, T Nakano, C Q Hu, J Q Jin, R E Kilkuskie, K H Lee

Article Affiliation:

Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.

Abstract:

A new kaurane type diterpene lactone, neotripterifordin (1), has been isolated from the roots of Tripterygium wilfordii. The structure of 1 was elucidated by spectroscopic methods, which included the concerted application of a number of 2-D NMR techniques including 1H-1H COSY, phase-sensitive NOESY, HETCOR, and long-range HETCOR. Compound 1 showed potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.

Study Type : In Vitro Study

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