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Article Publish Status: FREE
Abstract Title:

Specificity of Biogenic Selenium Nanoparticles for Prostate Cancer Therapy With Reduced Risk of Toxicity: AnandStudy.

Abstract Source:

Front Oncol. 2019 ;9:1541. Epub 2020 Jan 17. PMID: 32010628

Abstract Author(s):

Praveen Sonkusre

Article Affiliation:

Praveen Sonkusre

Abstract:

Selenium deficiency is associated with many physiological disorders including the high risk of cancer. The rehabilitation of selenium with different selenium supplements, however, fails due to their low therapeutic index. Therefore, it is advantageous to have a less toxic form of selenium for supplementation with potentially high anticancer activity. Here we showderived biogenic selenium nanoparticles at a minimal concentration of 2μg Se/ml induce necroptosis in LNCaP-FGC cells, without affecting the RBC integrity. Real-time gene expression analysis indicated the overexpression of tumor necrotic factor () and interferon regulatory factor () and decreased expression of androgen receptor () and prostate-specific antigen (). Furthermore, histopathological analysis showed the subsequent oral administrations of 10 times higher concentration of these endotoxin free selenium nanoparticles in C3H/HeJ mice (50 mg Se/kg of body weight), induce significantly lower toxicity compared to the L-selenomethionine (5 mg Se/kg). Our study suggested that the biogenic SeNP could emerge as the safest form of selenium supplementation with potent anticancer activity.

Study Type : Animal Study, In Vitro Study
Additional Links
Pharmacological Actions : Chemotherapeutic : CK(397) : AC(152)

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