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Abstract Title:

Sulfated polysaccharide from the red algae Gelidiella acerosa: Anticoagulant, antiplatelet and antithrombotic effects.

Abstract Source:

Int J Biol Macromol. 2020 May 6. Epub 2020 May 6. PMID: 32387607

Abstract Author(s):

Francisco Diêgo da Silva Chagas, Glauber Cruz Lima, Valesca Ingrid Nobre Dos Santos, Luís Eduardo Castanheira Costa, Willer Malta de Sousa, Venícios Gonçalves Sombra, Diego Freitas de Araújo, Francisco Clark Nogueira Barros, Eliane Marinho-Soriano, Judith Pessoa de Andrade Feitosa, Regina Célia Monteiro de Paula, Maria Gonçalves Pereira, Ana Lúcia Ponte Freitas

Article Affiliation:

Francisco Diêgo da Silva Chagas

Abstract:

A sulfated polysaccharide from the red algae Gelidiella acerosa (GaSP) was obtained through enzymatic extraction and subjected to chemical characterization by HPSEC, elemental microanalysis, FT-IR and NMR spectroscopies. The GaSP anticoagulant activity was investigated through APTT and PT tests and platelet aggregation assessed by turbidimetry. The antithrombotic and hemorrhagic activities were evaluated by venous thrombosis and hemorrhagic tendency models, respectively. FT-IR and NMR demonstrated that GaSP is a sulfated agaran. HPSEC and elemental microanalysis revealed a peak molar mass of 284.8 kDa and a degree of sulfation of 0.63, respectively. This molecule prolonged the coagulation time in 2.1 times and inhibited the platelet aggregation by 45%. Furthermore, it showed significant dose-dependent antithrombotic effect of 40%, 64% and 80% at 0.1, 0.5 and 1 mg/kg, respectively, without hemorrhage. These results suggest that GaSP has promising antithrombotic.

Study Type : In Vitro Study

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