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Abstract Title:

Mangiferin: A promising natural xanthone from Mangifera indica for the control of acyclovir - resistant herpes simplex virus 1 infection.

Abstract Source:

Bioorg Med Chem. 2020 Feb 15 ;28(4):115304. Epub 2020 Jan 7. PMID: 31956052

Abstract Author(s):

Daniele Zendrini Rechenchoski, Karoline Fontana Agostinho, Ligia Carla Faccin-Galhardi, Audrey Alesandra Stinghen Garcia Lonni, João Vinícius Honório da Silva, Fábio Goulart de Andrade, Arcelina Pacheco Cunha, Nágila Maria Pontes Silva Ricardo, Carlos Nozawa, Rosa Elisa Carvalho Linhares

Article Affiliation:

Daniele Zendrini Rechenchoski

Abstract:

Mangiferin is found in many plant species as the mango tree (Mangifera indica) with ethnopharmacological applications and scientific evidence. The emergence of resistant herpes simplex virus (HSV) strains to Acyclovir (ACV) has encouraged the search for new drugs. We investigated the in vitro and in vivo activity of mangiferin obtained from M. indica against ACV-resistant HSV-1 (AR-29) and sensitive (KOS) strains. The in vitro activity was performed under varying treatment protocols. The substance showed a CC > 500 μg/mL and ICof 2.9 μg/mL and 3.5 μg/mL, respectively, for the AR-29 and KOS strains. The in vivo activity was performed in Balb/c mice treated with 0.7% topical mangiferin formulation. This formulation inhibited most effectively the AR-29 strain, attenuated the lesions, postponed their appearance or enhanced healing, in comparison to control group. We demonstrated the potentiality of mangiferin from M. indica to control HSV replication with emphasis to ACV-resistant infection.

Study Type : Animal Study, In Vitro Study

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