Article Publish Status: FREE
Abstract Title:

Topical application ofhydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice.

Abstract Source:

Pharm Biol. 2019 Dec ;57(1):799-806. PMID: 31760838

Abstract Author(s):

Amin Daemi, Mahsa Lotfi, Mohammad Reza Farahpour, Ahmad Oryan, Sina Jangkhahe Ghayour, Ali Sonboli

Article Affiliation:

Amin Daemi


J. Presl. (Lauraceae) has a high number of polyphenols with insulin-like activity, increases glucose utilization in animal muscle, and might be beneficial for diabetic patients.This study evaluated the effectiveness of an ointment prepared fromhydroethanolic extract on wound healing in diabetic mice.A total of 54 male BALB/c mice were divided into three groups: (1) diabetic non-treated group mice that were treated with soft yellow paraffin, (2 and 3) mice that were treated with 5 and 10%. Two circular full-thickness excisional wounds were created in each mouse, and the trial lasted for 16 d following induction of the wound. Further evaluation was made on the wound contraction ratio, histopathology parameters and mRNA levels of cyclin D1, insulin-like growth factor 1 (IGF-1), glucose transporter-1 (GLUT-1), total antioxidant capacity, and malondialdehyde of granulation tissue contents. HPLC apparatus was utilized to identify the compounds.The HPLC data for cinnamon hydroethanolic extract identified cinnamaldehyde (11.26%) and 2-hydroxyl cinnamaldehyde (6.7%) as the major components. A significant increase was observed in wound contraction ratio, fibroblast proliferation, collagen deposition, re-epithelialization and keratin biosynthesis in the-treated groups in comparison to the diabetic non-treated group ( < 0.05). The expression level of cyclin D1, IGF1, GLUT 1 and antioxidant capacity increased in the-treated groups in comparison to the diabetic non-treated group ( < 0.05).Topical administration ofaccelerated wound healing and can possibly be employed in treating the wounds of diabetic patients.

Study Type : Animal Study

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