Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma. - GreenMedInfo Summary
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Article Publish Status: FREE
Abstract Title:
Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma.
Abstract Source:
J Hematol Oncol. 2016 08 23 ;9(1):72. Epub 2016 Aug 23. PMID: 27554093
Article Affiliation:
Kai Qing
Abstract:
We demonstrate the synergistic antitumor effect of oridonin and the PI3K/mTOR inhibitor NVP-BEZ235 on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma (non-GCB DLBCL) both in vitro and in vivo. The underlying mechanism may be multifunctional, involving apoptosis, AKT/mTOR and NF-kB inactivation, and ROS-mediated DNA damage response. Our findings pave the way for a new potential treatment option for non-GCB DLBCL with the combination of oridonin and NVP-BEZ235.
Article Published Date : Jan 22, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Oridonin : CK(15) : AC(10)
Diseases : Lymphoma: B-Cell : CK(22) : AC(13)
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)
Additional Keywords : Natural Substance/Drug Synergy : CK(352) : AC(142)
