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Abstract Title:

Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission.

Abstract Source:

J Neuroimmunol. 2017 May 15 ;306:46-52. Epub 2017 Mar 1. PMID: 28385187

Abstract Author(s):

Junghyung Park, Ju-Sik Min, Unbin Chae, Joon Yeop Lee, Kyung-Sik Song, Hyun-Shik Lee, Hong Jun Lee, Sang-Rae Lee, Dong-Seok Lee

Article Affiliation:

Junghyung Park

Abstract:

Oleuropein is a primary phenolic compound found in olive leaf and Fraxinus rhynchophylla. Here, we investigated the impact of oleuropein on LPS-induced BV-2 microglial cells. Oleuropein suppressed the LPS-induced increase in pro-inflammatory mediators, such as nitric oxide, and pro-inflammatory cytokines, via inhibition of ERK/p38/NF-κB activation and reactive oxygen species (ROS) generation. Furthermore, it suppressed LPS-induced excessive mitochondrial fission, which regulates mitochondrial ROS generation and pro-inflammatory response by diminishing Drp1 dephosphorylation. Collectively, we demonstrated that oleuropein suppresses pro-inflammatory response of microglia by inhibiting Drp1-dependent mitochondrial fission. Our findings suggest a potential role of oleuropein in microglial inflammation-mediated neurodegenerative disorders.

Study Type : In Vitro Study

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