Schisandra sphaerandra contains a compound which inhibits HIV-1 reverse transcriptase. - GreenMedInfo Summary
Abstract Title:
Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase.
Abstract Source:
J Nat Prod. 1996 May;59(5):525-7. PMID: 8778243
Article Affiliation:
Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, People's Republic of China.
Abstract:
An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV reverse transcriptase and polymerase assays.
Article Published Date : May 01, 1996
Study Type : In Vitro Study
Additional Links
Substances : Schisandra : CK(139) : AC(46)
Diseases : HIV Infections : CK(849) : AC(260)
Pharmacological Actions : Reverse Transcriptase Inhibitors : CK(42) : AC(24)
