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Article Publish Status: FREE
Abstract Title:

Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats.

Abstract Source:

Sci Rep. 2017 03 16 ;7:44819. Epub 2017 Mar 16. PMID: 28300221

Abstract Author(s):

Zhihong Ma, Li Chu, Hongying Liu, Weijie Wang, Jieru Li, Wenzao Yao, Jianfeng Yi, Yue Gao

Article Affiliation:

Zhihong Ma

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver diseases. This study sought to evaluate the insulin-sensitizing effect of paeoniflorin (PF) on high-fat diet-induced NAFLD and possible molecular mechanisms. Male Sprague Dawley rats were fed a high-fat diet (HFD) for 10 weeks to establish the NAFLD model, and PF (20 mg/kg/d) was gavaged to the NAFLD rats for another four weeks. Our results demonstrated that HFD resulted in hepatocellular ballooning, micro-/macrovesicular steatosis, and oxidative stress in the liver, accompanied by increased serum total cholesterol (TC), triglyceride (TG), free fatty acid (FFA), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels and homeostasis model of insulin resistance (HOMA-IR) index. PF treatment improved the biochemical and histopathological changes in NAFLD rats. Moreover, we also found that PF could inhibit lipid ectopic deposition via regulating lipid metabolism (inhibiting lipid synthesis of cholesterol and de novo pathway), and exert insulin sensitizing effect by regulating the insulin signaling pathway IRS/Akt/GSK3β and anti-oxidation. The study findings suggest that PF has therapeutic potential against NAFLD and that it actsthrough multiple signaling pathways.

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