Tea catechins inhibit renin activity. - GreenMedInfo Summary

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Article Publish Status: FREE
Abstract Title:

Inhibitory effect of catechin-related compounds on renin activity.

Abstract Source:

Biomed Res. 2013 Jun ;34(3):167-71. PMID: 23782751

Abstract Author(s):

Fengjuan Li, Yoko Takahashi, Kohji Yamaki

Article Affiliation:

Fengjuan Li

Abstract:

Renin is a crucial enzyme in the renin-angiotensin system, and the inhibition of its activity is considered as a useful approach to the treatment of hypertension. The inhibitory effect of catechin-related compounds on renin was investigated in this work. It was found that epigallocatechin gallate (EGCg) possessed the strongest activity with an IC₅₀ value of 44.53 μM and acted in an uncompetitive manner. Gallated catechins exerted higher inhibition than the ungallated forms, and gallic acid exhibited an inhibitory potency close to that of epicatechin gallate (ECg). Results indicated that the galloyl moiety and ortho-trihydroxy phenyl structures might be favorable for the renin-inhibitory activity of these compounds.

Study Type : Human In Vitro

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