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Abstract Title:

Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus.

Abstract Source:

Biomed Pharmacother. 2018 Sep ;105:151-158. Epub 2018 May 29. PMID: 29852392

Abstract Author(s):

Zhongfang Zhao, Ying Han, Zhihui Zhang, Wenwen Li, Xiaoli Ji, Xiaodan Liu, Jianqiu Jin, Si Xu, Hongmei Cui, Zhe Cheng, Qian Wang, Xing Wang, Xiang Guo, Yixiang Wang, Hongwei Liu

Article Affiliation:

Zhongfang Zhao

Abstract:

Mesenchymal stem cells (MSCs) have been used clinically and experimentally to relieve severe immune-related diseases due to their immunomodulatory properties, but these are impaired by inflammation. Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory mucosal disease. In the present study, we found MSCs from OLP with higher expression of interleukin (IL)-6, tumour necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β) and IL-10 compared with control. Total glucosides of paeony (TGP) significantly improves the immunomodulatory function of MSCs by inhibiting IL-6 and TNF-α expression and increasing TGF-β and IL-10 expression. Moreover, TGP can downregulate p-STAT3 expression through upregulation of miR-124. The changes of IL-6, TGF-β and p-STAT3 were further confirmed by overexpression and knockdown of miR-124 in MSCs. Taken together, the immune-regulating function of MSCs can be improved by TGP via the miR-124/STAT3 pathway.

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