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Article Publish Status: FREE
Abstract Title:

Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma.

Abstract Source:

J Hematol Oncol. 2016 08 23 ;9(1):72. Epub 2016 Aug 23. PMID: 27554093

Abstract Author(s):

Kai Qing, Zhen Jin, Wanbin Fu, Wenfang Wang, Zhao Liu, Xiaoyang Li, Zizhen Xu, Junmin Li

Article Affiliation:

Kai Qing

Abstract:

We demonstrate the synergistic antitumor effect of oridonin and the PI3K/mTOR inhibitor NVP-BEZ235 on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma (non-GCB DLBCL) both in vitro and in vivo. The underlying mechanism may be multifunctional, involving apoptosis, AKT/mTOR and NF-kB inactivation, and ROS-mediated DNA damage response. Our findings pave the way for a new potential treatment option for non-GCB DLBCL with the combination of oridonin and NVP-BEZ235.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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