Abstract Title:

Synergistic cytotoxic action of vitamin C and vitamin K3.

Abstract Source:

Anticancer Res. 2001 Sep-Oct;21(5):3439-44. PMID: 11848506

Abstract Author(s):

W Zhang, T Negoro, K Satoh, Y Jiang, K Hashimoto, H Kikuchi, H Nishikawa, T Miyata, Y Yamamoto, K Nakano, E Yasumoto, T Nakayachi, K Mineno, T Satoh, H Sakagami

Article Affiliation:

W Zhang


We investigated the combination effect of sodium ascorbate (vitamin C) and menadione (vitamin K3) on the viability of various cultured cells. Human oral squamous cell carcinoma (HSC-2, HSC-3) and human promyelocytic leukemia (HL-60) cells were more sensitive to these vitamins as compared to normal cells (human gingival fibroblast HGF, human periodontal ligament fibroblast HPLF, human pulp cell HPC). The combination of vitamin C and vitamin K3 produced synergistic cytotoxicity against all these 6 cell lines. Treatment with vitamin C or vitamin K3, or their combination, induced internucleosomal DNA fragmentation only in HL-60 cells, but not in the oral tumor cell lines (HSC-2, HSC-3, HSG). ESR spectroscopy showed that vitamins C and K3 produce radicals under alkaline conditions and that the combination of these two vitamins synergistically enhanced their respective radical intensities.

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