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Abstract Title:

Selenium affects the activity of black tea in preventing metabolic syndrome in high fat diet-fed Sprague-Dawley rats.

Abstract Source:

J Sci Food Agric. 2019 Sep 12. Epub 2019 Sep 12. PMID: 31512247

Abstract Author(s):

Ying Gao, Yongquan Xu, Jianyun Ruan, Junfeng Yin

Article Affiliation:

Ying Gao

Abstract:

BACKGROUND: Metabolic syndrome, a group of factors that increase the risk of health problems, is becoming increasingly common. Strategies to prevent metabolic syndrome have received substantial attention. Black tea consumption and selenium (Se) intake have been reported to be negatively associated with the prevalence of metabolic syndrome. Therefore, we sought to investigate whether Se-rich black tea might have a stronger effect than Se-deficient black tea in the prevention of metabolic syndrome.

RESULTS: Sprague-Dawley rats were divided into four groups and fed a normal rodent diet, high fat diet, high fat diet containing 3% Se-rich black tea or high fat diet containing 3% Se-deficient black tea for 4 weeks. Blood and tissue samples were tested at the end of the experiment. The results suggested that both types of black tea ameliorated high fat diet-induced body weight gain, lowered serum triglycerides and attenuated intestinal barrier dysfunction. Se-rich black tea showed stronger activity indecreasing fasting serum glucose and increasing insulin sensitivity, as well as stronger hepatoprotection, owing to higher total antioxidant capacity and activated hepatic antioxidant enzymes. However, it did not exhibit better effects in preventing fat accumulation. The different effects of Se-rich and Se-deficient black tea on the gut microbiota might have been partially responsible for the results.

CONCLUSION: Compared with Se-deficient black tea, Se-rich black tea displayed stronger activity in preventing high fat diet-induced hyperglycemia and liver damage but was not better at preventing fat accumulation and attenuating dysbiosis. More experiments are needed to further understand the underlying mechanisms. This article is protected by copyright. All rights reserved.

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