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Abstract Title:

Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells.

Abstract Source:

Food Chem Toxicol. 2012 Sep ;50(9):3133-41. Epub 2012 Jul 4. PMID: 22771365

Abstract Author(s):

Yannan Jia, Liu Ji, Shuai Zhang, Lina Xu, Lianhong Yin, Lei Li, Yanyan Zhao, Jinyong Peng

Article Affiliation:

Yannan Jia

Abstract:

The aim of the present study was to evaluate the protective effect and possible mechanism of the total flavonoids (TFs) from Rosa Laevigata Michx fruit (RLMF) against hydrogen peroxide (H(2)O(2)) induced damage in human umbilical vein endothelial cells (HUVECs). The cell injury caused by H(2)O(2) was protected by pretreatment with the TFs for 1h. Compared with the model group, the TFs decreased S phase cells, suppressed nuclear morphological damage, inhibited the collapse of mitochondrial membrane potentials (ΔΨm), attenuated excessive reactive oxygen species generation, reduced glutathione depletion, impacted the mitochondrial morphology change, decreased caspase-3, -9 activities, and decreased fragmented DNA. Further mechanism investigation showed that the TFs could increase the protein expressions of Procaspase-3, Bcl-2, and decrease the expressions of Bak, Bax, Bid and p53. Generally, the TFs from RLMF is an effective natural product for the treatment of cardiovascular and cerebrovascular diseases.

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