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Article Publish Status: FREE
Abstract Title:

Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes.

Abstract Source:

Int J Nanomedicine. 2018 ;13:1601-1610. Epub 2018 Mar 15. PMID: 29588587

Abstract Author(s):

Ming Zhao, Mengnan Zhao, Chen Fu, Yang Yu, Ailing Fu

Article Affiliation:

Ming Zhao

Abstract:

Background: Glioma is the most aggressive and lethal brain tumor in humans, it comprises about 30 per cent of all brain tumors and central nervous system tumors.

Purpose: The objective of this study was to create novel brain-targeting nanoliposomes to encapsulate curcumin as a promising option for glioma therapy.

Patients and methods: Human glioma cells (U251MG) were used to determine cell uptake efficiency and possible internalization mechanism of the curcumin-loaded nanoliposomes modified by a brain-targeting peptide RDP. In addition, intracranial glioma mice model was prepared by transplantation of U251MG cells into the mice striatum, and then the liposomes were intravenously administered into the glioma-bearing mice to evaluate the anti-glioma activity.

Results: RDP-modified liposomes (RCL) could enter the brain and glioma region, and were internalized by the glioma cells perhaps through acetylcholine receptor-mediated endocytosis pathway. Furthermore, the RCL prolonged the survival time of the glioma-bearing mice from 23 to 33 days, and the inhibition mechanism of the RCL on glioma cell was partly due to cell cycle arrest at the S phase and induction of cell apoptosis.

Conclusion: This study would provide a potential approach for targeted delivery of drug-loaded liposomes for glioma treatment.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)

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