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Article Publish Status: FREE
Abstract Title:

SARS-CoV-2 seroprevalence among parturient women in Philadelphia.

Abstract Source:

Sci Immunol. 2020 07 29 ;5(49). PMID: 32727884

Abstract Author(s):

Dustin D Flannery, Sigrid Gouma, Miren B Dhudasia, Sagori Mukhopadhyay, Madeline R Pfeifer, Emily C Woodford, Jeffrey S Gerber, Claudia P Arevalo, Marcus J Bolton, Madison E Weirick, Eileen C Goodwin, Elizabeth M Anderson, Allison R Greenplate, Justin Kim, Nicholas Han, Ajinkya Pattekar, Jeanette Dougherty, Oliva Kuthuru, Divij Mathew, Amy E Baxter, Laura A Vella, JoEllen Weaver, Anurag Verma, Rita Leite, Jeffrey S Morris, Daniel J Rader, Michal A Elovitz, E John Wherry, Karen M Puopolo, Scott E Hensley

Article Affiliation:

Dustin D Flannery

Abstract:

Limited data are available for pregnant women affected by SARS-CoV-2. Serological tests are critically important for determining SARS-CoV-2 exposures within both individuals and populations. We validated a SARS-CoV-2 spike receptor binding domain serological test using 834 pre-pandemic samples and 31 samples from COVID-19 recovered donors. We then completed SARS-CoV-2 serological testing of 1,293 parturient women at two centers in Philadelphia from April 4 to June 3, 2020. We found 80/1,293 (6.2%) of parturient women possessed IgG and/or IgM SARS-CoV-2-specific antibodies. We found race/ethnicity differences in seroprevalence rates, with higher rates in Black/non-Hispanic and Hispanic/Latino women. Of the 72 seropositive women who also received nasopharyngeal polymerase chain reaction testing during pregnancy, 46 (64%) were positive. Continued serologic surveillance among pregnant women may inform perinatal clinical practices and can potentially be used to estimate exposure to SARS-CoV-2 within the community.

Study Type : Human Study
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