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Abstract Title:

Inhibitors ofα-Synuclein Fibrillation and Oligomer Toxicity in: The All-Pervading Powers of Flavonoids and Phenolic Glycosides.

Abstract Source:

ACS Chem Neurosci. 2020 Sep 22. Epub 2020 Sep 22. PMID: 32886481

Abstract Author(s):

Hoda Eskandari, Mustafa Ghanadian, Clarice Noleto-Dias, Charlotte Lomax, Ahmed Tawfike, Gunna Christiansen, Duncan S Sutherland, Jane L Ward, Hossein Mohammad-Beigi, Daniel E Otzen

Article Affiliation:

Hoda Eskandari

Abstract:

There is an intense search for natural compounds that can inhibit the oligomerization and fibrillation ofα-synuclein (α-Syn), whose aggregation is key to the development of Parkinson's disease (PD).is a medicinal herb widely used in Middle Eastern food, ceremonies, and perfumes. The herb is known to contain many different polyphenols. Here we investigated the existence ofα-Syn fibrillation inhibitors inextract. Different HPLC fractions of the extract were assessed inα-Syn fibrillation and toxicity assays. The most active fractions led to the formation of more α-Syn oligomers but with less toxicity to SH-SY5Y cells, according to MTT and LDH assays. LC-MS analysis identified gallic acid, kaempferol 3-glucoside, kaempferol-3-O-β-rutinoside, and quercetin whichwere subsequently shown to be strong α-Syn fibrillation inhibitors. Our results highlight the benefits ofextract to combat PD at the population level.

Study Type : In Vitro Study

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