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Abstract Title:

Stilbenes contribute to the anticancer effects ofL. through activation of apoptosis.

Abstract Source:

Oncol Lett. 2019 Mar ;17(3):2953-2959. Epub 2019 Jan 14. PMID: 30854073

Abstract Author(s):

Tuy An Trinh, Dahae Lee, Seonju Park, Seung Hyun Kim, Jae Gyu Park, Ji Hwan Kim, Ki Sung Kang

Article Affiliation:

Tuy An Trinh

Abstract:

L. () is a medicinal plant used for the treatment of inflammatory diseases in East Asian countries. Numerous stilbenes isolated fromhave been revealed to possess anticancer effects. The aim of the present study was to evaluate the effect of extracts and compounds isolated fromon human gastric cancer cell viability and to elucidate their molecular mechanism of action on the apoptosis pathway. The results demonstrated that aloe-emodin and chrysophanol 1-O-β-D-glucopyranoside, isolated from the methanolic extract of dried rhizomes of, exhibited anti-proliferative effects on the human gastric carcinoma cell line AGS, with ICvalues of 84.66±0.44 and 68.28±0.29 µM, respectively. The percentage of apoptotic cells increased significantly following treatment with each compound at a concentration of 100 µM, compared with that in the non-treated group in the image-based cytometry assay. Western blot analysis revealed that these compounds activated the caspase cascade and inhibited B-cell lymphoma-2, an anti-apoptotic protein.

Study Type : In Vitro Study

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