Article Publish Status: FREE
Abstract Title:

Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer.

Abstract Source:

Oncotarget. 2016 Jun 13. Epub 2016 Jun 13. PMID: 27322681

Abstract Author(s):

Ke Su, Pengchao Hu, Xiaolan Wang, Changchun Kuang, Qingmin Xiang, Fang Yang, Jin Xiang, Shan Zhu, Lei Wei, Jingwei Zhang

Article Affiliation:

Ke Su


Berberine is a plant-derived compound used in traditional Chinese medicine, which has been shown to inhibit cell proliferation and migration in breast cancer. On the other hand, vasodilator-stimulated phosphoprotein (VASP) promotes actin filament elongation and cell migration. We previously showed that VASP is overexpressed in high-motility breast cancer cells. Here we investigated whether the anti-tumorigenic effects of berberine are mediated by binding VASP in basal-like breast cancer. Our results show that berberine suppresses proliferation and migration of MDA-MB-231 cells as well as tumor growth in MDA-MB-231 nude mouse xenografts. We also show that berberine binds to VASP, inducing changes in its secondary structure and inhibits actin polymerization. Our study reveals the mechanism underlying berberine's inhibition of cell proliferation and migration in basal-like breast cancer, highlighting the use of berberine as a potential adjuvant therapeutic agent.

Study Type : Animal Study, In Vitro Study

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