Abstract Title:

Rosa Mosqueta Oil Prevents Oxidative Stress and Inflammation through the Upregulation of PPAR-α and NRF2 in C57BL/6J Mice Fed a High-Fat Diet.

Abstract Source:

J Nutr. 2017 04 ;147(4):579-588. Epub 2017 Mar 15. PMID: 28298541

Abstract Author(s):

Daniel González-Mañán, Amanda D'Espessailles, Camila G Dossi, Marcela San Martín, Rodrigo A Mancilla, Gladys S Tapia

Article Affiliation:

Daniel González-Mañán


Rosa mosqueta (RM) oil is characterized by high concentrations of antioxidants andα-linolenic acid (ALA; 18:3n-3). We have previously demonstrated in male C57BL/6J mice that RM decreases hepatic steatosis, a condition strongly associated with oxidative stress and inflammation.We studied the molecular mechanisms that underlie the role of RM in preventing high-fat diet (HFD)-induced oxidative stress and inflammation.Male C57BL/6J mice aged 28 d and weighing 12-14 g were divided into the following groups and fed for 12 wk: control diet (CD; 10% fat, 20% protein, and 70% carbohydrates); CD + RM (1.94 mg ALA⋅ g body weight⋅ dadministered by oral gavage); HFD (60% fat, 20% protein, and 20% carbohydrates); and HFD + RM. General parameters (body weight, visceral fat, and histology); glucose metabolism [homeostasis model assessment and blood glucose area under the curve (AUC)]; oxidative stress [hepatic nuclear factor (erythroid-derived 2)-like-2 (NRF2) and heme oxygenase 1 (HO-1) concentrations]; and inflammation [hepatic peroxisome proliferator-activated receptorα (PPAR-α) and acyl-coenzyme A oxidase 1 (ACOX1) concentrations, blood tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) concentrations, andandmRNA expression in liver and visceral adipose tissue] were evaluated.In the HFD + RM mice, the final body weight (24.8± 1.1 g) was 19% lower than in the HFD mice (30.6 ± 2.8 g) (<0.05). Visceral fat was 34% lower in the HFD + RM mice than in the HFD mice (<0.05). The blood glucose AUC was 29% lower andandexpression levels were 47% and 59% lower, respectively, in the HFD + RM mice than in the HFD mice (<0.05). HFD + RM mice had 40% less hepatic steatosis (<0.05) and lower upregulation of PPAR-α (33%), ACOX1 (50%), NRF2 (39%), and HO-1 (68%) protein concentrations than did the HFD mice (<0.05).Our findings suggest that RM supplementation prevents the obese phenotype observed in HFD-fed mice by downregulating inflammatory cytokine expression and secretion and stimulating hepatic antioxidant and fatty acid oxidation markers.

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