Abstract Title:

Effect of sulforaphane on cell growth, G(0)/G(1) phase cell progression and apoptosis in human bladder cancer T24 cells.

Abstract Source:

Int J Oncol. 2006 Oct;29(4):883-8. PMID: 16964384

Abstract Author(s):

Yujuan Shan, Changhao Sun, Xiujuan Zhao, Kun Wu, Aedin Cassidy, Yongping Bao

Article Affiliation:

Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin 150081, P.R. China.

Abstract:

Isothiocyanates (ITCs) from cruciferous vegetables have been shown to be effective in blocking initiation as well as progression of a range of chemically-induced tumors in animal models. In this study, sulforaphane, the most extensively studied ITC, was found to suppress the growth of T24 bladder cancer cells in vitro in a dose-dependent manner. Sulforaphane inhibited the proliferation of T24 cells with IC(5)0 values 26.9 and 15.9 microM following 24 and 48 h treatments. Sulforaphane (5-20 microM) induced early apoptosis and blocked cell cycle progression at G(0)/G(1) phase which was associated with upregulation of cyclin-dependent kinase inhibitor p27 expression. These results support a role for sulforaphane as an effective agent in the chemoprevention of bladder cancer.

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