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Abstract Title:

Involvement of fat mass and obesity gene (FTO) in the anti-obesity action ofAnnonaceae: in silico and in vivo studies.

Abstract Source:

J Diabetes Metab Disord. 2020 Mar 12:1-8. Epub 2020 Mar 12. PMID: 32420297

Abstract Author(s):

Olusola Olalekan Elekofehinti, Akeem Olalekan Lawal, Oluwamodupe Cecilia Ejelonu, Olorunfemi Raphael Molehin, Courage Dele Famusiwa

Article Affiliation:

Olusola Olalekan Elekofehinti

Abstract:

Background: (Annonaceae) known as soursop is a common tropical plant species known for its numerous medicinal properties including obesity. The underlying mechanism of anti-obesity effect ofwas investigated. The fat mass and obesity associated protein (FTO) is a validated potential target for anti-obesity drugs.

Methods: The interaction of compounds previously characterized fromwas investigated against FTO using Autodock Vina. Also, modulation of FTO and STAT-3 mRNA expression bywas investigated in high fat diet induced obese rats (HFDR) using RT-PCR.

Results: A significant up-regulation of FTO gene was observed in HFDR when compared to control rats, while administration of(200 mg/kg) significantly ( < 0.05) down-regulated FTO gene expression when compared to HFDR group. The effect of obesity on STAT-3 gene expression was also reversed by(200 mg/kg). In silico study revealed annonaine and annonioside (-9.2 kcal/mol) exhibited the highest binding affinity with FTO, followed by anonaine and isolaureline (-8.6 kcal/mol). Arg-96 is a critical amino acid enhancing anonaine, isolaureline-FTO binding.

Conclusion: This study suggests the possible anti-obesity mechanism ofis via down-regulation of FTO with concomitant up-regulation of STAT-3 genes. This study confirmed the use of this plant in the management of obesity and the probable compounds responsible for its antiobesity effect are annonaine and annonioside.

Study Type : Animal Study

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