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Article Publish Status: FREE
Abstract Title:

Evaluation of cytotoxic activity from Temurui ([Linn.] Spreng) leaf extracts against HeLa cell line using MTT assay.

Abstract Source:

J Adv Pharm Technol Res. 2019 Apr-Jun;10(2):51-55. PMID: 31041182

Abstract Author(s):

Ulil Amna, Halimatussakdiah, Puji Wahyuningsih, Nurdin Saidi, Rosnani Nasution

Article Affiliation:

Ulil Amna

Abstract:

Temurui ([Linn.] Spreng) is a local plant of Aceh. The leaves ofare used in most of the local foods as spices. Nowadays, cancer is claimed as the second deadly disease in the world where the number of sufferers increases every year. Cervical cancer (HeLa) is one of the most dominant cancers that happen in developing country, including Indonesia. Some chemotherapeutic agents using synthetic drugs have been used to treat cancer, but they are relatively expensive and cause poisoning that limits their use. Based on literatures,serves the potential secondary metabolites that could be developed as anticancer agent. This study aims to evaluate the cytotoxic activity from three extracts ofleaves against HeLa cell line, including hexane, ethyl acetate, and methanol. Methodology used included extraction process, phytochemical screening, and cytotoxicity evaluation. The result showed that all the three extracts demonstrated a potent cytotoxic activity for HeLa cancer cells. Hexane and ethyl acetate showed a very strong cytotoxic effect with CDvalues<1μg/mL, whereas methanol extract showed cytotoxic effect with CDvalue of 2.25μg/mL. These results prove the potential ofas an anticancer agent.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Cytotoxic : CK(76) : AC(60)

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