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Article Publish Status: FREE
Abstract Title:

Paeoniflorin Attenuates Inflammatory Pain by Inhibiting Microglial Activation and Akt-NF-κB Signaling in the Central Nervous System.

Abstract Source:

Cell Physiol Biochem. 2018 ;47(2):842-850. Epub 2018 May 22. PMID: 29807368

Abstract Author(s):

Bo Hu, Guangtao Xu, Xiaomin Zhang, Long Xu, Hong Zhou, Zhenyi Ma, Xiaohua Shen, Jia Zhu, Ruilin Shen

Article Affiliation:

Bo Hu

Abstract:

BACKGROUND/AIMS: Paeoniflorin (PF) is known to have anti-inflammatory and paregoric effects, but the mechanism underlying its analgesic effect remains unclear. The aim of this study was to clarify the effect of PF on Freund's complete adjuvant (CFA)-induced inflammatory pain and explore the underlying molecular mechanism.

METHODS: An inflammatory pain model was established by intraplantar injection of CFA in C57BL/6J mice. After intrathecal injection of PF daily for 8 consecutive days, thermal and mechanical withdrawal thresholds, the levels of inflammatory factors TNF-α, IL-1β and IL-6, microglial activity, and the expression of Akt-NF-κB signaling pathway in the spinal cord tissue were detected by animal ethological test, cell culture, enzyme-linked immunosorbent assay, immunofluorescence histochemistry, and western blot.

RESULTS: PF inhibited the spinal microglial activation in the CFA-induced pain model. The production of proinflammatory cytokines was decreased in the central nervous system after PF treatment both in vivo and in vitro. PF further displayed a remarkable effect on inhibiting the activation of Akt-NF-κB signaling pathway in vivo and in vitro.

CONCLUSION: These results suggest that PF is a potential therapeutic agent for inflammatory pain and merits further investigation.

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